Article ; Online: In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19.
Advances in protein chemistry and structural biology
2023 Volume 138, Page(s) 233–255
Abstract: Immunosenescence is a pertinent factor in the mortality rate caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The changes in the immune system are strongly associated with age and provoke the deterioration of the individual's ... ...
Abstract | Immunosenescence is a pertinent factor in the mortality rate caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The changes in the immune system are strongly associated with age and provoke the deterioration of the individual's health. Traditional medical practices in ancient India effectively deal with COVID-19 by boosting natural immunity through medicinal plants. The anti-inflammatory and antiviral properties of Glycyrrhiza glabra are potent in fighting against COVID-19 and promote immunity boost against the severity of the infection. Athimadhura Chooranam, a polyherbal formulation containing Glycyrrhiza glabra as the main ingredient, is recommended as an antiviral Siddha herb by the Ministry of AYUSH. This paper is intended to identify the phytoconstituents of Glycyrrhiza glabra that are actively involved in preventing individuals from COVID-19 transmission. The modulated pathways, enrichment study, and drug-likeness are calculated from the target proteins of the phytoconstituents at the pharmacological activity (Pa) of more than 0.7. Liquiritigenin and Isoliquiritin, the natural compounds in Glycyrrhiza glabra, belong to the flavonoid class and exhibit ameliorative effects against COVID-19. The latter compound displays a higher protein interaction to a maximum of six, out of which HMOX1, PLAU, and PGR are top-hub genes. ADMET screening further confirms the significance of the abovementioned components containing better drug-likeness. The molecular docking and molecular dynamics method identified liquiritigenin as a possible lead molecule capable of inhibiting the activity of the major protease protein of SARS-CoV-2. The findings emphasize the importance of in silico network pharmacological assessments in delivering cost-effective, time-bound clinical drugs. |
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MeSH term(s) | Humans ; Plants, Medicinal ; Network Pharmacology ; Molecular Docking Simulation ; COVID-19 ; SARS-CoV-2 ; Glycyrrhiza/chemistry ; Glycyrrhiza/genetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use |
Chemical Substances | Antiviral Agents ; Phytochemicals |
Language | English |
Publishing date | 2023-06-17 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 2473077-4 |
ISSN | 1876-1631 ; 1876-1623 |
ISSN (online) | 1876-1631 |
ISSN | 1876-1623 |
DOI | 10.1016/bs.apcsb.2023.04.003 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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