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  1. Article ; Online: Probiotics in the management of gastrointestinal disease: analysis of the attitudes and prescribing practices of gastroenterologists and surgeons.

    Cordina, Claire / Shaikh, Irshad / Shrestha, Sussie / Camilleri-Brennan, John

    Journal of digestive diseases

    2011  Volume 12, Issue 6, Page(s) 489–496

    Abstract: Objective: Probiotics are increasingly advocated in the management of various gastrointestinal disorders. The aim of this study was to investigate the current attitudes and prescribing practices of surgeons and gastroenterologists for probiotics in the ... ...

    Abstract Objective: Probiotics are increasingly advocated in the management of various gastrointestinal disorders. The aim of this study was to investigate the current attitudes and prescribing practices of surgeons and gastroenterologists for probiotics in the treatment of gastrointestinal disorders.
    Methods: A questionnaire was designed to look at the frequency of probiotic prescribing, types of probiotics used, indications for and duration of treatment and clinicians' experiences with probiotic use. A total of 220 questionnaires were mailed to consultant gastroenterologists and surgeons practicing in the UK.
    Results: The overall response rate was 80.5%, of which 69.5% of respondents said they recommended or prescribed probiotic food supplements to their patients, including 53.4% of surgeons and 80.8% of gastroenterologists (P = 0.00013). The most popular probiotic supplements among surgeons were probiotic-containing yoghurt and drinks (79.5% and 71.8%, respectively), whereas VSL#3 was more popular with gastroenterologists (83.3%). The most popular indications were irritable bowel syndrome (70.7% of prescribers) and pouchitis (67.5% of prescribers). Many respondents prescribed long-term probiotics. Most consultants had been prescribing probiotics for a period of 1 to 5 years.
    Conclusion: Probiotics are popular among gastroenterologists and surgeons in the UK for the treatment of gastrointestinal disorders. Further evidence to support their routine use, by way of large, well-designed randomized controlled trials, is necessary.
    MeSH term(s) Attitude of Health Personnel ; Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy ; Data Collection ; Diarrhea/drug therapy ; Disease Management ; Gastrointestinal Diseases/drug therapy ; Humans ; Physicians/psychology ; Physicians/statistics & numerical data ; Practice Patterns, Physicians'/statistics & numerical data ; Practice Patterns, Physicians'/trends ; Probiotics/therapeutic use ; Surveys and Questionnaires ; Time Factors ; United Kingdom
    Language English
    Publishing date 2011-12
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2317117-0
    ISSN 1751-2980 ; 1751-2972
    ISSN (online) 1751-2980
    ISSN 1751-2972
    DOI 10.1111/j.1751-2980.2011.00534.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Logistical Factors Influencing Cold Ischemia Times in Deceased Donor Kidney Transplants.

    Shrestha, Sussie / Bradbury, Lisa / Boal, Matthew / Blackmur, James P / Watson, Christopher J E / Taylor, Craig J / Forsythe, John L R / Johnson, Rachel / Marson, Lorna P

    Transplantation

    2016  Volume 100, Issue 2, Page(s) 422–428

    Abstract: Background: Prolonged cold ischemia time (CIT) is associated with a significant risk of short- and long-term graft failure in deceased donor kidney transplants across the world. The aim of this prospective longitudinal study was to determine the ... ...

    Abstract Background: Prolonged cold ischemia time (CIT) is associated with a significant risk of short- and long-term graft failure in deceased donor kidney transplants across the world. The aim of this prospective longitudinal study was to determine the importance of logistical factors on CIT.
    Method: Data on 1763 transplants were collected prospectively over 14 months from personnel in 16 transplant centers, 19 histocompatibility and immunogenetics laboratories, transport providers, and National Health Service Blood and Transplant.
    Results: The overall mean CIT was 13.8 hours, with significant center variation (P < 0.0001). Factors that significantly reduced CIT were donation after circulatory death (P = 0.03), shorter transport time (P = 0.0002), use of virtual crossmatch (XM) (P < 0.0001), and use of donor blood for pretransplant XM (P < 0.0001). The CIT for transplants that went ahead with a virtual XM was 3 hours shorter than those requiring a pretransplant XM (P < 0.0001). There was a mean delay of 3 hours in starting transplants despite organ, recipient, and pretransplant XM result being ready, suggesting that theater access contributes significantly to increased CIT.
    Discussion: This study identifies logistical factors relating to donor, transport, crossmatching, recipient, and theater that impact significantly on CIT in deceased donor renal transplantation, some of which are modifiable; attention should be focussed on addressing all of these.
    MeSH term(s) Cold Ischemia/adverse effects ; Cold Ischemia/methods ; Delayed Graft Function/etiology ; Histocompatibility Testing ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Longitudinal Studies ; Multivariate Analysis ; Operating Rooms/organization & administration ; Patient Care Team/organization & administration ; Personnel Staffing and Scheduling/organization & administration ; Prospective Studies ; Risk Factors ; Time Factors ; Transportation ; Treatment Outcome ; United Kingdom ; Workflow
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000000844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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