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Article ; Online: A Systemic Functional Study of the System of Modality in Chinese

Shu Yang

SAGE Open, Vol

2021 Volume 11

Abstract: In previous systemic functional studies of modality in Chinese, the systems of types and degrees of modality have been discussed; however, the system that characterizes the realization of types and degrees of modality has been largely neglected, and ... ...

Abstract	In previous systemic functional studies of modality in Chinese, the systems of types and degrees of modality have been discussed; however, the system that characterizes the realization of types and degrees of modality has been largely neglected, and realizations of modality have not been systematically explored. This paper explores the system of MODALITY in Chinese and realizations derived from the system from the perspective of Systemic Functional Linguistics. In this study, the systems of types and values of modality in Chinese are re-examined. The system of types of modality excludes usuality, since it distinguishes itself from modalization and modulation essentially. The system of values of modality is treated as a cline. More importantly, the study gives a systematic and comprehensive description of the system of MANIFESTATIONS that describes the realization of modality, which distinguishes among explicitly subjective, explicitly objective, and implicitly subjective realizations of modality. The present study is the first attempt to systematically and critically examine the systems of types, values, and realizations of modality in Chinese. It may contribute to a better understanding of modality in the particular language of Chinese, and may lend support to system-based typology, supplementing structure-based typology.
Keywords	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online ; Thesis: The role of IKK/Nemo/NF-κB Signaling in Microglia Homeostasis and Polarization

Shu, Yang [Verfasser]

2022

Author's details	Yang Shu
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universität Ulm
Publishing place	Ulm
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Glycemic load, but not glycemic index, is associated with an increased risk of ovarian cancer: A systematic review and meta-analysis.

Zhu, Lin / Shu, Yang / Ran, Jing / Zhang, Chunxia

Nutrition research (New York, N.Y.)

2024 Volume 123, Page(s) 67–79

Abstract: The association between glycemic index (GI),glycemic load (GL) and ovarian cancer risk remains unclear. Carbohydrate intake promotes insulin secretion, leading to cell proliferation and invasion. We hypothesized that high GI and GL intake may increase ... ...

Abstract	The association between glycemic index (GI),glycemic load (GL) and ovarian cancer risk remains unclear. Carbohydrate intake promotes insulin secretion, leading to cell proliferation and invasion. We hypothesized that high GI and GL intake may increase ovarian cancer risk. Therefore, we conducted a meta-analysis after systematically searching PubMed, Embase, Web of Science, and Cochrane Library from inception to December 2022. Fixed- or random-effect models calculated the pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs). Subgroup, sensitivity, publication bias analysis, and dose-response analysis were performed. Nine original studies were included, involving 4716 cases and 119,960 controls. No significant association was observed between GI or GL and ovarian cancer risk (GI: RR = 1.02 [95% CI, 0.83-1.26]; GL: RR = 1.11 [95% CI, 0.84-1.47]). Subgroup analysis suggested the results were not significantly modified by any group. Sensitivity analysis identified the sources of heterogeneity. No publication bias was observed. A linear positive dose-response relationship was observed between dietary GL and ovarian cancer risk after removing heterogeneous sources (RR = 1.11 [95% CI, 1.05-1.17], I
MeSH term(s)	Humans ; Female ; Glycemic Index ; Blood Glucose ; Risk Factors ; Glycemic Load ; Diet ; Ovarian Neoplasms/etiology ; Dietary Carbohydrates
Chemical Substances	Blood Glucose ; Dietary Carbohydrates
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	582432-1
ISSN	1879-0739 ; 0271-5317
ISSN (online)	1879-0739
ISSN	0271-5317
DOI	10.1016/j.nutres.2024.01.003
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Article ; Online: Intelligent Segment Routing

Shu Yang / Ruiyu Chen / Laizhong Cui / Xiaolei Chang

Big Data Mining and Analytics, Vol 6, Iss 1, Pp 55-

Toward Load Balancing with Limited Control Overheads

2023 Volume 71

Abstract: Segment routing has been a novel architecture for traffic engineering in recent years. However, segment routing brings control overheads, i.e., additional packets headers should be inserted. The overheads can greatly reduce the forwarding efficiency for ... ...

Abstract	Segment routing has been a novel architecture for traffic engineering in recent years. However, segment routing brings control overheads, i.e., additional packets headers should be inserted. The overheads can greatly reduce the forwarding efficiency for a large network, when segment headers become too long. To achieve the best of two targets, we propose the intelligent routing scheme for traffic engineering (IRTE), which can achieve load balancing with limited control overheads. To achieve optimal performance, we first formulate the problem as a mapping problem that maps different flows to key diversion points. Second, we prove the problem is nondeterministic polynomial (NP)-hard by reducing it to a k-dense subgraph problem. To solve this problem, we develop an ant colony optimization algorithm as improved ant colony optimization (IACO), which is widely used in network optimization problems. We also design the load balancing algorithm with diversion routing (LBA-DR), and analyze its theoretical performance. Finally, we evaluate the IRTE in different real-world topologies, and the results show that the IRTE outperforms traditional algorithms, e.g., the maximum bandwidth is 24.6% lower than that of traditional algorithms when evaluating on BellCanada topology.
Keywords	traffic engineering ; segment routing ; bandwidth load balancing ; ant colony optimization ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	000
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Tsinghua University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: What contributes to the government-citizen knowledge sharing

Huajun Sun / Liping Fu / Shu Yang

Journal of Innovation & Knowledge, Vol 8, Iss 2, Pp 100362- (2023)

Analysis of 293 cities in China

2023

Abstract: Advocacy for knowledge sharing (KS) is increasing as it can improve novelty and agility in policy development and service delivery. To determine the combination of factors that best contributes to high-quality government–citizen KS, this study adopts ... ...

Abstract	Advocacy for knowledge sharing (KS) is increasing as it can improve novelty and agility in policy development and service delivery. To determine the combination of factors that best contributes to high-quality government–citizen KS, this study adopts necessary condition analysis (NCA) and a fuzzy-set qualitative comparative analysis (fsQCA). Three primary findings are supported. Cities with higher economic development achieve superior KS by enhancing citizens’ motivation to participate; traditional cities that are in transition succeed in KS by leveraging the established strength of the local government; in contrast, less developed cities succeed in KS based on central government guidance. These findings highlight the significance of comparing multi-factor configurations across scenarios. They can be utilised to discover suitable solutions for government–citizen KS in different cities.
Keywords	Knowledge sharing ; Government–citizens ; Fuzzy-set qualitative comparative analysis’ necessary condition analysis ; History of scholarship and learning. The humanities ; AZ20-999 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications.

Zhang, Chunlan / Qin, Yun / Wu, Yu / Xu, Heng / Shu, Yang

Chinese medical journal

2024 Volume 137, Issue 10, Page(s) 1151–1159

Abstract: Abstract: Metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, ... ...

Abstract	Abstract: Metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, drug resistance, and treatment outcome in solid cancers. Recently, a series of studies has highlighted its potential role in hematological malignancies in terms of these events. Similar to solid cancers, MALAT1 can regulate various target genes via sponging and epigenetic mechanisms, but the miRNAs sponged by MALAT1 differ from those identified in solid cancers. In this review, we systematically describe the role and underlying mechanisms of MALAT1 in multiple types of hematological malignancies, including regulation of cell proliferation, metastasis, stress response, and glycolysis. Clinically, MALAT1 expression is related to poor treatment outcome and drug resistance, therefore exhibiting potential prognostic value in multiple myeloma, lymphoma, and leukemia. Finally, we discuss the evaluation of MALAT1 as a novel therapeutic target against cancer in preclinical studies.
MeSH term(s)	RNA, Long Noncoding/genetics ; Humans ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/metabolism ; Cell Proliferation/genetics ; MicroRNAs/genetics
Chemical Substances	MALAT1 long non-coding RNA, human
Language	English
Publishing date	2024-04-01
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000003090
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Article ; Online: The Impact of Corporate Social Responsibility Practices on Customer Value Co-Creation and Perception in the Digital Context

Shu Yang / Yidan Huang / Hsin-Yi Chan / Cheng-Hsueh Yang

Sustainability, Vol 15, Iss 8567, p

A Case Study of Taiwan Bank Industry

2023 Volume 8567

Abstract: The rapid development of digitalization has introduced greater variability and trust-related risks to the banking industry. Enhancing customers’ perception of value co-creation with banks is a critical issue that requires attention. This study aims to ... ...

Abstract	The rapid development of digitalization has introduced greater variability and trust-related risks to the banking industry. Enhancing customers’ perception of value co-creation with banks is a critical issue that requires attention. This study aims to explore the impact and mechanism of a bank’s social responsibility practices on its customers’ value co-creation in the digital context. A cross-level analysis model was developed and analyzed based on in-depth surveys of 30 bank managers and 262 valid customers. The results reveal that (1) CSR practices have no impact on customer value co-creation in the digital context; (2) CSR practices have a positive impact on customers’ perception of a company’s social responsibility; (3) customers’ perception of a company’s social responsibility has a positive impact on customer value co-creation; and (4) customers’ perception plays a mediating role between CSR practices and customer value co-creation. Although corporate social responsibility is becoming increasingly important in the current digital economy, our study found that it does not necessarily lead to more customer value co-creation. Banks must enable customers to perceive their CSR practices in order to foster value co-creation. This study has important implications for banking practitioners seeking to strengthen their social responsibility practices and create value with their customers in the digital era.
Keywords	digitization ; corporate social responsibility practices ; customer perception ; value co-creation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LC-MS/MS-Based Serum Metabolomics and Transcriptome Analyses for the Mechanism of Augmented Renal Clearance

Yidan Wang / Yifan Luo / Shu Yang / Mingyan Jiang / Yang Chu

International Journal of Molecular Sciences, Vol 24, Iss 10459, p

2023 Volume 10459

Abstract: Augmented Renal Clearance (ARC) refers to the increased renal clearance of circulating solute in critically ill patients. In this study, the analytical research method of transcriptomics combined with metabolomics was used to study the pathogenesis of ... ...

Abstract	Augmented Renal Clearance (ARC) refers to the increased renal clearance of circulating solute in critically ill patients. In this study, the analytical research method of transcriptomics combined with metabolomics was used to study the pathogenesis of ARC at the transcriptional and metabolic levels. In transcriptomics, 534 samples from 5 datasets in the Gene Expression Omnibus database were analyzed and 834 differential genes associated with ARC were obtained. In metabolomics, we used Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry to determine the non-targeted metabolites of 102 samples after matching propensity scores, and obtained 45 differential metabolites associated with ARC. The results of the combined analysis showed that purine metabolism, arginine biosynthesis, and arachidonic acid metabolism were changed in patients with ARC. We speculate that the occurrence of ARC may be related to the alteration of renal blood perfusion by LTB4R, ARG1, ALOX5, arginine and prostaglandins E2 through inflammatory response, as well as the effects of CA4 , PFKFB2 , PFKFB3 , PRKACB , NMDAR, glutamate and cAMP on renal capillary wall permeability.
Keywords	augmented renal clearance ; metabolomics ; transcriptome ; vancomycin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A fluorescent probe for imaging nitroreductase with signal amplification in high-viscosity environments.

Liu, Yunfan / Li, Jiaying / Huang, Hongjin / Shu, Yang

Journal of materials chemistry. B

2023 Volume 11, Issue 39, Page(s) 9509–9515

Abstract: Herein, we developed a fluorescent probe ENBT ... ...

Abstract	Herein, we developed a fluorescent probe ENBT for
MeSH term(s)	Fluorescent Dyes/pharmacology ; Viscosity ; Cell Line, Tumor ; Microscopy, Fluorescence ; Nitroreductases
Chemical Substances	Fluorescent Dyes ; Nitroreductases (EC 1.7.-)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb01760e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bibliometrics and visual analysis of metformin and gut microbiota from 2012 to 2022: A systematic review.

Shu, Yang / Li, Weidong / Hu, Qiongying / Xiong, Daqian

Medicine

2023 Volume 102, Issue 50, Page(s) e36478

Abstract: Background: Metformin is an old drug used for the treatment of type 2 diabetes mellitus and can play a variety of roles by regulating the gut microbiota. The number of research articles on metformin in the gut microbiota has increased annually; however, ...

Abstract	Background: Metformin is an old drug used for the treatment of type 2 diabetes mellitus and can play a variety of roles by regulating the gut microbiota. The number of research articles on metformin in the gut microbiota has increased annually; however, no bibliometric tools have been used to analyze the research status and hot trends in this field. This study presents a bibliometric analysis of publications on metformin and gut microbiota. Methods: We searched the Web of Science core collection database on June 8, 2023, for papers related to metformin and gut microbiota from 2012 to 2022. We used Microsoft Excel 2021, VOSviewer1.6.19, CiteSpace 6.2.4, and R software package "bibliometrix" 4.0.0 to analyze the countries, institutions, authors, journals, citations, and keywords of the included publications. Results: We included 517 papers, and the trend in publications increased over the last 11 years. The 517 articles were from 57 countries, including 991 institutions and 3316 authors, and were published in 259 journals. China led all countries (233 papers) and the most influential institution was the Chinese Academy of Sciences (16 papers). PLOS ONE (19 papers) was the most popular journal, and Nature (1598 citations) was the most cited journal. Li and Kim were the 2 most published authors (six papers each), and Cani (272 co-citations) was the most co-cited author. "Metabolites," "aging," and "intestinal barrier" were emerging topics in this field. Conclusions: This bibliometric study comprehensively summarizes the research trends and progress of metformin and gut microbiota, and provides new research topics and trends for studying the effects of metformin on gut microbiota in different diseases.
MeSH term(s)	Humans ; Metformin/therapeutic use ; Gastrointestinal Microbiome ; Diabetes Mellitus, Type 2 ; Academies and Institutes ; Bibliometrics
Chemical Substances	Metformin (9100L32L2N)
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036478
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