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  1. AU="Shu-Ying Li"
  2. AU="Umemura, Yutaka"
  3. AU=Eiring A M
  4. AU="Eunhee Ha"
  5. AU="Espíndola, Otávio M"
  6. AU=Shahbazian Heshmatollah
  7. AU="Esmaeel Panahi kokhdan"
  8. AU=Peekhaus N
  9. AU="Ferrari-Toniolo, Simone"
  10. AU="Oleg M. Mikhailenok"

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  1. Artikel ; Online: Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions

    Zi-Wen Zhou / Xue-Yan Zhu / Shu-Ying Li / Si-En Lin / Yu-Han Zhu / Kunmei Ji / Jia-Jie Chen

    Molecules, Vol 28, Iss 5271, p

    2023  Band 5271

    Abstract: Formononetin (FNT) is a plant-derived isoflavone natural product with anti-inflammatory, antioxidant, and anti-allergic properties. We showed previously that FNT inhibits immunoglobulin E (IgE)-dependent mast cell (MC) activation, but the effect of FNT ... ...

    Abstract Formononetin (FNT) is a plant-derived isoflavone natural product with anti-inflammatory, antioxidant, and anti-allergic properties. We showed previously that FNT inhibits immunoglobulin E (IgE)-dependent mast cell (MC) activation, but the effect of FNT on IgE-independent MC activation is yet unknown. Our aim was to investigate the effects and possible mechanisms of action of FNT on IgE-independent MC activation and pseudoallergic inflammation. We studied the effects of FNT on MC degranulation in vitro with a cell culture model using compound C48/80 to stimulate either mouse bone marrow-derived mast cells (BMMCs) or RBL-2H3 cells. We subsequently measured β-hexosaminase and histamine release, the expression of inflammatory factors, cell morphological changes, and changes in NF-κB signaling. We also studied the effects of FNT in several in vivo murine models of allergic reaction: C48/80-mediated passive cutaneous anaphylaxis (PCA), active systemic anaphylaxis (ASA), and 2,4-dinitrobenzene (DNCB)-induced atopic dermatitis (AD). The results showed that FNT inhibited IgE-independent degranulation of MCs, evaluated by a decrease in the release of β-hexosaminase and histamine and a decreased expression of inflammatory factors. Additionally, FNT reduced cytomorphological elongation and F-actin reorganization and attenuated NF-κB p65 phosphorylation and NF-κB-dependent promoter activity. Moreover, the administration of FNT alleviated pseudoallergic responses in vivo in mouse models of C48/80-stimulated PCA and ASA, and DNCB-induced AD. In conclusion, we suggest that FNT may be a novel anti-allergic drug with great potential to alleviate pseudoallergic responses via the inhibition of IgE-independent MC degranulation and NF-κB signaling.
    Schlagwörter formononetin ; mast cell ; non-IgE ; compound 48/80 ; pseudoallergic reaction ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Initial rapid and proactive response for the COVID-19 outbreak — Taiwan's experience

    Hao-Yuan Cheng / Shu-Ying Li / Chin-Hui Yang

    Journal of the Formosan Medical Association, Vol 119, Iss 4, Pp 771-

    2020  Band 773

    Schlagwörter Medicine (General) ; R5-920 ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Safety practices and appropriate infection prevention mitigate potential staffing shortage

    Hao-Yuan Cheng / Shu-Ying Li / Chin-Hui Yang

    Journal of the Formosan Medical Association, Vol 119, Iss 9, Pp 1452-

    2020  Band 1453

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Global transmission of multiple-drug resistant Neisseria gonorrhoeae strains refractive to cephalosporin treatment

    Shu-Ying Li

    Journal of the Formosan Medical Association, Vol 111, Iss 9, Pp 463-

    2012  Band 464

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2012-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Antimicrobial activity and comparative metabolomic analysis of Priestia megaterium strains derived from potato and dendrobium

    Jia-Meng Liu / Yan-Tian Liang / Shan-Shan Wang / Nuo Jin / Jing Sun / Cong Lu / Yu-Feng Sun / Shu-Ying Li / Bei Fan / Feng-Zhong Wang

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 11

    Abstract: Abstract The growth of endophytic bacteria is influenced by the host plants and their secondary metabolites and activities. In this study, P. megaterium P-NA14 and P. megaterium D-HT207 were isolated from potato tuber and dendrobium stem respectively. ... ...

    Abstract Abstract The growth of endophytic bacteria is influenced by the host plants and their secondary metabolites and activities. In this study, P. megaterium P-NA14 and P. megaterium D-HT207 were isolated from potato tuber and dendrobium stem respectively. They were both identified as Priestia megaterium. The antimicrobial activities and metabolites of both strains were explored. For antimicrobial activities, results showed that P. megaterium P-NA14 exhibited a stronger inhibition effect on the pathogen of dendrobium, while P. megaterium D-HT207 exhibited a stronger inhibition effect on the pathogen of potato. The supernatant of P. megaterium P-NA14 showed an inhibition effect only on Staphylococcus aureus, while the sediment of P. megaterium D-HT207 showed an inhibition effect only on Escherichia coli. For metabolomic analysis, the content of L-phenylalanine in P. megaterium P-NA14 was higher than that of P. megaterium D-HT207, and several key downstream metabolites of L-phenylalanine were associated with inhibition of S. aureus including tyrosine, capsaicin, etc. Therefore, we speculated that the different antimicrobial activities between P. megaterium P-NA14 and P. megaterium D-HT207 were possibly related to the content of L-phenylalanine and its metabolites. This study preliminarily explored why the same strains isolated from different hosts exhibit different activities from the perspective of metabolomics.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: High-throughput sequencing–based analysis of the intestinal microbiota of broiler chickens fed with compound small peptides of Chinese medicine

    YuQing Cui / Chao Han / ShuYing Li / YuMeng Geng / YuanYuan Wei / WanYu Shi / YongZhan Bao

    Poultry Science, Vol 100, Iss 3, Pp 100897- (2021)

    2021  

    Abstract: The objective of this study was to determine the effects of compound small peptides of Chinese medicine (CSPCM) on the intestinal microbiota of broilers. A total of thirty-six 1-day-old Arbor Acres broilers were assigned to 6 dietary treatments that ... ...

    Abstract The objective of this study was to determine the effects of compound small peptides of Chinese medicine (CSPCM) on the intestinal microbiota of broilers. A total of thirty-six 1-day-old Arbor Acres broilers were assigned to 6 dietary treatments that include 250, 500, and 750 g/T of CSPCM in feed, 100 g/T of Bacillus subtilis and Clostridium butyricum in feed, and 100 g/T of 50,000 IU xylanase in feed. Each treatment had 2 replicates with 2 cages (3 birds per cage). The jejunal digesta samples were collected from chickens at 42 d. Operational taxonomic unit analysis showed that adding CSPCM at a concentration of 750 g/T of feed can increase the number of operational taxonomic unit samples than other groups. Compared with the control group, adding 250 g/T of CSPCM of feed can improve content of Lactobacillus, Cupriavidus, Ochrobactrum, Candidatus_Arthromitus, Acinetobacter, and Sphingomonas. Adding 500 g/T of CSPCM in feed resulted in varying degrees of improvement in Candidatus_Arthromitus, Acinetobacter, and Sphingomonas. Adding 750 g/T of CSPCM in feed can increase the content of Lactobacillus and Candidatus_Arthromitus. In PICRUSt function prediction analysis, CSPCM acts on the body by creating an environment suitable for the growth of beneficial bacteria. Adding 250 g/T of CSPCM in feed can improve amino acid metabolism, endocrine system function, membrane transport, and cell mobility function. Adding 500 g/T of CSPCM in feed can improve replication and repair and membrane transport function. Adding 750 g/T of CSPCM in feed can increase carbohydrate metabolism, replication and repair, and membrane transport function. Adding B. subtilis and C. butyricum in feed increased replication and repair and membrane transport function. Adding xylanase in feed increased membrane transport function. In conclusion, this study demonstrated that dietary supplementation of CSPCM to broiler diets increased beneficial flora content, metabolism of carbohydrates, amino acid metabolism, the deposition of proteins, renewal of bacteria, and maintenance of vigorous vitality. Among the 3 additive quantities of 250 g/t, 500 g/t, and 750 g/t of CSPCM in feed, 250 g/t of CSPCM improved parameters that are necessary for improved growth and production.
    Schlagwörter broiler ; compound small peptide of Chinese medicine ; high-throughput sequencing–based analysis ; intestinal microflora ; Animal culture ; SF1-1100
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Refractory hypotension under neuraxial anesthesia for cesarean delivery

    Shu-Ying Li / Xiao-Jing Chen / Xue-Mei Lin / Li-Min Chen

    Chinese Medical Journal, Vol 132, Iss 12, Pp 1509-

    2019  Band 1511

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Wolters Kluwer
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Delayed correlation between the incidence rate of indigenous murine typhus in humans and the seropositive rate of Rickettsia typhi infection in small mammals in Taiwan from 2007-2019.

    Pai-Shan Chiang / Shin-Wei Su / Su-Lin Yang / Pei-Yun Shu / Wang-Ping Lee / Shu-Ying Li / Hwa-Jen Teng

    PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e

    2022  Band 0010394

    Abstract: Murine typhus is a flea-borne zoonotic disease with acute febrile illness caused by Rickettsia typhi and is distributed widely throughout the world, particularly in port cities and coastal regions. We observed that murine typhus was an endemic disease ( ... ...

    Abstract Murine typhus is a flea-borne zoonotic disease with acute febrile illness caused by Rickettsia typhi and is distributed widely throughout the world, particularly in port cities and coastal regions. We observed that murine typhus was an endemic disease (number of annual indigenous cases = 29.23±8.76) with a low incidence rate (0.13±2.03*10-4 per 100,000 person-years) in Taiwan from 2007-2019. Most (45.79%, 174/380) indigenous infections were reported in May, June, and July. The incidence rates in both May and June were statistically higher than those in other months (p<0.05). Correspondingly, sera collected from small mammals (rodents and shrews) trapped in airports and harbors demonstrated anti-R. typhi antibody responses (seropositive rate = 8.24±0.33%). Interestingly, the ports with the highest seropositivity rates in small mammals are all inside/near the areas with the highest incidence rates of indigenous murine typhus. In addition, incidence rates in humans were positively correlated with the 1-month and 2-month prior seropositive rates in small mammals (R = 0.31 and 0.37, respectively). As early treatment with appropriate antibiotics for murine typhus could effectively shorten the duration of illness and reduce the risk of hospitalization and fatality, flea-related exposure experience should be considered in clinics during peak seasons and the months after a rise in seropositivity rates in small mammals. Surveillance in small mammals might be helpful for the development of real-time reporting or even early reminders for physicians of sporadic murine typhus cases based on the delayed correlation observed in this study.
    Schlagwörter Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Research on Simulink/Fluent Collaborative Simulation Zooming of Marine Gas Turbine

    Zhi-tao Wang / Jian Li / Tie-lei Li / Shu-ying Li

    Applied Computational Intelligence and Soft Computing, Vol

    2017  Band 2017

    Abstract: Based on the detailed analysis of collaborative running interface of Simulink/Fluent, a system simulation for the rated working condition as well as variable working condition of marine gas turbine has been achieved, which can improve the simulation ... ...

    Abstract Based on the detailed analysis of collaborative running interface of Simulink/Fluent, a system simulation for the rated working condition as well as variable working condition of marine gas turbine has been achieved, which can improve the simulation efficiency of marine gas turbine by developing simulation model of combustor with Fluent and simulation models of other components with Simulink. The result shows that the Simulink/Fluent collaborative simulation zooming can make the inner working conditions of combustor be observed specifically, based on the overall performance matching analysis; thus an effective technical means for the structural optimization design of combustor has been provided.
    Schlagwörter Electronic computers. Computer science ; QA75.5-76.95
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Hindawi Limited
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  10. Artikel ; Online: Dynamic Time-Delay Characteristics and Structural Optimization Design of Marine Gas Turbine Intercooler

    Ning-bo Zhao / Xue-you Wen / Shu-ying Li

    Mathematical Problems in Engineering, Vol

    2014  Band 2014

    Schlagwörter Mathematics ; QA1-939 ; Science ; Q ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Technology ; T
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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