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Article: Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer.

Kai, Kang / Han-Bing, Jiang / Bing-Lin, Cheng / Shu-Jun, Zhang

2023 Volume 9, Issue 7, Page(s) e17393

Abstract: Gastric cancer (GC) is a deadly malignant tumor with a high fatality rate and limited curative options. A growing body of research suggests that network pharmacology can replace traditional methods for determining the precise mechanism of action of ... ...

Abstract	Gastric cancer (GC) is a deadly malignant tumor with a high fatality rate and limited curative options. A growing body of research suggests that network pharmacology can replace traditional methods for determining the precise mechanism of action of medicinal substances in conditions such as cancer. The goal of this study was to clarify the biological mechanism of chelerythrine (CHE) and develop a prediction target for CHE against GC using network pharmacology. First, the genes related to GC were identified from the databases Genecards, Disgenet, Online Mendelian Inheritance in Man, Therapeutic Target Database, and Drugbank, and the targets of CHE were obtained from the SwissTargetPrediction database. Fifty linked targets were identified as
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17393
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice

Wen-jin Chen / Yin Zhuang / Wei Peng / Wei Cui / Shu-jun Zhang / Jian-wei Wang

Chinese Medicine, Vol 18, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract Background Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism ... ...

Abstract	Abstract Background Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism for treating KOA has not been revealed. In our previous study, we confirmed that DHJST inhibited the activation of NLRP3 signaling in rats and humans. In the current study, we aimed to determine how DHJST inhibits NLRP3 to alleviate knee cartilage damage. Methods Mice were injected with NLRP3 shRNA or Notch1-overexpressing adenovirus into the tail vein to construct systemic NLRP3 low-expressing or Notch1 high-expressing mice. Mice were injected with papain into the knee joint to replicate the KOA model. DHJST was used to treat KOA model mice with different backgrounds. The thickness of the right paw was measured to evaluate toe swelling. The pathohistological changes and the levels of IL-1β, MMP2, NLRP3, Notch1, collagen 2, collagen 4, HES1, HEY1, and Caspase3 were detected by HE staining, ELISA, immunohistochemical staining, western blotting, or real-time qPCR. Results DHJST reduced tissue swelling and serum and knee cartilage IL-1β levels, inhibited cartilage MMP2 expression, increased collagen 2 and collagen 4 levels, decreased Notch1 and NLRP3 positive expression rates in cartilage, and decreased HES1 and HEY1 mRNA levels in KOA model mice. In addition, NLRP3 interference decreased cartilage MMP2 expression and increased collagen 2 and collagen 4 levels without affecting the expression levels of notch1, HES1 and HEY1 mRNA levels in the synovium of KOA mice. In KOA mice with NLRP interference, DHJST further reduced tissue swelling and knee cartilage damage in mice. Finally, Notch1-overexpressing mice not only showed more severe tissue swelling and knee cartilage degradation but also abolished the therapeutic effect of DHJST on KOA mice. Importantly, the inhibitory effects of DHJST on the mRNA expression of NLRP3, Caspase3 and IL-1β in the knee joint of KOA ...
Keywords	Osteoarthritis ; DHJST ; NLRP3 ; Notch1 ; Mice ; Inflammation ; Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Emergence and spread patterns of antibiotic resistance genes during two different aerobic granular sludge cultivation processes

Ding-Chang Li / Jing-Feng Gao / Shu-Jun Zhang / Yong-Qing Gao / Li-Xin Sun

Environment International, Vol 137, Iss , Pp - (2020)

2020

Abstract: The prevalence and accumulation of antibiotic resistance genes (ARGs) were frequently detected in biological wastewater treatment processes, which might cause potential health crisis to human. In present study, the fates of ARGs during two different ... ...

Abstract	The prevalence and accumulation of antibiotic resistance genes (ARGs) were frequently detected in biological wastewater treatment processes, which might cause potential health crisis to human. In present study, the fates of ARGs during two different aerobic granular sludge (AGS) cultivation processes were investigated. The results showed that traditional AGS (T-AGS) cultivation process and enhanced AGS (E-AGS) cultivation process had significant differences (P < 0.005) in ARGs shift patterns. E-AGS process had higher average relative abundance (0.280 ± 0.079) of ARGs than T-AGS process (0.130 ± 0.041), while the intensity of ARGs enrichment during E-AGS (1.52–5.29 fold) was lower than T-AGS (3.79–75.31 fold) process. TnpA and intI1 as two different types of mobile genetic elements (MGEs) carrying ARGs, were observed to contribute significantly to the horizontal gene transfer (HGT) during T-AGS (r = 0.902, P < 0.050) and E-AGS (r = 0.823, P < 0.001) processes, respectively. Higher HGT level took place and more possible potential hosts (25 hosts) harboring ARGs were detected during E-AGS process comparing with T-AGS process (17 hosts). Meanwhile, over large AGS might increase the propagation of several antibiotic deactivation ARGs, so it was not advised. Overall, whether during T-AGS or during E-AGS process which was applied in a pilot-scale sequencing batch reactor treating municipal wastewater, the accumulation and spread of ARGs were inevitable. It should be valued that some suitable pre-treatments of seed sludge should be executed, meanwhile, advanced treatment for removing of ARGs in AGS should be conducted to maintain the relative abundances of ARGs at relatively low level. Keywords: Antibiotic resistance genes, Spread patterns, Aerobic granular sludge, Mobile genetic elements, Co-occurrence patterns
Keywords	Environmental sciences ; GE1-350
Subject code	660
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Lin Li / Qing-Song Lei / Shu-Jun Zhang / Ling-Na Kong / Bo Qin

PLoS ONE, Vol 11, Iss 7, p e

Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling.

2016 Volume 0159019

Abstract: This corrects the article DOI:10.1371/journal.pone.0156496.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pone.0156496.].
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling.

Lin Li / Qing-Song Lei / Shu-Jun Zhang / Ling-Na Kong / Bo Qin

PLoS ONE, Vol 11, Iss 5, p e

2016 Volume 0156496

Abstract: Ubiquitin-specific protease 18 (USP18, also known as UBP43) has both interferon stimulated gene 15 (ISG15) dependent and ISG15-independent functions. By silencing the expression of USP18 in HepG2.2.15 cells, we studied the effect of USP18 on the anti-HBV ...

Abstract	Ubiquitin-specific protease 18 (USP18, also known as UBP43) has both interferon stimulated gene 15 (ISG15) dependent and ISG15-independent functions. By silencing the expression of USP18 in HepG2.2.15 cells, we studied the effect of USP18 on the anti-HBV activity of IFN-F and demonstrated that knockdown of USP18 significantly Inhibited the HBV expression and increased the expression of ISGs. Levels of hepatitis B virus surface antigen (HBsAg), hepatitis B virus e antigen (HBeAg), HBV DNA and intracellular hepatitis B virus core antigen (HBcAg) were dramatically decreased with or without treatment of indicated dose of IFN-F. Suppression of USP18 activated the JAK/STAT signaling pathway as shown by the increased and prolonged expression of phosphorylated signal transducer and activator of transcription 1 (p-STAT1) in combination with enhanced expression of several interferon stimulated genes (ISGs). Our results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK/STAT signaling pathway in Hepg2.2.15 cells.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Two New Stachane Diterpenoids from the Bark of Ptychopetalum olacoides

Tang, Wan-Xia / Qing-Bin Wang / Shu-Jun Zhang / Wen-Zhi Zhang / Yoshiyasu Fukuyama

Chemistry of natural compounds. 2016 Sept., v. 52, no. 5

2016

Abstract: Phytochemical constituents investigation of the bark of Ptychopetalum olacoides led to the isolation of two new stachane diterpenoides, named stach-15-en-12Î±-ol-3-one (1) and stach-15-en-12Î²-ol-3-one (2). The structures of 1 and 2 were elucidated by ... ...

Abstract	Phytochemical constituents investigation of the bark of Ptychopetalum olacoides led to the isolation of two new stachane diterpenoides, named stach-15-en-12Î±-ol-3-one (1) and stach-15-en-12Î²-ol-3-one (2). The structures of 1 and 2 were elucidated by analyzing spectroscopic data and comparing their NMR data with those of the previously reported compound 1a. The bioassay experiment indicated that compounds 1 and 2 exhibited weak neurite outgrowth-promoting activity on PC12 cells at the concentration of 30 Î¼M.
Keywords	bark ; bioassays ; chemistry ; diterpenoids ; neurites ; nuclear magnetic resonance spectroscopy ; Ptychopetalum olacoides ; spectral analysis
Language	English
Dates of publication	2016-09
Size	p. 841-844.
Publishing place	Springer US
Document type	Article
ZDB-ID	213866-9
ISSN	0009-3130
ISSN	0009-3130
DOI	10.1007/s10600-016-1792-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Exploring candidate genes for pericarp russet pigmentation of sand pear (Pyrus pyrifolia) via RNA-Seq data in two genotypes contrasting for pericarp color.

Yue-zhi Wang / Mei-song Dai / Shu-jun Zhang / Ze-bin Shi

PLoS ONE, Vol 9, Iss 1, p e

2014 Volume 83675

Abstract: Sand pear (Pyrus pyrifolia) russet pericarp is an important trait affecting both the quality and stress tolerance of fruits. This trait is controlled by a relative complex genetic process, with some fundamental biological questions such as how many and ... ...

Abstract	Sand pear (Pyrus pyrifolia) russet pericarp is an important trait affecting both the quality and stress tolerance of fruits. This trait is controlled by a relative complex genetic process, with some fundamental biological questions such as how many and which genes are involved in the process remaining elusive. In this study, we explored differentially expressed genes between the russet- and green-pericarp offspring from the sand pear (Pyrus pyrifolia) cv. 'Qingxiang' × 'Cuiguan' F1 group by RNA-seq-based bulked segregant analysis (BSA). A total of 29,100 unigenes were identified and 206 of which showed significant differences in expression level (log2fold values>1) between the two types of pericarp pools. Gene Ontology (GO) analyses detected 123 unigenes in GO terms related to 'cellular_component' and 'biological_process', suggesting developmental and growth differentiations between the two types. GO categories associated with various aspects of 'lipid metabolic processes', 'transport', 'response to stress', 'oxidation-reduction process' and more were enriched with genes with divergent expressions between the two libraries. Detailed examination of a selected set of these categories revealed repressed expressions of candidate genes for suberin, cutin and wax biosynthesis in the russet pericarps.Genes encoding putative cinnamoyl-CoA reductase (CCR), cinnamyl alcohol dehydrogenase (CAD) and peroxidase (POD) that are involved in the lignin biosynthesis were suggested to be candidates for pigmentation of sand pear russet pericarps. Nine differentially expressed genes were analyzed for their expressions using qRT-PCR and the results were consistent with those obtained from Illumina RNA-sequencing. This study provides a comprehensive molecular biology insight into the sand pear pericarp pigmentation and appearance quality formation.
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Three New Diterpenoids from the Bark of Ptychopetalum olacoides

Tang, Wan-Xia / Ming Zhao / Qing-Bin Wang / Shu-Jun Zhang / Wen-Zhi Zhang / Yoshiyasu Fukuyama / Zi-Wei Gong

Chemistry of natural compounds. 2018 July, v. 54, no. 4

2018

Abstract: A phytochemical constituent investigation of the bark of Ptychopetalum olacoides led to the isolation of three new diterpenoides, named ptycholactone (1), 3(R)-hydroxysarcopetaloic acid (2), and 2β,3β-dihydroxylabda-8(17),12(13),14(15)-triene (3). The ... ...

Abstract	A phytochemical constituent investigation of the bark of Ptychopetalum olacoides led to the isolation of three new diterpenoides, named ptycholactone (1), 3(R)-hydroxysarcopetaloic acid (2), and 2β,3β-dihydroxylabda-8(17),12(13),14(15)-triene (3). The structures of 1, 2, and 3 were elucidated by analyzing spectroscopic data and comparing their NMR data with those of the previously reported compounds 2a and 3a.
Keywords	bark ; chemical constituents of plants ; chemistry ; diterpenoids ; nuclear magnetic resonance spectroscopy ; Ptychopetalum olacoides ; spectral analysis
Language	English
Dates of publication	2018-07
Size	p. 701-704.
Publishing place	Springer US
Document type	Article
ZDB-ID	213866-9
ISSN	0009-3130
ISSN	0009-3130
DOI	10.1007/s10600-018-2449-1
Database	NAL-Catalogue (AGRICOLA)

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Article: Toxic metals in children's toys and jewelry: Coupling bioaccessibility with risk assessment

Cui, Xin-Yi / Lena Q. Ma / Shi-Wei Li / Shu-Jun Zhang / Ying-Ying Fan

Environmental pollution. 2015 May, v. 200

2015

Abstract: A total of 45 children's toys and jewelry were tested for total and bioaccessible metal concentrations. Total As, Cd, Sb, Cr, Ni, and Pb concentrations were 0.22â19, 0.01â139, 0.1â189, 0.06â846, 0.14â2894 and 0.08â860,000Â mgÂ kgâ1. ... ...

Abstract	A total of 45 children's toys and jewelry were tested for total and bioaccessible metal concentrations. Total As, Cd, Sb, Cr, Ni, and Pb concentrations were 0.22â19, 0.01â139, 0.1â189, 0.06â846, 0.14â2894 and 0.08â860,000Â mgÂ kgâ1. Metallic products had the highest concentrations, with 3â7 out of 13 samples exceeding the European Union safety limit for Cd, Pb, Cr, or Ni. However, assessment based on hazard index >1 and bioaccessible metal showed different trends. Under saliva mobilization or gastric ingestion, 11 out of 45 samples showed HI >1 for As, Cd, Sb, Cr, or Ni. Pb with the highest total concentration showed HI <1 for all samples while Ni showed the most hazard with HI up to 113. Our data suggest the importance of using bioaccessibility to evaluate health hazard of metals in children's toys and jewelry, and besides Pb and Cd, As, Ni, Cr, and Sb in children's products also deserve attention.
Keywords	antimony ; arsenic ; bioavailability ; cadmium ; children ; chromium ; European Union ; health hazards ; ingestion ; lead ; nickel ; risk assessment ; saliva ; toxicity ; toys
Language	English
Dates of publication	2015-05
Size	p. 77-84.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2015.01.035
Database	NAL-Catalogue (AGRICOLA)

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Article: Two New Monoterpenoids from the Fresh Leaves of Syringa oblata

Zhao, Ming / Jin-Lan Wang / Jun Li / Li-Ming Bai / Shu-Jun Zhang / Wan-Xia Tang / Wen-Zhi Zhang

Chemistry of natural compounds. 2016 Nov., v. 52, no. 6

2016

Abstract: Two new iridoid type monoterpenoids, named syringopicrogenin D (1) and syringopicrogenin E (2), were isolated from the EtOH extract of the fresh leaves of Syringa oblate Lindl. The structures of 1 and 2 were elucidated by analyzing spectroscopic data and ...

Abstract	Two new iridoid type monoterpenoids, named syringopicrogenin D (1) and syringopicrogenin E (2), were isolated from the EtOH extract of the fresh leaves of Syringa oblate Lindl. The structures of 1 and 2 were elucidated by analyzing spectroscopic data and comparing their NMR data with those of the previously reported compound 1a.
Keywords	chemistry ; ethanol ; leaves ; monoterpenoids ; nuclear magnetic resonance spectroscopy ; spectral analysis ; Syringa
Language	English
Dates of publication	2016-11
Size	p. 1023-1025.
Publishing place	Springer US
Document type	Article
ZDB-ID	213866-9
ISSN	0009-3130
ISSN	0009-3130
DOI	10.1007/s10600-016-1852-8
Database	NAL-Catalogue (AGRICOLA)

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