Article ; Online: Intravenous Immunoglobulin and Methylprednisolone for Clozapine-Associated Perimyocarditis.
American journal of therapeutics
2018 Volume 26, Issue 4, Page(s) e485–e486
Abstract: Clinical features: Cardiotoxicity is a rare but serious side effect of clozapine. We present a case of a psychiatric patient on chronic clozapine 75 mg daily, who presented with congestive heart failure secondary to the cardiotoxic effects of the ... ...
Abstract | Clinical features: Cardiotoxicity is a rare but serious side effect of clozapine. We present a case of a psychiatric patient on chronic clozapine 75 mg daily, who presented with congestive heart failure secondary to the cardiotoxic effects of the psychiatric medication. Therapeutic challenge: Conventional heart failure treatment failed to improve symptoms. Solution: A course of 40 mg of intravenous immunoglobulin and 125 mg of steroids was implemented, after which the patient made a full recovery. We hope to raise awareness of concurrent clozapine-induced pericarditis and myocarditis and propose a role of intravenous immunoglobulin and steroids in the treatment of drug-induced cardiomyopathy. |
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MeSH term(s) | Adult ; Biopsy ; Cardiotoxicity/diagnosis ; Cardiotoxicity/drug therapy ; Cardiotoxicity/etiology ; Clozapine/adverse effects ; Drug Therapy, Combination ; Electrocardiography ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Methylprednisolone/therapeutic use ; Myocarditis/chemically induced ; Myocarditis/diagnosis ; Myocarditis/drug therapy ; Myocardium/pathology ; Pericarditis/chemically induced ; Pericarditis/diagnosis ; Pericarditis/drug therapy ; Pericardium/drug effects ; Pericardium/pathology ; Psychotic Disorders/drug therapy ; Treatment Outcome |
Chemical Substances | Immunoglobulins, Intravenous ; Clozapine (J60AR2IKIC) ; Methylprednisolone (X4W7ZR7023) |
Language | English |
Publishing date | 2018-04-13 |
Publishing country | United States |
Document type | Case Reports ; Journal Article |
ZDB-ID | 1280786-2 |
ISSN | 1536-3686 ; 1075-2765 |
ISSN (online) | 1536-3686 |
ISSN | 1075-2765 |
DOI | 10.1097/MJT.0000000000000751 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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