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  1. Book ; Online ; E-Book: Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy

    Yadav, Awesh K. / Shukla, Rahul / Ujjwal, Rewati Raman

    2024  

    Author's details Awesh K. Yadav, Rahul Shukla, and Rewati Raman Ujjwal
    Keywords Cancer/Chemotherapy
    Subject code 616.994061
    Language English
    Size 1 online resource (435 pages)
    Edition First edition.
    Publisher Elsevier
    Publishing place Kidlington, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-95304-2 ; 978-0-323-95304-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Drug Formulation Design

    Shukla, Rahul / Kuznetsov, Aleksey / Ali, Akbar

    2023  

    Keywords Pharmacology ; drug delivery ; bioactive compounds ; polymer ; bioavailability ; absorption ; hydrogels
    Language English
    Size 1 electronic resource (328 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030381330
    ISBN 9781837684731 ; 1837684731
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Nanomedical drug delivery for neurodegenerative diseases

    Yadav, Awesh K. / Shukla, Rahul / Flora, S. J. S.

    2022  

    Author's details Awesh K. Yadav, Rahul Shukla, and S. J. S. Flora
    Keywords Nervous system/Degeneration/Chemotherapy ; Nanomedicine
    Subject code 616.8047
    Language English
    Size 1 online resource (284 pages)
    Publisher Academic Press
    Publishing place London, UK
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-89801-7 ; 9780323855440 ; 978-0-323-89801-0 ; 032385544X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Role of Novel Drug Delivery Vehicles in Nanobiomedicine

    Tyagi, Rajeev K. / Garg, Neeraj / Shukla, Rahul / Singh Bisen, Prakash

    2020  

    Keywords Pharmacology
    Size 1 electronic resource (194 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046054
    ISBN 9781789843309 ; 1789843308
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Hydrogen- and halogen-bonding-directed trimeric supramolecular motifs in dihalogenated 1,2,4-triazoles.

    Shukla, Rahul / Sen, Anik

    Acta crystallographica Section B, Structural science, crystal engineering and materials

    2024  

    Abstract: Hydrogen-bonding and halogen-bonding interactions are important noncovalent interactions that play a significant role in the crystal structure of organic molecules. An in-depth analysis is given of the crystal packing of two previously reported crystal ... ...

    Abstract Hydrogen-bonding and halogen-bonding interactions are important noncovalent interactions that play a significant role in the crystal structure of organic molecules. An in-depth analysis is given of the crystal packing of two previously reported crystal structures of dihalogenated 1,2,4-triazole derivatives, namely 3,5-dichloro-1H-1,2,4-triazole and 3,5-dibromo-1H-1,2,4-triazole. This work provides insights into the complex interplay of hydrogen-bonding and halogen-bonding interactions resulting in the formation of multiple trimeric motifs in the crystal structure of 1,2,4-triazole derivatives. Analysis of the crystal packing of these isostructural crystal structures revealed that the molecular arrangement in these molecules is primarily stabilized by the formation of different trimeric motifs stabilized by N-H...N hydrogen bonds, N-H...X (X = Cl/Br) halogen bonds and C-X...X halogen-bonding interactions. Computational studies further revealed that all these trimers are energetically stable. A crystallographic database search further reveals that while the cyclic trimers reported in this study are present in other molecules, structures analyzed in this study are the sole instances where all are present simultaneously.
    Language English
    Publishing date 2024-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020841-8
    ISSN 2052-5206 ; 1600-5740 ; 1600-8650 ; 2052-5192
    ISSN (online) 2052-5206 ; 1600-5740 ; 1600-8650
    ISSN 2052-5192
    DOI 10.1107/S2052520624002427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring the electron donor-acceptor duality of B

    Shukla, Rahul / Sen, Anik

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 46, Page(s) 32040–32050

    Abstract: Boron nitrides are very important and are used as lubricants, insulating agents, ...

    Abstract Boron nitrides are very important and are used as lubricants, insulating agents,
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02656f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nanovesicular-Mediated Intranasal Drug Therapy for Neurodegenerative Disease.

    Singh, Shalu / Shukla, Rahul

    AAPS PharmSciTech

    2023  Volume 24, Issue 7, Page(s) 179

    Abstract: Numerous neurodegenerative conditions, such as Alzheimer's, Huntington's, Parkinson's, amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant concerns of global health. Formulation-related issues, physiological and ... ...

    Abstract Numerous neurodegenerative conditions, such as Alzheimer's, Huntington's, Parkinson's, amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant concerns of global health. Formulation-related issues, physiological and anatomical barriers, post-administration obstacles, physical challenges, regulatory limitations, environmental hurdles, and health and safety issues have all hindered successful delivery and effective outcomes despite a variety of treatment options. In the current review, we covered the intranasal route, an alternative strategic route targeting brain for improved delivery across the BBB. The trans-nasal pathway is non-invasive, directing therapeutics directly towards brain, circumventing the barrier and reducing peripheral exposure. The delivery of nanosized vesicles loaded with drugs was also covered in the review. Nanovesicle systems are organised in concentric bilayered lipid membranes separated with aqueous layers. These carriers surmount the disadvantages posed by intranasal delivery of rapid mucociliary clearance and enzymatic degradation, and enhance retention of drug to reach the site of target. In conclusion, the review covers in-depth conclusions on numerous aspects of formulation of drug-loaded vesicular system delivery across BBB, current marketed nasal devices, significant jeopardies, potential therapeutic aids, and current advancements followed by future perspectives.
    MeSH term(s) Humans ; Neurodegenerative Diseases/drug therapy ; Nose ; Drug Delivery Systems ; Brain ; Glioblastoma
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-023-02625-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rh(iii)-catalyzed sp

    Chaturvedi, Atul K / Shukla, Rahul K / Volla, Chandra M R

    Chemical science

    2024  Volume 15, Issue 17, Page(s) 6544–6551

    Abstract: The development of an efficient strategy for facile access to quinoline-based bis-heterocycles holds paramount importance in medicinal chemistry. Herein, we describe a unified approach for accessing 8-(indol-3-yl)methyl-quinolines by integrating Cp*Rh( ... ...

    Abstract The development of an efficient strategy for facile access to quinoline-based bis-heterocycles holds paramount importance in medicinal chemistry. Herein, we describe a unified approach for accessing 8-(indol-3-yl)methyl-quinolines by integrating Cp*Rh(iii)-catalyzed C(sp
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc06955a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Drug Nanocrystals: A Delivery Channel for Antiviral Therapies.

    Chaturvedi, Akanksha / Sharma, Swapnil / Shukla, Rahul

    AAPS PharmSciTech

    2024  Volume 25, Issue 3, Page(s) 41

    Abstract: Viral infections represent a significant threat to global health due to their highly communicable and potentially lethal nature. Conventional antiviral interventions encounter challenges such as drug resistance, tolerability issues, specificity concerns, ...

    Abstract Viral infections represent a significant threat to global health due to their highly communicable and potentially lethal nature. Conventional antiviral interventions encounter challenges such as drug resistance, tolerability issues, specificity concerns, high costs, side effects, and the constant mutation of viral proteins. Consequently, the exploration of alternative approaches is imperative. Therefore, nanotechnology-embedded drugs excelled as a novel approach purporting severe life-threatening viral disease. Integrating nanomaterials and nanoparticles enables ensuring precise drug targeting, improved drug delivery, and fostered pharmacokinetic properties. Notably, nanocrystals (NCs) stand out as one of the most promising nanoformulations, offering remarkable characteristics in terms of physicochemical properties (higher drug loading, improved solubility, and drug retention), pharmacokinetics (enhanced bioavailability, dose reduction), and optical properties (light absorptivity, photoluminescence). These attributes make NCs effective in diagnosing and ameliorating viral infections. This review comprises the prevalence, pathophysiology, and resistance of viral infections along with emphasizing on failure of current antivirals in the management of the diseases. Moreover, the review also highlights the role of NCs in various viral infections in mitigating, diagnosing, and other NC-based strategies combating viral infections. In vitro, in vivo, and clinical studies evident for the effectiveness of NCs against viral pathogens are also discussed.
    MeSH term(s) Humans ; Pharmaceutical Preparations/chemistry ; Biological Availability ; Drug Delivery Systems ; Virus Diseases/drug therapy ; Nanoparticles/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use
    Chemical Substances Pharmaceutical Preparations ; Antiviral Agents
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-024-02754-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Yet another perspective on hole interactions, part II: lp-hole

    Shukla, Rahul / Yu, Dongkun / Mu, Tiancheng / Kozuch, Sebastian

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 18, Page(s) 12641–12649

    Abstract: Most of the experimental and theoretical work in hole interactions (HIs) is mainly focused on exploiting the nature and characteristics of σ and π-holes. In this perspective, we focus our attention on understanding the origin and properties of lone-pair ... ...

    Abstract Most of the experimental and theoretical work in hole interactions (HIs) is mainly focused on exploiting the nature and characteristics of σ and π-holes. In this perspective, we focus our attention on understanding the origin and properties of lone-pair holes. These holes are present on an atom opposite to its lone-pair region. Utilizing some new and old examples, such as X
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp00225j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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