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  1. Artikel ; Online: Effect of Indian folk-dance therapy on physical performances and quality of life in elderly

    Mishra Siddharth S. / Shukla Shivani

    Biomedical Human Kinetics, Vol 14, Iss 1, Pp 244-

    2022  Band 251

    Abstract: Study aim: To study the effect of Indian folk-dance therapy on physical performances and quality of life in elderly. ...

    Abstract Study aim: To study the effect of Indian folk-dance therapy on physical performances and quality of life in elderly.
    Schlagwörter geriatrics ; dance therapy ; postural balance ; cognition ; quality of life ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Bilateral Humeral Head Avascular Necrosis: A Rare Presentation in Sickle Cell Trait.

    Banait, Shashank / Banait, Tanvi / Shukla, Shivani / Mane, Supriya / Jain, Jyoti

    Cureus

    2023  Band 15, Heft 8, Seite(n) e44006

    Abstract: Sickle cell disease (SCD) affects millions of people worldwide. It is an autosomal recessive hemoglobinopathy that occurs due to a point mutation in the sixth codon that replaces glutamic acid with valine in the beta-globin chain. Avascular necrosis (AVN) ...

    Abstract Sickle cell disease (SCD) affects millions of people worldwide. It is an autosomal recessive hemoglobinopathy that occurs due to a point mutation in the sixth codon that replaces glutamic acid with valine in the beta-globin chain. Avascular necrosis (AVN), also known as osteonecrosis, is one of its complications. In this report, we present a case of a 25-year-old female with sickle cell trait without any comorbidities who presented to us with pain in both shoulder joints for three months and was diagnosed with AVN in bilateral shoulder joints. Appropriate treatment can dramatically reduce pain and improve the quality of life for these patients. This case drew our attention due to its rare presentation.
    Sprache Englisch
    Erscheinungsdatum 2023-08-23
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.44006
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  3. Artikel ; Online: Systematic review of the barriers and facilitators to dietary modification in people living with type 2 diabetes and pre-diabetes from South Asian ethnic populations.

    Rai, Amar / Misra, Rohan / Khan, Hasaan / Shukla, Shivani / Patel, Dipesh C / Brown, Adrian

    Diabetic medicine : a journal of the British Diabetic Association

    2023  Band 40, Heft 8, Seite(n) e15132

    Abstract: Aims: Lifestyle and dietary modification are effective in the prevention and management of Type 2 diabetes Mellitus (T2DM). However, South Asian (SA) populations living in Western countries have low adherence rates to healthcare advice and experience ... ...

    Abstract Aims: Lifestyle and dietary modification are effective in the prevention and management of Type 2 diabetes Mellitus (T2DM). However, South Asian (SA) populations living in Western countries have low adherence rates to healthcare advice and experience poor diabetes control and clinical outcomes compared with the general population. This systematic review aimed to summarise the barriers and facilitators of dietary modification within people from South Asian (SA) ethnicity with T2DM or pre-diabetes.
    Methods: A systematic search of PubMed, Web of Science and Scopus generated 3739 articles, of which seven were included. Qualitative and quantitative data were inputted utilising COVIDENCE. Qualitative data were analysed by thematic analysis.
    Results: Thematic analysis identified three facilitators: (1) cultural sensitivity, (2) health education and (3) support networks. Barriers include (1) healthcare inequity, (2) cultural insensitivity, (3) social pressures, (4) misconceptions and (5) time constraints. Good access to health care and motivation were the most common facilitators discussed. Misconceptions on T2DM management and cultural insensitivity contributed to the majority of barriers discussed.
    Conclusions: Culturally tailored interventions could improve adherence to diet modification in people with T2DM from SA ethnicity. Interventions involving the application of social media to challenge intergenerational stigmas and misinformation, distributing culturally appropriate resources and providing diets tailored to the SA palate could help.
    Mesh-Begriff(e) Humans ; Asian People ; Diabetes Mellitus, Type 2/prevention & control ; Diet/ethnology ; Ethnicity ; Prediabetic State/therapy ; South Asian People ; Culturally Competent Care ; Health Services Accessibility
    Sprache Englisch
    Erscheinungsdatum 2023-05-23
    Erscheinungsland England
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 605769-x
    ISSN 1464-5491 ; 0742-3071 ; 1466-5468
    ISSN (online) 1464-5491
    ISSN 0742-3071 ; 1466-5468
    DOI 10.1111/dme.15132
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  4. Artikel: Simultaneous nitrification–denitrification by phosphate accumulating microorganisms

    Shukla, Shivani / Rajta, Ankita / Setia, Hema / Bhatia, Ranjana

    World journal of microbiology & biotechnology. 2020 Oct., v. 36, no. 10

    2020  

    Abstract: Nitrogen and phosphorous are important inorganic water pollutants that pose a major threat to the environment and health of both humans and animals. The physical and chemical ways to remove these pollutants from water and soil are expensive and harsh, so ...

    Abstract Nitrogen and phosphorous are important inorganic water pollutants that pose a major threat to the environment and health of both humans and animals. The physical and chemical ways to remove these pollutants from water and soil are expensive and harsh, so biological removal becomes the method of choice to alleviate the problem without any side effects. The identification of microorganisms capable of simultaneous heterotrophic nitrification and aerobic denitrification has greatly simplified the sequestration of nitrogen from ammonium (NH₄⁺) into dinitrogen (N₂). Further, the discovery of phosphorous accumulating organisms offers greater economic benefits because these organisms can favourably and simultaneously remove both nitrogen and phosphorous from wastewaters hence reducing the nutrient burden. The stability of the system and removal efficiency of inorganic pollutants can be enhanced by the use of immobilized organisms. However, limited work has been done so far in this direction and there is a need to further the efforts towards refining process efficiency by testing low-cost substrates and diverse microbial populations for the total eradication of these contaminants from wastewaters.
    Schlagwörter ammonium ; biotechnology ; denitrification ; nitrification ; nitrogen ; phosphates ; phosphorus ; soil ; wastewater
    Sprache Englisch
    Erscheinungsverlauf 2020-10
    Umfang p. 151.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean ; Review
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-020-02926-y
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  5. Artikel ; Online: Simultaneous nitrification-denitrification by phosphate accumulating microorganisms.

    Shukla, Shivani / Rajta, Ankita / Setia, Hema / Bhatia, Ranjana

    World journal of microbiology & biotechnology

    2020  Band 36, Heft 10, Seite(n) 151

    Abstract: Nitrogen and phosphorous are important inorganic water pollutants that pose a major threat to the environment and health of both humans and animals. The physical and chemical ways to remove these pollutants from water and soil are expensive and harsh, so ...

    Abstract Nitrogen and phosphorous are important inorganic water pollutants that pose a major threat to the environment and health of both humans and animals. The physical and chemical ways to remove these pollutants from water and soil are expensive and harsh, so biological removal becomes the method of choice to alleviate the problem without any side effects. The identification of microorganisms capable of simultaneous heterotrophic nitrification and aerobic denitrification has greatly simplified the sequestration of nitrogen from ammonium (NH
    Mesh-Begriff(e) Biodegradation, Environmental ; Denitrification/physiology ; Environmental Pollutants ; Heterotrophic Processes ; Immobilization ; Nitrification/physiology ; Nitrogen/analysis ; Phosphates/metabolism ; Phosphorus ; Waste Water ; Water Purification/methods
    Chemische Substanzen Environmental Pollutants ; Phosphates ; Waste Water ; Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75)
    Sprache Englisch
    Erscheinungsdatum 2020-09-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-020-02926-y
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  6. Artikel: Assessing preference and potential for working from anywhere: A spatial index for Ireland

    Kelly, J. Andrew / Kelleher, Luke / Guo, Yulu / Deegan, Ciaran / Larsen, Breanna / Shukla, Shivani / Collins, Amy

    Environmental and sustainability indicators. 2022 Sept., v. 15

    2022  

    Abstract: Workforce flexibility in regard to the time and location of work can offer many advantages for individuals, businesses, communities and countries. Whilst neither universally viable nor uniformly valuable, there are those who may have a preference for ... ...

    Abstract Workforce flexibility in regard to the time and location of work can offer many advantages for individuals, businesses, communities and countries. Whilst neither universally viable nor uniformly valuable, there are those who may have a preference for such flexibility and there is certainly untapped positive potential to be explored across multiple impact categories. The COVID 19 pandemic has improved acceptability from both employee and employer perspectives and delivered a global ‘crash course’ in remote working. The varied potentials to work from anywhere, as well as differences in associated impact outcomes point to the value of targeted supports and careful planning. The Working from Anywhere Index (WFAI) offers a transferable fine scale spatial methodology to identify both the preferences and potential for working from anywhere. The value for policy support is demonstrated through application to a case country, Ireland, where illustrative scenarios explore the role of broadband provision, the placement of remote working hubs and the effect of shifts in employment types on the preferences and potential for working from anywhere. Impact analysis indicates that the scale of annual benefits for a plausible ‘2 day a week’ national working from anywhere scenario are substantial and offer the potential to save in the region of 1 bn car commuting kilometres per annum with associated societal benefits for emissions reduction and individual time savings.
    Schlagwörter employment ; issues and policy ; labor force ; pandemic ; Ireland
    Sprache Englisch
    Erscheinungsverlauf 2022-09
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ISSN 2665-9727
    DOI 10.1016/j.indic.2022.100190
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  7. Artikel ; Online: AT1-AA Is Produced in Offspring in Response to Placental Ischemia and Is Lowered by B-Cell Depletion Without Compromising Overall Offspring Health.

    Campbell, Nathan / Deer, Evangeline / Solise, Dylan / Cornelius, Denise C / Turner, Ty / Amaral, Lorena M / Herrock, Owen / Jordan, Ariel / Shukla, Shivani / Ibrahim, Tarek / LaMarca, Babbette

    Journal of the American Heart Association

    2024  Band 13, Heft 4, Seite(n) e031417

    Abstract: Background: Preeclampsia, new-onset hypertension during pregnancy alongside other organ dysfunction, is the leading cause of mortality for the mother and low birth weight for the baby. Low birth weight contributes to high risk of cardiovascular ... ...

    Abstract Background: Preeclampsia, new-onset hypertension during pregnancy alongside other organ dysfunction, is the leading cause of mortality for the mother and low birth weight for the baby. Low birth weight contributes to high risk of cardiovascular disorders later in life. Women with preeclampsia have activated B cells producing agonistic autoantibodies to AT1-AA (angiotensin II type I receptor). We hypothesize that rituximab, a B cell-depleting chemotherapeutic, will deplete maternal B cells in reduced uterine perfusion pressure (RUPP) rats without worsening the effect of placental ischemia on pup growth and survival.
    Methods and results: To test this hypothesis, the RUPP procedure was performed, and rituximab was continuously infused via miniosmotic pump. Maternal blood and tissues were collected. A separate group of dams were allowed to deliver, pup weights were recorded, and at 4 months of age, tissues were collected from offspring. Immune cells were measured via flow cytometry, and AT1-AA was quantified using a contraction bioassay. Blood pressure increased in RUPP rats and was normalized with rituximab treatment. RUPP offspring also had increased circulating B cells, cytolytic natural killer cells, and increased circulating AT1-AA, which were normalized with maternal rituximab treatment. This is the first study to analyze the AT1-AA in RUPP offspring, which was normalized with rituximab.
    Conclusions: Our findings indicate that perinatal rituximab lowers maternal mean arterial pressure in RUPP rats and improves birth weight, circulating AT1-AA, and circulating natural killer cells, indicating that rituximab improves adverse fetal outcomes in response to placental ischemia.
    Mesh-Begriff(e) Rats ; Female ; Pregnancy ; Animals ; Humans ; Placenta/blood supply ; Pre-Eclampsia/drug therapy ; Pre-Eclampsia/prevention & control ; Rats, Sprague-Dawley ; Rituximab/pharmacology ; Rituximab/therapeutic use ; Blood Pressure/physiology ; Ischemia ; Receptor, Angiotensin, Type 1
    Chemische Substanzen Rituximab (4F4X42SYQ6) ; Receptor, Angiotensin, Type 1
    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031417
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  8. Artikel ; Online: Virtual exams: has COVID-19 provided the impetus to change assessment methods in medicine?

    Pettit, Matthew / Shukla, Shivani / Zhang, James / Sunil Kumar, Karadi Hari / Khanduja, Vikas

    Bone & joint open

    2021  Band 2, Heft 2, Seite(n) 111–118

    Abstract: Aims: The ongoing COVID-19 pandemic has disrupted and delayed medical and surgical examinations where attendance is required in person. Our article aims to outline the validity of online assessment, the range of benefits to both candidate and assessor, ... ...

    Abstract Aims: The ongoing COVID-19 pandemic has disrupted and delayed medical and surgical examinations where attendance is required in person. Our article aims to outline the validity of online assessment, the range of benefits to both candidate and assessor, and the challenges to its implementation. In addition, we propose pragmatic suggestions for its introduction into medical assessment.
    Methods: We reviewed the literature concerning the present status of online medical and surgical assessment to establish the perceived benefits, limitations, and potential problems with this method of assessment.
    Results: Global experience with online, remote virtual examination has been largely successful with many benefits conferred to the trainee, and both an economic and logistical advantage conferred to the assessor or organization. Advances in online examination software and remote proctoring are overcoming practical caveats including candidate authentication, cheating prevention, cybersecurity, and IT failure.
    Conclusion: Virtual assessment provides benefits to both trainee and assessor in medical and surgical examinations and may also result in cost savings. Virtual assessment is likely to be increasingly used in the post-COVID world and we present recommendations for the continued adoption of virtual examination. It is, however, currently unable to completely replace clinical assessment of trainees. Cite this article:
    Sprache Englisch
    Erscheinungsdatum 2021-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2633-1462
    ISSN (online) 2633-1462
    DOI 10.1302/2633-1462.22.BJO-2020-0142.R1
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  9. Artikel: Supply chain network competition in price and quality with multiple manufacturers and freight service providers

    Floden, Jonas / Nagurney, Anna / Saberi, Sara / Shukla, Shivani

    Transportation research : an international journal Vol. 77 , p. 248-267

    2015  Band 77, Seite(n) 248–267

    Verfasserangabe Anna Nagurney; Sara Saberi; Shivani Shukla; Jonas Floden
    Schlagwörter Supply chains ; Game theory ; Nash equilibrium ; Manufacturing ; Freight services ; Quality ; Competition ; Variational inequalities ; Projected dynamical systems
    Sprache Englisch
    Umfang graph. Darst.
    Verlag Elsevier
    Erscheinungsort Amsterdam
    Dokumenttyp Artikel
    ZDB-ID 1380969-6 ; 2013782-5
    ISSN 1366-5545
    ISSN 1366-5545
    Datenquelle ECONomics Information System

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  10. Artikel: Particle uptake driven phagocytosis in macrophages and neutrophils enhances bacterial clearance

    Sharma, Preeti / Vijaykumar, Anjali / Raghavan, Jayashree Vijaya / Rananaware, Supriya Rajendra / Alakesh, Alakesh / Bodele, Janhavi / Rehman, Junaid Ur / Shukla, Shivani / Wagde, Virta / Nadig, Savitha / Chakrabarti, Sveta / Visweswariah, Sandhya S. / Nandi, Dipankar / Gopal, Balasubramanian / Jhunjhunwala, Siddharth

    Journal of controlled release. 2022 Mar., v. 343

    2022  

    Abstract: Humans are exposed to numerous synthetic foreign particles in the form of drug delivery systems and diagnostic agents. Specialized immune cells (phagocytes) clear these particles by phagocytosing and attempting to degrade them. The process of recognition ...

    Abstract Humans are exposed to numerous synthetic foreign particles in the form of drug delivery systems and diagnostic agents. Specialized immune cells (phagocytes) clear these particles by phagocytosing and attempting to degrade them. The process of recognition and internalization of the particles may trigger changes in the function of phagocytes. Some of these changes, especially the ability of a particle-loaded phagocyte to take up and neutralize pathogens, remains poorly studied. Herein, we demonstrate that the uptake of non-stimulatory cargo-free particles enhances the phagocytic ability of monocytes, macrophages and neutrophils. The enhancement in phagocytic ability was independent of particle properties, such as size or the base material constituting the particle. Additionally, we show that the increased phagocytosis was not a result of cellular activation or cellular heterogeneity but was driven by changes in cell membrane fluidity and cellular compliance. A consequence of the enhanced phagocytic activity was that particulate-laden immune cells neutralize Escherichia coli (E. coli) faster in culture. Moreover, when administered in mice as a prophylactic, particulates enable faster clearance of E. coli and Staphylococcus epidermidis. Together, we demonstrate that the process of uptake induces cellular changes that favor additional phagocytic events. This study provides insights into using non-stimulatory cargo-free particles to engineer immune cell functions for applications involving faster clearance of phagocytosable abiotic and biotic material.
    Schlagwörter Escherichia coli ; Staphylococcus epidermidis ; cell membranes ; compliance ; drugs ; macrophages ; membrane fluidity ; monocytes ; neutrophils ; particulates ; phagocytosis
    Sprache Englisch
    Erscheinungsverlauf 2022-03
    Umfang p. 131-141.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2022.01.030
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