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  1. Article ; Online: Molecular Study of IL-7R Gene Polymorphism and their Associations with Male Multiple Sclerosis Patients in Erbil Province.

    Shukur wasman Smail

    Zanco Journal of Pure and Applied Sciences, Vol 33, Iss 1, Pp 21-

    2021  Volume 26

    Abstract: Multiple sclerosis (MS) is an autoimmune disease in which immune cells attacks the body cells mistakenly; it is characterized by chronic inflammation that leads to demyelination and conduction of nerve impulse is affected negatively. The cause of the ... ...

    Abstract Multiple sclerosis (MS) is an autoimmune disease in which immune cells attacks the body cells mistakenly; it is characterized by chronic inflammation that leads to demyelination and conduction of nerve impulse is affected negatively. The cause of the disease is unknown, but it may be partially under the control of genetics, including interleukin 7 receptor alpha (IL7Rα). In this case-control study, 40 relapsing-remitting MS (RRMS) male patients, which fulfills McDonald criteria and 40 healthy controls, with matched sex, were compared depending on the rs6897932 polymorphism within the exon 6 of IL7Rα gene by Tetra-amplification refractory mutation system polymerase chain reaction (Tetra-ARMS-PCR) method. The frequency of T allele of IL7Rα rs6897932 was considerably higher in male MS patients than healthy control males (31.25 vs 17.5%). Genotype distributions of the single nucleotide polymorphism (SNP) rs6897932 deviated from Hardy-Weinberg equilibrium with a p-value of 0.80. Both homozygous (TT) and Heterozygous (CT) were non-significantly positively associated with MS male patients (OR = 6.75, 95%CI = 0.73-62.4, p = 0.059, OR = 1.68, 95%CI = 0.64-4.38, p = 0.28) respectively. The distribution of the rs6897932 polymorphism is not significantly different in our case/control study in the Erbil province
    Keywords multiple sclerosis ; interleukin 7 receptor ; polymorphism ; amplified refractory mutation system ; relapsing-remitting multiple sclerosis ; Technology ; T ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Salahaddin University-Erbil
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Ct, IL-18 polymorphism, and laboratory biomarkers for predicting chemosensory dysfunctions and mortality in COVID-19

    Shukur Wasman Smail / Esmaeil Babaei / Kawa Amin

    Future Science OA, Vol 9, Iss

    2023  Volume 2

    Abstract: Aim: Patients with COVID-19 often experience chemosensory dysfunction. This research intends to uncover the association of RT-PCR Ct value with chemosensory dysfunctions and SpO2. This study also aims to investigate Ct, SpO2, CRP, D-dimer, and -607 IL-18 ...

    Abstract Aim: Patients with COVID-19 often experience chemosensory dysfunction. This research intends to uncover the association of RT-PCR Ct value with chemosensory dysfunctions and SpO2. This study also aims to investigate Ct, SpO2, CRP, D-dimer, and -607 IL-18 T/G polymorphism in order to find out predictors of chemosensory dysfunctions and mortality. Materials & methods: This study included 120 COVID-19 patients, of which 54 were mild, 40 were severe and 26 were critical. CRP, D-dimer, RT-PCR, and IL-18 polymorphism were evaluated. Results & conclusion: Low Ct was associated with SpO2 dropping and chemosensory dysfunctions. IL-18 T/G polymorphism did not show an association with COVID-19 mortality; conversely, age, BMI, D-dimer and Ct values did.
    Keywords chemosensory dysfunctions ; COVID-19 ; cyclic threshold ; polymorphism and predictors ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Demographic, clinical and genetic factors associated with COVID-19 disease susceptibility and mortality in a Kurdish population

    Shukur Wasman Smail / Esmaeil Babaei / Kawa Amin

    Annals of Saudi Medicine, Vol 43, Iss 3, Pp 125-

    2023  Volume 142

    Abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is a devastating pandemic that causes disease with a variability in susceptibility and mortality based on variants of various clinical and demographic factors, including particular genes among populations. ... ...

    Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) is a devastating pandemic that causes disease with a variability in susceptibility and mortality based on variants of various clinical and demographic factors, including particular genes among populations. OBJECTIVES: Determine associations of demographic, clinical, laboratory, and single nucleotide polymorphisms in the ACE2, TMPRSS2, TNF-α, and IFN-γ genes to the incidence of infection and mortality in COVID-19 patients. DESIGN: Prospective cohort study SETTINGS: Various cities in the Kurdistan Region of Iraq. PATIENTS AND METHODS: This prospective cohort study compared laboratory markers (D-dimer, tumor necrosis factor-alpha [TNF-α], interferon-gamma [IFN-γ], C-reactive protein [CRP], lymphocyte and neutrophil counts) between COVID-19 patients and healthy controls. DNA was extracted from blood, and genotypes were done by Sanger sequencing. MAIN OUTCOME MEASURES: Single nucleotide polymorphisms of the ACE2, TMPRSS2, TNF-α, and IFN-γ genes and demographic characteristics and laboratory markers for predicting mortality in COVID-19. SAMPLE SIZE: 203 (153 COVID-19 patients, 50 health control subjects). RESULTS: Forty-eight (31.4%) of the COVID-19 patients died. Age over 40 and comorbidities were risk factors for mortality, but the strongest associations were with serum IFN-γ, the neutrophil-to-lymphocyte ratio (NLR), and serum TNF-α. The AA genotype and A allele of TMPRSS2 rs2070788 decreased while the GA genotype and A allele of TNF-α increased susceptibility to COVID-19. Patients with the GA genotype of TNF-α rs1800629 had shorter survival times (9.9 days) than those carrying the GG genotype (18.3 days) (P<.0001 by log-rank test). The GA genotype versus the GG genotype was associated with higher levels of serum TNF-α. The GA genotype increased mortality rates by up to 3.8 fold. The survival rate for COVID-19 patients carrying the IFN-γ rs2430561 TT genotype (58.5%) was lower than in patients with the TA and AA genotypes (80.3%). The TT genotype increased the risk ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher King Faisal Specialist Hospital and Research Centre
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Does the cytomegalovirus infection cause kidney transplant rejection in Erbil city patients, Kurdistan region of Iraq?

    Sardar Hussein Rasool / Monika Henryka Miasko / Heshu Jalal Ahmed / Shukur Wasman Smail

    Zanco Journal of Pure and Applied Sciences, Vol 34, Iss 1, Pp 80-

    2022  Volume 86

    Abstract: Cytomegalovirus (CMV), the most significant infectious agent, belongs to the family of Herpesviridae. There is a high risk of severe viral reactivation among patients with kidney transplantation, particularly in the first three months after ... ...

    Abstract Cytomegalovirus (CMV), the most significant infectious agent, belongs to the family of Herpesviridae. There is a high risk of severe viral reactivation among patients with kidney transplantation, particularly in the first three months after transplantation (where patients are at the peak for immune suppression), The infection has a high morbidity rate. Hence, this study was designed to assess the association of CMV infection with kidney transplantation and recognize the symptoms that are more related to kidney transplantation (KT) in the Erbil city, Kurdistan region of Iraq. The study enrolled 72 patients who received renal allograft from March 2018 to December 2019, and this population has been characterized as Middle Eastern descent and ethnic miscegenation. Data included age and gender of the recipient, type of donor, symptomatic and asymptomatic CMV patients. Quantitative Polymerase Chain Reaction (qPCR) was used to detect and amplify the extracted virus DNA from blood samples. The CMV was found in 43 patients infected with CMV with graft rejection of about 37.21%. While, it was observed in low rate 13.79% in 20 other patients with graft rejection which had free from CMV. The graft rejection rates were significantly higher among the CMV positive group than controls (P= 0.029). In the light of the results of this study, it has been concluded that the CMV infection in patients after kidney transplantation surgery was deemed an important predisposing factor for acute allograft rejection. The study revealed that the screening of CMV among donor could decrease the possibility of kidney graft rejection among recipients.
    Keywords allograft rejection ; inflammation ; cytomegalovirus ; kidney transplantation ; polymerase chain reaction ; Technology ; T ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Salahaddin University-Erbil
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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