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  1. Book: Stem cell bioengineering and tissue engineering microenvironment

    Prakash, Satya / Shum-Tim, Dominique

    2011  

    Author's details ed. Satya Prakash & Dominique Shum-Tim
    Language English
    Size XXV, 542 S. : Ill., graph. Darst.
    Publisher World Scientific
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT016673473
    ISBN 978-981-283-788-2 ; 981-283-788-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4309 order for loan Magazin

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  2. Article ; Online: Redefining the bread and butter.

    Bassawon, Rayhaan / Shum-Tim, Dominique

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2022  Volume 61, Issue 6, Page(s) 1412–1413

    MeSH term(s) Animals ; Biomechanical Phenomena ; Bread ; Butter ; Coronary Artery Bypass ; Humans ; Saphenous Vein/transplantation ; Sheep
    Chemical Substances Butter (8029-34-3)
    Language English
    Publishing date 2022-01-17
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezac004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2303: Show issues Location:
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  3. Article ; Online: Extracorporeal life support in fulminant myocarditis: on the side or in the centre?

    Bassawon, Rayhaan / Shum-Tim, Dominique

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 60, Issue 5, Page(s) 1193–1194

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Humans ; Myocarditis/therapy ; Shock, Cardiogenic/therapy
    Language English
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab272
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  4. Article: Genome Editing and Cardiac Regeneration.

    Bassawon, Rayhaan / Khan, Kashif / Siddique, Ateeque / Shum-Tim, Dominique

    Advances in experimental medicine and biology

    2022  Volume 1396, Page(s) 37–52

    Abstract: Although the field of cardiac regeneration is relatively young, it is progressing rapidly with technological advancements. Genome editing tools are allowing researchers to creatively influence signaling pathways to be able to shed light on them and are ... ...

    Abstract Although the field of cardiac regeneration is relatively young, it is progressing rapidly with technological advancements. Genome editing tools are allowing researchers to creatively influence signaling pathways to be able to shed light on them and are important for addressing certain issues and limitations associated with in vitro and in vivo aspects of cardiac regeneration, such as imaging and immune rejection. In this chapter, the pathways involved in cardiac regeneration will be highlighted, and the role of gene-editing tools in endogenous and exogenous approaches to regenerate injured myocardium is discussed.
    MeSH term(s) Humans ; Gene Editing ; Heart ; Myocardium ; Research Personnel
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-19-5642-3_3
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  5. Article ; Online: Nanotechnology in development of next generation of stent and related medical devices: Current and future aspects.

    Islam, Paromita / Schaly, Sabrina / Abosalha, Ahmed Kh / Boyajian, Jacqueline / Thareja, Rahul / Ahmad, Waqar / Shum-Tim, Dominique / Prakash, Satya

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2024  Volume 16, Issue 2, Page(s) e1941

    Abstract: Coronary stents have saved millions of lives in the last three decades by treating atherosclerosis especially, by preventing plaque protrusion and subsequent aneurysms. They attenuate the vascular SMC proliferation and promote reconstruction of the ... ...

    Abstract Coronary stents have saved millions of lives in the last three decades by treating atherosclerosis especially, by preventing plaque protrusion and subsequent aneurysms. They attenuate the vascular SMC proliferation and promote reconstruction of the endothelial bed to ensure superior revascularization. With the evolution of modern stent types, nanotechnology has become an integral part of stent technology. Nanocoating and nanosurface fabrication on metallic and polymeric stents have improved their drug loading capacity as well as other mechanical, physico-chemical, and biological properties. Nanofeatures can mimic the natural nanofeatures of vascular tissue and control drug-delivery. This review will highlight the role of nanotechnology in addressing the challenges of coronary stents and the recent advancements in the field of related medical devices. Different generations of stents carrying nanoparticle-based formulations like liposomes, lipid-polymer hybrid NPs, polymeric micelles, and dendrimers are discussed highlighting their roles in local drug delivery and anti-restenotic properties. Drug nanoparticles like Paclitaxel embedded in metal stents are discussed as a feature of first-generation drug-eluting stents. Customized precision stents ensure safe delivery of nanoparticle-mediated genes or concerted transfer of gene, drug, and/or bioactive molecules like antibodies, gene mimics via nanofabricated stents. Nanotechnology can aid such therapies for drug delivery successfully due to its easy scale-up possibilities. However, limitations of this technology such as their potential cytotoxic effects associated with nanoparticle delivery that can trigger hypersensitivity reactions have also been discussed in this review. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
    MeSH term(s) Stents ; Drug-Eluting Stents ; Nanotechnology ; Antineoplastic Agents ; Paclitaxel
    Chemical Substances Antineoplastic Agents ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1941
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6781: Show issues Location:
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  6. Article ; Online: Transcatheter valve replacement: a revolution.

    Huu, Alice Le / Shum-Tim, Dominique

    Future cardiology

    2020  Volume 16, Issue 4, Page(s) 309–316

    Abstract: Degenerative aortic stenosis is the most common valvular disease worldwide; however, its physiopathology remains poorly understood. Although, developments in prevention of this disease have remained relatively stagnant, the last decade has brought about ... ...

    Abstract Degenerative aortic stenosis is the most common valvular disease worldwide; however, its physiopathology remains poorly understood. Although, developments in prevention of this disease have remained relatively stagnant, the last decade has brought about innovative treatment options incorporating different percutaneous and surgical approaches. These advances have allowed physicians to offer relief to high-risk patients, previously deemed nonsurgical. Increasingly, there is a shift toward offering percutaneous valve replacement to moderate and low-risk patients with aortic stenosis. Enthusiasm for a new treatment option must always be tempered by caution; as defining appropriate patient selection is essential to achieve optimal outcomes.
    MeSH term(s) Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis Implantation ; Humans ; Risk Factors ; Time Factors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2020-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2019-0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6836: Show issues Location:
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  7. Article ; Online: Synthesis and characterization of peptide conjugated human serum albumin nanoparticles for targeted cardiac uptake and drug delivery.

    Lomis, Nikita / Westfall, Susan / Shum-Tim, Dominique / Prakash, Satya

    PloS one

    2021  Volume 16, Issue 9, Page(s) e0254305

    Abstract: Congestive heart failure, a prominent cardiovascular disease results primarily from myocardial infarction or ischemia. Milrinone (MRN), a widely used clinical drug for heart failure, improves myocardial contractility and cardiac function through its ... ...

    Abstract Congestive heart failure, a prominent cardiovascular disease results primarily from myocardial infarction or ischemia. Milrinone (MRN), a widely used clinical drug for heart failure, improves myocardial contractility and cardiac function through its inotropic and vasodilatory effects. However, lacking target specificity, it exhibits low bioavailability and lower body retention time. Therefore, in this study, angiotensin II (AT1) peptide conjugated human serum albumin nanoparticles (AT1-HSA-MRN-NPs) have been synthesized for targeted delivery of MRN to the myocardium, overexpressing AT1 receptors under heart failure. The NPs were surface functionalized through a covalent conjugation reaction between HSA and AT1. Nanoparticle size was 215.2±4.7 nm and zeta potential -28.8±2.7 mV and cumulative release of MRN was ~72% over 24 hrs. The intracellular uptake of nanoparticles and cell viability was studied in H9c2 cells treated with AT1-MRN-HSA-NPs vs the control non-targeted drug, MRN Lactate under normal, hypoxic and hypertrophic conditions. The uptake of AT1-HSA-MRN-NPs in H9c2 cells was significantly higher as compared to non-targeted nanoparticles, and the viability of H9c2 cells treated with AT1-MRN-HSA-NPs vs MRN Lactate was 73.4±1.4% vs 44.9±1.4%, respectively. Therefore, AT1-HSA-MRN-NPs are safe for in vivo use and exhibit superior targeting and drug delivery characteristics for treatment of heart failure.
    MeSH term(s) Animals ; Biological Transport ; Cardiotonic Agents/chemistry ; Cardiotonic Agents/pharmacology ; Cell Survival ; Drug Carriers ; Drug Delivery Systems ; Humans ; Milrinone/chemistry ; Milrinone/pharmacology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacology ; Rats ; Serum Albumin, Human/chemistry
    Chemical Substances Cardiotonic Agents ; Drug Carriers ; Peptide Fragments ; Milrinone (JU9YAX04C7) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0254305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Snare or Scalpel: Challenges of Intracardiac Cement Embolism Retrieval.

    Bassawon, Rayhaan / Sirajuddin, Sarah / Martucci, Giuseppe / Shum-Tim, Dominique

    The Annals of thoracic surgery

    2021  Volume 113, Issue 2, Page(s) e107–e110

    Abstract: Intracardiac cement embolism after percutaneous vertebroplasty is a rare, but dangerous, complication, and guiding principles for its management are not well described. The management of this present case of intracardiac cement embolism offers insight to ...

    Abstract Intracardiac cement embolism after percutaneous vertebroplasty is a rare, but dangerous, complication, and guiding principles for its management are not well described. The management of this present case of intracardiac cement embolism offers insight to facilitate the treatment decision-making process in symptomatic patients requiring extraction.
    MeSH term(s) Bone Cements/adverse effects ; Embolectomy/methods ; Female ; Humans ; Microsurgery/methods ; Middle Aged ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/etiology ; Pulmonary Embolism/surgery ; Spinal Fractures/diagnosis ; Spinal Fractures/surgery ; Thoracic Vertebrae/injuries ; Tomography, X-Ray Computed ; Vertebroplasty/adverse effects
    Chemical Substances Bone Cements
    Language English
    Publishing date 2021-04-27
    Publishing country Netherlands
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2021.04.037
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    Zs.A 252: Show issues Location:
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  9. Article: Alginate-Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications.

    Schaly, Sabrina / Islam, Paromita / Abosalha, Ahmed / Boyajian, Jacqueline L / Shum-Tim, Dominique / Prakash, Satya

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 11

    Abstract: Hydrogel wound dressings are effective in their ability to provide a wound-healing environment but are limited by their ability to promote later stages of revascularization. Here, a biosafe recombinant baculovirus expressing VEGFA tagged with EGFP is ... ...

    Abstract Hydrogel wound dressings are effective in their ability to provide a wound-healing environment but are limited by their ability to promote later stages of revascularization. Here, a biosafe recombinant baculovirus expressing VEGFA tagged with EGFP is encapsulated in chitosan-coated alginate hydrogels using ionic cross-linking. The VEGFA, delivered by the baculovirus, significantly improves cell migration and angiogenesis to assist with the wound-healing process and revascularization. Moreover, the hydrogels have an encapsulation efficiency of 99.9%, no cytotoxicity, antimicrobial properties, good blood compatibility, promote hemostasis, and enable sustained delivery of baculoviruses over eight days. These hydrogels sustain baculovirus delivery and may have clinical implications in wound dressings or future gene therapy applications.
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15111382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Migration despite stabilization of an embolized transcatheter heart valve: A word of caution.

    Ghandour, Amale / Bassawon, Rayhaan / Langlois, Hugo / Ergina, Patrick L / Shum-Tim, Dominique

    Journal of cardiac surgery

    2022  

    Abstract: This case report describes an initially stabilized transcatheter heart valve that embolized in the ascending aorta, leading to a postprocedural acute type A aortic dissection. ...

    Abstract This case report describes an initially stabilized transcatheter heart valve that embolized in the ascending aorta, leading to a postprocedural acute type A aortic dissection.
    Language English
    Publishing date 2022-11-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.17141
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