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  1. Article: Supplementation of green coffee bean extract in healthy overweight subjects increases lean mass/fat mass ratio: A randomized, double-blind clinical study.

    Sudeep, H V / Shyam Prasad, K

    SAGE open medicine

    2021  Volume 9, Page(s) 20503121211002590

    Abstract: Objective: In this study, we have demonstrated that supplementation of a complex of chlorogenic acid isomers (CGA-7: Method: In a double-blind, placebo-controlled clinical study, healthy overweight (body mass index ⩾ 25 to <30 kg/m: Results: Sixty ...

    Abstract Objective: In this study, we have demonstrated that supplementation of a complex of chlorogenic acid isomers (CGA-7
    Method: In a double-blind, placebo-controlled clinical study, healthy overweight (body mass index ⩾ 25 to <30 kg/m
    Results: Sixty subjects completed the study. Mean body weight and body mass index were significantly reduced in CGA-7 group as compared to placebo (
    Conclusion: To conclude, this study provides scientific validation of the functionality of green coffee bean extract and recommends the safety of the supplementation in healthy individuals.
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121211002590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1.

    Vasavi, H S / Sudeep, H V / Lingaraju, H B / Shyam Prasad, K

    Microbial pathogenesis

    2017  Volume 104, Page(s) 64–71

    Abstract: Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with ...

    Abstract Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with QS mechanism offers an attractive strategy to combat bacterial infections. In the present study, anti-QS activity of a novel resveratrol formulation, Resveramax™, was detected using Chromobacterium violaceum biosensor bioassay and the effect of Resveramax on QS-regulated phenotypes in Pseudomonas aeruginosa PAO1 was assessed by standard protocols. Molecular docking analysis of resveratrol, the major active constituent of Resveramax, with LasR receptor protein was performed to evidence the QS-inhibitory potential of Resveramax. Results showed that Resveramax specifically inhibited the QS-mediated violacein pigment production in C. violaceum; pyocyanin production, proteolytic activity, swarming motility and biofilm formation in P. aeruginosa PAO1 in a concentration-dependent manner. Biofilms treated with Resveramax showed increased susceptibility to antibiotics when compared with the antibiotic treatment alone. Molecular docking analysis proved that resveratrol binds more rigidly with LasR receptor protein with docking score of -8.55 kJ/mol. These findings suggest that Resveramax could be used as novel QS-based antibacterial/anti-biofilm agent for the management of bacterial infections.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Biofilms/drug effects ; Biological Availability ; Biosensing Techniques ; Drug Synergism ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Conformation ; Protein Binding ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/physiology ; Quorum Sensing/drug effects ; Stilbenes/chemistry ; Stilbenes/pharmacokinetics ; Stilbenes/pharmacology ; Trans-Activators/chemistry ; Trans-Activators/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; LasR protein, Pseudomonas aeruginosa ; Stilbenes ; Trans-Activators ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2017.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Werden die Vorteile perkutaner Kanülierungstechnik durch ein erhöhtes Bluttrauma erkauft?

    Shyam Prasad, K / Tönz, M / von Segesser, L K / Leskosek, B / Pei, P / Turina, M

    Helvetica chirurgica acta

    1993  Volume 60, Issue 3, Page(s) 393–396

    Abstract: Unlabelled: The development of thin-walled cannulas which can be introduced by percutaneous technique into femoral artery and vein has revived interest in emergency cardiopulmonary support (CPS). To assess possible blood damaging effect due to the small- ...

    Title translation Are the advantages of percutaneous catheterization technique gained by increased blood trauma?.
    Abstract Unlabelled: The development of thin-walled cannulas which can be introduced by percutaneous technique into femoral artery and vein has revived interest in emergency cardiopulmonary support (CPS). To assess possible blood damaging effect due to the small-bore cannulas, 8 in vitro perfusions were performed with two parallel pump circuits: one circuit with a 17 F arterial and a 21 F venous cannula, one circuit without cannulas (control). The circuits were filled with 61 of bovine blood and run for 6 hours at a temperature of 37 degrees C and a flow of 4 l/min. Serial blood samples were taken before and during the experiment. There was a significantly higher level of free plasma haemoglobin (pl Hb) and a decreased number of leukocytes (Lc) after 6 hours of perfusion in the group with percutaneous cannulas as compared with control (pl Hb: 63.2 +/- 0.3 vs. 26.3 +/- 4.1 mumol/l, p < 0.05, Lc: 2.4 +/- 0.6 vs. 4.6 +/- 0.8 x 10(9)/l, p < 0.05, mean +/- se).
    Conclusion: percutaneous cannulas are associated with an increased blood trauma. If extended cardiopulmonary support is considered (more than several hours), percutaneous cannulas should be replaced by large-bore cannulas.
    MeSH term(s) Animals ; Assisted Circulation/instrumentation ; Blood Cell Count ; Catheterization, Peripheral/instrumentation ; Catheters, Indwelling ; Cattle ; Hemodynamics/physiology ; Hemoglobinometry ; Hemolysis/physiology ; Humans ; Leukocyte Count ; Models, Cardiovascular
    Language German
    Publishing date 1993-12
    Publishing country Switzerland
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 80127-6
    ISSN 0018-0181
    ISSN 0018-0181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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