LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article ; Online: ViphyllinTM, a Standardized Black Pepper Extract Exerts Antihyperglycemic Effect and Improves Sciatic Nerve Conduction in High Fat Diet/Streptozotocin-Induced Diabetic Model Rats

Ramanaiah I / Sudeep HV / Shyamprasad K

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 15, Pp 1819-

2022 Volume 1829

Abstract: Illuri Ramanaiah, Heggar Venkataramana Sudeep, Kodimule Shyamprasad Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, IndiaCorrespondence: Heggar Venkataramana Sudeep, Department of ... ...

Abstract	Illuri Ramanaiah, Heggar Venkataramana Sudeep, Kodimule Shyamprasad Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, IndiaCorrespondence: Heggar Venkataramana Sudeep, Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, India, Tel +91 80-42094158, Email research@vidyaherbs.comPurpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Here, we have investigated for the first time the therapeutic effects of a standardized Piper nigrum L., (black pepper) seed extract, ViphyllinTM in mitigating hyperglycemia and neuropathic pain of type 2 diabetes model rats.Methods: Type 2 diabetes was induced in male Wistar rats using high fat diet and a single dose of streptozotocin (60 mg/kg i.p.). The diabetic rats were orally administered with Viphyllin containing not less than 30% β-caryophyllene (BCP), at 25 mg, 50 mg and 100 mg/kg/day doses for 6 weeks. Changes in body weight, fasting blood glucose (FBG), glucose tolerance, and blood biochemical parameters were measured. The nociceptive response to thermal stimulus (tail flick test) and sciatic nerve conduction velocity (NCV) were recorded at the end of study.Results: Viphyllin treatment markedly improved the body weight and glucose tolerance in diabetic rats. Also, the extract could significantly reduce the diabetes-induced elevation in FBG, liver and kidney indices. Further, Viphyllin dose-dependently increased the nociception latency in tail flick test compared to untreated diabetic rats (p< 0.05). Viphyllin at 100 mg/kg significantly increased the NCV (44.12± 1.91*** m/s vs diabetic control 25.80± 1.88 m/s). The antioxidant enzyme activities in sciatic nerve tissue were considerably increased in Viphyllin-treated groups compared to diabetic control. A 6-week treatment with Viphyllin markedly reversed the ...
Keywords	diabetic neuropathy ; thermal hyperalgesia ; peripheral nerves ; black pepper ; Specialties of internal medicine ; RC581-951
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Molecular docking analysis of Withaferin A from Withania somnifera with the Glucose regulated protein 78 (GRP78) receptor and the SARS-CoV-2 main protease.

Sudeep, H V / Gouthamchandra, K / Shyamprasad, K

Bioinformation

2020 Volume 16, Issue 5, Page(s) 411–417

Abstract: Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) ...

Abstract	Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) with Withaferin A from Withania somnifera in the context of COVID-19 pandemic for further consideration. Here, we report the optimal interaction features of withaferin A, artemisinin, curcumin and andrographolide with the GRP78 receptor having low binding energies (-8.7, -7.89, -6.21 and -6.17 kcal/mol respectively) in this report. In order to gain additional insights, the interaction pattern of compounds with SARS-CoV-2 main protease (Mpro) was studied.
Keywords	covid19
Language	English
Publishing date	2020-04-30
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630016411
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency.

Sudeep, H V / Thomas, Jestin V / Shyamprasad, K

BMC urology

2020 Volume 20, Issue 1, Page(s) 86

Abstract: Background: The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency.: Methods: ... ...

Abstract	Background: The present clinical trial was conducted to evaluate the efficacy and tolerability of a standardized saw palmetto oil containing 3% β-sitosterol in the treatment of benign prostate hyperplasia (BPH) and androgen deficiency. Methods: Subjects aged 40-65 years with symptomatic BPH were randomized to 12-week double-blind treatment with 500 mg doses of β-sitosterol enriched saw palmetto oil, conventional saw palmetto oil and placebo orally in the form of capsules (n = 33 in each group). BPH severity was determined using the International Prostate Symptom Score (IPSS), uroflowmetry, serum measurement of prostate specific antigen (PSA), testosterone and 5α-reductase. During the trial, the androgen deficiency was evaluated using Aging Male Symptoms (AMS) scale, the Androgen Deficiency in the Aging Male (ADAM) questionnaire, serum levels of free testosterone. Results: Subjects treated with β-sitosterol enriched saw palmetto oil showed significant decrease in IPSS, AMS and ADAM scores along with reduced postvoiding residual volume (p < 0.001), PSA (p < 0.01) and 5α-reductase from baseline to end of 12-week treatment as compared to placebo. There was also a significant increment in the maximum and average urine flow rate (p < 0.001), and serum free testosterone level of subjects treated with enriched saw palmetto oil as compared to placebo. Conclusion: This study demonstrates the efficacy of β-sitosterol enriched saw palmetto oil superior to conventional oil thus extending the scope of effective BPH and androgen deficiency treatment with improved quality of life through the intake of functional ingredients. Trial registration: CTRI/2018/12/016724 dated 19/12/2018 prospectively registered. URL: http://ctri.nic.in/Clinicaltrials/advsearch.php.
MeSH term(s)	Adult ; Aged ; Androgens/deficiency ; Double-Blind Method ; Humans ; Male ; Middle Aged ; Phytosterols/therapeutic use ; Phytotherapy ; Plant Extracts/therapeutic use ; Plant Oils/therapeutic use ; Prostatic Hyperplasia/drug therapy ; Sitosterols/therapeutic use ; Treatment Outcome ; Urological Agents/therapeutic use
Chemical Substances	Androgens ; Phytosterols ; Plant Extracts ; Plant Oils ; Sitosterols ; Urological Agents ; gamma-sitosterol (5LI01C78DD) ; saw palmetto extract (J7WWH9M8QS)
Language	English
Publishing date	2020-07-03
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-020-00648-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Viphyllin

Ramanaiah, Illuri / Sudeep, Heggar Venkataramana / Shyamprasad, Kodimule

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 1819–1829

Abstract: Purpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Here, we have investigated for the first time the therapeutic ... ...

Abstract	Purpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Here, we have investigated for the first time the therapeutic effects of a standardized Methods: Type 2 diabetes was induced in male Wistar rats using high fat diet and a single dose of streptozotocin (60 mg/kg Results: Viphyllin treatment markedly improved the body weight and glucose tolerance in diabetic rats. Also, the extract could significantly reduce the diabetes-induced elevation in FBG, liver and kidney indices. Further, Viphyllin dose-dependently increased the nociception latency in tail flick test compared to untreated diabetic rats ( Conclusion: The study concludes that Viphyllin exerts antidiabetic effects and improves nerve conduction to mitigate neuropathic pain.
Language	English
Publishing date	2022-06-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S366609
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

Venkatakrishna K / Sundeep K / Sudeep HV / Gouthamchandra K / Shyamprasad K

Journal of Pain Research, Vol Volume 15, Pp 355-

2022 Volume 366

Abstract: Karempudi Venkatakrishna, Kuppam Sundeep, Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Kodimule Shyamprasad R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, 560 105, Karnataka, IndiaCorrespondence: Heggar Venkataramana Sudeep, Tel +91 ... ...

Abstract	Karempudi Venkatakrishna, Kuppam Sundeep, Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Kodimule Shyamprasad R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, 560 105, Karnataka, IndiaCorrespondence: Heggar Venkataramana Sudeep, Tel +91 80-42094158, Email research@vidyaherbs.comPurpose: Plant-based natural products as anti-nociceptors have enormous potential as safer alternatives to conventional opiates and NSAIDS. Piper nigrum (black pepper) is one of the major culinary spices with medicinal attributes.Methods: In the present study, the antinociceptive activity of a standardized black pepper seed extract (Viphyllin) containing not less than 30% β-caryophyllene (BCP) was evaluated using pain models in mice, namely acetic acid-induced writhing test, formalin-induced paw licking test, hot plate test and tail flick test. Further, the antagonists SR141716A (0.1 mg/kg i.p.), AM630 (5 mg/kg i.p.), capsazepine (0.1 mg/kg body weight i.p.), and GW6471 (1 mg/kg i.p.) were used to evaluate the involvement of cannabinoid receptors CB1 and CB2, TRPV1 ion channel and PPARα receptor, respectively. Molecular docking (AutoDock 4.2) was used to study the interaction of BCP with the agonist-binding sites of the selected pain receptors.Results: Viphyllin at 10 mg, 25 mg and 50 mg/kg (i.p.) significantly inhibited the writhings in mice as compared to untreated control group (p < 0.001). Further, Viphyllin at 50 mg/kg showed strong antinociceptive effect in formalin-induced paw licking test (p < 0.05). Pretreatment of mice with AM630 significantly reversed the antinociceptive activity of Viphyllin in both early and late phases of formalin test (p < 0.05). Administration of Viphyllin markedly increased the latency time of mice in hot plate test (p < 0.001). Further, Viphyllin markedly increased the latency time of tail flick compared to control group from 30 min to 90 min after treatment. AM630, Capsazepine, and GW6471 abolished the analgesic effect of Viphyllin. These findings clearly suggest the ...
Keywords	piper nigrum ; β-caryophyllene ; pain ; nociceptive receptors ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects - A 16-Week Randomized, Placebo-Controlled Study.

Sudeep, Heggar Venkataramana / Rashmi, Sriram / Jestin, Thomas V / Richards, Aleksander / Gouthamchandra, Kuluvar / Shyamprasad, Kodimule

Clinical, cosmetic and investigational dermatology

2023 Volume 16, Page(s) 3251–3266

Abstract: Purpose: Androgenetic alopecia (AGA) is the most common type of hair loss in humans, affecting self-esteem and emotional well-being. This study aimed to assess the safety and efficacy of VISPO: Methods: In a double-blind, placebo-controlled, four-arm ...

Abstract	Purpose: Androgenetic alopecia (AGA) is the most common type of hair loss in humans, affecting self-esteem and emotional well-being. This study aimed to assess the safety and efficacy of VISPO Methods: In a double-blind, placebo-controlled, four-arm clinical study, 80 healthy male and female subjects aged 18-50 years were randomly allocated (1:1:1:1) to receive either 400 mg capsules of VISPO or 5 mL of a topical formulation containing 20% VISPO or the respective placebo once daily for 16 weeks. The primary endpoints included hair count (hair comb and hair pull tests) and the self-assessment of perceived efficacy. Objective evaluation was performed using the global photographic assessment score. Hair density, thickness, and anagen/telogen ratio were evaluated using phototrichogram analysis. Results: At the end of the study, oral and topical formulations of VISPO reduced hair fall by up to 29% ( Conclusion: VISPO formulations reduced hair fall and promoted hair regrowth and scalp appearance in AGA patients.
Language	English
Publishing date	2023-11-11
Publishing country	New Zealand
Document type	Case Reports ; Clinical Trial
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S435795
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Aframomum melegueta

Sudeep, Heggar Venkataramana / Aman, Khanna / Jestin, Thomas V / Shyamprasad, Kodimule

Drug design, development and therapy

2022 Volume 16, Page(s) 3777–3791

Abstract: Purpose: Aframomum melegueta: Methods: In a double-blind, placebo-controlled clinical trial design, we have examined the thermogenic effects of a standardized : Results: Consumption of AfperFit significantly increased the energy expenditure (: ... ...

Abstract	Purpose: Aframomum melegueta Methods: In a double-blind, placebo-controlled clinical trial design, we have examined the thermogenic effects of a standardized Results: Consumption of AfperFit significantly increased the energy expenditure ( Conclusion: Overall, this study validates the health benefits of
MeSH term(s)	Adult ; Male ; Female ; Humans ; Overweight/drug therapy ; Overweight/metabolism ; Intra-Abdominal Fat/metabolism ; Quality of Life ; Zingiberaceae/chemistry ; Energy Metabolism ; Double-Blind Method ; Seeds ; Plant Extracts
Chemical Substances	6-paradol (BO24ID7E9U) ; Plant Extracts
Language	English
Publishing date	2022-10-28
Publishing country	New Zealand
Document type	Randomized Controlled Trial ; Case Reports ; Clinical Trial
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S367350
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A standardized extract of

Sudeep, Heggar Venkataramana / Gouthamchandra, Kuluvar / Ramanaiah, Illuri / Raj, Amritha / Naveen, Puttaswamy / Shyamprasad, Kodimule

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1211–1221

Abstract: Context: Preparations of : Objective: In this study, : Materials and methods: The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of : Results: The SEP extract inhibited DPPH (IC50 = 106.7 µg/mL), ABTS!# ...

Abstract	Context: Preparations of Objective: In this study, Materials and methods: The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of Results: The SEP extract inhibited DPPH (IC50 = 106.7 µg/mL), ABTS Conclusion: Our results strongly support SEP extract with 4% chicoric acid as a functional ingredient for immunomodulation.
MeSH term(s)	Mice ; Male ; Animals ; Echinacea/chemistry ; Nitric Oxide ; Cytokines ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Macrophages ; Immunosuppression Therapy ; Immunity
Chemical Substances	chicoric acid (S4YY3V8YHD) ; Nitric Oxide (31C4KY9ESH) ; Cytokines ; Plant Extracts
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2244000
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1300: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Molecular docking analysis of Withaferin A from Withania somnifera with the Glucose regulated protein 78 (GRP78) receptor and the SARS-CoV-2 main protease

Sudeep, H V / Gouthamchandra, K / Shyamprasad, K

Bioinformation

Abstract	Design and development of an effective compound to combat COVID-19 is clearly critical in the current circumstances. Therefore, it is of interest to document the molecular docking analysis data of the cellular receptor Glucose regulated protein 78 (GRP78) with Withaferin A from Withania somnifera in the context of COVID-19 pandemic for further consideration. Here, we report the optimal interaction features of withaferin A, artemisinin, curcumin and andrographolide with the GRP78 receptor having low binding energies (-8.7, -7.89, -6.21 and -6.17 kcal/mol respectively) in this report. In order to gain additional insights, the interaction pattern of compounds with SARS-CoV-2 main protease (Mpro) was studied.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #729743
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins.

Sudeep, H V / Venkatakrishna, K / Amritharaj / Gouthamchandra, K / Reethi, B / Naveen, P / Lingaraju, H B / Shyamprasad, K

Journal of food biochemistry

2021 Volume 45, Issue 12, Page(s) e13994

Abstract: β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using ... ...

Abstract	β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using supercritical fluid extraction, standardized to contain 30% BCP (Viphyllin
MeSH term(s)	Amnesia/chemically induced ; Amnesia/drug therapy ; Animals ; Brain-Derived Neurotrophic Factor ; Cognition ; Male ; Mice ; Piper nigrum ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Polycyclic Sesquiterpenes ; Scopolamine/toxicity
Chemical Substances	Brain-Derived Neurotrophic Factor ; Plant Extracts ; Polycyclic Sesquiterpenes ; caryophyllene (BHW853AU9H) ; Scopolamine (DL48G20X8X)
Language	English
Publishing date	2021-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13994
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED