Article ; Online: A Rare Case of Metaplastic Thymoma Presenting With Myasthenia Gravis.
International journal of surgical pathology
2023 Volume 32, Issue 1, Page(s) 155–159
Abstract: Thymomas are tumors of the mediastinum often associated with autoimmune conditions, in particular myasthenia gravis. In contrast, among the fewer than 40 reports of metaplastic thymoma, myasthenia gravis is rarely found. We describe the fourth patient, ... ...
Abstract | Thymomas are tumors of the mediastinum often associated with autoimmune conditions, in particular myasthenia gravis. In contrast, among the fewer than 40 reports of metaplastic thymoma, myasthenia gravis is rarely found. We describe the fourth patient, and first man, with metaplastic thymoma and myasthenia gravis. A 34-year-old had acute onset of double vision with associated dysphagia and was found to have an elevation of serum acetylcholine receptor antibodies. He underwent a transsternal thymectomy. Tissue sections showed a biphasic proliferation of keratin-positive epithelial cells with a complement of spindle cells confirming the diagnosis of metaplastic thymoma. Terminal deoxynucleotidyl transferase (TDT)-positive T lymphocytes were rare and only found in the periphery of the tumor, consistent with thymic remnant. A |
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MeSH term(s) | Male ; Humans ; Adult ; Thymoma/complications ; Thymoma/diagnosis ; Thymus Neoplasms/complications ; Thymus Neoplasms/diagnosis ; Myasthenia Gravis/complications ; Myasthenia Gravis/diagnosis ; T-Lymphocytes ; Thymectomy |
Language | English |
Publishing date | 2023-04-24 |
Publishing country | United States |
Document type | Case Reports ; Journal Article |
ZDB-ID | 1336393-1 |
ISSN | 1940-2465 ; 1066-8969 |
ISSN (online) | 1940-2465 |
ISSN | 1066-8969 |
DOI | 10.1177/10668969231168344 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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