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  1. Article ; Online: Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice.

    Xu, Jinyu / Zhang, Lianshuang / Si, Yaru / Huang, Wanyue / Liu, Ranran / Liu, Zhiyuan / Jiang, Zhonglin / Xu, Feibo

    Chemico-biological interactions

    2024  Volume 390, Page(s) 110870

    Abstract: Busulfan, a bifunctional alkylated chemotherapeutic agent, has male reproductive toxicity and induce oligospermia, which is associated with ferroptosis. However, the specific target cells of busulfan-induced oligospermia triggered by ferroptosis are ... ...

    Abstract Busulfan, a bifunctional alkylated chemotherapeutic agent, has male reproductive toxicity and induce oligospermia, which is associated with ferroptosis. However, the specific target cells of busulfan-induced oligospermia triggered by ferroptosis are largely elusive, and the detailed mechanisms also require further exploration. In the present study, busulfan (0.6, and 1.2 mM, 48 h) causes ferroptosis in GC-1 spg cells through inducing Fe
    MeSH term(s) Humans ; Male ; Animals ; Mice ; Busulfan/toxicity ; Spermatogonia ; Oligospermia/chemically induced ; Ferroptosis ; Autophagy ; Acetates ; Phenols
    Chemical Substances Busulfan (G1LN9045DK) ; GC 1 compound ; Acetates ; Phenols
    Language English
    Publishing date 2024-01-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2024.110870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Novel quantitative structure-activity relationship model to predict activities of natural products against COVID-19.

    Si, Yaru / Xu, Xinyue / Hu, Yingfeng / Si, Hongzong / Zhai, Honglin

    Chemical biology & drug design

    2021  Volume 97, Issue 4, Page(s) 978–983

    Abstract: Currently, COVID-19 is spreading in a large scale while no efficient vaccine has been produced. A high-effective drug for COVID-19 is very necessary now. We established a satisfied quantitative structure-activity relationship model by gene expression ... ...

    Abstract Currently, COVID-19 is spreading in a large scale while no efficient vaccine has been produced. A high-effective drug for COVID-19 is very necessary now. We established a satisfied quantitative structure-activity relationship model by gene expression programming to predict the IC50 value of natural compounds. A total of 27 natural products were optimized by heuristic method in CODESSA program to build a liner model. Based on it, only two descriptors were selected and utilized to build a nonlinear model in gene expression programming. The square of correlation coefficient and s2 of heuristic method were 0.80 and 0.10, respectively. In gene expression programming, the square of correlation coefficient and mean square error for training set were 0.91 and 0.04. The square of correlation coefficient and mean square error for test set are 0.86 and 0.1. This nonlinear model has stronger predictive ability to develop the targeted drugs of COVID-19.
    MeSH term(s) Algorithms ; Biological Products/pharmacology ; Biological Products/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Heuristics ; Humans ; Inhibitory Concentration 50 ; Quantitative Structure-Activity Relationship ; SARS-CoV-2/drug effects ; SARS-CoV-2/isolation & purification
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2216600-2
    ISSN 1747-0285 ; 1747-0277
    ISSN (online) 1747-0285
    ISSN 1747-0277
    DOI 10.1111/cbdd.13822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: hUMSCs Restore Uterine Function by Inhibiting Endometrial Fibrosis via Regulation of the MMP-9/TIMP-1 Ratio in CDDP-Induced Injury Rats.

    Tang, Yu / Si, Yaru / Liu, Chengen / Li, Cui / Qu, Li / Liu, Ying / Fu, Qiang / Luo, Qianqian

    Stem cells international

    2023  Volume 2023, Page(s) 8014052

    Abstract: The fertility of females of childbearing age who are cured of cancer by chemotherapy is gradually declining globally. As a broad-spectrum chemotherapy drug in clinic, the damage of cisplatin (CDDP) to female reproductive function cannot be ignored. At ... ...

    Abstract The fertility of females of childbearing age who are cured of cancer by chemotherapy is gradually declining globally. As a broad-spectrum chemotherapy drug in clinic, the damage of cisplatin (CDDP) to female reproductive function cannot be ignored. At present, the study of CDDP damage to the uterus is not sufficient, and the exact mechanism needs to be further explored. Therefore, we conducted this research to determine whether uterine injury in CDDP-induced injury rats might be improved by human umbilical cord mesenchymal stem cells (hUMSCs) and to further explore the precise mechanism. The rat model of CDDP-induced injury was established by intraperitoneal injection of CDDP, and hUMSCs were injected into the tail vein 7 days later.
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2023/8014052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Carbon Nanodots Inhibit Tumor Necrosis Factor-α-Induced Endothelial Inflammation through Scavenging Hydrogen Peroxide and Upregulating Antioxidant Gene Expression in EA.hy926 Endothelial Cells.

    Chavez, Jessica / Khan, Ajmal / Watson, Kenna R / Khan, Safeera / Si, Yaru / Deng, Alexandra Y / Koher, Grant / Anike, Mmesoma S / Yi, Xianwen / Jia, Zhenquan

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Carbon nanodots (CNDs) are a new type of nanomaterial with a size of less than 10 nanometers and excellent biocompatibility, widely used in fields such as biological imaging, transmission, diagnosis, and drug delivery. However, its potential and ... ...

    Abstract Carbon nanodots (CNDs) are a new type of nanomaterial with a size of less than 10 nanometers and excellent biocompatibility, widely used in fields such as biological imaging, transmission, diagnosis, and drug delivery. However, its potential and mechanism to mediate endothelial inflammation have yet to be explored. Here, we report that the uptake of CNDs by EA.hy926 endothelial cells is both time and dose dependent. The concentration of CNDs used in this experiment was found to not affect cell viability. TNF-α is a known biomarker of vascular inflammation. Cells treated with CNDs for 24 h significantly inhibited TNF-α (0.5 ng/mL)-induced expression of intracellular adhesion molecule 1 (
    Language English
    Publishing date 2024-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13020224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: hUMSCs Transplantation Regulates AMPK/NR4A1 Signaling Axis to Inhibit Ovarian Fibrosis in POI Rats.

    Cui, Linlu / Bao, Hongchu / Zhu, Wenqian / Tang, Yu / Luo, Qianqian / Si, Yaru / Fu, Qiang / Jiang, Zhonglin

    Stem cell reviews and reports

    2022  Volume 19, Issue 5, Page(s) 1449–1465

    Abstract: Background: The mechanism of human Umbilical Cord Mesenchymal Stem Cells (hUMSCs) transplantation to improve ovarian function in the rats with Premature Ovarian Insufficiency (POI) is still unclear. The aim of this study is to investigate the signal ... ...

    Abstract Background: The mechanism of human Umbilical Cord Mesenchymal Stem Cells (hUMSCs) transplantation to improve ovarian function in the rats with Premature Ovarian Insufficiency (POI) is still unclear. The aim of this study is to investigate the signal axis mechanism that is involved in the ovarian function recovery of POI rats following hUMSCs transplantation.
    Methods: The rat model with POI was established by intraperitoneal injection of cisplatin. The hUMSCs were transplanted by caudal vein injection into POI rats. Hematoxylin-eosin (H&E) staining was performed to examine the morphology of rat ovarian tissue. Masson staining, Sirus red staining and immunofluorescence were used to observe the fibrosis extent of ovarian tissue. The levels of serum sex hormones and the expression of fibrosis related markers in ovarian tissues were measured by enzyme-linked immunosorbent assay (ELISA). The expression of NR4A1, Phospho-NR4A1 and AMP-activated protein kinase (AMPK) signaling in rat ovarian tissues was measured by immunohistochemistry and immunofluorescence. The role of AMPK/NR4A1 signaling axis in the regulation of ovarian function recovery in POI rats following hUMSCs transplantation was further investigated by adenovirus and siRNA intervention in isolated stromal cells.
    Results: The results showed that the hUMSCs transplantation significantly inhibited ovarian tissue fibrosis and restored the ovarian function in POI rats. The level of NR4A1 and AMPK expression in ovarian tissue of POI rats after hUMSCs transplantation was significantly increased compared with the control group. In the cultured ovarian stromal cells, the similar results were obtained on the expression of NR4A1 and its regulation on fibrosis related molecular markers in Cisplatin (CDDP) damaged stromal cells following hUMSCs supernatant treatment. Both hUMSCs supernatant treatment and the addition of AMPK inhibitors increased NR4A1 expression in stromal cells. And after NR4A1 molecular intervention, fibrosis-related indicators in stromal cells changed. The data suggests that the AMPK/NR4A1 signaling axis is involved in the ovarian function changes in POI rats following hUMSCs transplantation.
    Conclusion: The data from this study indicate that the inhibition of tissue fibrosis and recovery of ovarian function is regulated by AMPK/NR4A1 signaling axis in POI rats following hUMSCs transplantation.
    MeSH term(s) Female ; Rats ; Humans ; Animals ; AMP-Activated Protein Kinases/metabolism ; Cisplatin ; Mesenchymal Stem Cell Transplantation/methods ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/therapy ; Primary Ovarian Insufficiency/metabolism ; Mesenchymal Stem Cells ; Fibrosis ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Cisplatin (Q20Q21Q62J) ; NR4A1 protein, human ; Nuclear Receptor Subfamily 4, Group A, Member 1
    Language English
    Publishing date 2022-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-022-10469-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6198: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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