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  1. Article: DYT-

    Fan, Yuhang / Si, Zhibo / Wang, Linlin / Zhang, Lei

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1216929

    Abstract: DYT- ...

    Abstract DYT-
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1216929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy.

    Si, Zhibo / Zheng, Yajuan / Zhao, Jing

    Biomolecules

    2023  Volume 13, Issue 6

    Abstract: Age-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to the formation of Drusen, while wet AMD is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a ... ...

    Abstract Age-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to the formation of Drusen, while wet AMD is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a key role in AMD pathogenesis. In particular, helioreceptor renewal depends on outer segment phagocytosis of RPE cells, while RPE autophagy can protect cells from oxidative stress damage. However, when the oxidative stress burden is too high and homeostasis is disturbed, the phagocytosis and autophagy functions of RPE become damaged, leading to AMD development and progression. Hence, characterizing the roles of RPE cell phagocytosis and autophagy in the pathogenesis of AMD can inform the development of potential therapeutic targets to prevent irreversible RPE and photoreceptor cell death, thus protecting against AMD.
    MeSH term(s) Aged ; Humans ; Phagocytosis/physiology ; Autophagy/physiology ; Macular Degeneration/metabolism ; Oxidative Stress ; Epithelial Cells/metabolism ; Retinal Pigments/metabolism
    Chemical Substances Retinal Pigments
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13060901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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