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  1. Article: The importance of the mesofascial interface in complete mesocolic excision.

    Siani, Luca Maria / Garulli, Gianluca

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2017  Volume 15, Issue 4, Page(s) 240–249

    Abstract: Complete mesocolic excision (CME) with Central Vascular Ligation (CVL) is progressively gaining acceptance as the most updated surgical treatment in the multimodal management of colonic cancer. The concept is based on excision of the affected organ with ... ...

    Abstract Complete mesocolic excision (CME) with Central Vascular Ligation (CVL) is progressively gaining acceptance as the most updated surgical treatment in the multimodal management of colonic cancer. The concept is based on excision of the affected organ with its related primitive dorsal mesenterium as an intact package to maximize local clearance, and high tie ligation to boost regional control, translating the original concept of Total Mesorectal Excision proposed by Heald for rectal cancer. Aim of this review is to analyze the modern concept of the mesenteric organ, with particular regard to the interfaces between its single components and the importance of the meso-fascial interface as the correct plane of separation. The integrity of the mesocolon excised along the meso-fascial interface (meso-fascial separation) prevents any breach of its surface and underlying structures, preserving the radial margin and the complex network of the meso-structure, avoiding any spillage of neoplastic cells within the surgical field. Central Vascular ligation allows for the most effective harvesting of lymph nodes, particularly of the apical ones, whose removal appears to be crucial in optimizing regional control. A surgical plane developed along the meso-fascial interface, coupled with high tie ligation, yields higher quality of surgical specimen, with better oncologic outcome in terms of local recurrence rate, disease-free and overall survival.
    Language English
    Publishing date 2017-08
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2016.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Laparoscopic complete mesocolic excision with central vascular ligation in right colon cancer: A comprehensive review.

    Siani, Luca Maria / Garulli, Gianluca

    World journal of gastrointestinal surgery

    2016  Volume 8, Issue 2, Page(s) 106–114

    Abstract: Aim of the study is to comprehensively review the latest trends in laparoscopic complete mesocolic excision (CME) with central vascular ligation (CVL) for the multimodal management of right colon cancer. Historical and up-to-date anatomo-embryological ... ...

    Abstract Aim of the study is to comprehensively review the latest trends in laparoscopic complete mesocolic excision (CME) with central vascular ligation (CVL) for the multimodal management of right colon cancer. Historical and up-to-date anatomo-embryological concepts are analyzed in detail, focusing on the latest studies of the mesenteric organ, its dissection by mesofascial and retrofascial cleavage planes, and questioning the need for a new terminology in colonic resections. The rationale behind Laparoscopic CME with CVL is thoroughly investigated and explained. Attention is paid to the current surgical techniques and the quality of the surgical specimen, yielded through mesocolic, intramesocolic and muscularis propria plane of surgery. We evaluate the impact on long term oncologic outcome in terms of local recurrence, overall and disease-free survival, according to the plane of resection achieved. Conclusions are drawn on the basis of the available evidence, which suggests a pivotal role of laparoscopic CME with CVL in the multimodal management of right sided colonic cancer: performed in the right mesocolic plane of resection, laparoscopic CME with CVL demonstrates better oncologic results when compared to standard non-mesocolic planes of surgery, with all the advantages of laparoscopic techniques, both in faster recovery and better immunological response. The importance of minimally invasive meso-resectional surgery is thus stressed and highlighted as the new frontier for a modern laparoscopic total right mesocolectomy.
    Language English
    Publishing date 2016-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v8.i2.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Laparoscopic complete mesocolic excision with central vascular ligation in 600 right total mesocolectomies: Safety, prognostic factors and oncologic outcome.

    Siani, Luca Maria / Lucchi, Andrea / Berti, Pierluigi / Garulli, Gianluca

    American journal of surgery

    2017  Volume 214, Issue 2, Page(s) 222–227

    Abstract: Background: To analyze our experience with laparoscopic right Mesocolectomy in right colonic cancers.: Methods: 600 consecutive patients were studied.: Results: Mortality was 0.5%; morbidity was 35.5%. Mean mesocolic area was 15339 ± 1639 mm3, ... ...

    Abstract Background: To analyze our experience with laparoscopic right Mesocolectomy in right colonic cancers.
    Methods: 600 consecutive patients were studied.
    Results: Mortality was 0.5%; morbidity was 35.5%. Mean mesocolic area was 15339 ± 1639 mm3, specimen length 24.3 ± 3.3 cm, distance from the tumor to high tie was 103 ± 6 mm and mean lymph nodes harvested was 27 ± 3; mesocolic plane was achieved in 81% of cases. Survival was 83%; stratified survival in patients with stage II, IIIA/B and in the subgroup of stage IIIC patients with negative apical nodes was 88.7%, 72.4%, 71.4% respectively; stage IIIC patients with positive apical nodes showed poor survival (27.7%). Recurrence occurred in 177 patients (29.5%) and was mainly systemic (22.7%). At the multivariate analysis, "non mesocolic" plane of resection, positive N3 apical nodes and CEA levels >5 ng/dL were found to be independent prognostic factors.
    Conclusions: Laparoscopic right Mesocolectomy showed to be safe and yielded surgical specimens of high quality, with impact on survival; positive N3 apical nodes and "non mesocolic" planes were independently associated to poor outcome.
    MeSH term(s) Aged ; Colectomy/adverse effects ; Colectomy/methods ; Colon/blood supply ; Colonic Neoplasms/surgery ; Female ; Humans ; Laparoscopy ; Ligation ; Male ; Mesocolon/surgery ; Prognosis ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2016.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Combined brachial embolectomy and stent graft endovascular exclusion in the treatment of acute arm ischemia due to subclavian artery aneurysms thrombosis or distal embolization.

    Siani, Andrea / Accrocca, Federico / de Vivo, Gennaro / Siani, Luca Maria / Mounayergi, Federica

    Annali italiani di chirurgia

    2017  Volume 87, Page(s) 577–582

    Abstract: Aim: Purpose of this study is to report our results after simultaneous transbrachial embolectomy and endovascular aneurysm exclusion with stentgraft in the treatment of upper limb acute ischemia due to subclavian artery aneurysm thrombosis and ... ...

    Abstract Aim: Purpose of this study is to report our results after simultaneous transbrachial embolectomy and endovascular aneurysm exclusion with stentgraft in the treatment of upper limb acute ischemia due to subclavian artery aneurysm thrombosis and embolization .
    Methods: From January 2010 to December 2015, seven consecutive patients (6 men; mean age 71.5, range 44-85) underwent to emergent revascularization for upper limb ischemia due to thrombosis/embolization of SAA by means of brachial embolectomy and endovascular exclusion. Demographics, clinical, surgical data, complications and survival were recorded. Univariate analysis by chi-square was carried out to evaluate the role of demographics data and risk factors variables on reconstruction patency rate. Primary, primary assisted and secondary patency and limb salvage were calculated using the Kaplan Meyer's life table method.
    Results: Successful treatment was achieved in all cases. No postoperative death or complications occurred. Primary and assisted primary patency rates at 1 and 3 years were respectively 85.7%, 71.4% and 100%.Secondary patency and limb salvage at 1 and 3 years was 100%. A fatal ischemic stroke occurred in 1 case at 6 months (14.2%). A redo PTA was carried out at 24 months. Univariate analysis showed as demographics data and risk factor variables did not influence the primary, assisted primary, secondary patency rate and limb salvage.
    Conclusion: Endovascular repair is a less invasive alternative to open repair especially in high risk patients. long term results must still be confirmed in further studies.
    Key words: Arm ischemia, Endovascular treatment, Subclavian aneurysm.
    MeSH term(s) Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Aneurysm/complications ; Arm/blood supply ; Brachial Artery ; Embolectomy/methods ; Embolization, Therapeutic/methods ; Endovascular Procedures ; Female ; Humans ; Ischemia/etiology ; Ischemia/surgery ; Male ; Middle Aged ; Stents ; Subclavian Artery ; Thrombosis/complications
    Language English
    Publishing date 2017-02-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anaphylactic Reaction during Implantation of Ovation Abdominal Stent Graft in Patients with Abdominal Aortic Aneurysm.

    Siani, Andrea / Accrocca, Federico / De Vivo, Gennaro / Mounayergi, Federica / Siani, Luca Maria / Antonelli, Roberto

    Annals of vascular surgery

    2017  Volume 39, Page(s) 289.e1–289.e4

    Abstract: The Ovation Abdominal Stent Graft System is a trimodular endoprosthesis planned to overcome the limitations of currently available stent grafts, allowing complex iliac and femoral access and providing a proximal seal in challenge infrarenal neck ... ...

    Abstract The Ovation Abdominal Stent Graft System is a trimodular endoprosthesis planned to overcome the limitations of currently available stent grafts, allowing complex iliac and femoral access and providing a proximal seal in challenge infrarenal neck morphology. The proximal sealing is achieved by means of a network of inflatable rings filled with low-viscosity radiopaque polyethylene glycol-based polymer during stent-graft deployment. The leakage of polymer outside the channel to fill the rings into the vascular system may induce an hypersensitivity reaction and anaphylactic shock. We report a case of anaphylactic reaction during Ovation Abdominal Stent Graft System implantation. The endovascular procedure was successfully concluded.
    MeSH term(s) Aged ; Anaphylaxis/chemically induced ; Anaphylaxis/diagnosis ; Anaphylaxis/therapy ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Aortography/methods ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Computed Tomography Angiography ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Humans ; Male ; Polymers/adverse effects ; Prosthesis Design ; Severity of Illness Index ; Stents
    Chemical Substances Polymers
    Language English
    Publishing date 2017-02
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2016.06.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: "Ultra" E.R.A.S. in laparoscopic colectomy for cancer: discharge after the first flatus? A prospective, randomized trial.

    Garulli, Gianluca / Lucchi, Andrea / Berti, Pierluigi / Gabbianelli, Carlo / Siani, Luca Maria

    Surgical endoscopy

    2017  Volume 31, Issue 4, Page(s) 1806–1813

    Abstract: Background: Enhanced Recovery After Surgery (E.R.A.S.) programs are now widely accepted in colonic laparoscopic resections because of faster recovery and less perioperative complications. The aim of this study was to assess safety and feasibility of ... ...

    Abstract Background: Enhanced Recovery After Surgery (E.R.A.S.) programs are now widely accepted in colonic laparoscopic resections because of faster recovery and less perioperative complications. The aim of this study was to assess safety and feasibility of discharging patients operated on by laparoscopic colectomy on postoperative day 2, so long as the first flatus has passed and in the absence of complication-related symptoms.
    Methods: This study was a non-inferiority, open-label, single-center, prospective, randomized study comparing "Ultra" to Classic E.R.A.S. with discharge on POD 2 and 4, respectively. Seven hundred and sixty-five patients with resectable non-metastatic colonic cancer were analyzed: 384 patients were assigned to "Ultra" E.R.A.S. and 381 to Classic E.R.A.S. Primary end-point was mortality; secondary end-points were morbidity, readmission and reoperation rate. Limitations are: it is a single-center experience; it is not double-blind, with the intrinsic risk of intentional or unconscious bias; exclusion criteria because of "non-compliance" may be considered arbitrary.
    Results: Mortality was 0.89 % in "Ultra" E.R.A.S. group and 0.59 % in Classic E.R.A.S. (p = 0.571). Morbidity was 34.1 % for "Ultra" E.R.A.S. arm and 35.4 % for Classic E.R.A.S. (p = 0.753). Readmissions were 5.6 % for "Ultra" E.R.A.S. and 5.9 % for Classic E.R.A.S. (p = 0.359). Reoperation rate was 3.8 % for "Ultra" ERAS and 4.7 % for Classic E.R.A.S. (p = 0.713). Multivariate regression analyses using Cox's proportional hazard model showed that mortality (primary end-point), morbidity, reoperation and readmission (secondary end-points) were not significantly influenced by the two different perioperative regimens; conversely, the global cost of "Ultra" E.R.A.S. regimen was more economically effective.
    Conclusion: "Ultra" E.R.A.S. showed to be safe, actual and effective; discharge on postoperative day 2 after the first flatus passage, in the absence of complication-related symptoms, should be actively considered in a modern, multidisciplinary, multimodal laparoscopic management of colonic cancer.
    MeSH term(s) Adenocarcinoma/mortality ; Adenocarcinoma/surgery ; Adult ; Aged ; Clinical Protocols ; Colectomy ; Colonic Neoplasms/mortality ; Colonic Neoplasms/surgery ; Double-Blind Method ; Feasibility Studies ; Female ; Flatulence ; Follow-Up Studies ; Humans ; Length of Stay ; Male ; Middle Aged ; Multivariate Analysis ; Patient Discharge/standards ; Postoperative Care/methods ; Postoperative Care/standards ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Prospective Studies ; Reoperation/statistics & numerical data ; Treatment Outcome
    Language English
    Publishing date 2017-04
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-016-5177-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Laparoscopic appendectomy: Hem-o-lok versus Endoloop in stump closure.

    Lucchi, Andrea / Berti, Pierluigi / Grassia, Michele / Siani, Luca Maria / Gabbianelli, Carlo / Garulli, Gianluca

    Updates in surgery

    2017  Volume 69, Issue 1, Page(s) 61–65

    Abstract: There are several techniques described to close the appendicular stump during laparoscopic appendectomy. The aim of this study was to investigate the safety and usefulness of the Hem-o-lok clip for the closure of appendicular stump, comparing these data ... ...

    Abstract There are several techniques described to close the appendicular stump during laparoscopic appendectomy. The aim of this study was to investigate the safety and usefulness of the Hem-o-lok clip for the closure of appendicular stump, comparing these data with those concerning the endo-loop. We conducted a retrospective study that compared two groups of patients who underwent laparoscopic appendectomy from 2010 to 2015 at our institution. We used the Endoloop to close the stump in the first group (group I) and the Hem-o-lok in the second group (group II). We reviewed patient's data including: complications, operative time, length of stay, costs. There were 121 patients in group I and 138 patients in group II. The mean operative times were 40.5 min in group I and 36.4 min in the group II. No intraoperative complications and no mortality were observed in either group. The mean postoperative length of hospital stay was similar for both groups. There was no rehospitalization after discharge. The complication rate did not reach statistical significance between the groups. The cost of the procedure using the Hem-o-lok has been lower than using the Endoloop. Both the Endoloop and Hem-o-lok are safe for the closure of the appendicular stump. Hem-o-lok appears to be superior than Endoloop in terms of easeness of use and cheapness, maintaining the same safety.
    Language English
    Publishing date 2017-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-016-0413-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lower limb ischemia after migration of a coronary artery stent into the femoral artery.

    Siani, Andrea / Siani, Luca Maria / Mounayergi, Federica / Baldassarre, Emanuele

    Interactive cardiovascular and thoracic surgery

    2008  Volume 7, Issue 3, Page(s) 447–448

    Abstract: A coronary stent may be lost in the peripheral or visceral arterial system with an incidence ranging from 0.9 to 8.4%, however, a limb or organ ischemia after stent migration is very uncommon. We report the case of an 83-year-old man who underwent ... ...

    Abstract A coronary stent may be lost in the peripheral or visceral arterial system with an incidence ranging from 0.9 to 8.4%, however, a limb or organ ischemia after stent migration is very uncommon. We report the case of an 83-year-old man who underwent coronary artery stenting at our Hospital's Cardiological Department. During this difficult procedure, due to the critical stenosis of the circumflex artery, the stent was accidentally lost and found at the level of the insertion of the right common femoral on the external iliac artery. After several attempts to rescue the stent through an omolateral and contralateral femoral approach with the hook technique, the right common, superficial and profunda femoral arteries were surgically exposed. The stent was easily removed from the origin of the profunda femoral artery by a longitudinal arteriotomy. Finally, the arteriotomy was closed with a homologous saphenous vein patch. We underline the importance of an early extraction of the stent, discussing the preferable surgical approach to minimize the possible dramatic complications in the peripheral artery system.
    MeSH term(s) Aged, 80 and over ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/instrumentation ; Arterial Occlusive Diseases/complications ; Arterial Occlusive Diseases/etiology ; Arterial Occlusive Diseases/surgery ; Coronary Stenosis/therapy ; Device Removal ; Femoral Artery/surgery ; Foreign-Body Migration/complications ; Foreign-Body Migration/etiology ; Foreign-Body Migration/surgery ; Humans ; Ischemia/etiology ; Ischemia/surgery ; Lower Extremity/blood supply ; Male ; Saphenous Vein/transplantation ; Stents ; Thrombectomy ; Treatment Outcome
    Language English
    Publishing date 2008-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1510/icvts.2007.170969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: An undescribed iatrogenic complication of varicose vein surgery: entrapment of the stripper in the proximal deep venous system.

    Siani, Andrea / Marcucci, Giustino / Siani, Luca Maria / Baldassarre, Emanuele

    World journal of surgery

    2007  Volume 31, Issue 7, Page(s) 1528; author reply 1529

    MeSH term(s) Aged ; Device Removal ; Female ; Humans ; Iatrogenic Disease/epidemiology ; Saphenous Vein/surgery ; Varicose Veins/surgery ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/instrumentation
    Language English
    Publishing date 2007-07
    Publishing country United States
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-007-9058-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Modulazione dell'estensione della linfadenectomia nell' "early gastric cancer". Review della letteratura e ruolo della laparoscopia.

    Siani, Luca Maria / Ferranti, Fabrizio / De Carlo, Antonio / Marzano, Marco / Quintiliani, Alberto

    Chirurgia italiana

    2009  Volume 61, Issue 5-6, Page(s) 551–558

    Abstract: Early gastric cancer is a gastric carcinoma confined to the mucosa or submucosa of the stomach, regardless of the presence of nodal involvement, which in any event is present only in about 20% of patients. This uncommon nodal involvement is a distinct ... ...

    Title translation Modulation of the extent of lymphadenectomy in early gastric cancer. Review of the literature and role of laparoscopy.
    Abstract Early gastric cancer is a gastric carcinoma confined to the mucosa or submucosa of the stomach, regardless of the presence of nodal involvement, which in any event is present only in about 20% of patients. This uncommon nodal involvement is a distinct clinical problem, because standard D2 lymphadenectomy constitutes overtreatment in more than 80% of patients. A review of the literature shows that the present surgical tendency for those patients who do not fulfill the Gotoda criteria (i.e. not amenable to an endoscopic mucosal or submucosal dissection) is to modulate the extent of the lymphadenectomy on the basis of the characteristics of the cancer: for mucosal early gastric cancers located in the upper third of the stomach, gastrectomy with D1 lymphadenectomy is sufficient; if located in the middle third the extent should be D1 +alpha (D1 + n. 7), while if located in the distal third, D1 +beta (D1 + n. 7,8a,9) is the best option. In all these cases, minimally invasive surgery can be a valid option, with results which are comparable to those of open surgery, but with all the advantages of the laparoscopic approach. For submucosal early gastric cancers, D1 +beta lymphadenectomy is indicated for neoplasia > 20 mm and of the protuberance type, while, for all other submucosal early gastric cancers (> 20 mm and of the depressed type, penetrating more than 500 micron into the submucosal layer, not differentiated, with lymphovascular invasion), standard D2 lymphadenectomy is the safest oncological procedure. In these cases, too, the laparoscopic approach can be a safe option, even if it requires greater laparoscopic skill.
    MeSH term(s) Algorithms ; Decision Trees ; Gastrectomy/methods ; Humans ; Laparoscopy ; Lymph Node Excision/methods ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
    Language Italian
    Publishing date 2009-09
    Publishing country Italy
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 603591-7
    ISSN 0009-4773
    ISSN 0009-4773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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