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  1. Article ; Online: Pneumococcal and Influenza Vaccines in Dialysis Patients

    Sibel Kara / Dilek Torun / Ebru Oruç / Mehmet Ali Habeşoğlu / Müşerref Şule Akçay

    Turkish Journal of Nephrology, Vol 31, Iss 2, Pp 165-

    Vaccination Information, Rates, and Patient Awareness

    2022  Volume 170

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Pulmonary Aspergillosis in immunocompetent patients

    Sibel Kara / Ebru Oruç / Zuhal Ekici Ünsal / H. Eda Alışkan / Şule Akçay

    Dicle Medical Journal, Vol 48, Iss 3, Pp 488-

    2021  Volume 497

    Abstract: Objective: Although pulmonary aspergillosis (PA) is often seen in patients with immunodeficiency, it also identifies a number of clinical diseases that cause morbidity and mortality, which can also occur in patients with immunodeficiency. The aim of this ...

    Abstract Objective: Although pulmonary aspergillosis (PA) is often seen in patients with immunodeficiency, it also identifies a number of clinical diseases that cause morbidity and mortality, which can also occur in patients with immunodeficiency. The aim of this study was to investigate the disease patterns, demographic and clinical features, treatment and prognosis of pulmonary aspergillosis in immune competent patients. Method: Our study is a descriptive cross-sectional study in which the data of immunocompetent patients diagnosed with PA in our hospital between January 2010 and Decenber 2019 were evaluated retrospectively. Patients over the age of 18 with a diagnosis of PA were included in the study. Demographic and clinical features, radiological findings, diagnosis and treatment methods and prognoses of the patients were recorded. Results: 8 of the patients were female, 3 were male and the mean age was 61 (53 ± 69). Nine patients were diagnosed with chronic pulmonary aspergillosis and two patients were diagnosed with IPA. Four of the patient diagnosed with KPA were chronic cavitary pulmonary aspergillosis, one was chronic fibrosing pulmonary aspergillosis, two were aspergilloma and two were aspergillus nodules. The most common comorbidity was diabetes mellitus (45.4%) and in total, 72.7% of patients had chronic lung disease such as COPD-asthma, tuberculosis, bronchiectasis. Cough, sputum and hemoptysis (90%, 72.7%, 45.4%, respectively) were the most common symptoms. The most common radiological finding on thorax tomography was crescent sign-cavity (72.7%). The diagnostic method used was mostly bronchoalveolar lavage and wedge resection/ lobectomy (45.4%, respectively). It was observed that eight (72.7%) patients were given voriconazole and three (27.2%) other patients surgical procedure performed and one patient was lost after surgery. Conclusions: Although pulmonary aspergilosis is more frequently seen in immunocompromised patients with malignancy, solid organ and hematological transplants, it has now begun to be ...
    Keywords pulmonary aspergillosis ; immunocompetent patinents ; disease patterns ; demographic ; clinical features ; prognosis ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Dicle University Medical School
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Side effects and antibody response of an inactive severe acute respiratory syndrome coronavirus 2 vaccine among health care workers

    Hatice Hale Gümüş / İlker Ödemiş / Hikmet Eda Alışka / Aslı Karslı / Sibel Kara / Murat Özkale / Eylem Gül

    Revista da Associação Médica Brasileira, Vol 67, Iss 12, Pp 1825-

    2021  Volume 1831

    Abstract: SUMMARY OBJECTIVE: This study aims to investigate the antibody response and the side effects of the two-dose inactive SARS-CoV-2 vaccine (CoronaVac, Sinovac, China) among a health care worker population in Turkey. METHODS: This study was a prospective, ... ...

    Abstract SUMMARY OBJECTIVE: This study aims to investigate the antibody response and the side effects of the two-dose inactive SARS-CoV-2 vaccine (CoronaVac, Sinovac, China) among a health care worker population in Turkey. METHODS: This study was a prospective, cross-sectional, single-center study conducted between December 16, 2020, and March 15, 2021. We evaluated the side effects from a questionnaire, and anti-spike immunoglobulin G response to the vaccine (0- and 28-day schedule) using an enzyme-linked immunosorbent assay. RESULTS: A total of 94 of 184 health care workers completed this study. The percentages of participants who were seronegative at baseline and achieved to the seropositivity were 21.3 and 97.9%, respectively, on day 21 after vaccinations. The seropositivity was predominantly detected in 31–45 years of the age group (55.4%, p=0.636), normal body mass index (47.8%, p=0.999), nonsmokers (64.1%, p=0.999), those without any comorbidities (73.9%, p=0.463), and those without any side effects (70.2%, p=0.256). The frequencies of overall side effects within seven days after the first and second doses of CoronaVac were 37.2 and 28.7%, respectively. The most common side effects was localized pain at the injection site (15.7 and 11.6%, respectively). CONCLUSIONS: We found that vaccination by two-dose CoronaVac could elicit a specific humoral response, and it was well tolerated in health care workers. The high seropositivity developed after the second dose attracted attention. Our study will be useful in terms of showing short-term immunity and side effects.
    Keywords COVID-19 ; Pandemics ; Vaccine ; Adverse events ; Health personnel ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Genç Erişkin Bir Olguda Konjenital Bronşiyal Arter - Pulmoner Arter Fistülü

    Sibel KARA / Nazan ŞEN / Uğur ÖZKAN / Şule AKÇAY

    Cukurova Medical Journal, Vol 40, Iss 4, Pp 830-

    2015  Volume 835

    Abstract: Bronşial arter ve pulmoner arter veya pulmoner ven arasındaki bağlantı gibi primer vasküler malformasyonlar olukça nadirdir. İlk kez olan masif hemoptizi ile başvuran 18 yaşındaki bir erkek hastada selektif bronşial anjiografide nadir bir vasküler ... ...

    Abstract Bronşial arter ve pulmoner arter veya pulmoner ven arasındaki bağlantı gibi primer vasküler malformasyonlar olukça nadirdir. İlk kez olan masif hemoptizi ile başvuran 18 yaşındaki bir erkek hastada selektif bronşial anjiografide nadir bir vasküler anomali olan bronşial arter-pulmoner arter fistülü saptandı. Öyküde hiç bir kazanılmış neden bulunmadığı için konjenital olarak düşünüldü. Olguya bronşial arter embolizasyonu uygulandı ve hemoptizisi endovasküler tedaviden sonra tamamen düzeldi. Masif hemoptizili hastalarda böyle vasküler anomalilerden şüphelenilmelidir. Bronşial arter embolizasyonu bu hastalarda güvenli ve etkili cerrahi olmayan bir tedavi yöntemidir.
    Keywords - ; hemoptysis ; vascular malformation ; bronchial artery-pulmonary artery fistula ; bronchial artery embolization ; hemoptizi ; vasküler malformasyon ; bronşial arter-pulmoner arter fistülü broşial arter embolizasyonu ; Medicine (General) ; R5-920
    Language English
    Publishing date 2015-10-01T00:00:00Z
    Publisher Cukurova University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Congenital Bronchial Artery-Pulmonary Artery Fistula in a Young Adult

    Sibel Kara / Nazan sen / Ugur Ozkan / sule Akcay

    Çukurova Üniversitesi Tıp Fakültesi Dergisi, Vol 40, Iss 4, Pp 830-

    2015  Volume 835

    Abstract: Primary vascular malformations such as connection between bronchial artery and pulmonary artery or pulmonary vein are quite rare. A 18-year-old male patient with the first episode of massive hemoptysis was found to have bronchial artery-pulmonary artery ... ...

    Abstract Primary vascular malformations such as connection between bronchial artery and pulmonary artery or pulmonary vein are quite rare. A 18-year-old male patient with the first episode of massive hemoptysis was found to have bronchial artery-pulmonary artery fistula, a rare vascular anomaly, on selective bronchial angiography. Since medical history revealed no acquired cause, it is considered congenital. He underwent bronchial artery embolization and hemoptysis was completely resolved after endovascular treatment. The presence of such vascular anomalies should be suspected in patients with massive hemoptysis. Bronchial artery embolization is a safe and effective nonsurgical treatment option for such patients. [Cukurova Med J 2015; 40(4.000): 830-835]
    Keywords hemoptysis ; vascular malformation ; bronchial artery-pulmonary artery fistula ; bronchial artery embolization ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Cukurova University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Genome-wide identification and comparative expression analysis of LEA genes in watermelon and melon genomes

    Celik Altunoglu, Yasemin / Esra Nurten Yer / Mehmet Cengiz Baloglu / Pinar Baloglu / Sibel Kara

    Physiology and molecular biology of plants. 2017 Jan., v. 23, no. 1

    2017  

    Abstract: Late embryogenesis abundant (LEA) proteins are large and diverse group of polypeptides which were first identified during seed dehydration and then in vegetative plant tissues during different stress responses. Now, gene family members of LEA proteins ... ...

    Abstract Late embryogenesis abundant (LEA) proteins are large and diverse group of polypeptides which were first identified during seed dehydration and then in vegetative plant tissues during different stress responses. Now, gene family members of LEA proteins have been detected in various organisms. However, there is no report for this protein family in watermelon and melon until this study. A total of 73 LEA genes from watermelon (ClLEA) and 61 LEA genes from melon (CmLEA) were identified in this comprehensive study. They were classified into four and three distinct clusters in watermelon and melon, respectively. There was a correlation between gene structure and motif composition among each LEA groups. Segmental duplication played an important role for LEA gene expansion in watermelon. Maximum gene ontology of LEA genes was observed with poplar LEA genes. For evaluation of tissue specific expression patterns of ClLEA and CmLEA genes, publicly available RNA-seq data were analyzed. The expression analysis of selected LEA genes in root and leaf tissues of drought-stressed watermelon and melon were examined using qRT-PCR. Among them, ClLEA-12-17-46 genes were quickly induced after drought application. Therefore, they might be considered as early response genes for water limitation conditions in watermelon. In addition, CmLEA-42-43 genes were found to be up-regulated in both tissues of melon under drought stress. Our results can open up new frontiers about understanding of functions of these important family members under normal developmental stages and stress conditions by bioinformatics and transcriptomic approaches.
    Keywords bioinformatics ; Citrullus lanatus var. lanatus ; developmental stages ; drought ; embryogenesis ; gene expression ; gene expression regulation ; gene ontology ; genes ; leaves ; plant tissues ; polypeptides ; proteins ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; sequence analysis ; stress response ; transcriptomics ; water stress ; watermelons
    Language English
    Dates of publication 2017-01
    Size p. 5-21.
    Publishing place Springer India
    Document type Article
    ZDB-ID 2487126-6
    ISSN 0974-0430 ; 0971-5894
    ISSN (online) 0974-0430
    ISSN 0971-5894
    DOI 10.1007/s12298-016-0405-8
    Database NAL-Catalogue (AGRICOLA)

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