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Article: Early experience in the use of the Advanced Breast Biopsy Instrumentation: a report of one hundred twenty-seven patients.

LaRaja, R D / Saber, A A / Sickles, A

1999 Volume 125, Issue 4, Page(s) 380–384

Abstract: Background: Recently there has been a great interest in developing alternative breast biopsy techniques that yield the appropriate histologic information in the least invasive and most cost-effective manner. The objective of this study was to evaluate ... ...

Abstract	Background: Recently there has been a great interest in developing alternative breast biopsy techniques that yield the appropriate histologic information in the least invasive and most cost-effective manner. The objective of this study was to evaluate the efficacy and results with the Advanced Breast Biopsy Instrumentation (ABBI) method for stereotactic excisional biopsies of nonpalpable mammographically detected breast lesions. Methods: All patients with nonpalpable mammographic abnormalities who fulfilled the selection criteria for the ABBI procedure were studied. Pathologic diagnosis, the size of the specimen, the length of the procedure, postoperative complications, patient satisfaction, and the cost of the ABBI procedure were analyzed. Results: One hundred twenty-seven of 139 patients (94.2%) underwent the ABBI procedure. Twelve patients (8.61%) required conversion to the needle localization procedure. Mammographically, 64 lesions revealed microcalcifications, 51 showed nodular densities, and 12 demonstrated both findings. Histologically, 21 lesions (16.5%) were malignant, whereas 106 were benign (83.5%). The mean operative time for the procedures was 62.5 minutes. Postoperatively 5 patients had local ecchymosis and 1 had a hematoma. The average cost per patient was found to be $1000, considerably less than for needle localization biopsy. Conclusion: With proper patient selection the ABBI procedure has proved to be a valuable tool in the armamentarium of the breast surgeon. Its efficiency, accuracy, and patient acceptance have been well documented in our hands.
MeSH term(s)	Anesthesia, Local ; Biopsy/economics ; Biopsy/methods ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Contraindications ; Female ; Humans ; Mammography ; Patient Satisfaction ; Postoperative Complications ; Time Factors ; Treatment Outcome
Language	English
Publishing date	1999-04
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
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Article ; Online: Caution Ahead: Research Challenges of a Randomized Controlled Trial Implemented to Improve Breast Cancer Treatment at Safety-Net Hospitals.

Bickell, Nina A / Shah, Ajay / Castaldi, Maria / Lewis, Theophilus / Sickles, Alan / Arora, Shalini / Clarke, Kevin / Kemeny, Margaret / Srinivasan, Anitha / Fei, Kezhen / Franco, Rebeca / Parides, Michael / Pappas, Peter / McAlearney, Ann Scheck

Journal of oncology practice

2018 Volume 14, Issue 3, Page(s) e158–e167

Abstract: Purpose: To implement and test a Web-based tracking and feedback (T&F) tool to close referral loops and reduce adjuvant breast cancer treatment underuse in safety-net hospitals (SNHs).: Patient and methods: We randomly assigned 10 SNHs, identified ... ...

Abstract	Purpose: To implement and test a Web-based tracking and feedback (T&F) tool to close referral loops and reduce adjuvant breast cancer treatment underuse in safety-net hospitals (SNHs). Patient and methods: We randomly assigned 10 SNHs, identified patients with new stage 1 to stage 3 breast cancer, assessed their connection with the oncologist, and relayed this information to surgeons for follow-up. We interviewed key informants about the tool's usefulness. We conducted intention-to-treat and pre- and poststudy analyses to assess the T&F tool and implementation effectiveness, respectively. Results: Between the study start and intervention implementation, several hospitals reorganized care delivery and 49% of patients scheduled to undergo breast cancer surgery were ineligible because they already were in contact with an oncologist. One high-volume hospital closed. Despite randomization of hospitals, intervention (INT) hospitals had fewer white patients (5% v 16%; P = .0005), and more underuse (28% v 15%; P = .002) compared with usual care (UC) hospitals. Over time, INT hospitals with poorer follow-up significantly reduced underuse compared with UC hospitals (INT hospitals, from 33% to 9%, P = .001 v UC hospitals, from 15% to 11%, P = .5). There was no difference in underuse (9% at INT hospitals, 11% at UC hospitals; P = .8). Hospitals with better follow-up (odds ratio, 0.85; 95% CI, 0.73 to 0.98) had less underuse. In settings with poor follow-up and tracking approaches, key informants found the tool useful. The rapidly changing delivery landscape posed significant challenges to this implementation research. Conclusion: A T&F tool did not significantly reduce adjuvant underuse but may help reduce underuse in SNHs with poor follow-up capabilities. Inability to discern T&F effectiveness is likely due to encountered challenges that inform lessons for future implementation research.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Female ; Hospitals ; Humans ; Intention to Treat Analysis ; Medical Informatics Applications ; New York City ; Quality Improvement ; Randomized Controlled Trials as Topic ; Safety-net Providers/methods ; Safety-net Providers/standards ; Treatment Outcome
Language	English
Publishing date	2018-01-03
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	2236338-5
ISSN	1935-469X ; 1554-7477
ISSN (online)	1935-469X
ISSN	1554-7477
DOI	10.1200/JOP.2017.026534
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Article ; Online: Organizational Factors Affect Safety-Net Hospitals' Breast Cancer Treatment Rates.

Bickell, Nina A / Moss, Alexandra DeNardis / Castaldi, Maria / Shah, Ajay / Sickles, Alan / Pappas, Peter / Lewis, Theophilus / Kemeny, Margaret / Arora, Shalini / Schleicher, Lori / Fei, Kezhen / Franco, Rebeca / McAlearney, Ann Scheck

Health services research

2017 Volume 52, Issue 6, Page(s) 2137–2155

Abstract: Objective: To identify key organizational approaches associated with underuse of breast cancer care.: Setting: Nine New York City area safety-net hospitals.: Study design: Mixed qualitative-quantitative, cross-sectional cohort.: Methods: We ... ...

Abstract	Objective: To identify key organizational approaches associated with underuse of breast cancer care. Setting: Nine New York City area safety-net hospitals. Study design: Mixed qualitative-quantitative, cross-sectional cohort. Methods: We used qualitative comparative analysis (QCA) of key stakeholder interviews, defined organizational "conditions," calibrated conditions, and identified solution pathways. We defined underuse as no radiation after lumpectomy in women <75 years or mastectomy in women with ≥4 positive nodes, or no systemic therapy in women with tumors ≥1 cm. We used hierarchical models to assess organizational and patient factors' impact on underuse. Principal findings: Underuse varied by hospital (8-29 percent). QCA found lower underuse sites designated individuals to track and follow-up no-shows; shared clinical information during handoffs; had fully integrated electronic medical records enabling transfer of responsibility across specialties; had strong system support; allocated resources to cancer clinics; had a patient-centered culture paying close organizational attention to clinic patients. High underuse sites lacked these characteristics. Multivariate modeling found that hospitals with strong approaches to follow-up had low underuse rates (RR = 0.28; 0.08-0.95); individual patient characteristics were not significant. Conclusions: At safety-net hospitals, underuse of needed cancer therapies is associated with organizational approaches to track and follow-up treatment. Findings provide varying approaches to safety nets to improve cancer care delivery.
Language	English
Publishing date	2017-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	410435-3
ISSN	1475-6773 ; 0017-9124
ISSN (online)	1475-6773
ISSN	0017-9124
DOI	10.1111/1475-6773.12605
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Article: Dopamine D1 and D2 antagonists block L-dopa-elicited air-stepping in neonatal rats.

Sickles, A E / Stehouwer, D J / Van Hartesveldt, C

Brain research. Developmental brain research

1992 Volume 68, Issue 1, Page(s) 17–22

Abstract: When administered to rat pups that have been suspended in air, L-3,4-dihydroxyphenylalanine (L-DOPA) induces a highly stereotypic locomotor response referred to as air-stepping. In order to determine the respective roles of dopamine D1 and D2 receptors ... ...

Abstract	When administered to rat pups that have been suspended in air, L-3,4-dihydroxyphenylalanine (L-DOPA) induces a highly stereotypic locomotor response referred to as air-stepping. In order to determine the respective roles of dopamine D1 and D2 receptors in the expression of air-stepping, the abilities of the selective D1 antagonist SCH 23390 and the selective D2 antagonist spiperone to block L-DOPA-induced air-stepping in 5-day-old rat pups were assessed. Both antagonists increased latency to onset, and both decreased total duration of air-stepping by decreasing the number and length of air-stepping episodes. Neither SCH 23390 nor spiperone altered the topography of the air-stepping response; however, subjects receiving lower doses of spiperone spent significantly more time with the body dorsiflexed and limbs extended (extension/tremor activity) than did control subjects. The results suggest that both the D1 and D2 receptor subtypes are involved in the production of L-DOPA-induced locomotor activity.
MeSH term(s)	Animals ; Animals, Newborn/psychology ; Benzazepines/pharmacology ; Dopamine Antagonists ; Female ; Levodopa/antagonists & inhibitors ; Male ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Spiperone/pharmacology ; Stereotyped Behavior/drug effects ; Time Factors
Chemical Substances	Benzazepines ; Dopamine Antagonists ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Levodopa (46627O600J) ; Spiperone (4X6E73CJ0Q)
Language	English
Publishing date	1992-07-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	8213-2
ISSN	1872-6755 ; 0165-3806
ISSN (online)	1872-6755
ISSN	0165-3806
DOI	10.1016/0165-3806(92)90243-p
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Article ; Online: Measurement of Direct-Photon Cross Section and Double-Helicity Asymmetry at sqrt[s]=510 GeV in p[over →]+p[over →] Collisions.

Abdulameer, N J / Acharya, U / Adare, A / Aidala, C / Ajitanand, N N / Akiba, Y / Akimoto, R / Alfred, M / Apadula, N / Aramaki, Y / Asano, H / Atomssa, E T / Awes, T C / Azmoun, B / Babintsev, V / Bai, M / Bandara, N S / Bannier, B / Barish, K N /

Bathe, S / Bazilevsky, A / Beaumier, M / Beckman, S / Belmont, R / Berdnikov, A / Berdnikov, Y / Bichon, L / Black, D / Blankenship, B / Bok, J S / Borisov, V / Boyle, K / Brooks, M L / Bryslawskyj, J / Buesching, H / Bumazhnov, V / Campbell, S / Canoa Roman, V / Chen, C-H / Chiu, M / Chi, C Y / Choi, I J / Choi, J B / Chujo, T / Citron, Z / Connors, M / Corliss, R / Corrales Morales, Y / Csanád, M / Csörgő, T / Datta, A / Daugherity, M S / David, G / Dean, C T / DeBlasio, K / Dehmelt, K / Denisov, A / Deshpande, A / Desmond, E J / Ding, L / Dion, A / Doomra, V / Do, J H / Drees, A / Drees, K A / Durham, J M / Durum, A / En'yo, H / Enokizono, A / Esha, R / Fadem, B / Fan, W / Feege, N / Fields, D E / Finger, M / Firak, D / Fitzgerald, D / Fokin, S L / Frantz, J E / Franz, A / Frawley, A D / Gallus, P / Gal, C / Garg, P / Ge, H / Giles, M / Giordano, F / Glenn, A / Goto, Y / Grau, N / Greene, S V / Grosse Perdekamp, M / Gunji, T / Guragain, H / Gu, Y / Hachiya, T / Haggerty, J S / Hahn, K I / Hamagaki, H / Hanks, J / Han, S Y / Harvey, M / Hasegawa, S / Hemmick, T K / He, X / Hill, J C / Hodges, A / Hollis, R S / Homma, K / Hong, B / Hoshino, T / Huang, J / Ikeda, Y / Imai, K / Imazu, Y / Inaba, M / Iordanova, A / Isenhower, D / Ivanishchev, D / Jacak, B V / Jeon, S J / Jezghani, M / Jiang, X / Ji, Z / Johnson, B M / Joo, E / Joo, K S / Jouan, D / Jumper, D S / Kang, J H / Kang, J S / Kawall, D / Kazantsev, A V / Key, J A / Khachatryan, V / Khanzadeev, A / Khatiwada, A / Kihara, K / Kim, C / Kim, D H / Kim, D J / Kim, E-J / Kim, H-J / Kim, M / Kim, T / Kim, Y K / Kincses, D / Kingan, A / Kistenev, E / Klatsky, J / Kleinjan, D / Kline, P / Koblesky, T / Kofarago, M / Koster, J / Kotov, D / Kovacs, L / Kurgyis, B / Kurita, K / Kurosawa, M / Kwon, Y / Lajoie, J G / Larionova, D / Lebedev, A / Lee, K B / Lee, S H / Leitch, M J / Leitgab, M / Lewis, N A / Lim, S H / Liu, M X / Li, X / Loomis, D A / Lynch, D / Lökös, S / Majoros, T / Makdisi, Y I / Makek, M / Manion, A / Manko, V I / Mannel, E / McCumber, M / McGaughey, P L / McGlinchey, D / McKinney, C / Meles, A / Mendoza, M / Meredith, B / Miake, Y / Mignerey, A C / Miller, A J / Milov, A / Mishra, D K / Mitchell, J T / Mitrankova, M / Mitrankov, Iu / Miyasaka, S / Mizuno, S / Mondal, M M / Montuenga, P / Moon, T / Morrison, D P / Moukhanova, T V / Muhammad, A / Mulilo, B / Murakami, T / Murata, J / Mwai, A / Nagamiya, S / Nagle, J L / Nagy, M I / Nakagawa, I / Nakagomi, H / Nakano, K / Nattrass, C / Nelson, S / Netrakanti, P K / Nihashi, M / Niida, T / Nouicer, R / Novitzky, N / Nukazuka, G / Nyanin, A S / O'Brien, E / Ogilvie, C A / Oh, J / Orjuela Koop, J D / Orosz, M / Osborn, J D / Oskarsson, A / Ozawa, K / Pak, R / Pantuev, V / Papavassiliou, V / Park, J S / Park, S / Patel, L / Patel, M / Pate, S F / Peng, J-C / Peng, W / Perepelitsa, D V / Perera, G D N / Peressounko, D Yu / PerezLara, C E / Perry, J / Petti, R / Pinkenburg, C / Pinson, R / Pisani, R P / Potekhin, M / Pun, A / Purschke, M L / Radzevich, P V / Rak, J / Ramasubramanian, N / Ravinovich, I / Read, K F / Reynolds, D / Riabov, V / Riabov, Y / Richford, D / Riveli, N / Roach, D / Rolnick, S D / Rosati, M / Rowan, Z / Rubin, J G / Runchey, J / Saito, N / Sakaguchi, T / Sako, H / Samsonov, V / Sarsour, M / Sato, S / Sawada, S / Schaefer, B / Schmoll, B K / Sedgwick, K / Seele, J / Seidl, R / Sen, A / Seto, R / Sett, P / Sexton, A / Sharma, D / Shein, I / Shibata, M / Shibata, T-A / Shigaki, K / Shimomura, M / Shi, Z / Shukla, P / Sickles, A / Silva, C L / Silvermyr, D / Singh, B K / Singh, C P / Singh, V / Slunečka, M / Smith, K L / Soltz, R A / Sondheim, W E / Sorensen, S P / Sourikova, I V / Stankus, P W / Stepanov, M / Stoll, S P / Sugitate, T / Sukhanov, A / Sumita, T / Sun, J / Sun, Z / Sziklai, J / Takahama, R / Takahara, A / Taketani, A / Tanida, K / Tannenbaum, M J / Tarafdar, S / Taranenko, A / Timilsina, A / Todoroki, T / Tomášek, M / Torii, H / Towell, M / Towell, R / Towell, R S / Tserruya, I / Ueda, Y / Ujvari, B / van Hecke, H W / Vargyas, M / Velkovska, J / Virius, M / Vrba, V / Vznuzdaev, E / Wang, X R / Wang, Z / Watanabe, D / Watanabe, Y / Watanabe, Y S / Wei, F / Whitaker, S / Wolin, S / Wong, C P / Woody, C L / Wysocki, M / Xia, B / Xue, L / Yalcin, S / Yamaguchi, Y L / Yanovich, A / Yoon, I / Younus, I / Yushmanov, I E / Zajc, W A / Zelenski, A / Zou, L

Physical review letters

2023 Volume 130, Issue 25, Page(s) 251901

Abstract: We present measurements of the cross section and double-helicity asymmetry A_{LL} of direct-photon production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed at midrapidity (|η|<0.25) with the PHENIX detector ... ...

Abstract	We present measurements of the cross section and double-helicity asymmetry A_{LL} of direct-photon production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed at midrapidity (\|η\|<0.25) with the PHENIX detector at the Relativistic Heavy Ion Collider. At relativistic energies, direct photons are dominantly produced from the initial quark-gluon hard scattering and do not interact via the strong force at leading order. Therefore, at sqrt[s]=510 GeV, where leading-order-effects dominate, these measurements provide clean and direct access to the gluon helicity in the polarized proton in the gluon-momentum-fraction range 0.02<x<0.08, with direct sensitivity to the sign of the gluon contribution.<br />
MeSH term(s)	Photons ; Food ; Motion
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.251901
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Article: Noradrenergic alpha-1 and alpha-2 antagonists block L-dopa-induced air-stepping in neonatal rats.

Taylor, L L / Sickles, A E / Stehouwer, D J / Van Hartesveldt, C

Brain research. Developmental brain research

1994 Volume 79, Issue 2, Page(s) 242–248

Abstract: Five-day-old rat pups suspended in air and administered L-3,4-dihydroxyphenylalanine (L-DOPA) engage in a highly stereotyped and coordinated locomotor behavior termed air-stepping. L-DOPA is a precursor for dopamine and noradrenaline and one or both of ... ...

Abstract	Five-day-old rat pups suspended in air and administered L-3,4-dihydroxyphenylalanine (L-DOPA) engage in a highly stereotyped and coordinated locomotor behavior termed air-stepping. L-DOPA is a precursor for dopamine and noradrenaline and one or both of these neurotransmitters could play a role in L-DOPA-induced air-stepping. The role of noradrenaline was investigated by assessing the abilities of the alpha-1 noradrenergic receptor antagonist prazosin and the alpha-2 noradrenergic receptor antagonist idazoxan to block L-DOPA-induced air-stepping in 5-day-old rats. Both antagonists decreased the duration of air-stepping. In addition, prazosin altered the topography of air-stepping by interfering with coordination of the hindlimbs. The results suggest that alpha-1 and alpha-2 noradrenergic receptor subtypes are involved in L-DOPA-induced air-stepping.
MeSH term(s)	Adrenergic alpha-1 Receptor Antagonists ; Adrenergic alpha-2 Receptor Antagonists ; Adrenergic alpha-Antagonists/pharmacology ; Animals ; Animals, Newborn/physiology ; Dioxanes/pharmacology ; Female ; Idazoxan ; Levodopa/antagonists & inhibitors ; Levodopa/pharmacology ; Locomotion/drug effects ; Locomotion/physiology ; Male ; Norepinephrine/physiology ; Prazosin/pharmacology ; Rats ; Rats, Sprague-Dawley ; Stereotyped Behavior/drug effects ; Stereotyped Behavior/physiology
Chemical Substances	Adrenergic alpha-1 Receptor Antagonists ; Adrenergic alpha-2 Receptor Antagonists ; Adrenergic alpha-Antagonists ; Dioxanes ; Levodopa (46627O600J) ; Norepinephrine (X4W3ENH1CV) ; Prazosin (XM03YJ541D) ; Idazoxan (Y310PA316B)
Language	English
Publishing date	1994-06-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	8213-2
ISSN	1872-6755 ; 0165-3806
ISSN (online)	1872-6755
ISSN	0165-3806
DOI	10.1016/0165-3806(94)90128-7
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Article: L-dopa-induced air-stepping in developing rats.

Van Hartesveldt, C / Sickles, A E / Porter, J D / Stehouwer, D J

Brain research. Developmental brain research

1991 Volume 58, Issue 2, Page(s) 251–255

Abstract: Rat pups at postnatal day (PN) 0, 5, 10, 15, and 20 were injected with 100 mg/kg L-3,4-dihydroxyphenylalanine (L-DOPA; s.c.) or the control vehicle and suspended in a sling. L-DOPA induced highly stereotyped air-stepping that varied along several ... ...

Abstract	Rat pups at postnatal day (PN) 0, 5, 10, 15, and 20 were injected with 100 mg/kg L-3,4-dihydroxyphenylalanine (L-DOPA; s.c.) or the control vehicle and suspended in a sling. L-DOPA induced highly stereotyped air-stepping that varied along several dimensions across development. The latency to air-stepping was constant across age, but the duration was significantly shorter in the older pups. At all ages, air-stepping was preceded or accompanied by raising of the head and dorsiflexion of the tail. The rate of stepping increased across age and gait varied with age. At PN 0, L-DOPA induced alternating forelimb movements with little involvement of the hindlimbs. At PN 5 and 10, both forelimb and hindlimb alternation were observed. At PN 10 and 15 swimming-like behavior emerged, and at PN 10, 15, and 20, episodes of galloping were interspersed with limb alternation. Thus, highly coordinated activity can be elicited by L-DOPA at all ages studied when the rat pup needs not support its own body weight and has no contact with a substrate. Drug-induced air-stepping promises to be an important new paradigm for pharmacological and behavioral studies of the development of locomotor controls in mammals.
MeSH term(s)	Animals ; Animals, Newborn/growth & development ; Animals, Newborn/physiology ; Gait ; Levodopa/pharmacology ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Time Factors ; Videotape Recording
Chemical Substances	Levodopa (46627O600J)
Language	English
Publishing date	1991-02-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	8213-2
ISSN	1872-6755 ; 0165-3806
ISSN (online)	1872-6755
ISSN	0165-3806
DOI	10.1016/0165-3806(91)90012-8
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Article: Cadmium effects on bone metabolism: accelerated resorption in ovariectomized, aged beagles.

Sacco-Gibson, N / Chaudhry, S / Brock, A / Sickles, A B / Patel, B / Hegstad, R / Johnston, S / Peterson, D / Bhattacharyya, M

Toxicology and applied pharmacology

1992 Volume 113, Issue 2, Page(s) 274–283

Abstract: The purpose of this study was to evaluate, in an animal whose skeleton is comparable to humans, the combined effects of estrogen depletion and Cd exposure on bone resorption by monitoring skeletal release of 45Ca and to determine whether Cd-induced bone ... ...

Abstract	The purpose of this study was to evaluate, in an animal whose skeleton is comparable to humans, the combined effects of estrogen depletion and Cd exposure on bone resorption by monitoring skeletal release of 45Ca and to determine whether Cd-induced bone resorption occurred independent of osteotropic hormone changes and renal dysfunction. Cd exposure following ovariectomy or sham surgery was for 7 months: 1 month by oral ingestion of capsules (1, 5, 15, 50 ppm) and 6 months via drinking water (15 ppm). Serum and fecal 45Ca were increased at 1 week following ovariectomy (OV) (54 +/- 9% and 122 +/- 40%, respectively), but this response was attenuated by 2 weeks. Five of seven exposed dogs had increased serum and fecal 45Ca during the 50-ppm Cd capsule period (15-40% and 15-190%, respectively). Serum 45Ca levels in OV/+Cd dogs showed a significant and consistent increase within 1 week of initiating each of three separate Cd.H2O exposure cycles. Blood Cd levels increased over time from 2 to 15 micrograms/l, coinciding with the elevated serum 45Ca concentrations. No correlation was observed between serum 45Ca increases and parathyroid hormone, 1,25-(OH)2-vitamin D, or calcitonin. No effects of ovariectomy and/or Cd were observed in total serum Ca, calciotropic hormone concentrations, serum or urinary phosphorus and creatinine, creatinine clearance, or urinary specific gravity. Urinary Cd concentrations ranged from 7 to 50 micrograms/l in exposed dogs but were not detectable in nonexposed dogs. Urinary protein concentrations showed no differences between groups. Cd increased bone resorption (skeletal 45Ca release) in ovariectomized and sham-operated dogs without renal dysfunction or calciotropic hormone interaction. Based on our results, Cd is an exogenous factor which exacerbates bone mineral loss in postmenopausal osteoporosis.
MeSH term(s)	Aging/metabolism ; Animals ; Body Burden ; Body Weight/drug effects ; Bone Resorption ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Cadmium/metabolism ; Cadmium/pharmacokinetics ; Cadmium/pharmacology ; Calcium/blood ; Calcium/metabolism ; Copper/metabolism ; Creatinine/blood ; Creatinine/urine ; Dogs ; Female ; Homeostasis/drug effects ; Ovariectomy ; Tissue Distribution ; Zinc/metabolism
Chemical Substances	Cadmium (00BH33GNGH) ; Copper (789U1901C5) ; Creatinine (AYI8EX34EU) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	1992-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/0041-008x(92)90125-c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Probing Gluon Spin-Momentum Correlations in Transversely Polarized Protons through Midrapidity Isolated Direct Photons in p^{↑}+p Collisions at sqrt[s]=200 GeV.

Acharya, U A / Aidala, C / Akiba, Y / Alfred, M / Andrieux, V / Apadula, N / Asano, H / Azmoun, B / Babintsev, V / Bandara, N S / Barish, K N / Bathe, S / Bazilevsky, A / Beaumier, M / Belmont, R / Berdnikov, A / Berdnikov, Y / Bichon, L / Blankenship, B /

Blau, D S / Bok, J S / Brooks, M L / Bryslawskyj, J / Bumazhnov, V / Campbell, S / Canoa Roman, V / Cervantes, R / Chi, C Y / Chiu, M / Choi, I J / Choi, J B / Citron, Z / Connors, M / Corliss, R / Corrales Morales, Y / Cronin, N / Csanád, M / Csörgő, T / Danley, T W / Daugherity, M S / David, G / DeBlasio, K / Dehmelt, K / Denisov, A / Deshpande, A / Desmond, E J / Dion, A / Dixit, D / Do, J H / Drees, A / Drees, K A / Durham, J M / Durum, A / Enokizono, A / En'yo, H / Esha, R / Esumi, S / Fadem, B / Fan, W / Feege, N / Fields, D E / Finger, M / Fitzgerald, D / Fokin, S L / Frantz, J E / Franz, A / Frawley, A D / Fukuda, Y / Gal, C / Gallus, P / Garg, P / Ge, H / Giles, M / Giordano, F / Goto, Y / Grau, N / Greene, S V / Grosse Perdekamp, M / Gunji, T / Guragain, H / Hachiya, T / Haggerty, J S / Hahn, K I / Hamagaki, H / Hamilton, H F / Han, S Y / Hanks, J / Harvey, M / Hasegawa, S / Haseler, T O S / He, X / Hemmick, T K / Hill, J C / Hill, K / Hodges, A / Hollis, R S / Homma, K / Hong, B / Hoshino, T / Hotvedt, N / Huang, J / Huang, S / Imai, K / Inaba, M / Iordanova, A / Isenhower, D / Ivanishchev, D / Jacak, B V / Jezghani, M / Ji, Z / Jiang, X / Johnson, B M / Jouan, D / Jumper, D S / Kang, J H / Kapukchyan, D / Karthas, S / Kawall, D / Kazantsev, A V / Khachatryan, V / Khanzadeev, A / Khatiwada, A / Kim, C / Kim, E-J / Kim, M / Kincses, D / Kingan, A / Kistenev, E / Klatsky, J / Kline, P / Koblesky, T / Kotov, D / Kudo, S / Kurgyis, B / Kurita, K / Kwon, Y / Lajoie, J G / Larionova, D / Lebedev, A / Lee, S / Lee, S H / Leitch, M J / Leung, Y H / Lewis, N A / Li, X / Lim, S H / Liu, M X / Loggins, V-R / Lökös, S / Loomis, D A / Lovasz, K / Lynch, D / Majoros, T / Makdisi, Y I / Makek, M / Manko, V I / Mannel, E / McCumber, M / McGaughey, P L / McGlinchey, D / McKinney, C / Mendoza, M / Mignerey, A C / Milov, A / Mishra, D K / Mitchell, J T / Mitrankov, Iu / Mitrankova, M / Mitsuka, G / Miyasaka, S / Mizuno, S / Mondal, M M / Montuenga, P / Moon, T / Morrison, D P / Mulilo, B / Murakami, T / Murata, J / Nagai, K / Nagashima, K / Nagashima, T / Nagle, J L / Nagy, M I / Nakagawa, I / Nakano, K / Nattrass, C / Nelson, S / Niida, T / Nouicer, R / Novák, T / Novitzky, N / Nukazuka, G / Nyanin, A S / O'Brien, E / Ogilvie, C A / Orjuela Koop, J D / Osborn, J D / Oskarsson, A / Ottino, G J / Ozawa, K / Pantuev, V / Papavassiliou, V / Park, J S / Park, S / Pate, S F / Patel, M / Peng, W / Perepelitsa, D V / Perera, G D N / Peressounko, D Yu / PerezLara, C E / Perry, J / Petti, R / Phipps, M / Pinkenburg, C / Pisani, R P / Potekhin, M / Pun, A / Purschke, M L / Radzevich, P V / Ramasubramanian, N / Read, K F / Reynolds, D / Riabov, V / Riabov, Y / Richford, D / Rinn, T / Rolnick, S D / Rosati, M / Rowan, Z / Runchey, J / Safonov, A S / Sakaguchi, T / Sako, H / Samsonov, V / Sarsour, M / Sato, S / Schaefer, B / Schmoll, B K / Sedgwick, K / Seidl, R / Sen, A / Seto, R / Sexton, A / Sharma, D / Shein, I / Shibata, T-A / Shigaki, K / Shimomura, M / Shioya, T / Shukla, P / Sickles, A / Silva, C L / Silvermyr, D / Singh, B K / Singh, C P / Singh, V / Slunečka, M / Smith, K L / Snowball, M / Soltz, R A / Sondheim, W E / Sorensen, S P / Sourikova, I V / Stankus, P W / Stoll, S P / Sugitate, T / Sukhanov, A / Sumita, T / Sun, J / Sun, Z / Sziklai, J / Tanida, K / Tannenbaum, M J / Tarafdar, S / Taranenko, A / Tarnai, G / Tieulent, R / Timilsina, A / Todoroki, T / Tomášek, M / Towell, C L / Towell, R S / Tserruya, I / Ueda, Y / Ujvari, B / van Hecke, H W / Velkovska, J / Virius, M / Vrba, V / Vukman, N / Wang, X R / Watanabe, Y S / Wong, C P / Woody, C L / Xu, C / Xu, Q / Xue, L / Yalcin, S / Yamaguchi, Y L / Yamamoto, H / Yanovich, A / Yoo, J H / Yoon, I / Yu, H / Yushmanov, I E / Zajc, W A / Zelenski, A / Zharko, S / Zou, L

Physical review letters

2021 Volume 127, Issue 16, Page(s) 162001

Abstract: Studying spin-momentum correlations in hadronic collisions offers a glimpse into a three-dimensional picture of proton structure. The transverse single-spin asymmetry for midrapidity isolated direct photons in p^{↑}+p collisions at sqrt[s]=200 GeV is ... ...

Abstract	Studying spin-momentum correlations in hadronic collisions offers a glimpse into a three-dimensional picture of proton structure. The transverse single-spin asymmetry for midrapidity isolated direct photons in p^{↑}+p collisions at sqrt[s]=200 GeV is measured with the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). Because direct photons in particular are produced from the hard scattering and do not interact via the strong force, this measurement is a clean probe of initial-state spin-momentum correlations inside the proton and is in particular sensitive to gluon interference effects within the proton. This is the first time direct photons have been used as a probe of spin-momentum correlations at RHIC. The uncertainties on the results are a 50-fold improvement with respect to those of the one prior measurement for the same observable, from the Fermilab E704 experiment. These results constrain gluon spin-momentum correlations in transversely polarized protons.
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.162001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cadmium effects on bone metabolism: accelerated resorption in ovariectomized, aged beagles

Sacco-Gibson, N / Chaudhry, S / Brock, A / Sickles, A.B / Patel, B / Hegstad, R / Johnston, S / Peterson, D / Bhattacharyya, M

Toxicology and applied pharmacology. Apr 1992. v. 113 (2)

1992

Abstract	The purpose of this study was to evaluate, in an animal whose skeleton is comparable to humans, the combined effects of estrogen depletion and Cd exposure on bone resorption by monitoring skeletal release of (45)Ca and to determine whether Cd-induced bone resorption occurred independent of osteotropic hormone changes and renal dysfunction. Cd exposure following ovariectomy or sham surgery was for 7 months: 1 month by oral ingestion of capsules (1, 5, 15, 50 ppm) and 6 months via drinking water (15 ppm). Serum and fecal (45)Ca were increased at 1 week following ovariectomy (OV) (54 +/- 9% and 122 +/- 40%, respectively), but this response was attenuated by 2 weeks. Five of seven exposed dogs had increased serum and fecal (45)Ca during the 50-ppm Cd capsule period (15-40% and 15-190%, respectively). Serum (45)Ca levels in OV/+Cd dogs showed a significant and consistent increase within 1 week of initiating each of three separate Cd.H2O exposure cycles. Blood Cd levels increased over time from 2 to 15 micrograms/l, coinciding with the elevated serum (45)Ca concentrations. No correlation was observed between serum (45)Ca increases and parathyroid hormone, 1,25-(OH)2-vitamin D, or calcitonin. No effects of ovariectomy and/or Cd were observed in total serum Ca, calciotropic hormone concentrations, serum or urinary phosphorus and creatinine, creatinine clearance, or urinary specific gravity. Urinary Cd concentrations ranged from 7 to 50 micrograms/l in exposed dogs but were not detectable in nonexposed dogs. Urinary protein concentrations showed no differences between groups. Cd increased bone resorption (skeletal 45(Ca) release) in ovariectomized and sham-operated dogs without renal dysfunction or calciotropic hormone interaction. Based on our results, Cd is an exogenous factor which exacerbates bone mineral loss in postmenopausal osteoporosis.
Keywords	cadmium ; mineral metabolism ; bone resorption ; dogs
Language	English
Dates of publication	1992-04
Size	p. 274-283.
Document type	Article
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
Database	NAL-Catalogue (AGRICOLA)

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