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Artikel: Phenotypic and Genotypic Characterization of Pan-Drug-Resistant

Sid Ahmed, Mazen A / Hamid, Jemal M / Hassan, Ahmed M M / Abu Jarir, Sulieman / Bashir Ibrahim, Emad / Abdel Hadi, Hamad

Antibiotics (Basel, Switzerland)

2024 Band 13, Heft 3

Abstract: In secondary healthcare, carbapenem-resistant Enterobacterales (CREs), such as those observed ... ...

Abstract	In secondary healthcare, carbapenem-resistant Enterobacterales (CREs), such as those observed in
Sprache	Englisch
Erscheinungsdatum	2024-03-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13030275
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The epidemiology and microbiological characteristics of infections caused by Gram-negative bacteria in Qatar: national surveillance from the Study for Monitoring of Antimicrobial Resistance Trends (SMART): 2017 to 2019.

Sid Ahmed, Mazen A / Petkar, Hawabibee Mahir / Saleh, Thoraya M / Albirair, Mohamed / Arisgado, Lolita A / Eltayeb, Faiha K / Mahmoud Hamed, Manal / Al-Maslamani, Muna A / Al Khal, Abdul Latif / Alsoub, Hussam / Ibrahim, Emad Bashir / Abdel Hadi, Hamad

JAC-antimicrobial resistance

2023 Band 5, Heft 4, Seite(n) dlad086

Abstract: Background: The global Study of Monitoring Antimicrobial Resistance Trends (SMART) is a surveillance program for evaluation of antimicrobial resistance (AMR) in Gram-negative bacteria (GNB) from different regions including Gulf countries.: Objectives!# ...

Abstract	Background: The global Study of Monitoring Antimicrobial Resistance Trends (SMART) is a surveillance program for evaluation of antimicrobial resistance (AMR) in Gram-negative bacteria (GNB) from different regions including Gulf countries. Objectives: To evaluate AMR in GNB from various clinical specimens including microbiological and genetic characteristics for existing and novel antimicrobials. Methods: A prospective study was conducted on clinical specimens from Hamad Medical Corporation, Qatar, between 2017 and 2019 according to the SMART protocol. Consecutive GNB from different sites were evaluated including lower respiratory, urinary tract, intrabdominal and bloodstream infections. Results: Over the 3 years study period, 748 isolates were evaluated from the specified sites comprising 37 different GNB outlining four key pathogens: Conclusions: Surveillance of GNB from Qatar showed prevalence of key pathogens similar to other regions but demonstrated significant resistance patterns to existing and novel antimicrobials with different underlying resistance mechanisms.
Sprache	Englisch
Erscheinungsdatum	2023-08-03
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2632-1823
ISSN (online)	2632-1823
DOI	10.1093/jacamr/dlad086
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association of

Sid Ahmed, Mazen A / Khan, Faisal Ahmad / Hadi, Hamad Abdel / Skariah, Sini / Sultan, Ali A / Salam, Abdul / Al Khal, Abdul Latif / Söderquist, Bo / Ibrahim, Emad Bashir / Omrani, Ali S / Jass, Jana

Antibiotics (Basel, Switzerland)

2022 Band 11, Heft 2

Abstract: Ceftazidime-avibactam and ceftolozane-tazobactam are approved for the treatment of complicated Gram-negative bacterial infections including multidrug-resistant (MDR) ...

Abstract	Ceftazidime-avibactam and ceftolozane-tazobactam are approved for the treatment of complicated Gram-negative bacterial infections including multidrug-resistant (MDR)
Sprache	Englisch
Erscheinungsdatum	2022-01-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11020130
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: β-lactamase-mediated resistance in MDR-Pseudomonas aeruginosa from Qatar.

Sid Ahmed, Mazen A / Khan, Faisal Ahmad / Sultan, Ali A / Söderquist, Bo / Ibrahim, Emad Bashir / Jass, Jana / Omrani, Ali S

Antimicrobial resistance and infection control

2020 Band 9, Heft 1, Seite(n) 170

Abstract: Background: The distribution of β-lactam resistance genes in P. aeruginosa is often closely related to the distribution of certain high-risk international clones. We used whole-genome sequencing (WGS) to identify the predominant sequence types (ST) and ... ...

Abstract	Background: The distribution of β-lactam resistance genes in P. aeruginosa is often closely related to the distribution of certain high-risk international clones. We used whole-genome sequencing (WGS) to identify the predominant sequence types (ST) and β-lactamase genes in clinical isolates of multidrug-resistant (MDR)-P. aeruginosa from Qatar METHODS: Microbiological identification and susceptibility tests were performed by automated BD Phoenix™ system and manual Liofilchem MIC Test Strips. Results: Among 75 MDR-P. aeruginosa isolates; the largest proportions of susceptibility were to ceftazidime-avibactam (n = 36, 48%), followed by ceftolozane-tazobactam (30, 40%), ceftazidime (n = 21, 28%) and aztreonam (n = 16, 21.3%). All isolates possessed Class C and/or Class D β-lactamases (n = 72, 96% each), while metallo-β-lactamases were detected in 20 (26.7%) isolates. Eight (40%) metallo-β-lactamase producers were susceptible to aztreonam and did not produce any concomitant extended-spectrum β-lactamases. High risk ST235 (n = 16, 21.3%), ST357 (n = 8, 10.7%), ST389 and ST1284 (6, 8% each) were most frequent. Nearly all ST235 isolates (15/16; 93.8%) were resistant to all tested β-lactams. Conclusion: MDR-P. aeruginosa isolates from Qatar are highly resistant to antipseudomonal β-lactams. High-risk STs are predominant in Qatar and their associated MDR phenotypes are a cause for considerable concern.
Mesh-Begriff(e)	Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/enzymology ; Pseudomonas aeruginosa/genetics ; Whole Genome Sequencing ; beta-Lactamases/genetics ; beta-Lactamases/physiology
Chemische Substanzen	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Sprache	Englisch
Erscheinungsdatum	2020-11-01
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2666706-X
ISSN	2047-2994 ; 2047-2994
ISSN (online)	2047-2994
ISSN	2047-2994
DOI	10.1186/s13756-020-00838-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Clinical outcomes, molecular epidemiology and resistance mechanisms of multidrug-resistant

Sid Ahmed, Mazen A / Hamid, Jemal M / Husain, Ahmed A / Hadi, Hamad Abdel / Skariah, Sini / Sultan, Ali A / Ibrahim, Emad Bashir / Al Khal, Abdul Latif / Soderquist, Bo / Jass, Jana / Omrani, Ali S

Annals of medicine

2021 Band 53, Heft 1, Seite(n) 2345–2353

Abstract: Background: Bloodstream infections (BSIs) caused by multidrug-resistant (MDR)-: Materials and methods: We included all MDR-: Results: Out of 362 : Conclusion: MDR- ...

Abstract	Background: Bloodstream infections (BSIs) caused by multidrug-resistant (MDR)- Materials and methods: We included all MDR- Results: Out of 362 Conclusion: MDR-
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial/genetics ; Humans ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Epidemiology ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/epidemiology ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/genetics ; Qatar/epidemiology ; Sepsis/drug therapy ; Sepsis/epidemiology
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2021-12-09
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2021.2012588
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 680: Hefte anzeigen

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Artikel ; Online: Prevalence and microbiological and genetic characteristics of multidrug-resistant

Sid Ahmed, Mazen A / Abdel Hadi, Hamad / Abu Jarir, Sulieman / Ahmad Khan, Faisal / Arbab, Mohammed A / Hamid, Jemal M / Alyazidi, Mohammed A / Al-Maslamani, Muna A / Skariah, Sini / Sultan, Ali A / Al Khal, Abdul Latif / Söderquist, Bo / Ibrahim, Emad Bashir / Jass, Jana / Ziglam, Hisham

Antimicrobial stewardship & healthcare epidemiology : ASHE

2022 Band 2, Heft 1, Seite(n) e96

Abstract: Objectives: Antimicrobial resistance (AMR) is a global priority with significant clinical and economic consequences. Multidrug-resistant (MDR) : Methods: Consecutive clinical specimens of : Results: The overall prevalence of MDR : Conclusions: ... ...

Abstract	Objectives: Antimicrobial resistance (AMR) is a global priority with significant clinical and economic consequences. Multidrug-resistant (MDR) Methods: Consecutive clinical specimens of Results: The overall prevalence of MDR Conclusions: MDR
Sprache	Englisch
Erscheinungsdatum	2022-06-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2022.226
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of an antimicrobial stewardship programme on antimicrobial utilization and the prevalence of MDR

Sid Ahmed, Mazen A / Abdel Hadi, Hamad / Abu Jarir, Sulieman / Al Khal, Abdul Latif / Al-Maslamani, Muna A / Jass, Jana / Ibrahim, Emad Bashir / Ziglam, Hisham

JAC-antimicrobial resistance

2020 Band 2, Heft 3, Seite(n) dlaa050

Abstract: Background: The excessive and inappropriate use of antibiotics is universal across all healthcare facilities. In Qatar there has been a substantial increase in antimicrobial consumption coupled with a significant rise in antimicrobial resistance (AMR). ... ...

Abstract	Background: The excessive and inappropriate use of antibiotics is universal across all healthcare facilities. In Qatar there has been a substantial increase in antimicrobial consumption coupled with a significant rise in antimicrobial resistance (AMR). Antimicrobial stewardship programmes (ASPs) have become a standard intervention for effective optimization of antimicrobial prescribing. Methods: A before-after study was conducted in Hamad General Hospital (603 bed acute care hospital): 1 year before implementation of a comprehensive ASP compared with the following 2 years. The ASP included a hospital-wide pre-authorization requirement by infectious diseases physicians for all broad-spectrum antibiotics. Prevalence of MDR Results: A total of 6501 clinical isolates of Conclusions: The successful implementation of the ASP led to a significant reduction in rates of MDR
Sprache	Englisch
Erscheinungsdatum	2020-08-07
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2632-1823
ISSN (online)	2632-1823
DOI	10.1093/jacamr/dlaa050
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar.

Sid Ahmed, Mazen A / Abdel Hadi, Hamad / Hassan, Abubaker A I / Abu Jarir, Sulieman / Al-Maslamani, Muna A / Eltai, Nahla Omer / Dousa, Khalid M / Hujer, Andrea M / Sultan, Ali A / Soderquist, Bo / Bonomo, Robert A / Ibrahim, Emad Bashir / Jass, Jana / Omrani, Ali S

The Journal of antimicrobial chemotherapy

2019 Band 74, Heft 12, Seite(n) 3497–3504

Abstract: Objectives: To investigate the in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against clinical isolates of MDR Pseudomonas aeruginosa from Qatar, as well as the mechanisms of resistance.: Methods: MDR P. aeruginosa isolated ... ...

Abstract	Objectives: To investigate the in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against clinical isolates of MDR Pseudomonas aeruginosa from Qatar, as well as the mechanisms of resistance. Methods: MDR P. aeruginosa isolated between October 2014 and September 2015 from all public hospitals in Qatar were included. The BD PhoenixTM system was used for identification and initial antimicrobial susceptibility testing, while Liofilchem MIC Test Strips (Liofilchem, Roseto degli Abruzzi, Italy) were used for confirmation of ceftazidime/avibactam and ceftolozane/tazobactam susceptibility. Ten ceftazidime/avibactam- and/or ceftolozane/tazobactam-resistant isolates were randomly selected for WGS. Results: A total of 205 MDR P. aeruginosa isolates were included. Of these, 141 (68.8%) were susceptible to ceftazidime/avibactam, 129 (62.9%) were susceptible to ceftolozane/tazobactam, 121 (59.0%) were susceptible to both and 56 (27.3%) were susceptible to neither. Twenty (9.8%) isolates were susceptible to ceftazidime/avibactam but not to ceftolozane/tazobactam and only 8 (3.9%) were susceptible to ceftolozane/tazobactam but not to ceftazidime/avibactam. Less than 50% of XDR isolates were susceptible to ceftazidime/avibactam or ceftolozane/tazobactam. The 10 sequenced isolates belonged to six different STs and all produced AmpC and OXA enzymes; 5 (50%) produced ESBL and 4 (40%) produced VIM enzymes. Conclusions: MDR P. aeruginosa susceptibility rates to ceftazidime/avibactam and ceftolozane/tazobactam were higher than those to all existing antipseudomonal agents, except colistin, but were less than 50% in extremely resistant isolates. Non-susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam was largely due to the production of ESBL and VIM enzymes. Ceftazidime/avibactam and ceftolozane/tazobactam are possible options for some patients with MDR P. aeruginosa in Qatar.
Mesh-Begriff(e)	Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds/pharmacology ; Ceftazidime/pharmacology ; Cephalosporins/pharmacology ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests ; Prospective Studies ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Qatar ; Tazobactam/pharmacology ; Whole Genome Sequencing
Chemische Substanzen	Anti-Bacterial Agents ; Azabicyclo Compounds ; Cephalosporins ; Drug Combinations ; avibactam, ceftazidime drug combination ; ceftolozane, tazobactam drug combination ; Ceftazidime (9M416Z9QNR) ; Tazobactam (SE10G96M8W)
Sprache	Englisch
Erscheinungsdatum	2019-11-25
Erscheinungsland	England
Dokumenttyp	Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkz379
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Verfügbar in ZB MED Köln/Königswinter

Zs.A 1197: Hefte anzeigen			Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Hefte anzeigen

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Artikel: The emergence of multidrug-resistant

AbdulWahab, Atqah / Zahraldin, Khalid / Sid Ahmed, Mazen A / Jarir, Sulieman Abu / Muneer, Mohammed / Mohamed, Shehab F / Hamid, Jemal M / Hassan, Abubaker A I / Ibrahim, Emad Bashir

Lung India : official organ of Indian Chest Society

2017 Band 34, Heft 6, Seite(n) 527–531

Abstract: Introduction: Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality.: Objective: The objective of the study was to ... ...

Abstract	Introduction: Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality. Objective: The objective of the study was to describe the frequency of MDR-PA recovered from the lower respiratory samples of pediatric and adult CF patients, and its antibiotic resistance pattern to commonly used antimicrobial agents including β-lactams, aminoglycosides, and fluoroquinolones. Materials and methods: The lower respiratory isolates of P. aeruginosa were obtained from inpatients and outpatients CF clinics from a tertiary care teaching hospital for the period from October 2014 to September 2015. The identification and antimicrobial susceptibility for all the isolates were performed by using the BD Phoenix™ and E-test in compliance with Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: A total of 61 P. aeruginosa samples were isolated from thirty CF patients from twenty families. Twelve sputum samples were positive for MDR-PA (seven nonmucoid and five mucoid isolates) from five CF patients (five families) with moderate-to-very severe lung disease given MDR-PA frequency of 19.7%. The median age of the study group was 20 (range 10-30) years. Three CF patients were on chronic inhaled tobramycin and two on nebulized colistin. The antimicrobial patterns of isolates MDR-PA showed the highest rate of resistance toward each gentamycin, amikacin, and cefepime (100%), followed by 91.7% to ciprofloxacin, 75% to tobramycin, 58.3% to meropenem, and 50% to piperacillin-tazobactam. None of the isolates were resistant to colistin during the study period. Conclusion: The study results emphasize that the emergence of a significant problem in the clinical isolates of P. aeruginosa in CF patients that dictate appropriate attention to the antibiotic management after proper surveillance.
Sprache	Englisch
Erscheinungsdatum	2017-11-03
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	2410801-7
ISSN	0974-598X ; 0970-2113
ISSN (online)	0974-598X
ISSN	0970-2113
DOI	10.4103/lungindia.lungindia_39_17
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Antimicrobial susceptibility and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae from intensive care units at Hamad Medical Corporation, Qatar.

Sid Ahmed, Mazen A / Bansal, Devendra / Acharya, Anushree / Elmi, Asha A / Hamid, Jemal M / Sid Ahmed, Abuelhassan M / Chandra, Prem / Ibrahim, Emad / Sultan, Ali A / Doiphode, Sanjay / Bilal, Naser Eldin / Deshmukh, Anand

Antimicrobial resistance and infection control

2016 Band 5, Seite(n) 4

Abstract: Background: The emergence of extended-spectrum beta-lactamase (ESBL)-producing isolates has important clinical and therapeutic implications. High prevalence of ESBL-producing Enterobacteriaceae has been reported in the literature for clinical samples ... ...

Abstract	Background: The emergence of extended-spectrum beta-lactamase (ESBL)-producing isolates has important clinical and therapeutic implications. High prevalence of ESBL-producing Enterobacteriaceae has been reported in the literature for clinical samples from a variety of infection sites. The present study was undertaken to evaluate the prevalence of ESBL-producing Enterobacteriaceae, and to perform molecular characterization and antimicrobial susceptibility testing of clinical isolates from patients admitted to the intensive care units at Hamad Medical Corporation, Doha, Qatar, from November 2012 to October 2013. Methods: A total of 629 Enterobacteriaceae isolates were included in the study. Identification and susceptibility testing was performed using Phoenix (Becton Dickinson) and the ESBL producers were confirmed by double-disk potentiation as recommended by the Clinical and Laboratory Standards Institute. Molecular analysis of the ESBL producers was performed by polymerase chain reaction. Results: In total, 109 isolates (17.3 %) were confirmed as ESBL producers and all were sensitive to meropenem in routine susceptibility assays. Most of the ESBL producers (99.1 %) were resistant to amoxicillin/clavulanic acid and ceftriaxone and 93.6 % were resistant to cefepime. Among the ESBL-producing genes, bla CTX-M (66.1 %) was the most prevalent, followed by bla SHV (53.2 %) and bla TEM (40.4 %). Conclusions: These findings show the high prevalence of ESBL-producing Enterobacteriaceae within the intensive care units at Hamad Medical Corporation, Qatar, and emphasize the need for judicious use of antibiotics and the implementation of strict infection control measures.
Sprache	Englisch
Erscheinungsdatum	2016
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2666706-X
ISSN	2047-2994
ISSN	2047-2994
DOI	10.1186/s13756-016-0103-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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