Article ; Online: Magnetic resonance imaging analysis predicts nanoparticle concentration delivered to the brain parenchyma.
Communications biology
2022 Volume 5, Issue 1, Page(s) 964
Abstract: Ultrasound in combination with the introduction of microbubbles into the vasculature effectively opens the blood brain barrier (BBB) to allow the passage of therapeutic agents. Increased permeability of the BBB is typically demonstrated with small- ... ...
| Abstract | Ultrasound in combination with the introduction of microbubbles into the vasculature effectively opens the blood brain barrier (BBB) to allow the passage of therapeutic agents. Increased permeability of the BBB is typically demonstrated with small-molecule agents (e.g., 1-nm gadolinium salts). Permeability to small-molecule agents, however, cannot reliably predict the transfer of remarkably larger molecules (e.g., monoclonal antibodies) required by numerous therapies. To overcome this issue, we developed a magnetic resonance imaging analysis based on the ΔR |
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| MeSH term(s) | Animals ; Antibodies, Monoclonal ; Brain/diagnostic imaging ; Drug Delivery Systems/methods ; Gadolinium ; Liposomes ; Magnetic Resonance Imaging/methods ; Nanoparticles ; Rats ; Salts |
| Chemical Substances | Antibodies, Monoclonal ; Liposomes ; Salts ; Gadolinium (AU0V1LM3JT) |
| Language | English |
| Publishing date | 2022-09-15 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2399-3642 |
| ISSN (online) | 2399-3642 |
| DOI | 10.1038/s42003-022-03881-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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