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  1. Article ; Online: Probing plasmon-induced surface reactions using two-dimensional correlation vibrational spectroscopy.

    Singh, Ruchi / Yadav, Vikas / Siddhanta, Soumik

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 8, Page(s) 6032–6043

    Abstract: Surface plasmon resonance (SPR) has the ability to drive catalytic conversion of the reactant ... ...

    Abstract Surface plasmon resonance (SPR) has the ability to drive catalytic conversion of the reactant molecules
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp05705k
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  2. Article ; Online: Evolution of Mn-Bi

    Kundu, Avinava / Dhillon, Ashish Kumar / Singh, Ruchi / Barman, Sanmitra / Siddhanta, Soumik / Chakraborty, Biswarup

    Dalton transactions (Cambridge, England : 2003)

    2024  

    Abstract: ... Mn-doped ... ...

    Abstract Mn-doped Bi
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d4dt00633j
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  3. Article ; Online: Ion-Mediated Protein Stabilization on Nanoscopic Surfaces.

    Sharma, Arti / Mondal, Soumya / Ahuja, Tripti / Karmakar, Tarak / Siddhanta, Soumik

    Langmuir : the ACS journal of surfaces and colloids

    2023  

    Abstract: The emergence of nanoparticles in biomedical applications has made their interactions with proteins inevitable. Nanoparticles conjugated with proteins and peptide-based constructs form an integral part of nanotherapeutics and have recently shown promise ... ...

    Abstract The emergence of nanoparticles in biomedical applications has made their interactions with proteins inevitable. Nanoparticles conjugated with proteins and peptide-based constructs form an integral part of nanotherapeutics and have recently shown promise in treating a myriad of diseases. The proper functioning of proteins is critical to achieve their biological functions. However, interface issues result in the denaturation of proteins, and the loss of orientation and steric hindrance can adversely affect the function of the conjugate. Furthermore, surface-induced denaturation also triggers protein aggregation, resulting in amyloid-like species. Understanding the mechanistic underpinnings of protein-nanoparticle interactions and controlling their interfacial characteristics are critical and challenging due to the complex nature of the conjugates. In this milieu, we demonstrate that ionic liquids can be suitable candidates for stabilizing protein-nanoparticle interactions by virtue of their excellent protein-preserving properties. We also probe the previously unexplored mechanism of ion-mediated stabilization of the protein molecules on the nanoparticle surface. The protein-nanoparticle conjugates consist of lysozyme and choline-based ionic liquids characterized by optical and electron microscopy techniques combined with surface-sensitive plasmon-enhanced Raman spectroscopy. Furthermore, atomistic molecular dynamics simulations of the conjugates delineate interfacial interactions of the protein molecules and the modulation by the ions, particularly the conformational changes and the dynamic correlation when the protein and specific ionic liquid molecules are adsorbed on the nanoparticle surface. The combined experimental and computational studies showed the synergistic behavior of the ions of the ionic liquids, specifically the orientation and coverage of the anions aided by the cations to control the surface interactions and hence the overall protein stability. These studies pave the way for using ionic liquids, particularly their biocompatible counterparts in nanoparticle-based complexes, as stabilizing agents for biomedical applications.
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.2c03010
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  4. Article ; Online: Photoactivated plasmonic nanohybrid fibers with prolonged trapping of excited charge carriers for SERS analysis of biomolecules.

    Sharma, Arti / Ahuja, Tripti / Yadav, Jatin / Majumdar, Shubhangi / Siddhanta, Soumik

    Journal of materials chemistry. B

    2023  Volume 11, Issue 38, Page(s) 9212–9222

    Abstract: The quest to enhance Raman spectroscopic signals through the rational design of plasmonic substrates has enabled the detection and characterization of pharmaceutically important molecules with low scattering cross-sections, such as amino acids and ... ...

    Abstract The quest to enhance Raman spectroscopic signals through the rational design of plasmonic substrates has enabled the detection and characterization of pharmaceutically important molecules with low scattering cross-sections, such as amino acids and proteins, and is helping in making forays into the diverse field of biomedical sciences. This work presents a simple strategy for synthesizing silver nanoparticles-incorporated alumina nanofibers (Ag-AlNFs) utilizing controlled microwave synthesis for enhancing the surface-enhanced Raman chemical enhancement factor through photo-induced charge accumulation at the plasmonic-dielectric interface. The plasmonic-dielectric fibers serve as excellent charge carrier trappers, as evident from the ultrafast transient absorption spectroscopy studies. Apart from chemical enhancement, the increase in electronic surface charge also enables the protein disulfide bonds to capture these electrons and form a transient disulfide electron adduct radical, which converts to free thiol radical on dissociation. This allows protein molecules to bind to the nanoparticle's surface with the favorable silver thiol bond leading to greater surface affinity and larger SERS enhancement. The proposed Ag-AlNFs represent a cost-effective material that can be potentially used to probe biological systems in a label-free manner by photoactivating the SERS substrate for obtaining higher enhancement factors.
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb00980g
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  5. Article ; Online: Reverse stable isotope labelling with Raman spectroscopy for microbial proteomics.

    Karlo, Jiro / Dhillon, Ashish Kumar / Siddhanta, Soumik / Singh, Surya Pratap

    Journal of biophotonics

    2023  Volume 17, Issue 2, Page(s) e202300341

    Abstract: Global proteome changes in microbes affect the survival and overall production of commercially relevant metabolites through different bioprocesses. The existing methods to monitor proteome level changes are destructive in nature. Stable isotope probing ( ... ...

    Abstract Global proteome changes in microbes affect the survival and overall production of commercially relevant metabolites through different bioprocesses. The existing methods to monitor proteome level changes are destructive in nature. Stable isotope probing (SIP) coupled with Raman spectroscopy is a relatively new approach for proteome analysis. However, applying this approach for monitoring changes in a large culture volume is not cost-effective. In this study, for the first time we are presenting a novel method of combining reverse SIP using
    MeSH term(s) Proteome/metabolism ; Spectrum Analysis, Raman/methods ; Isotope Labeling/methods ; Proteomics ; Escherichia coli
    Chemical Substances Proteome
    Language English
    Publishing date 2023-12-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202300341
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
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  6. Article ; Online: Monitoring of microbial proteome dynamics using Raman stable isotope probing.

    Karlo, Jiro / Dhillon, Ashish Kumar / Siddhanta, Soumik / Singh, Surya Pratap

    Journal of biophotonics

    2022  Volume 16, Issue 4, Page(s) e202200341

    Abstract: Abnormal protein kinetics could be a cause of several diseases associated with essential life processes. An accurate understanding of protein dynamics and turnover is essential for developing diagnostic or therapeutic tools to monitor these changes. ... ...

    Abstract Abnormal protein kinetics could be a cause of several diseases associated with essential life processes. An accurate understanding of protein dynamics and turnover is essential for developing diagnostic or therapeutic tools to monitor these changes. Raman spectroscopy in combination with stable isotope probes (SIP) such as carbon-13, and deuterium has been a breakthrough in the qualitative and quantitative study of various metabolites. In this work, we are reporting the utility of Raman-SIP for monitoring dynamic changes in the proteome at the community level. We have used
    MeSH term(s) Proteome ; Carbon ; Spectrum Analysis, Raman/methods ; Glucose/metabolism
    Chemical Substances Proteome ; Carbon (7440-44-0) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-12-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202200341
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
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  7. Article ; Online: Role of Aqueous-Phase Calcination in Synthesis of Ultra-Stable Dye-Embedded Fluorescent Nanoparticles for Cellular Probing.

    Rex, Rachel / Siddhanta, Soumik / Barman, Ishan

    Applied spectroscopy

    2021  Volume 75, Issue 8, Page(s) 1012–1021

    Abstract: Fluorescence imaging is a major driver of discovery in biology, and an invaluable asset in clinical diagnostics. To overcome quenching limitations of conventional fluorescent dyes and further improve intensity, nanoparticle-based constructs have been the ...

    Abstract Fluorescence imaging is a major driver of discovery in biology, and an invaluable asset in clinical diagnostics. To overcome quenching limitations of conventional fluorescent dyes and further improve intensity, nanoparticle-based constructs have been the subject of intense investigation, and within this realm, dye-doped silica-coated nanoparticles have garnered significant attention. Despite their growing popularity in research, fluorescent silica nanoparticles suffer from a significant flaw. The degradation of these nanoparticles in biological media by hydrolytic dissolution is underreported, leading to serious misinterpretations, and limiting their applicability for live cell and in vivo imaging. Here, the development of an ultra-stable, dye-embedded, silica-coated metal nanoparticle is reported, and its superior performance in long-term live cell imaging is demonstrated. While conventional dye-doped silica nanoparticles begin to degrade within an hour in aqueous media, by leveraging a modified liquid calcination process, this new construct is shown to be stable for at least 24 h. The stability of this metal-enhanced fluorescent probe in biologically relevant temperatures and media, and its demonstrated utility for cell imaging, paves the way for its future adoption in biomedical research.
    MeSH term(s) Fluorescence ; Fluorescent Dyes ; Metal Nanoparticles ; Nanoparticles ; Silicon Dioxide ; Water
    Chemical Substances Fluorescent Dyes ; Water (059QF0KO0R) ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3530
    ISSN (online) 1943-3530
    DOI 10.1177/00037028211027597
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  8. Article ; Online: Emergence of Raman Spectroscopy as a Probing Tool for Theranostics.

    Singh, Ruchi / Yadav, Vikas / Dhillon, Ashish Kumar / Sharma, Arti / Ahuja, Tripti / Siddhanta, Soumik

    Nanotheranostics

    2023  Volume 7, Issue 3, Page(s) 216–235

    Abstract: Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the ... ...

    Abstract Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.
    MeSH term(s) Precision Medicine ; Spectrum Analysis, Raman ; Photochemotherapy ; Nanostructures/therapeutic use ; Nanotechnology
    Language English
    Publishing date 2023-03-05
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2206-7418
    ISSN (online) 2206-7418
    DOI 10.7150/ntno.81936
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  9. Article ; Online: Monitoring the lipid oxidation and fatty acid profile of oil using algorithm-assisted surface-enhanced Raman spectroscopy.

    Nagpal, Tanya / Yadav, Vikas / Khare, Sunil K / Siddhanta, Soumik / Sahu, Jatindra K

    Food chemistry

    2023  Volume 428, Page(s) 136746

    Abstract: Deep-fat frying of food develops lipid oxidation products that deteriorate oil and pose a health risk. This necessitates the development of a rapid and accurate oil quality and safety detection technique. Herein, surface-enhanced Raman spectroscopy (SERS) ...

    Abstract Deep-fat frying of food develops lipid oxidation products that deteriorate oil and pose a health risk. This necessitates the development of a rapid and accurate oil quality and safety detection technique. Herein, surface-enhanced Raman spectroscopy (SERS) and sophisticated chemometric techniques were used for rapid and label-free determination of peroxide value (PV) and fatty acid composition of oil in-situ. In the study, plasmon-tuned and biocompatible Ag@Au core-shell nanoparticle-based SERS substrates were used to obtain optimum enhancement despite matrix interference to efficiently detect the oil components. The potent combination of SERS and the Artificial Neural Network (ANN) method could determine the fatty acid profile and PV with upto 99% accuracy. Moreover, the SERS-ANN method could quantify the low level of trans fats, i.e., < 2%, with 97% accuracy. Therefore, the developed algorithm-assisted SERS system enabled the sleek and rapid monitoring and on-site detection of oil oxidation.
    MeSH term(s) Spectrum Analysis, Raman/methods ; Fatty Acids ; Nanoparticles ; Oxidation-Reduction ; Algorithms ; Metal Nanoparticles/chemistry
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.136746
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    Z 3634: Show issues

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  10. Article ; Online: Raman spectroscopy and its plasmon-enhanced counterparts: A toolbox to probe protein dynamics and aggregation.

    Dhillon, Ashish Kumar / Sharma, Arti / Yadav, Vikas / Singh, Ruchi / Ahuja, Tripti / Barman, Sanmitra / Siddhanta, Soumik

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2023  Volume 16, Issue 1, Page(s) e1917

    Abstract: Protein unfolding and aggregation are often correlated with numerous diseases such as Alzheimer's, Parkinson's, Huntington's, and other debilitating neurological disorders. Such adverse events consist of a plethora of competing mechanisms, particularly ... ...

    Abstract Protein unfolding and aggregation are often correlated with numerous diseases such as Alzheimer's, Parkinson's, Huntington's, and other debilitating neurological disorders. Such adverse events consist of a plethora of competing mechanisms, particularly interactions that control the stability and cooperativity of the process. However, it remains challenging to probe the molecular mechanism of protein dynamics such as aggregation, and monitor them in real-time under physiological conditions. Recently, Raman spectroscopy and its plasmon-enhanced counterparts, such as surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS), have emerged as sensitive analytical tools that have the potential to perform molecular studies of functional groups and are showing significant promise in probing events related to protein aggregation. We summarize the fundamental working principles of Raman, SERS, and TERS as nondestructive, easy-to-perform, and fast tools for probing protein dynamics and aggregation. Finally, we highlight the utility of these techniques for the analysis of vibrational spectra of aggregation of proteins from various sources such as tissues, pathogens, food, biopharmaceuticals, and lastly, biological fouling to retrieve precise chemical information, which can be potentially translated to practical applications and point-of-care (PoC) devices. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > Diagnostic Nanodevices Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
    MeSH term(s) Spectrum Analysis, Raman/methods ; Nanotechnology/methods
    Language English
    Publishing date 2023-07-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1917
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6781: Show issues Location:
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