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Article ; Online: Myelokathexis in an 18-year-old male patient with severe neutropenia and lymphopenia.

Wang, Endi / Zhao, Yue / Parks, Sophie / Siddiqi, Imran

2023 Volume 99, Issue 3, Page(s) 459–460

MeSH term(s)	Male ; Humans ; Adolescent ; Neutropenia ; Lymphopenia/complications ; Bone Marrow Diseases
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.27097
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Article ; Online: Erythrophagocytosis by dysplastic neutrophils and their precursors.

Zhao, Yue / Parks, Sophie / Siddiqi, Imran / Wang, Endi

International journal of laboratory hematology

2023 Volume 46, Issue 3, Page(s) 423–424

MeSH term(s)	Humans ; Neutrophils/pathology ; Phagocytosis ; Male ; Erythrocytes/pathology ; Erythrocytes/metabolism ; Female
Language	English
Publishing date	2023-11-12
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14203
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Zs.A 1499: Show issues

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Book ; Online: Cursive Caption Text Detection in Videos

Mirza, Ali / Siddiqi, Imran

2023

Abstract: Textual content appearing in videos represents an interesting index for semantic retrieval of videos (from archives), generation of alerts (live streams) as well as high level applications like opinion mining and content summarization. One of the key ... ...

Abstract	Textual content appearing in videos represents an interesting index for semantic retrieval of videos (from archives), generation of alerts (live streams) as well as high level applications like opinion mining and content summarization. One of the key components of such systems is the detection of textual content in video frames and the same makes the subject of our present study. This paper presents a robust technique for detection of textual content appearing in video frames. More specifically we target text in cursive script taking Urdu text as a case study. Detection of textual regions in video frames is carried out by fine-tuning object detectors based on deep convolutional neural networks for the specific case of text detection. Since it is common to have videos with caption text in multiple-scripts, cursive text is distinguished from Latin text using a script-identification module. Finally, detection and script identification are combined in a single end-to-end trainable system. Experiments on a comprehensive dataset of around 11,000 video frames report an F-measure of 0.91. Comment: 19 pages, 16 figures
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
Publishing date	2023-01-08
Publishing country	us
Document type	Book ; Online
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Article ; Online: Blast Phase of Myeloproliferative Neoplasm Resembles Acute Myeloid Leukemia, Myelodysplasia-Related, in Clinical Presentation, Cytogenetic Pattern, and Genomic Profile, and Often Undergoes Reversion to Second Chronic Phase Status After Induction Chemotherapy.

Zhao, Yue / Siddiqi, Imran / Wildes, Tyler J / Charles, Derald / Deak, Kristen / Wang, Endi

Archives of pathology & laboratory medicine

2024

Abstract: Context.—: BCR::ABL-negative myeloproliferative neoplasm (MPN) has a prolonged clinical course, and some cases eventually undergo transformation to blast phase; its pathogenesis remains to be elucidated.: Objective.—: To evaluate the ... ...

Abstract	Context.—: BCR::ABL-negative myeloproliferative neoplasm (MPN) has a prolonged clinical course, and some cases eventually undergo transformation to blast phase; its pathogenesis remains to be elucidated. Objective.—: To evaluate the clinicopathologic characteristics of MPN in blast phase. Design.—: The study aimed to retrospectively analyze the clinical and laboratory data of 24 cases. Results.—: Median latency to blast phase was 48 months (range, 7-384 months). Complex karyotypes were seen in 12 of the 24 cases (50%). Overall, 16 cases (66.7%) exhibited high allele burdens of MPN driver mutations along with increased blasts, consistent with linear clonal evolution, whereas the remainder (8; 33.3%) showed loss or partial loss of the driver mutation suggestive of a parallel evolution. Additional mutations were noted in 23 cases (100%), including TP53 mutations in 10 of 24 cases (41.7%). Following chemotherapy, 15 of the 24 patients (62.5%) reverted to a second chronic phase while retaining or regaining MPN driver mutations and losing blast-related mutations, although 9 of the 15 patients (60%) later died of disease progression. Median overall survival was 10 months (CI, 4.6-15.4), with those harboring complex karyotypes demonstrating decreased survival (6 versus 29 months; P = .004). Conclusions.—: MPN-blast phase resembles acute myeloid leukemia, myelodysplasia-related, in cytogenetic pattern, mutation profile, and clinical outcome. Two patterns of clonal evolution are inferred by dynamic analysis of mutation profiles: linear and parallel evolutions. Although overall survival was dismal, 62.5% of our cases achieved second chronic phase, and they showed better survival than those without second chronic phase.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2023-0363-OA
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Article: The Use of Induction Sensors and Helmet-Based Shielding Technology to Identify Differences in Electromagnetic Fields in Patients With Cranial Neurological Disease Versus Healthy Controls.

Brazdzionis, James / Marino, Maxwell A / Siddiqi, Imran / Miulli, Dan E

Cureus

2023 Volume 15, Issue 9, Page(s) e45361

Abstract: Background and objective Electromagnetic fields (EMFs) stemming from neural circuits have been evaluated in healthy human subjects by using non-invasive induction sensor technologies with adjunctive shielding constrained to a helmet constructed of Mu- ... ...

Abstract	Background and objective Electromagnetic fields (EMFs) stemming from neural circuits have been evaluated in healthy human subjects by using non-invasive induction sensor technologies with adjunctive shielding constrained to a helmet constructed of Mu-metal and copper mesh. These EMF measurements have been analyzed and discerned to alter physiological states of movement, thoughts of movement, emotional thoughts, and planned activities. However, these technologies have not yet been investigated as a diagnostic tool in patients with cranial neurological pathology to evaluate differences in patterns in the pathologic state compared to healthy controls. In light of this, we conducted this study to address this scarcity of data. Methods An observational study was conducted in which patients at a single center with cranial neurological disease of all causes were eligible to enroll; they had real-time non-invasive continuous EMF measurements obtained using induction sensors and a shielded helmet. These measurements were obtained in the resting state and then compared to previously obtained measurements in healthy volunteers. Post-processing analysis was conducted to evaluate the derivatives of these EMFs to identify changes in patterns. Results Fourteen patients with traumatic injury, stroke, and neoplasm with ages ranging from 14 to 81 years underwent successful analysis and post-processing of their cortically generated EMF waves. Patterns of EMF waves were compared to previously obtained data from four healthy controls. It was identified that there was less variation in the EMF measurements in patients with neurological disease compared to healthy controls. This was identified based on differences in derivatives of the EMF waves and decreased numbers of peaks and valleys in the EMF waves. Conclusions Novel induction sensors with an engineered, layered Mu-metal and copper mesh helmet for shielding with Mu-metal EMF channels appear to be efficient in measuring neural circuit-driven EMF non-invasively, in real-time, and continuously and can discern differences in EMF patterns between healthy volunteers and patients with neural circuit pathology. The decreased variability in EMF measurements in patients with neural pathology and greater decreases in slope within low-frequency measurements may be correlated with disrupted neural signaling from dysfunctional neurons and abnormalities in spatial and temporal summation. Some EMF changes in ill individuals correspond to changes in the experimentally induced lesions in the animal model. Further studies are warranted to devise models of disease and healthy states to improve these technologies as a diagnostic modality.
Language	English
Publishing date	2023-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Heart rate estimation in PPG signals using Convolutional-Recurrent Regressor.

Ismail, Shahid / Siddiqi, Imran / Akram, Usman

Computers in biology and medicine

2022 Volume 145, Page(s) 105470

Abstract: Heart rate monitoring using PPG signal has emerged as an attractive as well as an applied research problem which enjoys a renewed interest in the recent years. Spectral analysis of PPG for heart rate monitoring, though effective when the subject is at ... ...

Abstract	Heart rate monitoring using PPG signal has emerged as an attractive as well as an applied research problem which enjoys a renewed interest in the recent years. Spectral analysis of PPG for heart rate monitoring, though effective when the subject is at rest, suffers from performance degradation in case of motion artifacts which mask the peak related with the actual heart rate. Leveraging the recent advancements in deep (machine) learning and exploiting the signal, spectral and time-frequency perspectives, we introduce an effective method for heart rate estimation from PPG signals acquired from subjects performing different exercises. We extract a set of features characterizing the signal and feed these feature sequences to a hybrid convolutional-recurrent neural network (C-RNN) in a regression framework. Experimental study on the benchmark IEEE signal processing cup dataset reports low error rates reading 2.41 ± 2.90 bpm for subject-dependent and 3.8 ± 2.3 bpm for subject-independent protocol thus, validating the ideas put forward in this study.
MeSH term(s)	Algorithms ; Artifacts ; Heart Rate/physiology ; Humans ; Photoplethysmography/methods ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2022.105470
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Article: Extraventricular Drain Care Bundle Decreases Cerebrospinal Fluid Infection Rates Associated With Extraventricular Drain-Related Procedures and Systemic Infection.

Lozano, Marissa / Wang, Alice S / Siddiqi, Imran / Dy, Opal / Ko, Katherine / Sweiss, Raed / Miulli, Dan E

Cureus

2024 Volume 16, Issue 1, Page(s) e52440

Abstract: Background: Infection associated with extraventricular drain (EVD)-related procedures is well known.: Objective: To investigate the impact of our institution's EVD care bundle on the infection rates associated with EVD-related procedures.: Methods!# ...

Abstract	Background: Infection associated with extraventricular drain (EVD)-related procedures is well known. Objective: To investigate the impact of our institution's EVD care bundle on the infection rates associated with EVD-related procedures. Methods: A retrospective study was conducted from June 2022 to June 2023 to compare the infection rate six months before and six months after the implantation of the EVD care bundle. Results: A total of 58 patients were included in the study (n=33 patients in 2022 and n=25 patients in 2023). The infection rate was 21.2% (7/33) prior to the implementation of the EVD care bundle and 0.0% (0/25) afterward. The seven patients with cerebrospinal fluid (CSF) infection did not have a higher total number of EVD-related procedures compared to the other 26 patients without CSF infection (8.0 vs. 9.4, p=0.7364); however, the mean number of EVD replacements was higher in patients with CSF infection (1.4 vs. 3.4, p=0.0028). The total number of EVD-related procedures was not different between 2022 and 2023 (8.3 vs. 5.2, respectively, p=0.1892); however, the mean number of EVD replacements was lower in 2023 (1.8 vs. 1.0, p=0.0257). In 2022, 22/33 patients had systemic infection, among which 7/22 also had CSF infection. In 2023, 13/25 patients had a systemic infection, among which 0/13 had CSF infection. Conclusions: The EVD care bundle consisting of standardizations, checklists, and monitoring reduces the CSF infection rates associated with EVD-related procedures and systemic infection.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52440
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Article ; Online: Cellular Mechanisms of Electromagnetic Field in Traumatic Brain Injury.

Siddiqi, Imran / Marino, Maxwell / Agrawal, Devendra K / Baron, Dave / Connett, David A / Miulli, Daniel

Journal of biotechnology and biomedicine

2023 Volume 6, Issue 2, Page(s) 95–104

Abstract: This paper presents a comprehensive review of the extant literature from 1980 through 2023 on the role and utility of Electromagnetic Fields (EMF) in the treatment of brain trauma and brain neuropathology resulting from disease. Brain trauma resulting ... ...

Abstract	This paper presents a comprehensive review of the extant literature from 1980 through 2023 on the role and utility of Electromagnetic Fields (EMF) in the treatment of brain trauma and brain neuropathology resulting from disease. Brain trauma resulting from accident, injury and disease is a significant contributor to short and long-term morbidity, as well as a leading cause of mortality globally. To date, limited effective treatments strategies exist, and are focused primarily on symptom relief, not restoring primary preinjury function and structure. Much of the current clinical literature is based on retrospective case reports and limited animal model prospective trials exploring core etiology and alterations in post-injury clinical phenotypes. The current findings reported in the scientific literature suggest that electromagnetic therapy may hold promise as a potential non-invasive treatment for traumatic brain injury and neuropathology. Although promising, well designed clinical trials are needed to better determine its potential clinical effectiveness in this diverse patient population. Future trials will need to determine the impact of clinical variables, such as sex, age, type and extent of injury and pathology, pre-injury baseline health status and a comprehensive biopsychosocial assessment to determine a more effective personalized approach to patient care. Although initially showing promise, much work needs to be done.
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article
ISSN	2642-9128
ISSN (online)	2642-9128
DOI	10.26502/jbb.2642-91280075
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Article ; Online: The Ubiquitin-Specific Protease TNI/UBP14 Functions in Ubiquitin Recycling and Affects Auxin Response.

Majumdar, Parinita / Karidas, Premananda / Siddiqi, Imran / Nath, Utpal

Plant physiology

2020 Volume 184, Issue 3, Page(s) 1499–1513

Abstract: The ubiquitin-mediated proteasomal pathway regulates diverse cellular processes in plants by rapidly degrading target proteins, including the repressors of hormone signaling. Though ubiquitin proteases play a key role in this process by cleaving ... ...

Abstract	The ubiquitin-mediated proteasomal pathway regulates diverse cellular processes in plants by rapidly degrading target proteins, including the repressors of hormone signaling. Though ubiquitin proteases play a key role in this process by cleaving polyubiquitin chains to monomers, their function has not been studied in detail by mutational analysis. Here, we show that mutation in
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/metabolism ; Gene Expression Regulation, Plant ; Genes, Plant ; Genetic Variation ; Genotype ; Indoleacetic Acids/metabolism ; Mutation ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitin-Specific Proteases/genetics ; Ubiquitin-Specific Proteases/metabolism
Chemical Substances	Indoleacetic Acids ; Ubiquitin ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.20.00689
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Z 1193: Show issues

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Article ; Online: Acquired Holmes Tremor in a Human Immunodeficiency Virus Immune Reconstitution Inflammatory Syndrome Patient Treated with Deep Brain Stimulation.

Ghanchi, Hammad / Siddiqi, Imran / Patchana, Tye / Ananda, Ajay

World neurosurgery

2020 Volume 141, Page(s) 253–259

Abstract: Background: The authors present a case of a 66-year-old male who was diagnosed with human immunodeficiency virus, and his medical course of highly active antiretroviral therapy was complicated with the development of immune reconstitution inflammatory ... ...

Abstract	Background: The authors present a case of a 66-year-old male who was diagnosed with human immunodeficiency virus, and his medical course of highly active antiretroviral therapy was complicated with the development of immune reconstitution inflammatory syndrome, which led to development of movement disorder consisting of right-sided resting tremor, neck dystonia, and jaw clenching. Case description: The patient's symptoms resembled that of rubral tremor, and he underwent placement of a deep brain stimulation electrode into the left ventral intermediate nucleus of the thalamus with significant improvement of symptoms. Conclusions: This is the first reported case in the literature of a human immunodeficiency virus-positive patient's treatment course complicated with immune reconstitution inflammatory syndrome with neurologic manifestation, which was refractory to medical therapy and thus treated with deep brain stimulation.
MeSH term(s)	Aged ; Ataxia/therapy ; Ataxia/virology ; Deep Brain Stimulation/adverse effects ; HIV/pathogenicity ; Humans ; Immune Reconstitution Inflammatory Syndrome/complications ; Immune Reconstitution Inflammatory Syndrome/therapy ; Immune Reconstitution Inflammatory Syndrome/virology ; Male ; Thalamus/surgery ; Thalamus/virology ; Tremor/diagnosis ; Tremor/etiology ; Tremor/surgery ; Tremor/virology
Language	English
Publishing date	2020-06-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.06.099
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