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  1. Book ; Thesis: Prescribing practices of public and private health care providers and over-the-counter use of drugs in Attock district of Pakistan

    Siddiqi, Sameen

    2002  

    Author's details submitted by Sameen Siddiqi
    Language English
    Size 216 Bl. : Ill.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2003
    HBZ-ID HT013809792
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 E 2964 order for loan Magazin

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  2. Article ; Online: Insight into Private General Physicians' Practices: an Exploratory Qualitative Study in a Rural District of Pakistan.

    Akber Pradhan, Nousheen / Zaidi, Tahani Waqar / Siddiqi, Sameen

    BMJ open

    2024  Volume 14, Issue 2, Page(s) e074412

    Abstract: Objective: The study aimed to assess private general physicians'(GPs) healthcare practices, identifying perceived malpractices, the support they receive, and barriers they experience in providing healthcare services.: Design: Qualitative exploratory ... ...

    Abstract Objective: The study aimed to assess private general physicians'(GPs) healthcare practices, identifying perceived malpractices, the support they receive, and barriers they experience in providing healthcare services.
    Design: Qualitative exploratory study.
    Setting: Rural district, Thatta in Province of Sindh, Pakistan.
    Participants: 15 GPs.
    Results: Our results include increased motivation among GPs for continued professional development, the high influence of pharmaceutical companies on providers' prescribing practices, perceived malpractices by GPs, and the prevalence of quackery and ineffective regulatory mechanisms for private GPs in a rural district.
    Conclusion: Our findings have implications for the capacity building of GPs by academic institutions, enforcement of regulatory measures by the authorities, and the introduction of measures to curb practices by unqualified practitioners. Finally, more research will be needed to further understand the perceptions of GPs, their needs and the service delivery interventions that will enhance the quality of care they provide.
    MeSH term(s) Humans ; Pakistan ; General Practitioners ; Delivery of Health Care ; Qualitative Research ; Private Practice
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-074412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Perivascular epithelioid cell tumour-mimicking retroperitoneal leiomyosarcoma.

    Siddiqi, Shirin / Mesropyan, Lusine

    BMJ case reports

    2022  Volume 15, Issue 8

    Abstract: A young man in his 40s was evaluated in the emergency department for abdominal and right flank pain. A CT scan of the abdomen and pelvis showed a solid, well-circumscribed lesion measuring 7.1×8.1×5.4 cm, which was arising from the retroperitoneum and ... ...

    Abstract A young man in his 40s was evaluated in the emergency department for abdominal and right flank pain. A CT scan of the abdomen and pelvis showed a solid, well-circumscribed lesion measuring 7.1×8.1×5.4 cm, which was arising from the retroperitoneum and extending from the third portion of the duodenum towards the right kidney. A percutaneous core biopsy was obtained, demonstrating an atypical smooth muscle neoplasm suggestive of a low-grade leiomyosarcoma. The patient underwent surgery for an en-block resection of the mass and the final pathology confirmed a perivascular epithelioid cell neoplasm without significant pleomorphism, mitosis or necrosis. Our case adds to the small number of perivascular epithelioid cell tumour cases reported in the literature and we present it in order to increase our understanding of this tumour and to assist in its appropriate diagnosis and management.
    MeSH term(s) Humans ; Leiomyosarcoma/diagnostic imaging ; Leiomyosarcoma/surgery ; Male ; Perivascular Epithelioid Cell Neoplasms/diagnostic imaging ; Perivascular Epithelioid Cell Neoplasms/surgery ; Retroperitoneal Neoplasms/diagnostic imaging ; Retroperitoneal Neoplasms/surgery ; Retroperitoneal Space/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reforming the WHO regional director elections: an opportunity to restore trust.

    Buse, Kent / Lin, Vivian Kwang-Wen / Siddiqi, Sameen / Clark, Helen

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) q167

    MeSH term(s) Humans ; Trust ; World Health Organization
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.q167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pakistan's Progress on Universal Health Coverage: Lessons Learned in Priority Setting and Challenges Ahead in Reinforcing Primary Healthcare.

    Alwan, Ala / Jamison, Dean T / Siddiqi, Sameen / Vassall, Anna

    International journal of health policy and management

    2024  

    Abstract: Pakistan developed an essential package of health services at the primary health care level as a key component of health reforms aiming to achieve universal health coverage. This supplement describes the methods and processes adopted for evidence- ... ...

    Abstract Pakistan developed an essential package of health services at the primary health care level as a key component of health reforms aiming to achieve universal health coverage. This supplement describes the methods and processes adopted for evidence-informed prioritization of services, policy decisions adopted, and the lessons learned in package design as well as in the transition to effective rollout. The papers conclude that evidenceinformed deliberative processes can be effectively applied to design affordable packages of services that represent good value for money and address a major part of the disease burden. Transition to implementation requires a comprehensive assessment of health system gaps, strong engagement of the planning and financing sectors, serious involvement of key national stakeholders and the private health sector, capacity building, and institutionalization of technical and managerial skills. Pakistan's experience highlights the need for updating the evidence and model packages of the Disease Control Priorities 3 initiative and reinforcing international collaboration to support technical guidance to countries in priority setting and UHC reforms.
    Language English
    Publishing date 2024-03-10
    Publishing country Iran
    Document type Editorial
    ZDB-ID 2724317-5
    ISSN 2322-5939 ; 2322-5939
    ISSN (online) 2322-5939
    ISSN 2322-5939
    DOI 10.34172/ijhpm.2024.8450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Associations of childhood hearing loss and adverse childhood experiences in deaf adults.

    Hall, Wyatte C / Dye, Timothy D V / Siddiqi, Shazia

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287024

    Abstract: Childhood trauma and adverse childhood experiences have a strong relationship with health disparities across the lifespan. Despite experiencing approximately doubled rates of trauma, Adverse Childhood Experiences (ACEs) are poorly characterized in deaf ... ...

    Abstract Childhood trauma and adverse childhood experiences have a strong relationship with health disparities across the lifespan. Despite experiencing approximately doubled rates of trauma, Adverse Childhood Experiences (ACEs) are poorly characterized in deaf populations. We sought to characterize deaf-specific demographic factors and their association with multiple experiences of ACEs before the age of 18 years old. An analytical cross-sectional approach was used to ascertain associations of deaf-specific demographic factors and experiences with ACEs. The complete dataset included 520 participants for a total response rate of 56%. After adjusting for confounding effects, less severe hearing loss of 16-55 dB (2+ OR: 5.2, 4+ OR: 4.7), having a cochlear implant (2+ OR: 2.1, 4+ OR: 2.6), and not attending at least one school with signing access (2+ OR: 2.4, 4+ OR: 3.7) were significantly and independently associated with reported experiences of multiple ACEs. We conclude that factors associated with childhood hearing loss and language experiences increase risk of experiencing ACEs. Given the strong relationship between ACEs and poor social outcomes, early intervention clinical practice and health policies should consider interventions to support healthy home environments for deaf children.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Adverse Childhood Experiences/statistics & numerical data ; Deafness/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Does contracting out lead to improvement in service volumes at primary and secondary health services? Evidence from rural districts of Sindh, Pakistan.

    Abbasi, Imran Naeem / Fatmi, Zafar / Siddiqi, Sameen

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 72, Issue 10, Page(s) 1947–1953

    Abstract: Objective: To determine the improvement in service volumes from baseline, if any, in the contracted out primary and secondary healthcare facilities against key performance indicators, and to explore the perceptions of health managers and experience of ... ...

    Abstract Objective: To determine the improvement in service volumes from baseline, if any, in the contracted out primary and secondary healthcare facilities against key performance indicators, and to explore the perceptions of health managers and experience of patients in this regard.
    Methods: The mixed-method study was conducted at Aga Khan University, Karachi, from November 2019 to April 2020, and comprised secondary data extracted from the district health information system related to Thatta and Sujawal districts of the Sindh province of Pakistan from July 2016 to June 2019. Apart from data analysis for baseline versus end-line comparison of key performance indicators, the study also comprised of a cross-sectional survey of health facilities, patient exit interviews and in-depth interviews with healthcare managers.
    Results: The key performance indicators showed improved service volumes compared to the baseline. All services, including general outpatient department (33%), consultancy services (91%) and emergency services (106%) increased in volumes. Facility-based deliveries increased by 37% and antenatal care visits increased by 100% but immunisation volumes declined. Specialist workforce increased by 47%. Healthcare managers perceived delayed/partial budget release as the key determinant of staff retention, availability of drugs, equipment, supplies, water and electricity at health facilities. Lack of control over government-appointed employees coupled with political interference created workforce shortage. Patients were satisfied with service delivery, but unavailability of medicine was the main concern for 64.3%.
    Conclusions: Contracting out showed improvement in service volumes, but lack of autonomy over budget allocation and utilisation, staff appointment and poor coordination among the stakeholders were key barriers.
    MeSH term(s) Humans ; Female ; Pregnancy ; Pakistan ; Cross-Sectional Studies ; Rural Health Services ; Prenatal Care ; Emergency Medical Services ; Health Services Accessibility
    Language English
    Publishing date 2023-01-24
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.2235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: α-Tocopherol reduces VLDL secretion through modulation of intracellular ER-to-Golgi transport of VLDL.

    Clay, Ryan / Siddiqi, Shaila / Siddiqi, Shadab A

    Canadian journal of physiology and pharmacology

    2023  Volume 101, Issue 11, Page(s) 554–564

    Abstract: Avoiding hepatic steatosis is crucial for preventing liver dysfunction, and one mechanism by which this is accomplished is through synchronization of the rate of very low density lipoprotein (VLDL) synthesis with its secretion. Endoplasmic reticulum (ER)- ...

    Abstract Avoiding hepatic steatosis is crucial for preventing liver dysfunction, and one mechanism by which this is accomplished is through synchronization of the rate of very low density lipoprotein (VLDL) synthesis with its secretion. Endoplasmic reticulum (ER)-to-Golgi transport of nascent VLDL is the rate-limiting step in its secretion and is mediated by the VLDL transport vesicle (VTV). Recent in vivo studies have indicated that α-tocopherol (α-T) supplementation can reverse steatosis in nonalcoholic fatty liver disease, but its effects on hepatic lipoprotein metabolism are poorly understood. Here, we investigated the impact of α-T on hepatic VLDL synthesis, secretion, and intracellular ER-to-Golgi VLDL trafficking using an in vitro model. Pulse-chase assays using [
    MeSH term(s) Humans ; Lipoproteins, VLDL/metabolism ; alpha-Tocopherol/pharmacology ; alpha-Tocopherol/metabolism ; Liver/metabolism ; Transport Vesicles/metabolism ; Fatty Liver/metabolism ; Endoplasmic Reticulum/metabolism ; Triglycerides/metabolism
    Chemical Substances Lipoproteins, VLDL ; alpha-Tocopherol (H4N855PNZ1) ; Triglycerides
    Language English
    Publishing date 2023-09-08
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2023-0086
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  9. Article: Overcoming the challenges of community-engaged emergency referrals in a rural district of Pakistan.

    Abbasi, Imran Naeem / Siddiqi, Sameen

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71, Issue 11, Page(s) 2648–2651

    Abstract: A functional referral system for addressing health emergencies requires coordinated efforts by health system's stakeholders and the community. Using the Rural Health Programme (RHP) Thatta as a platform provided by an academic institution, district ... ...

    Abstract A functional referral system for addressing health emergencies requires coordinated efforts by health system's stakeholders and the community. Using the Rural Health Programme (RHP) Thatta as a platform provided by an academic institution, district health system stakeholders and the community of Mirpur Sakro, taluka of Thatta, were engaged to strengthen the referral system for health emergencies through active community engagement. Through consultations with stakeholders, a referral system plan was developed with community volunteers from each village as focal persons for transportation, referring patients to health facilities and maintaining referral documentation. The stakeholders' experience and perceptions about the referral system were assessed through qualitative in-depth interviews. Patients' experiences of referral system improved with enhanced transport availability, but they faced structural challenges, including out of pocket transport expenses, weak back-referral links, lack of trust between the community and healthcare providers and poor availability of medicines.
    MeSH term(s) Emergencies ; Health Facilities ; Humans ; Pakistan ; Qualitative Research ; Referral and Consultation ; Rural Population
    Language English
    Publishing date 2021-11-16
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.011253
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  10. Article ; Online: Appeal to the WHO Executive Board on election of regional directors.

    Buse, Kent / Lin, Vivian Kwang-Wen / Siddiqi, Sameen / Clark, Helen

    Lancet (London, England)

    2023  Volume 402, Issue 10418, Page(s) 2193

    MeSH term(s) Humans ; Politics ; Governing Board ; World Health Organization
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02579-5
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