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  1. Article ; Online: Molecular Detection of

    Mohammed, Rebin Rafaat / Enferadi, Ahmad / Sidiq, Karzan R / Sarani, Saeedeh / Khademi, Peyman / Jaydari, Amin / Ahmed, Avin Kawa

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2023  Volume 23, Issue 10, Page(s) 514–519

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2023.0022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6137: Show issues Location:
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  2. Article: Does Early Childhood Vaccination Protect Against COVID-19?

    Sidiq, Karzan R / Sabir, Dana Khdr / Ali, Shakhawan M / Kodzius, Rimantas

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 120

    Abstract: The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alanine metabolism in Bacillus subtilis.

    Sidiq, Karzan R / Chow, Man W / Zhao, Zhao / Daniel, Richard A

    Molecular microbiology

    2020  Volume 115, Issue 4, Page(s) 739–757

    Abstract: Both isomeric forms of alanine play a crucial role in bacterial growth and viability; the L-isomer of this amino acid is one of the building blocks for protein synthesis, and the D-isomer is incorporated into the bacterial cell wall. Despite a long ... ...

    Abstract Both isomeric forms of alanine play a crucial role in bacterial growth and viability; the L-isomer of this amino acid is one of the building blocks for protein synthesis, and the D-isomer is incorporated into the bacterial cell wall. Despite a long history of genetic manipulation of Bacillus subtilis using auxotrophic markers, the genes involved in alanine metabolism have not been characterized fully. In this work, we genetically characterized the major enzymes involved in B. subtilis alanine biosynthesis and identified an alanine permease, AlaP (YtnA), which we show has a major role in the assimilation of D-alanine from the environment. Our results provide explanations for the puzzling fact that growth of B. subtilis does not result in the significant accumulation of extracellular D-alanine. Interestingly, we find that in B. subtilis, unlike E. coli where multiple enzymes have a biochemical activity that can generate alanine, the primary synthetic enzyme for alanine is encoded by alaT, although a second gene, dat, can support slow growth of an L-alanine auxotroph. However, our results also show that Dat mediates the synthesis of D-alanine and its activity is influenced by the abundance of L-alanine. This work provides valuable insights into alanine metabolism that suggests that the relative abundance of D- and L-alanine might be linked with cytosolic pool of D and L-glutamate, thereby coupling protein and cell envelope synthesis with the metabolic status of the cell. The results also suggest that, although some of the purified enzymes involved in alanine biosynthesis have been shown to catalyze reversible reactions in vitro, most of them function unidirectionally in vivo.
    MeSH term(s) Alanine/metabolism ; Amino Acid Transport Systems/genetics ; Amino Acid Transport Systems/metabolism ; Bacillus subtilis/enzymology ; Bacillus subtilis/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biosynthetic Pathways ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Transaminases/metabolism
    Chemical Substances Amino Acid Transport Systems ; Bacterial Proteins ; Membrane Transport Proteins ; Transaminases (EC 2.6.1.-) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2020-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14640
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2502: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Does Early Childhood Vaccination Protect Against COVID-19?

    Sidiq, Karzan R. / Sabir, Dana Khdr / Ali, Shakhawan M. / Kodzius, Rimantas

    Frontiers in Molecular Biosciences

    2020  Volume 7

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00120
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Does Early Childhood Vaccination Protect Against COVID-19?

    Sidiq, Karzan R. / Sabir, Dana Khdr / Ali, Shakhawan M. / Kodzius, Rimantas

    Front. Mol. Biosci.

    Abstract: The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #615537
    Database COVID19

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  6. Article ; Online: Does early childhood vaccination protect against COVID-19?

    Sidiq, Karzan R. / Sabir, Dana Khdr / Ali, Shakhawan M. / Kodžius, Rimantas

    Frontiers in Molecular Biosciences, Lausanne : Frontiers Media SA, 2020, Vol. 7, art. no. 120, p. 1-6 ; ISSN 2296-889X

    2020  

    Abstract: The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
    Keywords children ; COVID-19 ; immunity ; measles ; rubella ; vaccination ; virus ; covid19
    Language English
    Publishing country lt
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The emerging roles of NGS in clinical oncology and personalized medicine.

    Hussen, Bashdar Mahmud / Abdullah, Sara Tharwat / Salihi, Abbas / Sabir, Dana Khdr / Sidiq, Karzan R / Rasul, Mohammed Fatih / Hidayat, Hazha Jamal / Ghafouri-Fard, Soudeh / Taheri, Mohammad / Jamali, Elena

    Pathology, research and practice

    2022  Volume 230, Page(s) 153760

    Abstract: Next-generation sequencing (NGS) has been increasingly popular in genomics studies over the last decade, as new sequencing technology has been created and improved. Recently, NGS started to be used in clinical oncology to improve cancer therapy through ... ...

    Abstract Next-generation sequencing (NGS) has been increasingly popular in genomics studies over the last decade, as new sequencing technology has been created and improved. Recently, NGS started to be used in clinical oncology to improve cancer therapy through diverse modalities ranging from finding novel and rare cancer mutations, discovering cancer mutation carriers to reaching specific therapeutic approaches known as personalized medicine (PM). PM has the potential to minimize medical expenses by shifting the current traditional medical approach of treating cancer and other diseases to an individualized preventive and predictive approach. Currently, NGS can speed up in the early diagnosis of diseases and discover pharmacogenetic markers that help in personalizing therapies. Despite the tremendous growth in our understanding of genetics, NGS holds the added advantage of providing more comprehensive picture of cancer landscape and uncovering cancer development pathways. In this review, we provided a complete overview of potential NGS applications in scientific and clinical oncology, with a particular emphasis on pharmacogenomics in the direction of precision medicine treatment options.
    MeSH term(s) Animals ; Biomarkers, Tumor/genetics ; Clinical Decision-Making ; Epigenome ; Epigenomics ; Gene Expression Profiling ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Pharmacogenetics ; Phenotype ; Precision Medicine ; Predictive Value of Tests ; Prognosis ; Transcriptome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-01-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.153760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.20: Show issues Location:
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  8. Article: Factors Contributing to the Containment of the COVID-19 in Kurdistan Region of Iraq

    Sabir, Dana Khdr / Sidiq, Karzan R. / Abdullah, Hadi M. / Ali, Shakhawan M. / Khwarahm, Nabaz R.

    Advanced Journal of Emergency Medicine

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #679450
    Database COVID19

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  9. Article ; Online: Factors Contributing to the Containment of the COVID-19 in Kurdistan Region of Iraq

    Sabir, Dana Khdr / Sidiq, Karzan R. / Abdullah, Hadi M. / Ali, Shakhawan M. / Khwarahm, Nabaz R.

    Advanced Journal of Emergency Medicine; Vol 4 No 2s (2020): COVID-19 ; 2588-400X

    2020  

    Abstract: A highly contagious coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which was first identified in Wuhan, China in December 2019. The virus primarily affects the respiratory system of human ... ...

    Abstract A highly contagious coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which was first identified in Wuhan, China in December 2019. The virus primarily affects the respiratory system of human beings and results in the symptoms of headache, fever, dry cough, sore throat, shortness of breath and fatigue with abnormal chest computed tomography (CT) scan. In some cases, nasal sputum discharge and diarrhea have been also reported. Up to the 26thof April 2020, more than three million laboratory confirmed cases of COVID-19 have been recorded worldwide with more than 220,000 confirmed deaths.In the Kurdistan region of Iraq, the first case of laboratory confirmed COVID-19 was recorded in March 1st, 2020 in Sulaymaniyah province.
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publisher Tehran University of Medical Sciences
    Publishing country ir
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Factors Contributing to the Containment of the COVID-19 in Kurdistan Region of Iraq

    Sabir, Dana Khdr / Sidiq, Karzan R. / Abdullah, Hadi M. / Ali, Shakhawan M. / Khwarahm, Nabaz R.

    Advanced Journal of Emergency Medicine; Vol 4 No 2s (2020): COVID-19; e47 ; 2588-400X ; 10.22114/ajem.v4i2s

    2020  

    Abstract: A highly contagious coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which was first identified in Wuhan, China in December 2019. The virus primarily affects the respiratory system of human ... ...

    Abstract A highly contagious coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which was first identified in Wuhan, China in December 2019. The virus primarily affects the respiratory system of human beings and results in the symptoms of headache, fever, dry cough, sore throat, shortness of breath and fatigue with abnormal chest computed tomography (CT) scan. In some cases, nasal sputum discharge and diarrhea have been also reported. Up to the 26thof April 2020, more than three million laboratory confirmed cases of COVID-19 have been recorded worldwide with more than 220,000 confirmed deaths.In the Kurdistan region of Iraq, the first case of laboratory confirmed COVID-19 was recorded in March 1st, 2020 in Sulaymaniyah province.
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publisher Tehran University of Medical Sciences
    Publishing country ir
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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