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Article ; Online: Morbihan disease: successful treatment with slow-releasing doxycycline monohydrate.

Chaidemenos, G / Apalla, Z / Sidiropoulos, T

Journal of the European Academy of Dermatology and Venereology : JEADV

2017 Volume 32, Issue 2, Page(s) e68–e69

MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Delayed-Action Preparations ; Doxycycline/administration & dosage ; Doxycycline/therapeutic use ; Edema/drug therapy ; Erythema/drug therapy ; Facial Dermatoses/drug therapy ; Female ; Humans ; Middle Aged
Chemical Substances	Anti-Bacterial Agents ; Delayed-Action Preparations ; Doxycycline (N12000U13O)
Language	English
Publishing date	2017-09-14
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.14521
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Article ; Online: Enhanced optical conductivity and many-body effects in strongly-driven photo-excited semi-metallic graphite.

Sidiropoulos, T P H / Di Palo, N / Rivas, D E / Summers, A / Severino, S / Reduzzi, M / Biegert, J

Nature communications

2023 Volume 14, Issue 1, Page(s) 7407

Abstract: The excitation of quasi-particles near the extrema of the electronic band structure is a gateway to electronic phase transitions in condensed matter. In a many-body system, quasi-particle dynamics are strongly influenced by the electronic single-particle ...

Abstract	The excitation of quasi-particles near the extrema of the electronic band structure is a gateway to electronic phase transitions in condensed matter. In a many-body system, quasi-particle dynamics are strongly influenced by the electronic single-particle structure and have been extensively studied in the weak optical excitation regime. Yet, under strong optical excitation, where light fields coherently drive carriers, the dynamics of many-body interactions that can lead to new quantum phases remain largely unresolved. Here, we induce such a highly non-equilibrium many-body state through strong optical excitation of charge carriers near the van Hove singularity in graphite. We investigate the system's evolution into a strongly-driven photo-excited state with attosecond soft X-ray core-level spectroscopy. We find an enhancement of the optical conductivity of nearly ten times the quantum conductivity and pinpoint it to carrier excitations in flat bands. This interaction regime is robust against carrier-carrier interaction with coherent optical phonons acting as an attractive force reminiscent of superconductivity. The strongly-driven non-equilibrium state is markedly different from the single-particle structure and macroscopic conductivity and is a consequence of the non-adiabatic many-body state.
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43191-5
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Article: En-Bloc Resection of Renal Cell Carcinoma With Tumor Thrombus Propagating Into the Intrapericardial Inferior Vena Cava: Efficacy and Safety of Transabdominal Approach.

Sidiropoulos, Theodoros / Parasyris, Stavros / Ntella, Vassiliki / Margaris, Ioannis / Christodoulou, Spyridon / Theodoraki, Kassiani / Vassiliu, Panteleimon / Smyrniotis, Vassilios / Arkadopoulos, Nikolaos

Cureus

2023 Volume 15, Issue 7, Page(s) e42394

Abstract: Background: Renal cell carcinoma (RCC) is the most common primary kidney cancer. In up to 4-10% of patients, the tumor is complicated with a malignant thrombus extending to the inferior vena cava (IVC). Complete surgical excision of the RCC and the ... ...

Abstract	Background: Renal cell carcinoma (RCC) is the most common primary kidney cancer. In up to 4-10% of patients, the tumor is complicated with a malignant thrombus extending to the inferior vena cava (IVC). Complete surgical excision of the RCC and the neoplastic thrombus can be curative. We aim to present a safe and feasible alternative transabdominal operative technique with the omission of thoracotomy, as applied in six patients diagnosed with RCC and IVC thrombus extending over the diaphragm. Methods: This case series study was conducted in a tertiary university hospital in Athens, Greece. All six patients, who were operated on for RCC and a malignant thrombus exceeding in the intrapericardial IVC in our department from January 2009 until March 2020, were screened. Intraoperatively, the infrarenal and intrapericardial IVC were clamped simultaneously with the renal and liver blood inflow. Access to the intrapericardial IVC was obtained via the central tendon of the diaphragm. Intrathoracic extension of the tumor was confirmed by transesophageal or intraoperative ultrasonography. The intrathoracic IVC was exposed to direct vision and two finger palpation was applied to secure the clamping of the IVC above the tip of the thrombus. The tumor was resected through a longitudinal venotomy and the operation was completed on a standard radical nephrectomy. Results: During the study period six patients presented with RCC and intrapericardial IVC thrombus. All patients, five female and one male, underwent radical nephrectomy combined with IVC thrombectomy, without the need for a thoracotomy. The mean age was 66 years old and the mean operative time was 122.5 minutes. Mean blood loss was 338 ml and only four of the patients were transfused with two units of RBC. Operative and hospital mortality was 0%. The hospital stay was seven (six to nine) days. Only one patient required readmission and reoperation 30 days later, due to intrapericardial herniation. Conclusions: The proposed surgical technique may be curative in patients with advanced intracaval thrombus and helps reduce the associated morbidity, mortality, and the overall cost of more extended operations.
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42394
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Article ; Online: Clinical evidence on the use of brodalumab for the treatment of psoriasis in Greece: Experience from clinical practice of four tertiary hospitals.

Tampouratzi, Eleftheria / Papakonstantis, Markos / Katsantonis, John / Sidiropoulos, Theodoros / Delli, Florentina / Efthymiadis, Konstantinos / Sfaelos, Konstantinos / Christodoulou, Athina / Chasapi, Vasiliki / Panagakis, Pantelis

Dermatologic therapy

2022 Volume 35, Issue 7, Page(s) e15532

Abstract: Despite brodalumad demonstrated efficacy in clinical trials, real-world data reflecting clinical benefits in unselected patient populations treated in routine clinical practice are limited. Thus, we performed a longitudinal, retrospective, real-world ... ...

Abstract	Despite brodalumad demonstrated efficacy in clinical trials, real-world data reflecting clinical benefits in unselected patient populations treated in routine clinical practice are limited. Thus, we performed a longitudinal, retrospective, real-world analysis assessing the long-term clinical benefits of patients with moderate-to-severe psoriasis treated with brodalumab in Greece in the long term (up to 24 months). Main efficacy assessments included changes from baseline in the psoriasis area and severity index (PASI) and proportions of patients achieving at least 50%, 75%, 90% and 100% reduction from baseline in PASI scores (PASI50, PASI75, PASI90 and PASI100) at different timepoints up to 24 months. Other endpoints included changes in the dermatology life quality index (DLQI) and body surface area (BSA) involvement. Data from medical records of 180 patients with moderate-to-severe psoriasis treated with brodalumab for up to 24 months were assessed. Following treatment, mean [standard deviation (SD)] PASI scores were decreased across all visits compared to baseline (p < 0.001). The proportion of patients achieving PASI50, PASI75, PASI90 or PASI100 were high as early as at month 1 and consistently tended to increase over time, mainly during the first 6 months. Improvements on disease severity were further reflected by reductions from baseline on BSA scores across all visits (p < 0.001). Concurrent improvements on DLQI scores were observed across all visits (p < 0.001). This retrospective analysis provides real-world evidence supporting the long-term efficacy profile of brodalumab in Greek patients with moderate-to-severe psoriasis treated in standard clinical practice, which is characterized by a rapid onset of action generally sustained over time.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Greece ; Humans ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Retrospective Studies ; Severity of Illness Index ; Tertiary Care Centers ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; brodalumab (6ZA31Y954Z)
Language	English
Publishing date	2022-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15532
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Zs.A 5181: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Presenting vertebral deformities in bottlenose dolphin Tursiops truncatus calves from a protected population in northeast Scotland.

Robinson, Kevin P / Haskins, Gary N / Eisfeld-Pierantonio, Sonja M / Sidiropoulos, Theofilos / Bamford, Connor C G

Diseases of aquatic organisms

2020 Volume 140, Issue 1, Page(s) 103–108

Abstract: Photographs collected during a 23 yr photo-identification study in the Moray Firth were examined to assess the prevalence, type and severity of vertebral deformations present in bottlenose dolphin Tursiops truncatus calves. Fifteen cases of presenting ... ...

Abstract	Photographs collected during a 23 yr photo-identification study in the Moray Firth were examined to assess the prevalence, type and severity of vertebral deformations present in bottlenose dolphin Tursiops truncatus calves. Fifteen cases of presenting spinal anomalies (scoliosis, kyphosis, lordosis and combinations thereof) of variable severity were identified in 7.4% of all known calves from the population. Thirteen of the 15 anomalies were either manifest from birth or acquired from an early age, as ascertained from longitudinal sightings histories of their mothers. Most afflicted calves died during early development or shortly after maternal separation. However, 3 survived to adulthood and persist in the population to date, in addition to 2 dependent infants whose fate remains to be established. At 15+ yr of age, the oldest surviving individual was remarkably one of the most severe cases identified, highlighting the ability of these delphinids for adaptation to such gross structural deformities. The aetiology of the observed conditions could be attributed to a range of causative factors that may have implications for the well-being and health of this North Sea coastal dolphin population, a topic which merits further investigation.
MeSH term(s)	Animals ; Bottle-Nosed Dolphin ; Kyphosis/veterinary ; Lordosis/veterinary ; Maternal Deprivation ; Scotland
Language	English
Publishing date	2020-07-23
Publishing country	Germany
Document type	Journal Article
ISSN	0177-5103
ISSN	0177-5103
DOI	10.3354/dao03498
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Book ; Online: Enhanced optical conductivity and many-body effects in strongly-driven photo-excited semi-metallic graphite

Sidiropoulos, T. P. H. / Di Palo, N. / Rivas, D. E. / Summers, A. / Severino, S. / Reduzzi, M. / Biegert, J.

2023

Abstract	The excitation of quasi-particles near the extrema of the electronic band structure is a gateway to electronic phase transitions in condensed matter. In a many-body system, quasi-particle dynamics are strongly influenced by the electronic single-particle structure and have been extensively studied in the weak optical excitation regime. Yet, under strong optical excitation, where light fields coherently drive carriers, the dynamics of many-body interactions that can lead to new quantum phases remain largely unresolved. Here, we induce such a highly non-equilibrium many-body state through strong optical excitation of charge carriers near the van Hove singularity in graphite. We investigate the system's evolution into a strongly-driven photo-excited state with attosecond soft X-ray core-level spectroscopy. Surprisingly, we find an enhancement of the optical conductivity of nearly ten times the quantum conductivity and pinpoint it to carrier excitations in flat bands. This interaction regime is robust against carrier-carrier interaction with coherent optical phonons acting as an attractive force reminiscent of superconductivity. The strongly-driven non-equilibrium state is markedly different from the single-particle structure and macroscopic conductivity and is a consequence of the non-adiabatic many-body state.
Keywords	Condensed Matter - Materials Science
Subject code	535
Publishing date	2023-08-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ecological habitat partitioning and feeding specialisations of coastal minke whales (Balaenoptera acutorostrata) using a recently designated MPA in northeast Scotland.

Robinson, Kevin P / MacDougall, Duncan A I / Bamford, Connor C G / Brown, William J / Dolan, Ciaran J / Hall, Rebecca / Haskins, Gary N / Russell, Grace / Sidiropoulos, Theofilos / Sim, Texa M C / Spinou, Evgenia / Stroud, Elice / Williams, Genevieve / Culloch, Ross M

PloS one

2023 Volume 18, Issue 7, Page(s) e0246617

Abstract: In the design of protected areas for cetaceans, spatial maps rarely take account of the life-history and behaviour of protected species relevant to their spatial ambit, which may be important for their management. In this study, we examined the ... ...

Abstract	In the design of protected areas for cetaceans, spatial maps rarely take account of the life-history and behaviour of protected species relevant to their spatial ambit, which may be important for their management. In this study, we examined the distribution and feeding behaviours of adult versus juvenile minke whales (Balaenoptera acutorostrata) from long-term studies in the Moray Firth in northeast Scotland, where a Marine Protected Area (MPA) has recently been designated. Data were collected during dedicated boat surveys between 2001 and 2022 inclusive, from which 784 encounters with 964 whales of confirmed age-class (471 juveniles and 493 adults) were recorded from 56,263 km of survey effort, resulting in 238 focal follows. Adults and juveniles were occasionally seen together, but their distributions were not statistically correlated, and GIS revealed spatial separation / habitat partitioning by age-class-with juveniles preferring shallower, inshore waters with sandy-gravel sediments, and adults preferring deeper, offshore waters with greater bathymetric slope. GAMs suggested that the partitioning between age-classes was predominantly based on the differing proximity of animals to the shore, with juveniles showing a preference for the gentlest seabed slopes, and both adults and juveniles showing a similar preference for sandy gravel sediment types. However, the GAMs only used sightings data with available survey effort (2008 to 2022) and excluded depth due to collinearity issues. Whilst adult minkes employed a range of "active" prey-entrapment specialisations, showing inter-individual variation and seasonal plasticity in their targeted prey, juveniles almost exclusively used "passive" (low energy) feeding methods targeting low-density patches of inshore prey. These findings corroborate the need to incorporate demographic and behavioural data into spatial models when identifying priority areas for protected cetacean species. Not all areas within an MPA have equal value for a population and a better knowledge of the spatial preferences of these whales within the designated Scottish MPAs, appointed for their protection, is considered vital for their conservation.
MeSH term(s)	Animals ; Minke Whale ; Ecosystem ; Cetacea ; Feeding Behavior ; Scotland
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0246617
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Article ; Online: Versatile tabletop setup for picosecond time-resolved resonant soft-x-ray scattering and spectroscopy.

Borchert, Martin / Braenzel, Julia / Gnewkow, Richard / Lunin, Leonid / Sidiropoulos, Themistoklis / Tümmler, Johannes / Will, Ingo / Noll, Tino / Reichel, Oliver / Rohloff, Dirk / Erko, Alexei / Krist, Thomas / von Korff Schmising, Clemens / Pfau, Bastian / Eisebitt, Stefan / Stiel, Holger / Schick, Daniel

The Review of scientific instruments

2023 Volume 94, Issue 6

Abstract: We present a laser-driven, bright, and broadband (50 to 1500 eV) soft-x-ray plasma source with <10 ps pulse duration. This source is employed in two complementary, laboratory-scale beamlines for time-resolved, magnetic resonant scattering and ... ...

Abstract	We present a laser-driven, bright, and broadband (50 to 1500 eV) soft-x-ray plasma source with <10 ps pulse duration. This source is employed in two complementary, laboratory-scale beamlines for time-resolved, magnetic resonant scattering and spectroscopy, as well as near-edge x-ray absorption fine-structure (NEXAFS) spectroscopy. In both beamlines, dedicated reflection zone plates (RZPs) are used as single optical elements to capture, disperse, and focus the soft x rays, reaching resolving powers up to E/ΔE > 1000, with hybrid RZPs at the NEXAFS beamline retaining a consistent E/ΔE > 500 throughout the full spectral range, allowing for time-efficient data acquisition. We demonstrate the versatility and performance of our setup by a selection of soft-x-ray spectroscopy and scattering experiments, which so far have not been possible on a laboratory scale. Excellent data quality, combined with experimental flexibility, renders our approach a true alternative to large-scale facilities, such as synchrotron-radiation sources and free-electron lasers.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0151613
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Article ; Online: Severity of Pancreatic Leak in Relation to Gut Restoration After Pancreaticoduodenectomy: The Role of the Roux-en-Y Configuration.

Smyrniotis, Vasileios / Parasyris, Stavros / Gemenetzis, Georgios / Margaris, Ioannis / Petropoulou, Zoe / Papadoliopoulou, Maria / Sidiropoulos, Theodoros / Dellaportas, Dionysios / Vezakis, Antonios / Polydorou, Andreas / Kokoropoulos, Panagiotis / Theodoraki, Kassiani / Matsota, Paraskevi / Vassiliu, Panteleimon / Arkadopoulos, Nikolaos

Annals of surgery open : perspectives of surgical history, education, and clinical approaches

2022 Volume 3, Issue 2, Page(s) e161

Abstract: Background: Pancreatic leak after pancreaticoduodenectomy and gut restoration via a single jejunal loop remains the crucial predictor of patients' outcome. Our reasoning that active pancreatic enzymes may be more disruptive to the pancreatojejunostomy ... ...

Abstract	Background: Pancreatic leak after pancreaticoduodenectomy and gut restoration via a single jejunal loop remains the crucial predictor of patients' outcome. Our reasoning that active pancreatic enzymes may be more disruptive to the pancreatojejunostomy prompted us to explore a Roux-en-Y configuration for the gut restoration, anticipating diversion of bile salts away from the pancreatic stump. Our study aims at comparing two techniques regarding the severity of postoperative pancreatic fistula (POPF) and patients' outcome. Methods: The files of 415 pancreaticoduodenectomy patients were retrospectively reviewed. Based on gut restoration, the patients were divided into: cohort A (n = 105), with gut restoration via a single jejunal loop, cohort B (n = 140) via a Roux-en-Y technique assigning the draining of pancreatic stump to the short limb and gastrojejunostomy and bile (hepaticojejunostomy) flow to long limb, and cohort C (n = 170) granting the short limb to the gastric and pancreatic anastomosis, whereas hepaticojejunostomy was performed to the long limp. The POPF-related morbidity and mortality were analyzed. Results: Overall POPF in cohort A versus cohorts B and C was 19% versus 12.1% and 9.4%, respectively ( Conclusion: Roux-en-Y configuration showed lower incidence and severity of POPF. Irrespective of technical skill, creating a gastrojejunostomy close to pancreatojejunostomy renders the pancreatic enzymes less active by leaping the bile salts away from the pancreatic duct and providing a lower pH.
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article
ISSN	2691-3593
ISSN (online)	2691-3593
DOI	10.1097/AS9.0000000000000161
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Article ; Online: Pancreaticoduodenectomy as a feasible choice for periampullary malignancy in octogenarians.

Parasyris, Stavros / Hatzaras, Ioannis / Ntella, Vasiliki / Sidiropoulos, Theodoros / Margaris, Ioannis / Pantazis, Nikos / Kokoropoulos, Panagiotis / Vassiliu, Panteleimon / Matsota, Paraskevi / Smyrniotis, Vasileios / Arkadopoulos, Nikolaos

Molecular and clinical oncology

2022 Volume 17, Issue 4, Page(s) 148

Abstract: The efficacy and safety of pancreaticoduodenectomy (PD) has not been yet studied in octogenarians in Greece. The present study reviewed records of all consecutive patients that underwent PD at the 4th Surgical Department of Attikon University Hospital ( ... ...

Abstract	The efficacy and safety of pancreaticoduodenectomy (PD) has not been yet studied in octogenarians in Greece. The present study reviewed records of all consecutive patients that underwent PD at the 4th Surgical Department of Attikon University Hospital (Athens, Greece) between January 1st, 2010 and December 31st, 2019. Differences between two age groups (group Y <80 years; group O >80 years) were analyzed. Study endpoints were length of stay, overall morbidity, 30-day mortality and overall survival (OS). There were 198 patients in Group Y (mean age, 65 years) and 20 patients in Group O (mean age, 82 years). Octogenarians had worse American Society of Anesthesiology score (>2; 31.3 vs. 65%; P=0.018). Median stay was not significantly different between the two groups (14 days vs. 16 days; P=0.307), neither was the 30-day mortality (6.1 vs. 5.0%; P>0.99). Median OS was similar between the two groups (35 months vs. 28 months; P=0.577). In a tertiary center in Greece, morbidity and mortality rates after PD were similar between the two groups. Patients should not be denied a PD, solely based on advanced age.
Language	English
Publishing date	2022-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2796865-0
ISSN	2049-9469 ; 2049-9450
ISSN (online)	2049-9469
ISSN	2049-9450
DOI	10.3892/mco.2022.2581
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