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  1. Article ; Online: Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry.

    Siebeneichler, Aline Stalder / Schumann, Desiree M / Karakioulaki, Meropi / Brachsler, Nora / Darie, Andrei M / Grize, Leticia / Heck, Thiago G / Tamm, Michael / Latzin, Philipp / Stolz, Daiana

    BMJ open respiratory research

    2024  Volume 11, Issue 1

    Abstract: Background: Methods used to assess ventilation heterogeneity through inert gas washout have been standardised and showed high sensitivity in diagnosing many respiratory diseases. We hypothesised that nitrogen single or multiple breath washout tests, ... ...

    Abstract Background: Methods used to assess ventilation heterogeneity through inert gas washout have been standardised and showed high sensitivity in diagnosing many respiratory diseases. We hypothesised that nitrogen single or multiple breath washout tests, respectively nitrogen single breath washout (N
    Study design and methods: This prospective, observational, single-centre study included patients with suspicion of asthma with normal spirometry. Patients completed questionnaires on symptoms and health-related quality-of-life and underwent the following lung function tests: N
    Results: 182 patients were screened and 106 were included in the study, with mean age of 41.8±14 years. The majority were never-smokers (58%) and women (61%). MCT was abnormal in 48% of participants, N
    Conclusions: Both MCT and N
    MeSH term(s) Humans ; Asthma/diagnosis ; Asthma/physiopathology ; Methacholine Chloride/administration & dosage ; Female ; Male ; Prospective Studies ; Adult ; Spirometry ; Breath Tests/methods ; Middle Aged ; Nitrogen/analysis ; Bronchial Provocation Tests/methods ; Forced Expiratory Volume ; Respiratory Function Tests/methods ; Lung/physiopathology ; Bronchoconstrictor Agents/administration & dosage
    Chemical Substances Methacholine Chloride (0W5ETF9M2K) ; Nitrogen (N762921K75) ; Bronchoconstrictor Agents
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article ; Observational Study ; Comparative Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-001919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Airway smooth muscle area to predict steroid responsiveness in COPD patients receiving triple therapy (HISTORIC): a randomised, placebo-controlled, double-blind, investigator-initiated trial.

    Stolz, Daiana / Papakonstantinou, Eleni / Pascarella, Maria / Jahn, Kathleen / Siebeneichler, Aline / Darie, Andrei M / Herrmann, Matthias J / Strobel, Werner / Salina, Anna / Grize, Leticia / Savic Prince, Spasenija / Tamm, Michael

    The European respiratory journal

    2023  Volume 62, Issue 1

    Abstract: Background: Although inhaled corticosteroids (ICS) are highly effective in asthma, they provide significant, but modest, clinical benefit in COPD. Here, we tested the hypothesis that high bronchial airway smooth muscle cell (ASMC) area in COPD is ... ...

    Abstract Background: Although inhaled corticosteroids (ICS) are highly effective in asthma, they provide significant, but modest, clinical benefit in COPD. Here, we tested the hypothesis that high bronchial airway smooth muscle cell (ASMC) area in COPD is associated with ICS responsiveness.
    Methods: In this investigator-initiated and -driven, double-blind, randomised, placebo-controlled trial (HISTORIC), 190 COPD patients, Global Initiative for Chronic Obstructive Lung Disease stage B-D, underwent bronchoscopy with endobronchial biopsy. Patients were divided into groups A and B, with high ASMC area (HASMC: >20% of the bronchial tissue area) and low ASMC area (LASMC: ≤20% of the bronchial tissue area), respectively, and followed a run-in period of 6 weeks on open-label triple inhaled therapy with aclidinium (ACL)/formoterol (FOR)/budesonide (BUD) (400/12/400 μg twice daily). Subsequently, patients were randomised to receive either ACL/FOR/BUD or ACL/FOR/placebo and followed for 12 months. The primary end-point of the study was the difference in post-bronchodilator forced expiratory volume in 1 s (FEV
    Results: In patients with LASMC, ACL/FOR/BUD did not significantly improve FEV
    Conclusion: COPD patients with ΗASMC respond better to ICS than patients with LASMC, suggesting that this type of histological analysis may predict ICS responsiveness in COPD patients receiving triple therapy.
    MeSH term(s) Humans ; Bronchodilator Agents ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Budesonide ; Respiratory System ; Adrenal Cortex Hormones/therapeutic use ; Administration, Inhalation ; Muscle, Smooth ; Double-Blind Method ; Forced Expiratory Volume
    Chemical Substances Bronchodilator Agents ; Budesonide (51333-22-3) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00218-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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  3. Article ; Online: Does trumpet playing affect lung function?-A case-control study.

    Studer, Lia / Schumann, Desiree M / Stalder-Siebeneichler, Aline / Tamm, Michael / Stolz, Daiana

    PloS one

    2019  Volume 14, Issue 5, Page(s) e0215781

    Abstract: Objectives: The effect a wind instrument has on lung function is a much-discussed topic with inconclusive data, not least because existing studies combine all wind instruments as one entity. The aim of this study was to investigate the effect of playing ...

    Abstract Objectives: The effect a wind instrument has on lung function is a much-discussed topic with inconclusive data, not least because existing studies combine all wind instruments as one entity. The aim of this study was to investigate the effect of playing a trumpet/cornet/flugelhorn on lung function.
    Methods: A prospective, multicentre, cross-sectional, case-control study. Participants were recruited from wind orchestra or brass bands throughout Switzerland. Inclusion criteria: aged 16 or older, reporting at least one year of playing a trumpet/cornet/flugelhorn. Controls were members of an orchestra, who had never played a wind instrument. The primary end-point of the study was the difference in FEV1%predicted between trumpet/cornet/flugelhorn players and controls.
    Results: 147 subjects were included in the study. Controls (n = 48) were significantly younger, more commonly male, current smokers and had a lower body mass index compared to trumpet/cornet/flugelhorn players (n = 99). There was no significant difference in FEV1%predicted (91.9% vs 94.2%; p = 0.316) or FVC %predicted (89.4% vs 92.6%; p = 0.125) between controls and trumpet/cornet/flugelhorn players, respectively, in crude and adjusted analyses. However, there was a significant negative association between the number of years playing a trumpet/cornet/flugelhorn and FVC %predicted after adjusting for smoking status, gender, and height. Trumpet/cornet/flugelhorn players had a similar amount of respiratory symptoms to controls (questionnaire score 3.2±3.2 vs 2.8±2.4, p = 0.717).
    Conclusion: Lung function in trumpet/cornet/flugelhorn players was similar to controls. However, the number of years playing a trumpet/cornet/flugelhorn seems to have an adverse effect on forced vital capacity.
    MeSH term(s) Adult ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Forced Expiratory Flow Rates ; Humans ; Lung/physiology ; Male ; Music ; Respiration
    Language English
    Publishing date 2019-05-02
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0215781
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  4. Article ; Online: A pilot study to test the feasibility of histological characterisation of asthma-COPD overlap.

    Papakonstantinou, Eleni / Savic, Spasenjia / Siebeneichler, Aline / Strobel, Werner / Jones, Paul W / Tamm, Michael / Stolz, Daiana

    The European respiratory journal

    2019  Volume 53, Issue 6

    MeSH term(s) Aged ; Aged, 80 and over ; Asthma/complications ; Asthma/pathology ; Asthma/therapy ; Bronchoscopy ; Feasibility Studies ; Female ; Forced Expiratory Volume ; Humans ; Male ; Middle Aged ; Pilot Projects ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Disease, Chronic Obstructive/therapy ; Vital Capacity
    Language English
    Publishing date 2019-06-05
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01941-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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  5. Article ; Online: Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients.

    Affolter, Kristina / Schumann, Desiree M / Tamm, Michael / Jahn, Kathleen / Siebeneichler, Aline / Junker, Lilian / Wagner, Karoline / Keller, Peter M / Frei, Reno / Stolz, Daiana

    Chest

    2018  Volume 154, Issue 3, Page(s) 722–725

    MeSH term(s) Bronchoalveolar Lavage Fluid/chemistry ; Female ; Humans ; Immunocompromised Host ; Lung Diseases/diagnosis ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Prospective Studies
    Language English
    Publishing date 2018-09-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2018.06.018
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    Zs.MO 349: Show issues

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  6. Article ; Online: Diabetes gestacional: um algoritmo de tratamento multidisciplinar.

    Weinert, Letícia Schwerz / Silveiro, Sandra Pinho / Oppermann, Maria Lúcia / Salazar, Cristiano Caetano / Simionato, Bárbara Marina / Siebeneichler, Aline / Reichelt, Angela Jacob

    Arquivos brasileiros de endocrinologia e metabologia

    2011  Volume 55, Issue 7, Page(s) 435–445

    Abstract: Effective treatment of gestational diabetes is important as an attempt to avoid unfavorable maternal and fetal outcomes. The objective of this paper is to describe the available therapies to optimize gestational diabetes treatment and to suggest a ... ...

    Title translation Gestational diabetes management: a multidisciplinary treatment algorithm.
    Abstract Effective treatment of gestational diabetes is important as an attempt to avoid unfavorable maternal and fetal outcomes. The objective of this paper is to describe the available therapies to optimize gestational diabetes treatment and to suggest a multidisciplinary approach algorithm. Nutrition therapy is the first option for the majority of these pregnancies; light to moderate physical activity is recommended in the absence of obstetrical contraindications. Medical treatment is recommended if glycemic control is not achieved or if excessive fetal growth is detected by ultrasound. Insulin is the standard treatment although oral antidiabetic drugs have recently been considered an effective and safe option. The monitoring of gestational diabetes treatment includes capillary glucose measurements and evaluation of fetal abdominal circumference by ultrasound performed around the 28th gestational week.
    MeSH term(s) Algorithms ; Diabetes, Gestational/diet therapy ; Diabetes, Gestational/therapy ; Exercise Therapy ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Practice Guidelines as Topic/standards ; Pregnancy ; Prenatal Care/standards
    Chemical Substances Hypoglycemic Agents
    Language Portuguese
    Publishing date 2011-12-02
    Publishing country Brazil
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302011000700002
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    Zs.B 264: Show issues Location:
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