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Book: Das TMS-Buch

Siebner, Hartwig Roman

Handbuch der transkraniellen Magnetstimulation ; mit 40 Tabellen

2007

Author's details	Hartwig Siebner ... (Hrsg.)
Keywords	Transkranielle magnetische Stimulation
Subject	Transkranielle Magnetstimulation ; Transkranielle magnetoelektrische Stimulation ; Transkranielle kortikale Magnetstimulation ; Kortikale Magnetstimulation ; Transcranielle corticale Magnetstimulation ; TMS
Language	German
Size	XXVI, 652 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book
HBZ-ID	HT015351015
ISBN	978-3-540-71904-5 ; 3-540-71904-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: What is the threshold for developing and applying optimized procedures to determine the corticomotor threshold?

Siebner, H R / Ziemann, U

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2014 Volume 125, Issue 1, Page(s) 1–2

MeSH term(s)	Evoked Potentials, Motor/physiology ; Female ; Humans ; Male ; Motor Cortex/physiology ; Patient Safety ; Transcranial Magnetic Stimulation/standards
Language	English
Publishing date	2014-01
Publishing country	Netherlands
Document type	Comment ; Editorial
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2013.07.012
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Article ; Online: Probing motor dynamics at the muscle level-Acoustic myography in Parkinson's disease.

Celicanin, M / Harrison, A P / Kvistgaard Olsen, J / Korbo, L / Løkkegård, A / Danneskiold-Samsøe, B / Siebner, H R / Ilic, T V / Bartels, E M

Physiological reports

2023 Volume 11, Issue 6, Page(s) e15631

Abstract: Acoustic myography (AMG) noninvasively probes muscle activity. We explored whether AMG captures abnormal motor activity in patients with Parkinson's disease (PD) and how this activity is modulated by antiparkinsonian medication. Twenty patients with PD ... ...

Abstract	Acoustic myography (AMG) noninvasively probes muscle activity. We explored whether AMG captures abnormal motor activity in patients with Parkinson's disease (PD) and how this activity is modulated by antiparkinsonian medication. Twenty patients with PD underwent AMG of the biceps, triceps, extensor carpi radialis longus, and adductor policis muscles of the more affected arm during active and passive movements, using a mobile AMG device (CURO, Denmark). AMG and assessment of motor symptoms were performed in a pragmatic off-medication state, as well as one and 3 h after oral intake of 200 mg levodopa. Three AMG parameters were calculated using the CURO analysis system. Motor efficiency was expressed by the E-score, muscle fiber recruitment by the temporal T-score, spatial summation by the S-score, and S/T ratio. Twenty age- and sex-matched healthy subjects served as controls. Group mean values were statistically compared using unpaired two-tailed adjusted t-test and ANOVA with Tukey´s correction for multiple comparison (p ≤ 0.05). For the biceps and extensor carpi radialis longus muscles, the active movement S:T ratio was lower in PD relative to healthy controls. The E-score was also lower during active and passive flexion/extension movements in the off-medication state. No significant between-group differences in the AMG scores were noted for the triceps muscle during active or passive movements. The active S:T ratio and the E-score during active elbow flexion and extension may offer a useful means to quickly assess abnormal motor activity and the effect of drug treatment in PD.
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Myography ; Muscle, Skeletal/physiology ; Movement/physiology ; Acoustics ; Electromyography
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15631
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Article ; Online: NfL and GFAP in serum are associated with microstructural brain damage in progressive multiple sclerosis.

Ammitzbøll, C / Dyrby, T B / Börnsen, L / Schreiber, K / Ratzer, R / Romme Christensen, J / Iversen, P / Magyari, M / Lundell, H / Jensen, P E H / Sørensen, P S / Siebner, H R / Sellebjerg, F

Multiple sclerosis and related disorders

2023 Volume 77, Page(s) 104854

Abstract: Background: The potential of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) as biomarkers of disease activity and severity in progressive forms of multiple sclerosis (MS) is unclear.: Objective: To investigate the ... ...

Abstract	Background: The potential of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) as biomarkers of disease activity and severity in progressive forms of multiple sclerosis (MS) is unclear. Objective: To investigate the relationship between serum concentrations of NfL, GFAP, and magnetic resonance imaging (MRI) in progressive MS. Methods: Serum concentrations of NfL and GFAP were measured in 32 healthy controls and 32 patients with progressive MS from whom clinical and MRI data including diffusion tensor imaging (DTI) were obtained during three years of follow-up. Results: Serum concentrations of NfL and GFAP at follow-up were higher in progressive MS patients than in healthy controls and serum NfL correlated with the EDSS score. Decreasing fractional anisotropy (FA) in normal-appearing white matter (NAWM) correlated with worsening EDSS scores and higher serum NfL. Higher serum NfL and increasing T2 lesion volume correlated with worsening paced autitory serial addition test scores. In multivariable regression analyses with serum GFAP and NfL as independent factors and DTI measures of NAWM as dependent factors, we showed that high serum NfL at follow-up was independently associated with decreasing FA and increasing MD in NAWM. Moreover, we found that high serum GFAP was independently associated with decreasing MD in NAWM and with decreasing MD and increasing FA in cortical gray matter. Conclusion: Serum concentrations of NfL and GFAP are increased in progressive MS and are associated with distinct microstructural changes in NAWM and CGM.
MeSH term(s)	Humans ; Multiple Sclerosis/pathology ; Diffusion Tensor Imaging ; Glial Fibrillary Acidic Protein ; Intermediate Filaments/pathology ; Multiple Sclerosis, Chronic Progressive/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Biomarkers ; Brain/diagnostic imaging ; Brain/pathology
Chemical Substances	Glial Fibrillary Acidic Protein ; Biomarkers
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2023.104854
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Article: Joint contribution of left dorsal premotor cortex and supramarginal gyrus to rapid action reprogramming

Hartwigsen, Gesa / Siebner, Hartwig R.

Brain Stimulation

2015 Volume 8, Issue 5, Page(s) 945–952

Abstract: Background: The rapid adaptation of actions to changes in the environment is crucial for survival. We previously demonstrated a joint contribution of left dorsal premotor cortex (PMd) and left supramarginal gyrus (SMG) to action reprogramming. However, ... ...

Abstract	Background: The rapid adaptation of actions to changes in the environment is crucial for survival. We previously demonstrated a joint contribution of left dorsal premotor cortex (PMd) and left supramarginal gyrus (SMG) to action reprogramming. However, we did not probe the contribution of PMd to the speed and accuracy of action reprogramming and how the functional relevance of PMd changes in the presence of a dysfunctional SMG. Objective: This study further dissociated the unique contribution of left PMd and SMG to action reprogramming. Specifically, we tested whether the critical contribution of PMd during action reprogramming depends on the functional integrity of SMG. Methods: Adopting a condition-and-perturb repetitive transcranial magnetic stimulation (rTMS) approach, we first transiently conditioned left SMG with 1 Hz offline rTMS and then perturbed PMd activity with online rTMS whilst human subjects performed a spatially-precued reaction time task. Results: Relative to sham rTMS, effective online perturbation of left PMd significantly impaired both the response speed and accuracy in trials that were invalidly pre-cued and required the subject to reprogram the prepared action. Moreover, the disruptive effect of rTMS over left PMd on response speed became stronger after SMG had been conditioned with offline rTMS. Conclusions: These results corroborate the notion that left PMd and SMG jointly contribute to rapid action reprogramming. Moreover, the strong virtual lesion effect observed with rTMS over PMd suggest that this area represents a key node for both the suppression of activation based on the precue and response activation based on the response target. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords	Motor Cortex ; Motor Processes ; Motorische Prozesse ; Motorischer Kortex ; Parietal Lobe ; Parietallappen ; Reaction Time ; Reaktionsparameter ; Reaktionszeit ; Response Parameters ; Transcranial Magnetic Stimulation ; Transkranielle Magnetstimulation
Language	English
Document type	Article
ZDB-ID	2394410-9
ISSN	1935-861X
ISSN	1935-861X
Database	PSYNDEX

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Article ; Online: Low-intensity repetitive paired associative stimulation targeting the motor hand area at theta frequency causes a lasting reduction in corticospinal excitability.

Rizzo, V / Mastroeni, C / Maggio, R / Terranova, C / Girlanda, P / Siebner, H R / Quartarone, A

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2020 Volume 131, Issue 10, Page(s) 2402–2409

Abstract: Objective: Sub-motor threshold 5 Hz repetitive paired associative stimulation (5 Hz-rPAS: Methods: 20 healthy volunteers received two minutes of 5 Hz-rPAS: Results: Subthreshold 5-Hz rPAS: Conclusions: Subthreshold 5-Hz rPAS: Significance: ... ...

Abstract	Objective: Sub-motor threshold 5 Hz repetitive paired associative stimulation (5 Hz-rPAS Methods: 20 healthy volunteers received two minutes of 5 Hz-rPAS Results: Subthreshold 5-Hz rPAS Conclusions: Subthreshold 5-Hz rPAS Significance: The results of the present study provide a new short-time paradigm of long term depression (LTD) induction in human sensory-motor cortex.
MeSH term(s)	Adult ; Electromyography ; Evoked Potentials, Motor/physiology ; Female ; Humans ; Male ; Motor Cortex/physiology ; Muscle, Skeletal/physiology ; Neural Inhibition/physiology ; Neuronal Plasticity/physiology ; Theta Rhythm/physiology ; Transcranial Magnetic Stimulation ; Young Adult
Language	English
Publishing date	2020-08-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2020.06.033
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Article: Cerebellar - Premotor cortex interactions underlying visuomotor adaptation

Tzvi, Elinor / Koeth, Fabian / Karabanov, Anke N. / Siebner, Hartwig R. / Kraemer, Ulrike M.

NeuroImage

2020

Abstract: Visuomotor adaptation (VMA) is a form of motor learning essential for performing day to day routines. Theoretical models and empirical evidence suggest a specific cortico-striato-cerebellar loop that mediates early and late learning in VMA. Here, we ... ...

Title translation	Interaktionen zwischen Kleinhirn und prämotorischem Kortex, die der visuomotorischen Anpassung zugrunde liegen (DeepL)
Abstract	Visuomotor adaptation (VMA) is a form of motor learning essential for performing day to day routines. Theoretical models and empirical evidence suggest a specific cortico-striato-cerebellar loop that mediates early and late learning in VMA. Here, we investigated dynamic changes in neural activity and connectivity when learning a novel visuomotor rotation using fMRI. We found that motor cortical regions, parietal cortex and cerebellum are recruited in the early phase of VMA, gradually reduce their activity as learning reaches plateau and rebound when the visuomotor rotation is removed. At this phase, dubbed de-adaptation, individual performance correlated with activity in motor and parietal cortex such that stronger activity was associated with better performance. Theory suggests that VMA is governed by the cortico-striato-cerebellar network during the early phase of learning and by the cortico-cerebellar loop at later stages. We tested this hypothesis using dynamic causal modelling and found distinct modulation of a cerebellar to dorsal premotor cortex (dPMC) loop. Specifically, the cerebellar to dPMC connection was modulated during adaptation, suggesting a release of inhibition and net excitatory effect of cerebellum on dPMC. The modulation of cerebellar to dPMC connection during de-adaptation was specifically related to behavioral learning parameter: stronger release of inhibition of the cerebellar to dPMC connection was associated with better de-adaptation. We interpret these findings to reflect dynamic interactions between representation of movement in cerebellum and visuomotor integration in dPMC.
Keywords	Adaptation ; Cerebellum ; Functional Magnetic Resonance Imaging ; Funktionelle Magnetresonanztomographie ; Kleinhirn ; Motor Cortex ; Motorischer Kortex ; Perceptual Motor Learning ; Sensumotorisches Lernen ; Striatum ; Visual Motor Integration ; Visual Perception ; Visuelle Wahrnehmung ; Visuomotorische Integration
Language	English
Document type	Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2020.117142
Database	PSYNDEX

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Article ; Online: Thalamocortical Connectivity and Microstructural Changes in Congenital and Late Blindness.

Reislev, N H / Dyrby, T B / Siebner, H R / Lundell, H / Ptito, M / Kupers, R

Neural plasticity

2017 Volume 2017, Page(s) 9807512

Abstract: There is ample evidence that the occipital cortex of congenitally blind individuals processes nonvisual information. It remains a debate whether the cross-modal activation of the occipital cortex is mediated through the modulation of preexisting ... ...

Abstract	There is ample evidence that the occipital cortex of congenitally blind individuals processes nonvisual information. It remains a debate whether the cross-modal activation of the occipital cortex is mediated through the modulation of preexisting corticocortical projections or the reorganisation of thalamocortical connectivity. Current knowledge on this topic largely stems from anatomical studies in animal models. The aim of this study was to test whether purported changes in thalamocortical connectivity in blindness can be revealed by tractography based on diffusion-weighted magnetic resonance imaging. To assess the thalamocortical network, we used a clustering method based on the thalamic white matter projections towards predefined cortical regions. Five thalamic clusters were obtained in each group representing their cortical projections. Although we did not find differences in the thalamocortical network between congenitally blind individuals, late blind individuals, and normal sighted controls, diffusion tensor imaging (DTI) indices revealed significant microstructural changes within thalamic clusters of both blind groups. Furthermore, we find a significant decrease in fractional anisotropy (FA) in occipital and temporal thalamocortical projections in both blind groups that were not captured at the network level. This suggests that plastic microstructural changes have taken place, but not in a degree to be reflected in the tractography-based thalamocortical network.
MeSH term(s)	Adult ; Anisotropy ; Blindness/congenital ; Blindness/pathology ; Cerebral Cortex/pathology ; Diffusion Magnetic Resonance Imaging ; Diffusion Tensor Imaging ; Humans ; Middle Aged ; Neural Pathways/pathology ; Thalamus/pathology ; White Matter/pathology
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	1454938-4
ISSN	1687-5443 ; 2090-5904 ; 0792-8483
ISSN (online)	1687-5443
ISSN	2090-5904 ; 0792-8483
DOI	10.1155/2017/9807512
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Article: Novel methods to study aphasia recovery after stroke

Hartwigsen, Gesa / Siebner, Hartwig R.

(In: Naritomi, Hiroaki; Krieger, Derk W. (Ed.), Clinical recovery from CNS damage (pp. 101-111). Basel: Karger)

2013

Abstract: The neural mechanisms that support aphasia recovery are not yet fully understood. It has been argued that the functional reorganization of language networks after left-hemisphere stroke may engage perilesional left brain areas as well as homologous right- ...

Series title	In: Naritomi, Hiroaki; Krieger, Derk W. (Ed.), Clinical recovery from CNS damage (pp. 101-111). Basel: Karger
Abstract	The neural mechanisms that support aphasia recovery are not yet fully understood. It has been argued that the functional reorganization of language networks after left-hemisphere stroke may engage perilesional left brain areas as well as homologous right-hemisphere regions. In this chapter, we summarize how noninvasive brain stimulation can be used to elucidate mechanisms of plasticity in language networks and enhance language recovery after stroke. We first outline some basic principles of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). We then present evidence from studies in healthy volunteers for a causal role of the right hemisphere in different language functions. Finally, we review recent studies that used TMS or tDCS to promote language recovery after stroke. Most of these studies applied noninvasive brain stimulation over contralateral right-hemisphere areas to suppress maladaptive plasticity. However, some studies also suggest that right-hemisphere regions may beneficially contribute to recovery in some patients. More recently, some investigators have targeted perilesional brain regions to promote neurorehabilitation. In sum, these studies indicate that language recovery after stroke may integrate left- as well as right-hemisphere brain regions to a different degree over the time course of recovery. Although the results of these preliminary studies provide some evidence that noninvasive brain stimulation may promote aphasia recovery, the reported effect sizes are not striking. Future studies on larger patient collectives are needed to explore whether noninvasive brain stimulation can enhance language functions at a level that is clinically relevant.
Keywords	Aphasia ; Aphasie ; Brain Stimulation ; Electrical Brain Stimulation ; Elektrische Hirnstimulation ; Genesung ; Hirnstimulation ; Left Hemisphere ; Linke Gehirnhälfte ; Neurorehabilitation ; Rechte Gehirnhälfte ; Recovery (Disorders) ; Right Hemisphere ; Transcranial Magnetic Stimulation ; Transkranielle Magnetstimulation
Language	English
Document type	Article
DOI	10.1159/000346431
Database	PSYNDEX

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Article: Simultaneous repetitive transcranial magnetic stimulation does not speed fine movement in PD.

Siebner, H R

Neurology

2000 Volume 54, Issue 1, Page(s) 272; author reply 273

MeSH term(s)	Brain/physiopathology ; Humans ; Movement ; Parkinson Disease/physiopathology ; Parkinson Disease/therapy ; Physical Stimulation ; Transcranial Magnetic Stimulation ; Treatment Failure
Language	English
Publishing date	2000-01-11
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/wnl.54.1.272-a
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