Artikel ; Online: Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management.
Annals of diagnostic pathology
2016 Band 25, Seite(n) 20–25
Abstract: The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with ... ...
Abstract | The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to mandatory surgical excision in all cases. We report the findings at our institution, where virtually every core needle biopsy diagnosis of lobular neoplasia results in follow-up excision. The goal of the study was to identify potential predictors of upgrade to a more significant lesion. We identified 76 patients over a 15-year period with a core biopsy diagnosis of pure lobular neoplasia and no other high-risk lesions. Subsequent surgical excision identified 10 cases (13%) that were upgraded to carcinoma. Upgrade diagnoses included invasive ductal carcinoma (n=1), invasive lobular carcinoma (n=4), ductal carcinoma in situ (n=3), and pleomorphic lobular carcinoma in situ (n=2). All 10 upgraded cases had imaging findings suspicious for malignancy including irregular masses, asymmetric densities, or pleomorphic calcifications. Of the 10 upgraded cases, 7 were diagnosed as lobular carcinoma in situ on core biopsy. The data support a role for radiologic-pathologic correlation in the evaluation of suspicious breast lesions and suggest that the extent of lobular neoplasia in core biopsy specimens may be an indicator of the likelihood of upgrade to carcinoma. |
|||||
---|---|---|---|---|---|---|
Mesh-Begriff(e) | Adult ; Aged ; Aged, 80 and over ; Biopsy, Large-Core Needle/methods ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Carcinoma in Situ/pathology ; Carcinoma in Situ/therapy ; Carcinoma, Lobular/diagnosis ; Carcinoma, Lobular/pathology ; Female ; Humans ; Hyperplasia/diagnosis ; Hyperplasia/pathology ; Mammography ; Middle Aged ; Precancerous Conditions/pathology | |||||
Sprache | Englisch | |||||
Erscheinungsdatum | 2016-12 | |||||
Erscheinungsland | United States | |||||
Dokumenttyp | Journal Article | |||||
ZDB-ID | 1440011-x | |||||
ISSN | 1532-8198 ; 1092-9134 | |||||
ISSN (online) | 1532-8198 | |||||
ISSN | 1092-9134 | |||||
DOI | 10.1016/j.anndiagpath.2016.07.009 | |||||
Signatur |
|
|||||
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 5463: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.