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Article ; Online: The effect of coping strategies on health-related quality of life in acromegaly patients.

Schock, Lisa / Chmielewski, Witold X / Siegel, Sonja / Detomas, Mario / Deutschbein, Timo / Giese, Sabrina / Honegger, Jürgen / Unger, Nicole / Kreitschmann-Andermahr, Ilonka

Endocrine

2024

Abstract: Purpose: Patients with acromegaly oftentimes exhibit a reduced physical and psychological health-related quality of life (HRQoL). Maladaptive coping styles are associated with poor HRQoL in a number of diseases and patients with pituitary adenomas in ... ...

Abstract	Purpose: Patients with acromegaly oftentimes exhibit a reduced physical and psychological health-related quality of life (HRQoL). Maladaptive coping styles are associated with poor HRQoL in a number of diseases and patients with pituitary adenomas in general exhibit less effective coping styles than healthy controls. This study aimed to assess coping strategies in acromegaly patients in order to explore leverage points for the improvement of HRQoL. Methods: In this cross-sectional study, we administered self-report surveys for coping strategies and HRQoL (Short Form SF-36, Freiburg questionnaire on coping with illness, FKV-LIS) in patients with acromegaly. These were set into relation with a variety of health variables. Results: About half of the 106 patients (44.3% female) with a mean age of 56.4 ± 1.3 years showed impaired physical and psychological HRQoL on average 11.2 years after the initial diagnosis. Body mass index, age at survey date and concomitant radiotherapy explained 27.8% of the variance of physical HRQoL, while depressive coping added an additional 9.2%. Depressive coping style and trivialization and wishful thinking were pivotal predictors of an impaired psychological HRQoL with a total explained variance of 51.6%, whereas patient health variables did not affect psychological HRQoL. Conclusion: Our results show that maladaptive coping styles have a substantial negative impact on psychological HRQoL in patients with acromegaly, whereas physical HRQoL is influenced to a lesser extent. Specialized training programs aimed at improving coping strategies could reduce long-term disease burden and increase HRQoL in the affected patients.
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-024-03813-4
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Book ; Online ; Thesis: Medizinische Versorgung von Menschen mit Foltererfahrung – Wirksamkeit eines Trainingsmoduls für medizinisches Personal

Siegel, Sonja [Verfasser] / Ritz-Timme, Stefanie [Gutachter] / Hugger, Alfons [Gutachter]

2023

Author's details	Sonja Siegel ; Gutachter: Stefanie Ritz-Timme, Alfons Hugger
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
Publishing place	Düsseldorf
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Book ; Online ; Thesis: Towards a biopsychosocial explanation of headache in patients with tumors of the sellar region

Siegel, Sonja [Verfasser] / Kreitschmann-Andermahr, Ilonka [Akademischer Betreuer]

the role of personality, stress coping and pain catastrophizing

2022

Author's details	Sonja Siegel ; Betreuer: Ilonka Kreitschmann-Andermahr
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	Multiple languages
Publisher	Duisburg ; Universität Duisburg-Essen
Publishing place	Essen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Not Simply a Structural Problem: Psychological Determinants of Headache in Patients with Tumors of the Sellar Region.

Siegel, Sonja / Schenk, Thomas / Brabant, Georg / Scholl, Renata Carneiro / Buchfelder, Michael / Kreitschmann-Andermahr, Ilonka

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2022 Volume 130, Issue 10, Page(s) 693–700

Abstract: Objective: Headache in patients with tumors of the sellar region (TSR) has previously been attributed entirely to biomechanical causes. This study aimed to investigate the influence of psychological determinants for the occurrence of and disability due ... ...

Abstract	Objective: Headache in patients with tumors of the sellar region (TSR) has previously been attributed entirely to biomechanical causes. This study aimed to investigate the influence of psychological determinants for the occurrence of and disability due to headaches in patients with TSR. Methods: This was a cross-sectional single-center study with a logistic regression approach. Eighty-four patients (75%) with pituitary adenomas and 28 with other TSR prior to first-time neurosurgery were investigated. One-hundred and twelve patients received standardized questionnaires on personality, headache characteristics, and disability due to headache. Fifty-nine patients additionally filled in questionnaires about coping with stress and pain catastrophizing. Separate logistic regression models were used to predict the risk of headache occurrence and disability due to headache by personality, stress coping, and pain catastrophizing. Results: Conscientiousness, neuroticism, and pain catastrophizing were significant predictors of headache occurrence. The amount of explained variance for both models predicting headache occurrence was comparable to that in primary headache. Neuroticism, pain catastrophizing, and humor as a coping strategy predicted disability due to headache with a high variance explanation of 20-40%. Conclusion: For the first time, we report data supporting a strong psychological influence on headache and headache-related disability in patients with TSR, which argue against purely mechanistic explanatory models. Physicians treating patients with TSR and headaches should adopt an integrative diagnostic and treatment approach, taking the biopsychosocial model of pain into account.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Headache/etiology ; Adaptation, Psychological ; Pain/complications ; Pain/psychology ; Surveys and Questionnaires ; Pituitary Neoplasms/complications
Language	English
Publishing date	2022-08-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1851-5017
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Article ; Online: Illness-related burden, personal resources and need for support in patients with acromegaly: Results of a focus group analysis.

Siegel, Sonja / Kirstein, Cedric Fabian / Schröder, Bernadette / Unger, Nicole / Kreitschmann-Andermahr, Ilonka

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

2021 Volume 60-61, Page(s) 101422

Abstract: Objective: It was the aim of this study to evaluate illness-related burdens and support needs of patients with acromegaly to identify hitherto unadressed research questions and to open up avenues for improvements in patient care. This was done by using ... ...

Abstract	Objective: It was the aim of this study to evaluate illness-related burdens and support needs of patients with acromegaly to identify hitherto unadressed research questions and to open up avenues for improvements in patient care. This was done by using the focus group approach as a qualitative research method. Design: Seven patients with acromegaly took part in a focus group moderated by an external medical communication specialist. The discourse focused on topics such as impact of the illness on everyday life, support needs and personal resources. The discussion was recorded and transcribed and analyzed by qualitative content analysis. Results: Participants reported a huge impact of acromegaly on daily life, ranging from time expenditure for managing their illness, to bodily and mental sequelae and strain caused by physical disfigurement. Patients' coping strategies included family support, physical activities and humor. The participants wished for a sound patient-doctor relationship, more interdisciplinary and holistic treatment, medical rehabilitation services with special knowledge on acromegaly-related morbidity, a stable contact person in the medical process and reliable information material for themselves and their relatives. Conclusions: The results provide multi-facetted impressions of the overwhelming impact of acromegaly and unmet support needs of the afflicted patients. Further quantitative research is necessary to examine the generalisibility of the present results in order to implement tailored support measures. We suggest to develop standardized questionnaires to explore the prevalence and severity of the addressed problems in a large patient sample and to establish screening instruments to monitor disease burden in clinical practice.
MeSH term(s)	Acromegaly/economics ; Acromegaly/pathology ; Acromegaly/psychology ; Acromegaly/therapy ; Adult ; Cost of Illness ; Female ; Focus Groups/methods ; Follow-Up Studies ; Health Services Needs and Demand/statistics & numerical data ; Humans ; Male ; Middle Aged ; Personal Autonomy ; Prognosis ; Quality of Life
Language	English
Publishing date	2021-08-05
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1436781-6
ISSN	1532-2238 ; 1096-6374
ISSN (online)	1532-2238
ISSN	1096-6374
DOI	10.1016/j.ghir.2021.101422
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Zs.A 3319: Show issues

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Article: [No title information]

Siegel, Sonja / Schenk, Thomas / Brabant, Georg / Scholl, Renata Carneiro / Buchfelder, Michael / Kreitschmann-Andermahr, Ilonka

Experimental and Clinical Endocrinology & Diabetes

2022 Volume 130, Issue 10, Page(s) 693–700

Abstract	Objective: Headache in patients with tumors of the sellar region (TSR) has previously been attributed entirely to biomechanical causes. This study aimed to investigate the influence of psychological determinants for the occurrence of and disability due to headaches in patients with TSR. Methods: This was a cross-sectional single-center study with a logistic regression approach. Eighty-four patients (75%) with pituitary adenomas and 28 with other TSR prior to first-time neurosurgery were investigated. One-hundred and twelve patients received standardized questionnaires on personality, headache characteristics, and disability due to headache. Fifty-nine patients additionally filled in questionnaires about coping with stress and pain catastrophizing. Separate logistic regression models were used to predict the risk of headache occurrence and disability due to headache by personality, stress coping, and pain catastrophizing. Results: Conscientiousness, neuroticism, and pain catastrophizing were significant predictors of headache occurrence. The amount of explained variance for both models predicting headache occurrence was comparable to that in primary headache. Neuroticism, pain catastrophizing, and humor as a coping strategy predicted disability due to headache with a high variance explanation of 20–40%. Conclusion: For the first time, we report data supporting a strong psychological influence on headache and headache-related disability in patients with TSR, which argue against purely mechanistic explanatory models. Physicians treating patients with TSR and headaches should adopt an integrative diagnostic and treatment approach, taking the biopsychosocial model of pain into account.
Keywords	pain ; pituitary adenoma ; coping ; personality ; pain catastrophizing
Language	English
Publishing date	2022-08-17
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1851-5017
Database	Thieme publisher's database

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Article: Not simply a structural problem

Siegel, Sonja / Schenk, Thomas / Brabant, Georg / Scholl, Renata Carneiro / Buchfelder, Michael / Kreitschmann-Andermahr, Ilonka

Experimental and Clinical Endocrinology & Diabetes

Psychological determinants of headache in patients with tumors of the sellar region

2022 Volume 130, Issue 10, Page(s) 693–700

Title translation	Nicht nur ein strukturelles Problem: Psychologische Determinanten des Kopfschmerzes bei Patienten mit Tumoren der Sellarregion
Abstract	Objective: Headache in patients with tumors of the sellar region (TSR) has previously been attributed entirely to biomechanical causes. This study aimed to investigate the influence of psychological determinants for the occurrence of and disability due to headaches in patients with TSR. Methods: This was a cross-sectional single-center study with a logistic regression approach. Eighty-four patients (75%) with pituitary adenomas and 28 with other TSR prior to first-time neurosurgery were investigated. One-hundred and twelve patients received standardized questionnaires on personality, headache characteristics, and disability due to headache. Fifty-nine patients additionally filled in questionnaires about coping with stress and pain catastrophizing. Separate logistic regression models were used to predict the risk of headache occurrence and disability due to headache by personality, stress coping, and pain catastrophizing. Results: Conscientiousness, neuroticism, and pain catastrophizing were significant predictors of headache occurrence. The amount of explained variance for both models predicting headache occurrence was comparable to that in primary headache. Neuroticism, pain catastrophizing, and humor as a coping strategy predicted disability due to headache with a high variance explanation of 20-40%. Conclusion: For the first time, we report data supporting a strong psychological influence on headache and headache-related disability in patients with TSR, which argue against purely mechanistic explanatory models. Physicians treating patients with TSR and headaches should adopt an integrative diagnostic and treatment approach, taking the biopsychosocial model of pain into account.
Keywords	At Risk Populations ; Behinderungen ; Bewältigungsverhalten ; Brain Neoplasms ; Comorbidity ; Coping Behavior ; Disabilities ; Headache ; Hirntumore ; Humor ; Hypophyse ; Ko-Morbidität ; Kopfschmerz ; Neuroticism ; Neurotizismus ; Personality Correlates ; Persönlichkeitskorrelate ; Pituitary Gland ; Risikogruppen ; Stress Management ; Stressverarbeitung
Language	English
Document type	Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1851-5017
Database	PSYNDEX

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Article: Measuring Patient Experience and Patient Satisfaction-How Are We Doing It and Why Does It Matter? A Comparison of European and U.S. American Approaches.

Friedel, Anna Lena / Siegel, Sonja / Kirstein, Cedric Fabian / Gerigk, Monja / Bingel, Ulrike / Diehl, Anke / Steidle, Oliver / Haupeltshofer, Steffen / Andermahr, Bernhard / Chmielewski, Witold / Kreitschmann-Andermahr, Ilonka

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 6

Abstract: 1) ...

Abstract	(1)
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11060797
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Article ; Online: Neuropsychological Functioning in Patients with Cushing's Disease and Cushing's Syndrome.

Siegel, Sonja / Kirstein, Cedric Fabian / Grzywotz, Agnieszka / Hütter, Bernd Otto / Wrede, Karsten Henning / Kuhna, Victoria / Kreitschmann-Andermahr, Ilonka

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2020 Volume 129, Issue 3, Page(s) 194–202

Abstract: Purpose: To present a systematic review of the presence and severity of neuropsychological impairment in the six main neuropsychological domains (attention, executive function, language, visuospatial processing, intelligence, and memory) in patients ... ...

Abstract	Purpose: To present a systematic review of the presence and severity of neuropsychological impairment in the six main neuropsychological domains (attention, executive function, language, visuospatial processing, intelligence, and memory) in patients with Cushing's disease (CD) and/or Cushing's Syndrome (CS) at various stages of the illness. The work aims to identify neuropsychological leverage points for focused diagnosis and rehabilitation in CS/CD patients. Methods: A pubmed literature search was performed and augmented by searching the reference lists of review articles identified by this search strategy. After excluding irrelevant hits, we systematically extracted data from 27 studies for each main neuropsychological domain, differentiating between active disease, short- and long-term remission. Results: The literature gives evidence for neuropsychological impairment in all domains in Cushing patients with active disease. The most consistent impairments concerned memory and visuo-spatial processing, whereas the data are discordant for all other domains. Significant improvement of neuropsychological function - although not returning to normal in all domains - is shown in short-term and long-term remission of the disease. However, the published literature is thin, suffering from repetitive subsample analyses publishing, methodological concerns as lack of control for confounders such as depression. Conclusions: Memory is the most extensively investigated domain in CS/CD patients and impairment is most prominent in active disease. Patients should be counseled that neuropsychological function will improve with normalization of hypercortisolism and over time. More studies with more stringent methodological criteria, larger patient samples and controlling for confounders are required to enhance our understanding of neuropsychological function in patients with CS/CD.
MeSH term(s)	Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/rehabilitation ; Cushing Syndrome/complications ; Cushing Syndrome/therapy ; Humans ; Pituitary ACTH Hypersecretion/complications ; Pituitary ACTH Hypersecretion/therapy
Language	English
Publishing date	2020-09-29
Publishing country	Germany
Document type	Journal Article ; Systematic Review
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1247-4651
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neuropsychological Functioning in Patients with Cushing’s Disease and Cushing’s Syndrome

Siegel, Sonja / Kirstein, Cedric Fabian / Grzywotz, Agnieszka / Hütter, Bernd Otto / Wrede, Karsten Henning / Kuhna, Victoria / Kreitschmann-Andermahr, Ilonka

Experimental and Clinical Endocrinology & Diabetes

(Special Issue Pituitary Gland)

2020 Volume 129, Issue 03, Page(s) 194–202

Series title	Special Issue Pituitary Gland
Abstract	Purpose: To present a systematic review of the presence and severity of neuropsychological impairment in the six main neuropsychological domains (attention, executive function, language, visuospatial processing, intelligence, and memory) in patients with Cushing’s disease (CD) and/or Cushing’s Syndrome (CS) at various stages of the illness. The work aims to identify neuropsychological leverage points for focused diagnosis and rehabilitation in CS/CD patients. Methods: A pubmed literature search was performed and augmented by searching the reference lists of review articles identified by this search strategy. After excluding irrelevant hits, we systematically extracted data from 27 studies for each main neuropsychological domain, differentiating between active disease, short- and long-term remission. Results: The literature gives evidence for neuropsychological impairment in all domains in Cushing patients with active disease. The most consistent impairments concerned memory and visuo-spatial processing, whereas the data are discordant for all other domains. Significant improvement of neuropsychological function – although not returning to normal in all domains – is shown in short-term and long-term remission of the disease. However, the published literature is thin, suffering from repetitive subsample analyses publishing, methodological concerns as lack of control for confounders such as depression. Conclusions: Memory is the most extensively investigated domain in CS/CD patients and impairment is most prominent in active disease. Patients should be counseled that neuropsychological function will improve with normalization of hypercortisolism and over time. More studies with more stringent methodological criteria, larger patient samples and controlling for confounders are required to enhance our understanding of neuropsychological function in patients with CS/CD.
Keywords	Cushing’s disease ; Cushing’s syndrome ; neuropsychological impairment ; depression ; rehabilitation
Language	English
Publishing date	2020-09-29
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1247-4651
Database	Thieme publisher's database

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