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  1. Article ; Online: How to Mitigate the Risk of Postoperative Thromboembolism in Thoracic Cancer Surgery: Comments on the Joint 2022 European Society of Thoracic Surgery and American Association of Thoracic Surgery Guidelines for the Prevention of Cancer-Associated Venous Thromboembolism in Thoracic Surgery.

    Bolliger, Daniel / Hojski, Aljaz / Siegemund, Martin

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 6, Page(s) 863–866

    MeSH term(s) Humans ; United States ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Thoracic Surgery ; Thoracic Surgical Procedures/adverse effects ; Neoplasms ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Risk Factors ; Anticoagulants
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.02.033
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    Zs.A 2203: Show issues Location:
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  2. Article ; Online: The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis.

    Abdelhamid, Salim / Achermann, Rita / Hollinger, Alexa / Hauser, Madlaina / Trutmann, Maren / Gallacchi, Laura / Siegemund, Martin

    Critical care medicine

    2024  Volume 52, Issue 5, Page(s) e234–e244

    Abstract: Objectives: The aim of this study was to analyze the development of albumin administration in patients admitted to the adult ICU. In addition, we assessed the impact of albumin administration on serum hemoglobin concentration.: Design: We conducted a ...

    Abstract Objectives: The aim of this study was to analyze the development of albumin administration in patients admitted to the adult ICU. In addition, we assessed the impact of albumin administration on serum hemoglobin concentration.
    Design: We conducted a retrospective single-center study including all patients who were admitted to the ICU from January 2013 to December 2021 and stayed at least 24 hours.
    Setting: The study was conducted in an academic hospital (University Hospital Basel, Switzerland).
    Patients: A total of 20,927 admissions were included, of which 3748 received albumin at least once during their ICU stay. To analyze volume expansion, 2006 admissions met the inclusion criteria, namely at least two hemoglobin measurements within 12 hours, one albumin delivery, and experienced no bleeding, dialysis, or transfusions during this period.
    Interventions: None.
    Measurements: We examined the hemoglobin levels before and after albumin administration and compared them with a matched control group to assess the amount and duration of volume expansion.
    Main results: From 2013 to 2021 the proportion of critically ill patients treated with albumin rose from 5.0% to 32.5%. An overproportioned increase in albumin use could be seen in surgical patients (4.7-47.2%) and in those receiving RBC transfusion (13.7-72.6%). In those patients receiving albumin, a significant drop in hemoglobin of around 5 g/L on average could be observed following treatment with albumin.
    Conclusion: Hemodilution was observable for at least 12 hours after albumin administration and may have caused a decrease in hemoglobin concentration of greater than 8 g/L when isooncotic albumin solution (5%, 25 g in 500 mL) was administered. This makes albumin, especially in its isooncotic form, an ideal colloid to achieve long-lasting volume expansion. However, RBC transfusions may increase under albumin therapy, as transfusion thresholds may be undershot after albumin administration.
    MeSH term(s) Adult ; Humans ; Blood Transfusion ; Critical Illness/therapy ; Hemoglobins/analysis ; Renal Dialysis ; Retrospective Studies
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006218
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    Zs.A 1261: Show issues Location:
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  3. Article ; Online: Comment on 'Effect of intraoperative haemoadsorption therapy on cardiac surgery for active infective endocarditis with confirmed Staphylococcus aureus bacteraemia'.

    Amacher, Simon A / Miazza, Jules / Siegemund, Martin / Santer, David

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 37, Issue 1

    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Editorial ; Comment
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad051
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  4. Article: Acute and Long-Term Cardiovascular Complications among Patients with Sepsis and Septic Shock.

    Merdji, Hamid / Siegemund, Martin / Meziani, Ferhat

    Journal of clinical medicine

    2022  Volume 11, Issue 24

    Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is the leading cause of death within intensive care units (ICUs) [ ... ]. ...

    Abstract Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is the leading cause of death within intensive care units (ICUs) [...].
    Language English
    Publishing date 2022-12-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11247362
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  5. Book ; Thesis: Einfluß der Sympathikus-Stimulation auf die adrenerge Rezeptor-vermittelte Vasomotorik epicardialer Koronararterien beim Menschen

    Siegemund, Martin

    1991  

    Author's details vorgelegt von Martin Siegemund
    Language German
    Size 1 Mikrofiche : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 1993
    Note Mikroreprod. eines Ms. 60 Bl.: Ill., graph. Darst.
    HBZ-ID HT004973593
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1993 MB 837 order for loan Magazin

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  6. Article ; Online: In Reply to Bevelacqua et al.

    Finazzi, Tobias / Papachristofilou, Alexandros / Siegemund, Martin

    International journal of radiation oncology, biology, physics

    2021  Volume 110, Issue 5, Page(s) 1551

    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.04.026
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    Zs.A 1218: Show issues Location:
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  7. Article ; Online: Severe acute respiratory syndrome coronavirus 2, primary varicella zoster virus coinfection, and a polymicrobial ventilator-associated tracheobronchitis in an adult immunocompetent male: a case report.

    Bruno, Jowita / Ragozzino, Silvio / Quitt, Jonas / Siegemund, Martin / Labhardt, Niklaus

    Journal of medical case reports

    2022  Volume 16, Issue 1, Page(s) 45

    Abstract: Background: The spectrum of clinical manifestations and differential diagnosis associated with coronavirus disease 2019 is broad, ranging from fever and cutaneous eruptions to respiratory distress or even neurological disorders. Coexisting multipathogen ...

    Abstract Background: The spectrum of clinical manifestations and differential diagnosis associated with coronavirus disease 2019 is broad, ranging from fever and cutaneous eruptions to respiratory distress or even neurological disorders. Coexisting multipathogen infections significantly increase the complexity of the proper diagnostic and therapeutic approach and correlate with the rate of intensive care unit admissions and in-hospital mortality.
    Case presentation: We present a case of multipathogen respiratory infection with severe acute respiratory syndrome coronavirus 2, varicella zoster virus, and polymicrobial tracheobronchitis in a 48-year-old Caucasian male hospitalized after traumatic brain injury. The patient tested positive for severe acute respiratory syndrome coronavirus 2 infection upon admission. During his stay in the intensive care unit, the patient developed a vesicular exanthema along with respiratory failure and signs of septic shock.
    Conclusion: This case of an adult presenting with severe acute respiratory syndrome coronavirus 2 infection and simultaneous primary varicella zoster virus infection illustrates the importance of considering coinfections in patients with coronavirus disease 2019 with unusual clinical manifestations.
    MeSH term(s) Adult ; COVID-19 ; Coinfection ; Herpes Zoster ; Herpesvirus 3, Human ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Ventilators, Mechanical
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-022-03253-6
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  8. Article ; Online: Vasoactive agents to improve brain perfusion: pathophysiology and clinical utilization.

    Steiner, Luzius A / Siegemund, Martin

    Current opinion in critical care

    2019  Volume 25, Issue 2, Page(s) 110–116

    Abstract: Purpose of review: This review highlights the aspects of pathophysiology that make it difficult to predict the effects of any attempt to improve brain perfusion and reviews the options to improve brain perfusion according to the needs of an individual ... ...

    Abstract Purpose of review: This review highlights the aspects of pathophysiology that make it difficult to predict the effects of any attempt to improve brain perfusion and reviews the options to improve brain perfusion according to the needs of an individual patient, focusing on the choice of a suitable threshold for cerebral perfusion pressure.
    Recent findings: Typically, vasopressors or vasodilators that do not directly influence the cerebral vascular bed are used to improve cerebral perfusion. Positive inotropic substances are rarely used, as the relationship between cardiac output and cerebral blood flow is complex and difficult to measure. Combining perfusion pressure monitoring with monitoring of brain metabolism or oxygenation to adapt cerebral perfusion to the needs of an individual patient has been disappointing. Recently, attempts to individualize perfusion pressure based on measurements of cerebrovascular autoregulation have shown promising results in the management of traumatic brain injury and during cardiac surgery. Currently, only preliminary data are available linking optimized cerebral perfusion to improved outcome.
    Summary: Optimizing cerebral perfusion remains a difficult goal. All our attempts to manipulate brain perfusion are influenced in an unpredictable manner by underlying diseases. Autoregulation-based strategies to individualize cerebral perfusion management warrant further investigation.
    MeSH term(s) Brain ; Brain Injuries, Traumatic/drug therapy ; Cerebrovascular Circulation/drug effects ; Homeostasis ; Humans ; Intracranial Pressure ; Perfusion ; Vasoconstrictor Agents
    Chemical Substances Vasoconstrictor Agents
    Language English
    Publishing date 2019-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000586
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    Zs.A 4999: Show issues Location:
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  9. Article ; Online: A bedside swallowing screen for the identification of post-extubation dysphagia on the intensive care unit - validation of the Gugging Swallowing Screen (GUSS)-ICU.

    Troll, Claudia / Trapl-Grundschober, Michaela / Teuschl, Yvonne / Cerrito, Adrien / Compte, Montserrat Gallego / Siegemund, Martin

    BMC anesthesiology

    2023  Volume 23, Issue 1, Page(s) 122

    Abstract: Purpose: Screening for dysphagia at the intensive care unit (ICU) soon after extubation can prevent aspiration, pneumonia, lower mortality, and shorten re-feeding interval. This study aimed to modify the Gugging Swallowing Screen (GUSS), which was ... ...

    Abstract Purpose: Screening for dysphagia at the intensive care unit (ICU) soon after extubation can prevent aspiration, pneumonia, lower mortality, and shorten re-feeding interval. This study aimed to modify the Gugging Swallowing Screen (GUSS), which was developed for acute stroke patients, and to validate it for extubated patients in the ICU.
    Methods: In this prospective study, forty-five patients who had been intubated for at least 24 h were recruited consecutively at the earliest 24 h after extubation. The modified GUSS-ICU was performed twice by two speech and language therapists independently. Concurrently, gold standard the flexible endoscopic evaluation of swallowing (FEES) was performed by an otorhinolaryngologist. Measurements were conducted within a three-hour period; all testers were blinded to each other's results.
    Results: According to FEES, 36 of 45 (80%) participants were diagnosed with dysphagia; 13 of those were severe, 12 moderate, and 11 mild. Compared to FEES, the GUSS-ICU predicted dysphagia well (area under the curve for the initial rater pair: 0.923, 95% CI 0.832-1.000 and 0.923, 95% CI 0.836 -1.000 for the second rater pair). The sensitivity was 91.7% (95% CI 77.5-98.3%) and 94.4% (95% CI 81.3-99.3%); the specificity was 88.9% (51.8-99.7%) and 66.7% (29.9-92.5%); the positive predictive values were 97.1% (83.8-99.5%) and 91.9% (81.7-96.6%), and the negative predictive values were 72.7% (46.8-89%) and 75% (41.9-92.6%) for the first and second rater pairs, respectively. Dysphagia severity classification according to FEES and GUSS-ICU correlated strongly (Spearman's rho: 0.61 for rater 1 and 0.60 for rater 2, p < 0.001). Agreement by all testers was good (Krippendorffs Alpha: 0.73). The interrater reliability showed good agreement (Cohen`s Kappa: 0.84, p < 0.001).
    Conclusion: The GUSS-ICU is a simple, reliable, and valid multi-consistency bedside swallowing screen to identify post-extubation dysphagia at the ICU.
    Trial registration: ClinicalTrials.gov Identifier: NCT04532398,31/08/2020.
    MeSH term(s) Humans ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Deglutition ; Prospective Studies ; Airway Extubation ; Reproducibility of Results ; Intensive Care Units
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-023-02072-6
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  10. Article: Microcirculatory dysfunction in cardiogenic shock.

    Merdji, Hamid / Levy, Bruno / Jung, Christian / Ince, Can / Siegemund, Martin / Meziani, Ferhat

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 38

    Abstract: Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate between 40% and 50% despite recent advances. Many studies have now ... ...

    Abstract Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate between 40% and 50% despite recent advances. Many studies have now evidenced that cardiogenic shock not only involves systemic macrocirculation, such as blood pressure, left ventricular ejection fraction, or cardiac output, but also involves significant systemic microcirculatory abnormalities which seem strongly associated with the outcome. Although microcirculation has been widely studied in the context of septic shock showing heterogeneous alterations with clear evidence of macro and microcirculation uncoupling, there is now a growing body of literature focusing on cardiogenic shock states. Even if there is currently no consensus regarding the treatment of microcirculatory disturbances in cardiogenic shock, some treatments seem to show a benefit. Furthermore, a better understanding of the underlying pathophysiology may provide hypotheses for future studies aiming to improve cardiogenic shock prognosis.
    Language English
    Publishing date 2023-05-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01130-z
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