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  1. Article ; Online: The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene

    Zacher, Christoph / Schönfelder, Kristina / Rohn, Hana / Siffert, Winfried / Möhlendick, Birte

    Frontiers in immunology

    2024  Volume 15, Page(s) 1355193

    Abstract: Background and aims: Several factors, such as hypertension and diabetes mellitus, are known to influence the course of coronavirus disease 2019 (COVID-19). However, there is currently little information on genetic markers that influence the severity of ... ...

    Abstract Background and aims: Several factors, such as hypertension and diabetes mellitus, are known to influence the course of coronavirus disease 2019 (COVID-19). However, there is currently little information on genetic markers that influence the severity of COVID-19. In this study, we specifically investigated the single nucleotide polymorphism (SNP) rs4986790 in the
    Methods: We analyzed the influence of demographics, pre-existing conditions, inflammatory parameters at the time of hospitalization, and
    Results: We confirmed that younger patient age and absence of pre-existing conditions were protective factors against disease progression. Furthermore, when comparing patients with mild SARS-CoV-2 infection with patients who required hospitalization or intensive care or even died due to COVID-19, the AG/GG genotype of
    Conclusion: In this study, we identified an additional genetic factor that may serve as an invariant predictor of COVID-19 outcome. The
    MeSH term(s) Humans ; Protective Factors ; Toll-Like Receptor 4/genetics ; Interleukin-6/genetics ; Polymorphism, Single Nucleotide ; COVID-19/genetics ; SARS-CoV-2 ; Procalcitonin ; Disease Progression
    Chemical Substances Toll-Like Receptor 4 ; Interleukin-6 ; Procalcitonin ; TLR4 protein, human
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1355193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Institutional profile: Institute of Pharmacogenetics at the University Hospital Essen.

    Siffert, Winfried

    Pharmacogenomics

    2013  Volume 14, Issue 3, Page(s) 241–243

    Abstract: Established in 2005, the Institute of Pharmacogenetics at the University Hospital Essen (Essen, Germany), headed by Winfried Siffert, is devoted to the discovery and validation of genetic variants that may impact upon drug responses especially in the ... ...

    Abstract Established in 2005, the Institute of Pharmacogenetics at the University Hospital Essen (Essen, Germany), headed by Winfried Siffert, is devoted to the discovery and validation of genetic variants that may impact upon drug responses especially in the field of cardiovascular disorders and cancer. Moreover, the institute provides pharmacogenetic testing for those drugs for which pharmacogenetic testing is recommended in order to prevent adverse drug reactions.
    MeSH term(s) Aquaporin 5/genetics ; GTP-Binding Protein alpha Subunits/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11 ; Genes, bcl-2 ; Genome-Wide Association Study ; Heterotrimeric GTP-Binding Proteins/genetics ; Hospitals, University ; Humans ; Pharmacogenetics ; Polymorphism, Single Nucleotide
    Chemical Substances Aquaporin 5 ; G-protein beta3 subunit ; GNAQ protein, human ; GTP-Binding Protein alpha Subunits ; GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1) ; Heterotrimeric GTP-Binding Proteins (EC 3.6.5.1)
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs.12.212
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  3. Book ; Thesis: Aktivität und Isoenzymmuster der Carboanhydrase im Skelettmuskel des Kaninchens

    Siffert, Winfried

    1983  

    Author's details vorgelegt von Winfried Siffert
    Size 85 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Essen, Gesamthochsch., Diss., 1983
    HBZ-ID HT002118758
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    85 E 1540 order for loan Magazin

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  4. Article: Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in

    Čiučiulkaitė, Ieva / Siffert, Winfried / Elsner, Carina / Dittmer, Ulf / Wichert, Marc / Wagner, Bernd / Volbracht, Lothar / Mosel, Frank / Möhlendick, Birte

    Vaccines

    2023  Volume 11, Issue 7

    Abstract: The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination ...

    Abstract The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination with the COVID-19 vaccines are variable within a population. Host genetic factors probably contribute to this variability. In this study, we investigated the effect of the single-nucleotide polymorphisms rs12252 and rs34481144 in the
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11071257
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  5. Article ; Online: Single-Nucleotide Polymorphism in Genes Encoding G Protein Subunits

    Birkner, Simon / Möhlendick, Birte / Wilde, Benjamin / Schoenfelder, Kristina / Boss, Kristina / Siffert, Winfried / Kribben, Andreas / Friebus-Kardash, Justa

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Single-nucleotide polymorphisms in G protein subunits are linked to an increased risk of cardiovascular events among the general population. We assessed the effects ... ...

    Abstract Single-nucleotide polymorphisms in G protein subunits are linked to an increased risk of cardiovascular events among the general population. We assessed the effects of
    MeSH term(s) Humans ; Male ; Coronary Stenosis ; Genotype ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Heterotrimeric GTP-Binding Proteins/genetics ; Polymorphism, Single Nucleotide ; Protein Subunits/genetics ; Renal Dialysis/adverse effects ; Renal Replacement Therapy ; Female
    Chemical Substances GNAQ protein, human ; GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1) ; Heterotrimeric GTP-Binding Proteins (EC 3.6.5.1) ; Protein Subunits
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015260
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  6. Article: Characteristics and Long-Term Outcome of 535 Patients with Autoimmune Hepatitis-The 20-Year Experience of a High-Volume Tertiary Center.

    Buechter, Matthias / Dorn, Dominik / Möhlendick, Birte / Siffert, Winfried / Baba, Hideo A / Gerken, Guido / Kahraman, Alisan

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background and aims: ...

    Abstract Background and aims:
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134192
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  7. Article: Molecular genetics of G proteins and atherosclerosis risk.

    Siffert, W

    Basic research in cardiology

    2001  Volume 96, Issue 6, Page(s) 606–611

    Abstract: Using a classical candidate gene approach, we have described a common C825T polymorphism in the gene GNB3 which encodes the ubiquitously expressed beta3 subunit of heterotrimeric G proteins. The 825T allele is associated with alternative splicing of the ... ...

    Abstract Using a classical candidate gene approach, we have described a common C825T polymorphism in the gene GNB3 which encodes the ubiquitously expressed beta3 subunit of heterotrimeric G proteins. The 825T allele is associated with alternative splicing of the gene and the formation of a truncated but functionally active beta3 subunit which is referred to as Gbeta3s. Expression of the splice variant results in an enhanced G protein activation on stimulation of G protein-coupled receptors. Carriers of the 825T allele show an increased risk for hypertension and left ventricular hypertrophy. Homo- and heterozygous 825T allele carriers respond with a stronger decrease in blood pressure to therapy with a thiazide diuretic than homozygous 825C allele carriers. Moreover, 825T allele carriers appear to have an increased risk for obesity which appears sensible given the established role of G protein signaling in adipogenesis. The highest frequencies of the 825T allele are found in ethnicities with the highest lifestyle-dependent risk for obesity, e.g., black Africans and East Asians. This suggests that the 825T allele fulfills the criteria of a thrifty genotype.
    MeSH term(s) Arteriosclerosis/epidemiology ; Arteriosclerosis/genetics ; GTP-Binding Proteins/genetics ; Genetic Predisposition to Disease/epidemiology ; Humans ; Hypertension/epidemiology ; Hypertension/genetics ; Obesity/epidemiology ; Obesity/genetics ; Risk Factors
    Chemical Substances GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2001-09-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s003950170012
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    Ui IV Zs.30: Show issues Location:
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  8. Article ; Online: The

    Möhlendick, Birte / Schmid, Kurt W / Siffert, Winfried

    Pharmacogenomics

    2019  Volume 20, Issue 7, Page(s) 553–562

    Abstract: G-protein receptor signaling plays a key role in multiple signal transduction pathways. Aberrant activity of the stimulatory ... ...

    Abstract G-protein receptor signaling plays a key role in multiple signal transduction pathways. Aberrant activity of the stimulatory G
    MeSH term(s) Biomarkers, Tumor/genetics ; Chromogranins/genetics ; Disease Progression ; GTP-Binding Protein alpha Subunits, Gs/genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Polymorphism, Single Nucleotide/genetics ; Survival Analysis
    Chemical Substances Biomarkers, Tumor ; Chromogranins ; GNAS protein, human (EC 3.6.1.-) ; GTP-Binding Protein alpha Subunits, Gs (EC 3.6.5.1)
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2018-0199
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  9. Article: G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy.

    Siffert, W

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2000  Volume 15, Issue 9, Page(s) 1298–1306

    Abstract: The 825T allele of the gene GNB3 which encodes the beta 3 subunit of heterotrimeric G proteins is associated with enhanced signal transduction via G proteins through the generation of a splice variant termed Gbeta3s. It was detected following a classical ...

    Abstract The 825T allele of the gene GNB3 which encodes the beta 3 subunit of heterotrimeric G proteins is associated with enhanced signal transduction via G proteins through the generation of a splice variant termed Gbeta3s. It was detected following a classical candidate gene approach using cell lines from patients with enhanced signal transduction and essential hypertension. The high frequency of the 825T allele in 'old' ethnicities, e.g. bushmen and Australian aborigines as well as in black populations, together with its strong association with obesity suggests that the 825T allele is a true 'thrifty genotype'. Development of obesity associated with the 825T allele is strongly influenced by lifestyle, e.g. physical activity, and other exogenous influences like pregnancy. In hypertension the 825T allele is associated with low renin activity and appears to strongly predict the development of left ventricular hypertrophy. In type 2 diabetes the 825T allele was reported to be predispose for end-stage renal disease, whereas this effect has not yet been confirmed for patients with type 1 diabetes.
    MeSH term(s) Alleles ; Diabetic Nephropathies/genetics ; GTP-Binding Proteins/genetics ; Humans ; Hypertension/genetics ; Obesity/genetics
    Chemical Substances GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2000-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/15.9.1298
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    Zs.MO 329: Show issues

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  10. Article ; Online: Lack of association of common polymorphisms linked to empathic behavior with self-reported trait empathy in healthy volunteers.

    Huetter, Franz Korbinian / Moehlendick, Birte / Knop, Dietmar / Siffert, Winfried

    Hormones and behavior

    2020  Volume 126, Page(s) 104841

    Abstract: Background: In a previously specified sample of 421 healthy subjects, we found associations of a common oxytocin receptor (OXTR) polymorphism with self-reported trait empathy. In this study, we used this sample to explore polymorphisms in other genes ... ...

    Abstract Background: In a previously specified sample of 421 healthy subjects, we found associations of a common oxytocin receptor (OXTR) polymorphism with self-reported trait empathy. In this study, we used this sample to explore polymorphisms in other genes which have been frequently linked to empathic behavior for associations with self-reported trait empathy: CD38 (CD38), involved in oxytocin secretion, the serotonin transporter (SLC6A4), the Catechol-O-Methyltransferase (COMT) and the corticotropin releasing hormone receptor 1 (CRHR1).
    Methods: We genotyped our sample for the following common polymorphisms: rs3796863 in the CD38 gene, 5-HTTLPR in the SLC6A4 gene, rs4680 in the COMT gene and rs242924 in the CRHR1 gene. Dispositional empathy was tested using Davis' Interpersonal Reactivity Index (IRI). We used a Bonferroni corrected alpha level of p = 0.002 to adjust for multiple comparisons.
    Results: None of the genotypes were associated with any of the IRI scales for the complete sample (n = 421) or for the sub-groups of male (n = 213) and female (n = 190) participants. Our sample of 421 participants achieved 95% power to detect effects greater than r = ±0.18. For smaller effects, however, false negatives could not be rejected with equal confidence as false positives.
    Conclusions: We conclude that an association between the four polymorphisms with trait empathy measured by the IRI may not be present. We propose that the associations that have been found in other studies can be largely explained by differences in empathy-related constructs and measurements.
    MeSH term(s) ADP-ribosyl Cyclase 1/genetics ; Adolescent ; Adult ; Aged ; Catechol O-Methyltransferase/genetics ; Empathy/genetics ; Female ; Genetic Association Studies ; Genotype ; Healthy Volunteers ; Humans ; Interpersonal Relations ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Personality/genetics ; Phenotype ; Polymorphism, Single Nucleotide ; Quantitative Trait, Heritable ; Receptors, Corticotropin-Releasing Hormone/genetics ; Receptors, Oxytocin/genetics ; Self Report ; Serotonin Plasma Membrane Transport Proteins/genetics ; Social Skills ; Young Adult
    Chemical Substances Membrane Glycoproteins ; Receptors, Corticotropin-Releasing Hormone ; Receptors, Oxytocin ; SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins ; CRF receptor type 1 (5CLY6W2H1M) ; Catechol O-Methyltransferase (EC 2.1.1.6) ; CD38 protein, human (EC 3.2.2.5) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2020.104841
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