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  1. Article: Postcarotid Endarterectomy Hematoma Induced Arrhythmia: Report of a Rare Case.

    Galyfos, George / Chamzin, Alexandros / Sigala, Fragiska / Filis, Konstantinos

    Case reports in vascular medicine

    2023  Volume 2023, Page(s) 4633731

    Abstract: Postcarotid endarterectomy (CEA) hematomas are common although they are rarely threatening and necessitate reoperation. We aim to report a rare case of an expanding hematoma that caused a cardiac arrhythmia (bigeminy) which was reversed after hematoma ... ...

    Abstract Postcarotid endarterectomy (CEA) hematomas are common although they are rarely threatening and necessitate reoperation. We aim to report a rare case of an expanding hematoma that caused a cardiac arrhythmia (bigeminy) which was reversed after hematoma evacuation.
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2629916-1
    ISSN 2090-6994 ; 2090-6986
    ISSN (online) 2090-6994
    ISSN 2090-6986
    DOI 10.1155/2023/4633731
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  2. Article: Utilization of low-temperature helium plasma (J-Plasma) for dissection and hemostasis during carotid endarterectomy.

    Filis, Konstantinos / Galyfos, George / Sigala, Fragiska / Zografos, Georgios

    Journal of vascular surgery cases and innovative techniques

    2020  Volume 6, Issue 1, Page(s) 152–155

    Abstract: Herein we report nine cases of carotid endarterectomy in which we used a cold atmospheric helium plasma device (J-Plasma; Apyx Medical Corporation, Clearwater, Fla). Although clinical reports are limited, experimental data indicate that this technology ... ...

    Abstract Herein we report nine cases of carotid endarterectomy in which we used a cold atmospheric helium plasma device (J-Plasma; Apyx Medical Corporation, Clearwater, Fla). Although clinical reports are limited, experimental data indicate that this technology could be used for dissection and coagulation during surgery, yielding limited adjacent tissue damage. As a result, it could be extremely useful in procedures like carotid endarterectomy that necessitate careful dissection and coagulation with limited damage of adjacent neurovascular structures.
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Case Reports
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2020.01.008
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  3. Article ; Online: Accurate adventitia reconstruction; significant or not in atherosclerotic plaque growth simulationsƒ A comparative study.

    Pleouras, Dimitrios S / Siogkas, Panagiotis K / Tsakanikas, Vasilis D / Mantzaris, Michalis D / Potsika, Vassiliki T / Sakellarios, Antonis / Sigala, Fragiska / Fotiadis, Dimitrios I

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Volume 2023, Page(s) 1–4

    Abstract: A reform in the diagnosis and treatment process is urgently required as carotid artery disease remains a leading cause of death in the world. To this purpose, all computational techniques are now being applied to enhancing the most cutting-edge diagnosis ...

    Abstract A reform in the diagnosis and treatment process is urgently required as carotid artery disease remains a leading cause of death in the world. To this purpose, all computational techniques are now being applied to enhancing the most cutting-edge diagnosis techniques. Computational modeling of plaque generation and evolution is being refined over the past years to forecast the atherosclerotic progression and the corresponding risk in patient-specific carotid arteries. A prerequisite to their implementation is the reconstruction of the precise three-dimensional models of patient-specific main carotid arteries. Even with the most sophisticated algorithms, accurate reconstruction of the arterial vessel is frequently difficult. Furthermore, there are several works of plaque growth modeling that ignore the reconstruction of the artery's outer layer in favor of a virtual one. In this paper, we investigate the importance of an accurate adventitia layer in plaque growth modeling. This is done as a comparative study by implementing a novel plaque growth model in two reconstructed carotid arterial segments using either their realistic or virtual adventitia layer as input. The results indicate that accurate adventitia reconstruction is of minor importance regarding species distributions and plaque growth in carotid segments, which initially did not contain any plaque regions.Clinical Relevance- The findings of this comparative study emphasize the importance of precise adventitia geometry in plaque growth modeling. As a result, this work sets a higher standard for publishing new plaque growth models.
    MeSH term(s) Humans ; Plaque, Atherosclerotic/diagnosis ; Adventitia ; Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases/diagnostic imaging ; Computer Simulation
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340557
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  4. Article ; Online: Weekend effect among patients undergoing elective vascular surgery.

    Galyfos, George / Sigala, Fragiska / Bazigos, Gerasimos / Filis, Konstantinos

    Journal of vascular surgery

    2019  Volume 70, Issue 6, Page(s) 2038–2045

    Abstract: Objective: Several studies have described a higher mortality among patients admitted or operated during the weekend for various diseases. However, pooled data on patients undergoing elective vascular surgery procedures are sparse.: Methods: The ... ...

    Abstract Objective: Several studies have described a higher mortality among patients admitted or operated during the weekend for various diseases. However, pooled data on patients undergoing elective vascular surgery procedures are sparse.
    Methods: The PubMed, Embase, Scopus, and Cochrane Library databases were systematically searched to identify eligible studies. Studies comparing short-term mortality (≤30 days) between patients undergoing elective vascular surgery during the weekend and working days were included. When studies included patients undergoing mixed types of surgery, only the vascular surgery subgroups were evaluated. Urgent/emergency vascular procedures were excluded according to certain definitions provided by each study. Data were analyzed by using the StatsDirect Statistical software (Version 2.8.0, StatsDirect Ltd, Cambridge, UK).
    Results: Overall, four retrospective studies including 131,201 patients undergoing elective vascular surgery (on working days, n = 130,163; on the weekend, n = 1038) were evaluated. The pooled short-term mortality risk was higher among patients operated during the weekend compared with working days (odds ratio [OR], 2.41; 95% confidence interval [CI], 1.58-3.67; P = .0004). This weekend effect was more evident among patients undergoing abdominal aortic aneurysm repair and carotid surgery (OR, 3.62 [95% CI, 1.49-8.82; P = .0046] and OR, 3.48 [95% CI, 1.15-10.54; P = .027], respectively). In the United States, the weekend effect was more evident among patients undergoing aortic aneurysm repair (OR, 3.61; 95% CI, 1.99-6.53; P < .0001). However, data from Canada originated from one study on patients undergoing carotid and peripheral arterial surgery only.
    Conclusions: Elective vascular surgery is associated with a higher short-term mortality risk when conducted over the weekend. Improvement of perioperative management during these days may be necessary to improve outcomes.
    MeSH term(s) After-Hours Care/statistics & numerical data ; Elective Surgical Procedures/mortality ; Hospital Mortality ; Humans ; Postoperative Complications/mortality ; Vascular Surgical Procedures/mortality
    Language English
    Publishing date 2019-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2019.03.020
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  5. Article ; Online: Regarding "Outcomes after elective abdominal aortic aneurysm repair in obese versus nonobese patients".

    Galyfos, George / Sigala, Fragiska / Filis, Konstantinos

    Journal of vascular surgery

    2019  Volume 69, Issue 6, Page(s) 2008

    MeSH term(s) Aortic Aneurysm, Abdominal/surgery ; Elective Surgical Procedures ; Endovascular Procedures ; Humans ; Obesity
    Language English
    Publishing date 2019-11-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2018.12.053
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  6. Article ; Online: Letter by Galyfos et al Regarding Article, "Weekend Effect in Carotid Endarterectomy".

    Galyfos, George / Sigala, Fragiska / Filis, Konstantinos

    Stroke

    2019  Volume 50, Issue 4, Page(s) e110

    MeSH term(s) Carotid Stenosis ; Endarterectomy, Carotid ; Humans ; Stents
    Language English
    Publishing date 2019-03-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.024303
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  7. Article ; Online: Re: "Editor's Choice - Cerebral Hyperperfusion Syndrome after Carotid Artery Stenting: A Systematic Review and Meta-analysis".

    Galyfos, George / Sigala, Fragiska / Filis, Konstantinos

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2019  Volume 57, Issue 6, Page(s) 892

    MeSH term(s) Carotid Arteries ; Carotid Artery, Common ; Stents
    Language English
    Publishing date 2019-02-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2018.11.022
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    Zs.A 2283: Show issues Location:
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  8. Article ; Online: Regarding "The effect of preoperative cognitive impairment and type of vascular surgery procedure on postoperative delirium with associated cost implications".

    Galyfos, George / Sigala, Fragiska / Filis, Konstantinos

    Journal of vascular surgery

    2018  Volume 68, Issue 5, Page(s) 1615–1616

    MeSH term(s) Cognitive Dysfunction ; Delirium ; Humans ; Vascular Surgical Procedures
    Language English
    Publishing date 2018-11-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2018.07.032
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  9. Article ; Online: Rivaroxaban Plus Aspirin After CABG: More Evidence Is Needed.

    Tsilimigras, Diamantis I / Sigala, Fragiska / Kontogiannis, Christos / Moris, Dimitrios

    Journal of the American College of Cardiology

    2019  Volume 73, Issue 18, Page(s) 2359–2360

    MeSH term(s) Aspirin ; Coronary Artery Bypass ; Factor Xa Inhibitors ; Platelet Aggregation Inhibitors ; Rivaroxaban
    Chemical Substances Factor Xa Inhibitors ; Platelet Aggregation Inhibitors ; Rivaroxaban (9NDF7JZ4M3) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-04-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.01.075
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    Zs.MO 196: Show issues

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  10. Article ; Online: Enhancing risk prediction capabilities in patients with carotid artery disease using a 2-level computational approach.

    Siogkas, Panagiotis K / Pleouras, Dimitrios S / Tsakanikas, Vasilis D / Mantzaris, Michalis D / Potsika, Vassiliki T / Sakellarios, Antonis / Charalampopoulos, George / Galyfos, George / Sigala, Fragiska / Fotiadis, Dimitrios I

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Volume 2023, Page(s) 1–4

    Abstract: One of the main causes of death worldwide is carotid artery disease, which causes increasing arterial stenosis and may induce a stroke. To address this problem, the scientific community aims to improve our understanding of the underlying atherosclerotic ... ...

    Abstract One of the main causes of death worldwide is carotid artery disease, which causes increasing arterial stenosis and may induce a stroke. To address this problem, the scientific community aims to improve our understanding of the underlying atherosclerotic mechanisms, as well as to make it possible to forecast the progression of atherosclerosis. Additionally, over the past several years, developments in the field of cardiovascular modeling have made it possible to create precise three-dimensional models of patient-specific main carotid arteries. The aforementioned 3D models are then implemented by computational models to forecast either the progression of atherosclerotic plaque or several flow-related metrics which are correlated to risk evaluation. A precise representation of both the blood flow and the fundamental atherosclerotic process within the arterial wall is made possible by computational models, therefore, allowing for the prediction of future lumen stenoses, plaque areas and risk prediction. This work presents an attempt to integrate the outcomes of a novel plaque growth model with advanced blood flow dynamics where the deformed luminal shape derived from the plaque growth model is compared to the actual patient-specific luminal model in terms of several hemodynamic metrics, to identify the prediction accuracy of the aforementioned model. Pressure drop ratios had a mean difference of <3%, whereas OSI-derived metrics were identical in 2/3 cases.Clinical Relevance-This establishes the accuracy of our plaque growth model in predicting the arterial geometry after the desired timeline.
    MeSH term(s) Humans ; Carotid Artery Diseases/diagnosis ; Carotid Arteries ; Plaque, Atherosclerotic ; Stroke ; Hemodynamics ; Atherosclerosis
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340085
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