LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Book ; Thesis: Staging von Kopf-Hals-Tumoren

    Sigg, Martin Bea

    die Positronen-Emissions-Tomographie im retrospektiven Vergleich mit konventionellen Untersuchungsmethoden

    2002  

    Author's details vorgelegt von Martin Bea Sigg
    Language German
    Size 71 ,VIII S. : Ill., graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 2002
    HBZ-ID HT013644695
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 E 1511 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Thesis: Currarino-Triade

    Sigg, Martin Alexander

    eine Analyse von 16 eigenen Fällen mit Übersicht der Literatur

    1996  

    Author's details vorgelegt von Martin Alexander Sigg
    Language German
    Size 85 Bl. : Ill.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1996
    HBZ-ID HT007554171
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    97 E 1164 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Thesis: WITTERUNG UND INTERNMEDIZINISCHE ERKRANKUNGEN

    Sigg, Martin

    1979  

    Author's details VON MARTIN SIGG
    Size 21, (14) S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis ZUERICH, UNIV., MED. FAK., DISS., 1979
    HBZ-ID HT000374477
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    80 D 1866 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.

    Buckley, Peter T / Chan, Rita / Fernandez, Jeffrey / Luo, Jinquan / Lacey, Keenan A / DuMont, Ashley L / O'Malley, Aidan / Brezski, Randall J / Zheng, Songmao / Malia, Thomas / Whitaker, Brian / Zwolak, Adam / Payne, Angela / Clark, Desmond / Sigg, Martin / Lacy, Eilyn R / Kornilova, Anna / Kwok, Debra / McCarthy, Steve /
    Wu, Bingyuan / Morrow, Brian / Nemeth-Seay, Jennifer / Petley, Ted / Wu, Sam / Strohl, William R / Lynch, Anthony Simon / Torres, Victor J

    Cell host & microbe

    2023  Volume 31, Issue 5, Page(s) 751–765.e11

    Abstract: Treating and preventing infections by antimicrobial-resistant bacterial pathogens is a worldwide problem. Pathogens such as Staphylococcus aureus produce an array of virulence determinants, making it difficult to identify single targets for the ... ...

    Abstract Treating and preventing infections by antimicrobial-resistant bacterial pathogens is a worldwide problem. Pathogens such as Staphylococcus aureus produce an array of virulence determinants, making it difficult to identify single targets for the development of vaccines or monoclonal therapies. We described a human-derived anti-S. aureus monoclonal antibody (mAb)-centyrin fusion protein ("mAbtyrin") that simultaneously targets multiple bacterial adhesins, resists proteolysis by bacterial protease GluV8, avoids Fc engagement by S. aureus IgG-binding proteins SpA and Sbi, and neutralizes pore-forming leukocidins via fusion with anti-toxin centyrins, while maintaining Fc- and complement-mediated functions. Compared with the parental mAb, mAbtyrin protected human phagocytes and boosted phagocyte-mediated killing. The mAbtyrin also reduced pathology, reduced bacterial burden, and protected from different types of infections in preclinical animal models. Finally, mAbtyrin synergized with vancomycin, enhancing pathogen clearance in an animal model of bacteremia. Altogether, these data establish the potential of multivalent mAbs for treating and preventing S. aureus diseases.
    MeSH term(s) Animals ; Humans ; Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/prevention & control ; Staphylococcal Infections/microbiology ; Antibodies, Monoclonal/therapeutic use ; Phagocytes/metabolism ; Leukocidins/metabolism ; Leukocidins/therapeutic use ; Methicillin-Resistant Staphylococcus aureus
    Chemical Substances Antibodies, Monoclonal ; Leukocidins
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons.

    Muroi, Yukiko / Ru, Fei / Kollarik, Marian / Canning, Brendan J / Hughes, Stephen A / Walsh, Stacey / Sigg, Martin / Carr, Michael J / Undem, Bradley J

    The Journal of physiology

    2011  Volume 589, Issue Pt 23, Page(s) 5663–5676

    Abstract: There has been much information learned in recent years about voltage gated sodium channel (Na(V)) subtypes in somatosensory pain signalling, but much less is known about the role of specific sodium channel subtypes in the vagal sensory system. In this ... ...

    Abstract There has been much information learned in recent years about voltage gated sodium channel (Na(V)) subtypes in somatosensory pain signalling, but much less is known about the role of specific sodium channel subtypes in the vagal sensory system. In this study, we developed a technique using adeno-associated viruses (AAVs) to directly introduce shRNA against Na(V)1.7 subtype gene into the vagal sensory ganglia of guinea pigs in vivo. Na(V)1.7 gene expression in nodose ganglia was effectively and selectively reduced without influencing the expression of other sodium channel subtype genes including Na(V)1.1, 1.2, 1.3 1.6, 1.8, or 1.9. Using a whole cell patch-clamp technique, this effect on Na(V)1.7 gene expression coincided with a reduction in tetrodotoxin-sensitive sodium current, a requirement for much larger depolarizing stimulus to initiate action potentials, and reduction in repetitive action potential discharge. Extracellular recordings in the isolated vagus nerve revealed that the conduction of action potentials in sensory A- and C-fibres in many neurons was effectively abolished after Na(V)1.7 shRNA introduction. Moreover, bilateral Na(V)1.7 shRNA injected animals survived for several months and the vagal reflex behaviour, exemplified by citric acid-induced coughing, was significantly suppressed. These data indicate that selectively silencing Na(V)1.7 ion channel expression leads to a substantial decrease in neural excitability and conduction block in vagal afferent nerves.
    MeSH term(s) Action Potentials/drug effects ; Animals ; Citric Acid ; Cough/chemically induced ; Cough/physiopathology ; Dependovirus/genetics ; Green Fluorescent Proteins/genetics ; Guinea Pigs ; Male ; Neurons, Afferent/physiology ; Nodose Ganglion/physiology ; Patch-Clamp Techniques ; RNA, Small Interfering/genetics ; Sensory Receptor Cells/physiology ; Sodium Channel Blockers/pharmacology ; Sodium Channels/genetics ; Sodium Channels/physiology ; Tetrodotoxin/pharmacology ; Transduction, Genetic
    Chemical Substances RNA, Small Interfering ; Sodium Channel Blockers ; Sodium Channels ; Green Fluorescent Proteins (147336-22-9) ; Citric Acid (2968PHW8QP) ; Tetrodotoxin (4368-28-9)
    Language English
    Publishing date 2011-10-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2011.215384
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Thesis: Witterung und internmedizinische Erkrankungen

    Sigg, Martin

    1979  

    Author's details Martin Sigg
    Language Undetermined
    Size 35 S
    Publishing place Zürich
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Zürich, Univ., Diss. : 1979
    Database Former special subject collection: coastal and deep sea fishing

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Staging of head and neck tumors: [18F]fluorodeoxyglucose positron emission tomography compared with physical examination and conventional imaging modalities.

    Sigg, Martin Beat / Steinert, Hans / Grätz, Klaus / Hugenin, Pia / Stoeckli, Sandro / Eyrich, Gerold Klaus

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2002  Volume 61, Issue 9, Page(s) 1022–1029

    Abstract: Purpose: The aims of this study were to evaluate the use of [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) in the staging of primary and recurrent tumors of the head and neck in comparison to routine clinical methods (physical ... ...

    Abstract Purpose: The aims of this study were to evaluate the use of [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) in the staging of primary and recurrent tumors of the head and neck in comparison to routine clinical methods (physical examination, ultrasonography, computed tomography) and to investigate the effect of FDG-PET scanning on therapeutic strategy.
    Materials and methods: Retrospective analysis of the results of FDG-PET and conventional diagnostic modalities were compared with biopsy results or patient outcome or both. In a period of 6 years, 78 FDG-PET studies were performed on 56 patients; 24 of them before therapy and 54 on suspicion of residual or recurrent tumor. The evaluation of the diagnostic results was performed separately for the primary site and the nodal sites of the neck and for tumor occurrence in the trunk.
    Results: In detecting the primary site, FDG-PET results reached a sensitivity of 93%, a specificity of 100%, and an accuracy of 94%. In detecting the nodal sites, similar results of 94%, 97%, and 96% were seen, respectively. In detecting tumor occurrence in the trunk, results were 83%, 100%, and 98%, respectively. The McNemar test did not prove any statistically significant difference between FDG-PET and the evaluated conventional methods. When used in conjunction with conventional diagnostic tests, 22% of the PET scans gave important additional information. Finally, 11% of the performed PET scans led to a change in therapeutic planning.
    Conclusions: Our results show that FDG-PET is a reliable method to detect tumors in all tumor sites. Therefore, we recommend that FDG-PET scanning be performed routinely as a first diagnostic step in pretherapeutic staging of patients with biopsy-proven head and neck cancer.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Chi-Square Distribution ; Female ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/pathology ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/secondary ; Lymph Nodes/diagnostic imaging ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Radiopharmaceuticals ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, Emission-Computed
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2002-09-04
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/s0278-2391(03)00314-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.113: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Functional and binding studies of HS3.2 of the beta-globin locus control region.

    Molete, Joseph M / Petrykowska, Hanna / Sigg, Martin / Miller, Webb / Hardison, Ross

    Gene

    2002  Volume 283, Issue 1-2, Page(s) 185–197

    Abstract: The distal locus control region (LCR) is required for high-level expression of the complex of genes (HBBC) encoding the beta-like globins of mammals in erythroid cells. Several major DNase hypersensitive sites (HSs 1-5) mark the LCR. Sequence ... ...

    Abstract The distal locus control region (LCR) is required for high-level expression of the complex of genes (HBBC) encoding the beta-like globins of mammals in erythroid cells. Several major DNase hypersensitive sites (HSs 1-5) mark the LCR. Sequence conservation and direct experimental evidence have implicated sequences within and between the HS cores in function of the LCR. In this report we confirm the mapping of a minor HS between HS3 and HS4, called HS3.2, and show that sequences including it increase the number of random integration sites at which a drug resistance gene is expressed. We also show that nuclear proteins including GATA1 and Oct1 bind specifically to sequences within HS3.2. However, the protein Pbx1, whose binding site is the best match to one highly conserved sequence, does not bind strongly. GATA1 and Oct1 also bind in the HS cores of the LCR and to promoters in HBBC. Their binding to this minor HS suggests that they may be used in assembly of a large complex containing multiple regulatory sequences.
    MeSH term(s) Base Sequence ; Binding Sites/genetics ; Conserved Sequence/genetics ; DNA/genetics ; DNA/metabolism ; DNA-Binding Proteins/metabolism ; Deoxyribonucleases/metabolism ; Electrophoretic Mobility Shift Assay ; Erythroid-Specific DNA-Binding Factors ; GATA1 Transcription Factor ; Globins/genetics ; Globins/metabolism ; Humans ; K562 Cells ; Locus Control Region/genetics ; Molecular Sequence Data ; Organic Cation Transporter 1/metabolism ; Protein Binding ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Transcription Factors/metabolism
    Chemical Substances DNA-Binding Proteins ; Erythroid-Specific DNA-Binding Factors ; GATA1 Transcription Factor ; GATA1 protein, human ; Organic Cation Transporter 1 ; Transcription Factors ; Globins (9004-22-2) ; DNA (9007-49-2) ; Deoxyribonucleases (EC 3.1.-)
    Language English
    Publishing date 2002-01-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/s0378-1119(01)00858-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top