Article ; Online: Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures.
Environmental health : a global access science source
2019 Volume 18, Issue 1, Page(s) 114
Abstract: Background: Basal cell carcinoma of the skin (BCC) is the most common cancer in populations of European ancestry. Although consistently linked with basal cell carcinoma of the skin in case-control studies, few prospective cohort studies have evaluated ... ...
Abstract | Background: Basal cell carcinoma of the skin (BCC) is the most common cancer in populations of European ancestry. Although consistently linked with basal cell carcinoma of the skin in case-control studies, few prospective cohort studies have evaluated the shape of the exposure-response of basal cell carcinoma associated with cumulative radiant solar ultraviolet exposure (UVR). Methods: We followed 63,912 white cancer-free US radiologic technologists from entry (1983-1998) to exit (2003-2005) with known ultraviolet irradiance at up to 5 residential locations. Using generalized-additive and relative risk models we analyzed the exposure-response of basal cell carcinomas associated with ambient cumulative ultraviolet radiant exposure using ground-based National Solar Radiation database Average Daily Total Global data and satellite-based National Aeronautics and Space Administration Total Ozone Mapping Spectrometer data. Results: There were 2151 technologists with an incident primary basal cell carcinoma. Risk of basal cell carcinoma rose with increasing cumulative ultraviolet radiation exposure using both measures, such that 1 MJ cm Conclusions: We observed increases in risk of basal cell carcinoma and a similar exposure-response for ground-based and satellite ultraviolet radiation measures. Our observations suggest that interventions should concentrate on persons with higher levels of ultraviolet radiation exposure. |
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MeSH term(s) | Adolescent ; Adult ; Aged ; Carcinoma, Basal Cell/epidemiology ; Carcinoma, Basal Cell/etiology ; Child ; Environmental Exposure/adverse effects ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Sunlight ; Ultraviolet Rays/adverse effects ; United States/epidemiology ; Young Adult |
Language | English |
Publishing date | 2019-12-27 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 1476-069X |
ISSN (online) | 1476-069X |
DOI | 10.1186/s12940-019-0536-9 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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