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  1. AU="Sijing Wu"
  2. AU="Rus, Mircea"
  3. AU="Yanqin Yang"
  4. AU="von Paris, Philip"
  5. AU=Tanaka K
  6. AU="Olesen, Jes"
  7. AU="Liao, Walter"
  8. AU="Lindfeldt, Isis"
  9. AU="A Bataineh, Ziad"

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  1. Artikel ; Online: Modeling di (2-ethylhexyl) Phthalate (DEHP) and Its Metabolism in a Body’s Organs and Tissues through Different Intake Pathways into Human Body

    Ao Li / Lingyi Kang / Runjie Li / Sijing Wu / Ke Liu / Xinke Wang

    International Journal of Environmental Research and Public Health, Vol 19, Iss 5742, p

    2022  Band 5742

    Abstract: Phthalate esters (PAEs) are ubiquitous in indoor environments as plasticizers in indoor products. Residences are often exposed to indoor PAEs in the form of gas, particles, settled dust, and surface phases. To reveal the mechanism behind the accumulation ...

    Abstract Phthalate esters (PAEs) are ubiquitous in indoor environments as plasticizers in indoor products. Residences are often exposed to indoor PAEs in the form of gas, particles, settled dust, and surface phases. To reveal the mechanism behind the accumulation of PAEs in different tissues or organs such as the liver and the lungs when a person exposed to indoor PAEs with different phases, a whole-body physiologically based pharmacokinetic model for PAEs is employed to characterize the dynamic process of phthalates by different intake pathways, including oral digestion, dermal adsorption, and inhalation. Among three different intake pathways, dermal penetration distributed the greatest accumulation of DEHP in most of the organs, while the accumulative concentration through oral ingestion was an order of magnitude lower than the other two doses. Based on the estimated parameters, the variation of di-ethylhexyl phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) concentration in the venous blood, urine, the liver, the thymus, the pancreas, the spleen, the lungs, the brain, the heart, and the kidney for different intake scenarios was simulated. The simulated results showed a different accumulation profile of DEHP and MEHP in different organs and tissues and demonstrated that the different intake pathways will result in different accumulation distributions of DEHP and MEHP in organs and tissues and may lead to different detrimental health outcomes.
    Schlagwörter exposure ; indoor ; metabolism ; PBPK model ; phthalate esters ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Commingled Division of Visual Attention.

    Yuechuan Sun / Sijing Wu / Ian Spence

    PLoS ONE, Vol 10, Iss 6, p e

    2015  Band 0130611

    Abstract: Many critical activities require visual attention to be distributed simultaneously among distinct tasks where the attended foci are not spatially separated. In our two experiments, participants performed a large number of trials where both a primary task ...

    Abstract Many critical activities require visual attention to be distributed simultaneously among distinct tasks where the attended foci are not spatially separated. In our two experiments, participants performed a large number of trials where both a primary task (enumeration of spots) and a secondary task (reporting the presence/absence or identity of a distinctive shape) required the division of visual attention. The spots and the shape were commingled spatially and the shape appeared unpredictably on a relatively small fraction of the trials. The secondary task stimulus (the shape) was reported in inverse proportion to the attentional load imposed by the primary task (enumeration of spots). When the shape did appear, performance on the primary task (enumeration) suffered relative to when the shape was absent; both speed and accuracy were compromised. When the secondary task required identification in addition to detection, reaction times increased by about 200 percent. These results are broadly compatible with biased competition models of perceptual processing. An important area of application, where the commingled division of visual attention is required, is the augmented reality head-up display (AR-HUD). This innovation has the potential to make operating vehicles safer but our data suggest that there are significant concerns regarding driver distraction.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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