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  1. Article ; Online: Select sequencing of clonally expanded CD8

    Huang, Huang / Sikora, Michael J / Islam, Saiful / Chowdhury, Roshni Roy / Chien, Yueh-Hsiu / Scriba, Thomas J / Davis, Mark M / Steinmetz, Lars M

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 18, Page(s) 8995–9001

    Abstract: To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen-MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell ... ...

    Abstract To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen-MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell clonality, we have developed a method that allows selection of rare cells, based on RNA expression, before in-depth scRNA-seq (named SELECT-seq). We applied SELECT-seq to collect both TCR sequences and then transcriptomes from single cells of peripheral blood lymphocytes activated by a
    MeSH term(s) Antigens/metabolism ; Base Sequence/genetics ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Clonal Selection, Antigen-Mediated/physiology ; Cytokines/metabolism ; Humans ; Lymphocyte Activation/genetics ; Lymphocyte Activation/physiology ; Mucosal-Associated Invariant T Cells/immunology ; Natural Killer T-Cells/immunology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/isolation & purification ; Sequence Analysis ; Sequence Analysis, RNA/methods
    Chemical Substances Antigens ; Cytokines ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1902649116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  2. Article: Modeling the contrasting Neolithic male lineage expansions in Europe and Africa.

    Sikora, Michael J / Colonna, Vincenza / Xue, Yali / Tyler-Smith, Chris

    Investigative genetics

    2013  Volume 4, Issue 1, Page(s) 25

    Abstract: Background: Patterns of genetic variation in a population carry information about the prehistory of the population, and for the human Y chromosome an especially informative phylogenetic tree has previously been constructed from fully-sequenced ... ...

    Abstract Background: Patterns of genetic variation in a population carry information about the prehistory of the population, and for the human Y chromosome an especially informative phylogenetic tree has previously been constructed from fully-sequenced chromosomes. This revealed contrasting bifurcating and starlike phylogenies for the major lineages associated with the Neolithic expansions in sub-Saharan Africa and Western Europe, respectively.
    Results: We used coalescent simulations to investigate the range of demographic models most likely to produce the phylogenetic structures observed in Africa and Europe, assessing the starting and ending genetic effective population sizes, duration of the expansion, and time when expansion ended. The best-fitting models in Africa and Europe are very different. In Africa, the expansion took about 12 thousand years, ending very recently; it started from approximately 40 men and numbers expanded approximately 50-fold. In Europe, the expansion was much more rapid, taking only a few generations and occurring as soon as the major R1b lineage entered Europe; it started from just one to three men, whose numbers expanded more than a thousandfold.
    Conclusions: Although highly simplified, the demographic model we have used captures key elements of the differences between the male Neolithic expansions in Africa and Europe, and is consistent with archaeological findings.
    Language English
    Publishing date 2013-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2572461-7
    ISSN 2041-2223
    ISSN 2041-2223
    DOI 10.1186/2041-2223-4-25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Opposing T cell responses in experimental autoimmune encephalomyelitis.

    Saligrama, Naresha / Zhao, Fan / Sikora, Michael J / Serratelli, William S / Fernandes, Ricardo A / Louis, David M / Yao, Winnie / Ji, Xuhuai / Idoyaga, Juliana / Mahajan, Vinit B / Steinmetz, Lars M / Chien, Yueh-Hsiu / Hauser, Stephen L / Oksenberg, Jorge R / Garcia, K Christopher / Davis, Mark M

    Nature

    2019  Volume 572, Issue 7770, Page(s) 481–487

    Abstract: Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded ... ...

    Abstract Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4
    MeSH term(s) Adult ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Celiac Disease ; Clone Cells/cytology ; Clone Cells/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; H-2 Antigens/immunology ; Humans ; Immunization ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Myelin-Associated Glycoprotein/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; Young Adult
    Chemical Substances H-2 Antigens ; Myelin-Associated Glycoprotein ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2019-08-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-019-1467-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  4. Article: Human KIR

    Li, Jing / Zaslavsky, Maxim / Su, Yapeng / Sikora, Michael J / van Unen, Vincent / Christophersen, Asbjørn / Chiou, Shin-Heng / Chen, Liang / Li, Jiefu / Ji, Xuhuai / Wilhelmy, Julie / McSween, Alana M / Palanski, Brad A / Aditya Mallajosyula, Venkata Vamsee / Dhondalay, Gopal Krishna R / Bhamidipati, Kartik / Pai, Joy / Kipp, Lucas B / Dunn, Jeffrey E /
    Hauser, Stephen L / Oksenberg, Jorge R / Satpathy, Ansuman T / Robinson, William H / Steinmetz, Lars M / Khosla, Chaitan / Utz, Paul J / Sollid, Ludvig M / Heath, James R / Fernandez-Becker, Nielsen Q / Nadeau, Kari C / Saligrama, Naresha / Davis, Mark M

    bioRxiv : the preprint server for biology

    2021  

    Abstract: Previous reports show that Ly49 : One-sentence summary: Here we identified ... ...

    Abstract Previous reports show that Ly49
    One-sentence summary: Here we identified KIR
    Language English
    Publishing date 2021-12-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.12.23.473930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: KIR

    Li, Jing / Zaslavsky, Maxim / Su, Yapeng / Guo, Jing / Sikora, Michael J / van Unen, Vincent / Christophersen, Asbjørn / Chiou, Shin-Heng / Chen, Liang / Li, Jiefu / Ji, Xuhuai / Wilhelmy, Julie / McSween, Alana M / Palanski, Brad A / Mallajosyula, Venkata Vamsee Aditya / Bracey, Nathan A / Dhondalay, Gopal Krishna R / Bhamidipati, Kartik / Pai, Joy /
    Kipp, Lucas B / Dunn, Jeffrey E / Hauser, Stephen L / Oksenberg, Jorge R / Satpathy, Ansuman T / Robinson, William H / Dekker, Cornelia L / Steinmetz, Lars M / Khosla, Chaitan / Utz, Paul J / Sollid, Ludvig M / Chien, Yueh-Hsiu / Heath, James R / Fernandez-Becker, Nielsen Q / Nadeau, Kari C / Saligrama, Naresha / Davis, Mark M

    Science (New York, N.Y.)

    2022  Volume 376, Issue 6590, Page(s) eabi9591

    Abstract: In this work, we find that ... ...

    Abstract In this work, we find that CD8
    MeSH term(s) Animals ; Autoimmune Diseases ; CD8-Positive T-Lymphocytes ; COVID-19 ; Humans ; Mice ; Receptors, KIR ; T-Lymphocytes, Regulatory
    Chemical Substances Receptors, KIR
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abi9591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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