Article: Assessment of toxicity and genotoxic safety profile of novel fisetin ruthenium-p-cymene complex in mice.
2022 Volume 39, Issue 2, Page(s) 213–229
Abstract: Throughout the last decades flavonoids have been considered as a powerful bioactive molecule. Complexation of these flavonoids with metal ions demonstrated the genesis of unique organometallic complexes which provide improved pharmacological and ... ...
| Abstract | Throughout the last decades flavonoids have been considered as a powerful bioactive molecule. Complexation of these flavonoids with metal ions demonstrated the genesis of unique organometallic complexes which provide improved pharmacological and therapeutic activities. In this research, the fisetin ruthenium-p-cymene complex was synthesized and characterized via different analytical methods like UV-visible spectroscopy, Fourier-transform infrared spectroscopy, mass spectroscopy, and scanning electron microscope. The toxicological profile of the complex was evaluated by acute and sub-acute toxicity. Additionally, the mutagenic and genotoxic activity of the complex was assessed by Ames test, chromosomal aberration test, and micronucleus based assay in Swiss albino mice. The acute oral toxicity study exhibited the LD |
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| Language | English |
| Publishing date | 2022-12-12 |
| Publishing country | Singapore |
| Document type | Journal Article |
| ZDB-ID | 2727978-9 |
| ISSN | 2234-2753 ; 1976-8257 |
| ISSN (online) | 2234-2753 |
| ISSN | 1976-8257 |
| DOI | 10.1007/s43188-022-00158-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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