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  1. AU="Sillano, V"
  2. AU=Das Amiya AU=Das Amiya
  3. AU="Almadi, Faris Soloman"
  4. AU="Veloso, Carlos E"
  5. AU=Oderda Marco
  6. AU="J Peacock, Sharon"
  7. AU="Aravena, Carlos"
  8. AU="Sharma, Disha"
  9. AU="Aspan, Anna"
  10. AU="Zhang, Dongheyu"
  11. AU="Dossena, Matteo"
  12. AU="Caron, Nicholas"
  13. AU="Mimura, Naoki"
  14. AU="Warren, Sarah H"
  15. AU="David J. Abson" AU="David J. Abson"
  16. AU="Kataoka K."
  17. AU="Vernon, Madeleine A"
  18. AU=Thomas Simon H L
  19. AU="Siegel, Sonja"
  20. AU="Alghanemi, Ryan"
  21. AU="Jacomet, Christine"
  22. AU="Jowett, Nate"
  23. AU="Macrae, Rhiannon K"
  24. AU="Canha, Lauren"
  25. AU="Cynthia Strout"
  26. AU="Li, Yan-Xia"
  27. AU="Carsten Schmidt-Weber"
  28. AU="Song, Hui rong"
  29. AU="Ihuegbu, Nnamdi"
  30. AU="Berger, Jacob"
  31. AU="Shea, Martin J"
  32. AU="Vecchié, Alessandra"

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  1. Artikel: Effects of sublingual immunotherapy in patients sensitised to Ambrosia. An open controlled study.

    Valle, C / Bazzi, S / Berra, D / Sillano, V / Puccinelli, P / Parmiani, S

    Allergologia et immunopathologia

    2000  Band 28, Heft 6, Seite(n) 311–317

    Abstract: Background: Allergy to Ambrosia is a disease of growing importance in Europe. Injective and non-injective immunotherapy have been recognised as safe and effective but no evidence is currently available for sublingual immunotherapy (SLIT) in patients ... ...

    Abstract Background: Allergy to Ambrosia is a disease of growing importance in Europe. Injective and non-injective immunotherapy have been recognised as safe and effective but no evidence is currently available for sublingual immunotherapy (SLIT) in patients sensitised to Ambrosia. This study was planned to assess the effects and the safety of SLIT in patients clinically sensitised to Ambrosia.
    Methods: 19 patients clinically sensitised to Ambrosia and treated with SLIT were compared to 14 patients treated only with drugs. Diary cards with symptoms and drug consumption were filled-in by patients during the pollen season whereas specific nasal challenge and skin prick test were run two months before and after the pollen season. Patients and doctors were also asked to express their subjective assessment about symptoms and drug consumption during the season.
    Results: SLIT-treated patients had less symptoms and a significantly minor drug intake (p = 0.04) as compared to untreated patients. Nasal challenge test improved significantly in the SLIT group (p = 0.0001) but not in the control group (p = 0.6875) with a significant difference between groups at the end (p = 0.0413) but not at the beginning of the trial (p = 0.213). The decrease in skin reactivity was significant in the control group (p = 0.0186) and highly significant in the SLIT group (p < 0.0001), with no difference between groups (p = 0.2987). Subjective assessment from both patients and doctors was favorable to SLIT (p = 0.0005 for symptoms; p = 0.0019 for drug consumption). Only one minor local side effect was registered during SLIT.
    Conclusions: According to our data, SLIT in patients allergic to Ambrosia is safe and able to improve both subjective and objective parameters.
    Mesh-Begriff(e) Administration, Sublingual ; Adolescent ; Adult ; Allergens ; Antigens, Plant ; Desensitization, Immunologic/methods ; Female ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/therapy ; Male ; Middle Aged ; Nasal Provocation Tests ; Plant Proteins/administration & dosage ; Plant Proteins/therapeutic use ; Pollen/immunology ; Skin Tests
    Chemische Substanzen Allergens ; Amb a I protein, Ambrosia artemisiifolia ; Antigens, Plant ; Plant Proteins
    Sprache Englisch
    Erscheinungsdatum 2000-11
    Erscheinungsland Spain
    Dokumenttyp Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Sublingual immunotherapy in polysensitized patients: effect on quality of life.

    Ciprandi, G / Cadario, G / Valle, C / Ridolo, E / Verini, M / Di Gioacchino, M / Minelli, M / Gangemi, S / Sillano, V / Colangelo, C / Pravettoni, V / Pellegrino, R / Borrelli, P / Fiorina, A / Carosso, A / Gasparini, A / Riario-Sforza, G G / Incorvaia, C / Puccinelli, P /
    Scurati, S / Frati, F

    Journal of investigational allergology & clinical immunology

    2010  Band 20, Heft 4, Seite(n) 274–279

    Abstract: Background: Quality of life (QOL) is an important issue in allergic rhinitis and has been evaluated in a number of studies that have shown how it is impaired in untreated patients and improved by effective treatment. However, there are no data ... ...

    Abstract Background: Quality of life (QOL) is an important issue in allergic rhinitis and has been evaluated in a number of studies that have shown how it is impaired in untreated patients and improved by effective treatment. However, there are no data concerning QOL after sublingual immunotherapy (SLIT) in polysensitized patients.
    Objective: To evaluate the effect, in real-life clinical practice, of SLIT on QOL in a population of polysensitized patients with allergic rhinitis.
    Methods: We prospectively evaluated 167 consecutively enrolled polysensitized patients with allergic rhinitis. QOL was measured in all cases with the Rhinoconjunctivitis Quality of Life Questionnaire at baseline and after 1 year of SLIT (performed in approximately 70% of cases using single allergen extracts provided by the same manufacturer).
    Results: The most frequent causes of sensitization were grass pollen, Parietaria, and house dust mites. The mean number of sensitizations per patient was 3.65. SLIT was performed with 1 extract in 123 patients (73.6%), with 2 extracts in 31 patients (18.6%), and with more than 2 extracts in 13 patients (7.8%). The mean values of all the QOL items improved significantly (P < .01 in all cases), with the following reductions noted: activities, 3.96 to 2.89; sleep, 2.07 to 1.56; general problems, 2.16 to 1.5; practical problems, 3.69 to 2.58; nasal symptoms, 3.57 to 2.50; eye symptoms, 2.92 to 1.83; and emotional aspects, 2.2 to 1.44.
    Conclusions: This study provides evidence that QOL can be improved in polysensitized patients treated with SLIT, and that the use of just 1 or 2 allergen extracts seems to be sufficient and effective in terms of improving QOL.
    Mesh-Begriff(e) Administration, Sublingual ; Adolescent ; Adult ; Animals ; Antigens, Dermatophagoides/therapeutic use ; Antigens, Plant/therapeutic use ; Desensitization, Immunologic ; Female ; Humans ; Immunization ; Male ; Parietaria/immunology ; Poaceae/immunology ; Pollen/adverse effects ; Pyroglyphidae/immunology ; Quality of Life ; Rhinitis, Allergic, Perennial/diagnosis ; Rhinitis, Allergic, Perennial/immunology ; Rhinitis, Allergic, Perennial/physiopathology ; Rhinitis, Allergic, Perennial/therapy ; Rhinitis, Allergic, Seasonal/diagnosis ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/physiopathology ; Rhinitis, Allergic, Seasonal/therapy
    Chemische Substanzen Antigens, Dermatophagoides ; Antigens, Plant
    Sprache Englisch
    Erscheinungsdatum 2010
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Safety and pharmacoeconomics of a cluster administration of mite immunotherapy compared to the traditional one.

    Mauro, Marina / Russello, Marina / Alesina, Roberta / Sillano, Valeria / Alessandrini, Arnaldo / Dama, Annarita / Passalacqua, Giovanni / Senna, Gianenrico

    European annals of allergy and clinical immunology

    2006  Band 38, Heft 1, Seite(n) 31–34

    Abstract: Accelerated schedules of administration of immunotherapy (rush or clustered) allow to reach the maintenance dosage in shorter times with respect to traditional schedules. Nowadays formal assessments of the safety and economic aspects of those schedule ... ...

    Abstract Accelerated schedules of administration of immunotherapy (rush or clustered) allow to reach the maintenance dosage in shorter times with respect to traditional schedules. Nowadays formal assessments of the safety and economic aspects of those schedule lack for inhalant allergens. We compared in a prospective randomized open study a cluster and a traditional immunotherapy with standardized mite extracts. Thirty eight adult patients with persistent allergic rhinitis due to mites were randomized to receive either a traditional (N= 19) or a cluster (N=19) up-dosing scheme, lasting 13 and 3 weeks respectively. Side effects were carefully evaluated and recorded by physician and costs were calculated as well. In the cluster and traditional updosing 148 and 241 injections were given respectively. With the cluster up-dosing there were 8 local reactions (15.9% of patients and 5.4% of injections). With the traditional schedule 6 local reactions (31.5 % of patients and 2.4% of injections) occurred. There was no difference between the two treatments in occurrence of side effects per patient and per injection (chi-square 1.31 and 2.23, p= NS). No systemic reaction was recorded. Considering the cost of the extract, the cost of injections and the time spent, the cluster regimen resulted in a global spare of 244.95 euros per patient in the build-up phase. The cluster up-dosing is as safe as the traditional one and allows a significant economical save.
    Mesh-Begriff(e) Adolescent ; Adult ; Animals ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/economics ; Desensitization, Immunologic/methods ; Drug Administration Schedule ; Humans ; Pyroglyphidae/immunology ; Rhinitis, Allergic, Perennial/immunology ; Rhinitis, Allergic, Perennial/therapy
    Sprache Englisch
    Erscheinungsdatum 2006-01
    Erscheinungsland Italy
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2105540-3
    ISSN 1764-1489 ; 0397-9148
    ISSN 1764-1489 ; 0397-9148
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The role of suggestion in asthma. II. Effects of a bronchoconstrictor drug on bronchial reactivity under bronchoconstrictor or bronchodilator suggestion.

    Pastorello, E A / Codecasa, L R / Gerosa, A / Buonocore, E / Sillano, V / Zanussi, C

    Annals of allergy

    1987  Band 59, Heft 5, Seite(n) 339–340

    Abstract: Previous studies have shown that suggestion may modify bronchial reactivity to both inactive diluents and pharmacologically bronchoconstrictor or dilator substances. In our study, 14 patients were subjected to two methacholine challenge tests presented, ... ...

    Abstract Previous studies have shown that suggestion may modify bronchial reactivity to both inactive diluents and pharmacologically bronchoconstrictor or dilator substances. In our study, 14 patients were subjected to two methacholine challenge tests presented, respectively, as a bronchoconstrictor or as a bronchodilator drug. Forced expiratory volumes in one second were recorded and a PD20 was determined. No significant differences were reported in PD20 values of each patient after the two kinds of suggestion.
    Mesh-Begriff(e) Adolescent ; Adult ; Asthma/physiopathology ; Asthma/psychology ; Asthma/therapy ; Bronchi/drug effects ; Bronchi/physiopathology ; Bronchial Provocation Tests ; Bronchodilator Agents ; Child ; Female ; Forced Expiratory Volume ; Humans ; Male ; Methacholine Chloride ; Methacholine Compounds ; Middle Aged ; Suggestion
    Chemische Substanzen Bronchodilator Agents ; Methacholine Compounds ; Methacholine Chloride (0W5ETF9M2K)
    Sprache Englisch
    Erscheinungsdatum 1987-11
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 80042-9
    ISSN 0003-4738
    ISSN 0003-4738
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Evaluation of allergic etiology in perennial rhinitis.

    Pastorello, E / Ortolani, C / Luraghi, M T / Pravettoni, V / Sillano, V / Froldi, M / Amabile, G / Zanussi, C

    Annals of allergy

    1985  Band 55, Heft 6, Seite(n) 854–856

    Abstract: In 197 patients with perennial rhinitis, 49 patients (24.9%) were found to be allergic to perennial inhalant allergens, 37 patients (18.8%) allergic to seasonal allergens, 52 patients (26.4%) had food intolerance, 12 patients (6.6%) showed evidence of ... ...

    Abstract In 197 patients with perennial rhinitis, 49 patients (24.9%) were found to be allergic to perennial inhalant allergens, 37 patients (18.8%) allergic to seasonal allergens, 52 patients (26.4%) had food intolerance, 12 patients (6.6%) showed evidence of nasal infection, and in 46 patients (23.3%) etiology was undetermined.
    Mesh-Begriff(e) Adult ; Dairy Products ; Dust ; Edible Grain ; Eggs ; Female ; Food Additives ; Food Hypersensitivity/complications ; Hair ; Humans ; Immunoglobulin E/analysis ; Male ; Middle Aged ; Nuts ; Respiratory Tract Infections/complications ; Rhinitis, Allergic, Perennial/etiology ; Yeasts
    Chemische Substanzen Dust ; Food Additives ; Immunoglobulin E (37341-29-0)
    Sprache Englisch
    Erscheinungsdatum 1985-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80042-9
    ISSN 0003-4738
    ISSN 0003-4738
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Characteristics of patients with allergic polysensitization: the POLISMAIL study.

    Ciprandi, G / Alesina, R / Ariano, R / Aurnia, P / Borrelli, P / Cadario, G / Capristo, A / Carosso, A / Casino, G / Castiglioni, G / Cesinaro Di Rocco, P / Colangelolo, C / Di Gioacchino, M / Di Paola, M G / Errico, G / Fiorina, A / Gambuzza, F / Gangemi, S / Gasparini, A /
    Giugno, R / Iemoli, E / Isola, S / Maniero, G / Marengo, F / Mazzali, P / Minelli, M / Mosca, M / Pellegrino, R / Piconi, S / Pravettoni, V / Quaglio, L / Ricciardi, L / Ridolo, E / Sillano, V / Valle, C / Varin, E / Verini, M / Zambito, M / Riario-Sforza, G G / Incorvaia, C / Puccinelli, P / Scurati, S / Frati, F

    European annals of allergy and clinical immunology

    2008  Band 40, Heft 3, Seite(n) 77–83

    Abstract: Background: The natural history of respiratory allergy is commonly characterized by a worsening of symptom severity, frequent comorbidity of rhinitis and asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts since ... ...

    Abstract Background: The natural history of respiratory allergy is commonly characterized by a worsening of symptom severity, frequent comorbidity of rhinitis and asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts since childhood and is rare to find monosensitized adult patients. However, there are few studies investigating the characteristics of polysensitized patients.
    Methods: This study was performed on a large cohort of patients with allergic rhinitis (assessed by ARIA criteria) and/or mild to moderate asthma (assessed by GINA). The kind and the number of sensitizations, their patterns, and the relation with quality of life (QoL) measured by the Juniper's RQLQ guestionnaire, were evaluated.
    Results: Globally 418 patients (50.2% males, 49.8% females, mean age 26.4 years, range 3.5-65 years, 64 smokers, 371 non-smokers) were enrolled: 220 had allergic rhinitis alone, and 198 allergic rhinitis and asthma. The mean number ofsensitizations was 2.6. Three hundred-five patients (73%) had persistent rhinitis (PER), 220 of them with moderate-severe form. There was no significant derence in rate of rhinitis and asthma in monosensitized or polysensitized patients. Most patients were sensitized to pollens, whereas only 24.2% of them were sensitized to perennial allergens. Polysensitization was significantly associated with some issues of QoL, confirming previous findings, but not with number ofsensitizations.
    Conclusions: This study provides data confirming for poly-sensitized patients the relevance of ARIA classification of AR. PER is the most common form of AR in this cohort, symptoms are frequently moderate-severe, and asthma is present in about the half of patients with AR.
    Mesh-Begriff(e) Adolescent ; Adult ; Age Factors ; Aged ; Allergens/adverse effects ; Animals ; Anti-Allergic Agents/therapeutic use ; Antigens, Plant/adverse effects ; Asthma/drug therapy ; Asthma/epidemiology ; Asthma/etiology ; Cats ; Child ; Child, Preschool ; Cohort Studies ; Dogs ; Female ; Fungi ; Humans ; Immunization ; Italy/epidemiology ; Male ; Middle Aged ; Pollen/adverse effects ; Prospective Studies ; Pyroglyphidae ; Quality of Life ; Rhinitis, Allergic, Perennial/drug therapy ; Rhinitis, Allergic, Perennial/epidemiology ; Rhinitis, Allergic, Perennial/etiology ; Rhinitis, Allergic, Seasonal/drug therapy ; Rhinitis, Allergic, Seasonal/epidemiology ; Rhinitis, Allergic, Seasonal/etiology ; Skin Tests ; Smoking/epidemiology ; Young Adult
    Chemische Substanzen Allergens ; Anti-Allergic Agents ; Antigens, Plant
    Sprache Englisch
    Erscheinungsdatum 2008-11
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2105540-3
    ISSN 1764-1489 ; 0397-9148
    ISSN 1764-1489 ; 0397-9148
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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