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  1. AU="Sillos, E M"
  2. AU="Vu An Do"
  3. AU=Rockstroh J K AU=Rockstroh J K
  4. AU="Ma, Di"
  5. AU="Chahine, A Alfred"
  6. AU=Pruimboom Leo
  7. AU="Naama, Moriyah"
  8. AU=Khan Israr
  9. AU="Ansary, Delwar"
  10. AU="Gamerra, Mario"
  11. AU="Eric M. Yoshida"
  12. AU="Raj, Rahul"
  13. AU="Semaan, Marie"
  14. AU="Trafton, Jodie"
  15. AU="Victoria Walker-Sperling"
  16. AU="Song, Wuqi"
  17. AU="Pham, K.‐C"
  18. AU="Boria Alegre, Felix"
  19. AU="Vecsey-Nagy, Milán"
  20. AU=Bazak Remon
  21. AU="Shaaban, Mahmoud"
  22. AU="Perminow, Gøri"
  23. AU="Akrim, Faraz"
  24. AU="Haider, Najm"
  25. AU="Jain, Divyanu"
  26. AU="Halpert, Richard"
  27. AU="Alkorta, Ibon"
  28. AU="Kwon, Kyungmi"
  29. AU="Bernardo Salasnich"
  30. AU="Hassan, Zurina"
  31. AU="Belarbi, M"
  32. AU="Rout, Ranjeet K"
  33. AU="Moreira, Catarina"
  34. AU=Warn-Cramer Bonnie J
  35. AU="Morral, Núria"
  36. AU="Silman, Miles R."
  37. AU="Palfi Salavat, Mădălina-Casiana"
  38. AU="Mohamed, Eid"
  39. AU="Hudson, Lance"
  40. AU="Imane Mihoub" AU="Imane Mihoub"
  41. AU="D. M. Wuchenich"

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  1. Artikel: Unilateral diaphragmatic paralysis inhibits postnatal lung growth in the piglet.

    Sillos, E M / Donnelly, D F / Mansell, A L

    Pediatric research

    1988  Band 23, Heft 5, Seite(n) 463–465

    Abstract: To test the hypothesis that regional growth of lung parenchyma depends on regional distending pressure, left cervical phrenectomy was done in ten 2-month-old piglets. The unilateral diaphragmatic paralysis reduced mean transpulmonary pressure in the left ...

    Abstract To test the hypothesis that regional growth of lung parenchyma depends on regional distending pressure, left cervical phrenectomy was done in ten 2-month-old piglets. The unilateral diaphragmatic paralysis reduced mean transpulmonary pressure in the left hemithorax from 5.5 +/- 1.0 (means +/- SD) to 2.5 +/- 1.2 cm H2O (p less than 0.01, n = 5). When five of the piglets were killed 48 h later, wet lung weight, total protein content, and nucleic acid content did not differ from values in the five sham operated controls. The five remaining phrenectomized piglets were compared to their five sham-operated controls 7 days after surgery. Wet weight of the left lung was reduced by 29% (p less than 0.01) and DNA content was reduced by 18% (p less than 0.05). Wet weight of the right lung, contralateral to the paralyzed hemidiaphragm, was reduced by 11% (p less than 0.05). At this time, body weight, bilateral transpulmonary pressure, and ratios of total protein/DNA and RNA/DNA in lung tissue did not differ from the sham-operated controls. These results suggest that regional growth of lung parenchyma by cell proliferation adjusted to changes in regional transpulmonary pressure caused by the unilateral phrenectomy.
    Mesh-Begriff(e) Animals ; Lung/growth & development ; Lung/physiology ; Lung/physiopathology ; Male ; Phrenic Nerve/physiology ; Pressure ; Pulmonary Alveoli/innervation ; Pulmonary Alveoli/physiology ; Respiratory Paralysis/physiopathology ; Swine
    Sprache Englisch
    Erscheinungsdatum 1988-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1203/00006450-198805000-00005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature.

    Sillos, E M / Shenep, J L / Burghen, G A / Pui, C H / Behm, F G / Sandlund, J T

    Cancer

    2001  Band 92, Heft 9, Seite(n) 2237–2246

    Abstract: Background: Lactic acidosis (LA) associated with hematologic malignancies is rare, ominous, and generally occurs in adults. Its pathogenesis is poorly understood.: Methods: The authors present one case of childhood lymphoma and two cases of childhood ...

    Abstract Background: Lactic acidosis (LA) associated with hematologic malignancies is rare, ominous, and generally occurs in adults. Its pathogenesis is poorly understood.
    Methods: The authors present one case of childhood lymphoma and two cases of childhood leukemia associated with LA, and they review the available literature. Plasma concentrations of insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and tumor necrosis factor (TNF)-alpha were retrospectively measured to elucidate the pathogenesis of LA.
    Results: Lactic acidosis has been reported to date in 28 cases of lymphoma and 25 cases of leukemia, including the authors' cases. Ongoing rapid cellular proliferation was indicated in all leukemia cases. The liver was involved in 43 of the 53 cases, and hypoglycemia was present in 20. The acidosis improved only if the disease responded to chemotherapy. Remission was achieved in only five of the reported cases. In the authors' three cases, LA was associated with altered concentrations of IGFs, IGFBPs, and TNF-alpha, although causality was not established.
    Conclusions: Lactic acidosis in association with hematologic malignancies carries an extremely poor prognosis. Because cancer cells have a high rate of glycolysis and produce a large quantity of lactate, this condition may result from an imbalance between lactate production and hepatic lactate utilization. The authors speculate that the IGF system is involved in the pathophysiology of LA in these patients. Only chemotherapy so far has been effective in correcting the acute acidosis in a few patients; however, it has not necessarily improved ultimate outcome.
    Mesh-Begriff(e) Acidosis, Lactic/etiology ; Acidosis, Lactic/pathology ; Adolescent ; Child ; Female ; Glycolysis ; Humans ; Leukemia/complications ; Leukemia-Lymphoma, Adult T-Cell/complications ; Lymphoma/complications ; Male ; Prognosis ; Retrospective Studies ; Somatomedins/pharmacology
    Chemische Substanzen Somatomedins
    Sprache Englisch
    Erscheinungsdatum 2001-11-01
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/1097-0142(20011101)92:9<2237::aid-cncr1569>3.0.co;2-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Characteristics associated with successful weaning in ventilator-dependent preterm infants.

    Sillos, E M / Veber, M / Schulman, M / Krauss, A N / Auld, P A

    American journal of perinatology

    1992  Band 9, Heft 5-6, Seite(n) 374–377

    Abstract: Eighteen ventilator-dependent preterm infants with hyaline membrane disease were studied for 24 hours before and after an attempt at extubation. All were treated with theophylline prior to weaning and achieved average levels of 8.9 +/- 1.7 micrograms/ml ( ...

    Abstract Eighteen ventilator-dependent preterm infants with hyaline membrane disease were studied for 24 hours before and after an attempt at extubation. All were treated with theophylline prior to weaning and achieved average levels of 8.9 +/- 1.7 micrograms/ml (49 +/- 9 mumol/liter) in 13 successfully weaned infants and 8.4 +/- 1.1 micrograms/ml (47 +/- 6 mumol/liter) in 5 infants not extubated, p > 0.05. Infants successfully weaned were significantly (p < 0.01) older, more mature (29 +/- 1 versus 26 +/- 2 weeks' gestational age) and heavier (1107 +/- 236 versus 1016 +/- 256 gm) than infants not successfully extubated. Infants successfully weaned differed only in developing a greater maximal inspiratory force (33.8 +/- 12.3 versus 23.3 +/- 15.0 cm H2O) and higher compliance (1.1 +/- 0.3 versus 0.7 +/- 0.3) during the preweaning treatment period. These results indicate that maturity and size play a significant role in the ability to wean a preterm infant from the ventilator successfully, that maximal inspiratory force and compliance are higher in preterm infants who can be successfully extubated, and that methylxanthines do not uniformly improve pulmonary function in all potentially extubatable preterm infants.
    Mesh-Begriff(e) Humans ; Hyaline Membrane Disease/therapy ; Infant ; Infant, Newborn ; Inspiratory Capacity ; Intubation, Intratracheal ; Lung Compliance ; Theophylline/therapeutic use ; Time Factors ; Ventilator Weaning
    Chemische Substanzen Theophylline (C137DTR5RG)
    Sprache Englisch
    Erscheinungsdatum 1992-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-2007-999268
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Effects of aerosolized synthetic surfactant, atovaquone, and the combination of these on murine Pneumocystis carinii pneumonia.

    Hughes, W T / Sillos, E M / LaFon, S / Rogers, M / Woolley, J L / Davis, C / Studenberg, S / Pattishall, E / Freeze, T / Snyder, G / Staton, S

    The Journal of infectious diseases

    1998  Band 177, Heft 4, Seite(n) 1046–1056

    Abstract: An immunosuppressed rat model was used to determine the pharmacokinetics of aerosolized atovaquone (administered with and without a synthetic surfactant) and to evaluate the efficacy of inhaled atovaquone in the prevention and treatment of Pneumocystis ... ...

    Abstract An immunosuppressed rat model was used to determine the pharmacokinetics of aerosolized atovaquone (administered with and without a synthetic surfactant) and to evaluate the efficacy of inhaled atovaquone in the prevention and treatment of Pneumocystis carinii pneumonia (PCP). After a single dose by aerosol, mean peak concentrations of atovaquone averaged 52 microg/mL in plasma and 31 microg/g in lungs of rats infected with P. carinii. When atovaquone was combined with surfactant, mean peak concentrations of 94 microg/mL in plasma and 51 microg/g in lung were achieved. Aerosolized synthetic surfactant alone significantly increased survival of rats with PCP and, when combined with atovaquone, increased plasma and lung concentrations of the drug and eradication of the organism.
    Mesh-Begriff(e) Administration, Inhalation ; Animals ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Antifungal Agents/administration & dosage ; Antifungal Agents/blood ; Antifungal Agents/pharmacokinetics ; Atovaquone ; Dexamethasone/administration & dosage ; Dexamethasone/pharmacology ; Drug Therapy, Combination ; Lung/chemistry ; Lung/microbiology ; Male ; Naphthoquinones/administration & dosage ; Naphthoquinones/blood ; Naphthoquinones/pharmacokinetics ; Pneumonia, Pneumocystis/drug therapy ; Pneumonia, Pneumocystis/prevention & control ; Pulmonary Surfactants/administration & dosage ; Pulmonary Surfactants/chemical synthesis ; Pulmonary Surfactants/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage ; Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology
    Chemische Substanzen Anti-Infective Agents ; Anti-Inflammatory Agents ; Antifungal Agents ; Naphthoquinones ; Pulmonary Surfactants ; Dexamethasone (7S5I7G3JQL) ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Atovaquone (Y883P1Z2LT)
    Sprache Englisch
    Erscheinungsdatum 1998-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1086/515252
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Diaphragmatic activity is a determinant of postnatal lung growth.

    Mansell, A L / Rojas, J V / Sillos, E M / Stolar, C J / Collins, M H / Rozovski, S J

    Journal of applied physiology (Bethesda, Md. : 1985)

    1986  Band 61, Heft 3, Seite(n) 1098–1103

    Abstract: To test the hypothesis that activity of respiratory muscles determines regional growth of lung parenchyma, we studied the effects of unilateral diaphragmatic paralysis on contralateral/ipsilateral lung growth in cats and piglets. Five 10- to 12-wk-old ... ...

    Abstract To test the hypothesis that activity of respiratory muscles determines regional growth of lung parenchyma, we studied the effects of unilateral diaphragmatic paralysis on contralateral/ipsilateral lung growth in cats and piglets. Five 10- to 12-wk-old cats and five 8-wk-old piglets underwent unilateral diaphragmatic paralysis by thoracic and cervical phrenectomy, respectively. Five to seven weeks after surgery, when the cats were killed for studies of lung growth, gain in body weight was the same as in five sham-operated controls. At this time, mean pleural pressure ipsilateral to the paralyzed hemidiaphragm was the same as contralateral mean pleural pressure during tidal breathing, and values did not differ from controls. However overall functional residual capacity was lower in the phrenectomized cats (35 +/- 4 ml) than in the controls (55 +/- 11 ml, P less than 0.01). Growth of contralateral lungs relative to ipsilateral lungs was greater in the phrenectomized cats than in the controls, as shown by ratios of contralateral/ipsilateral wet lung weight (1.44 vs. 1.34, P less than 0.01), maximum inflation volume (1.53 vs. 1.33, P less than 0.05), and total protein content (1.45 vs. 1.26, P less than 0.05). Ratios of total protein to DNA and RNA to DNA were unchanged. One week after surgery in the piglets, the ratio of contralateral/ipsilateral wet lung weight was increased (1.61 vs. 1.29, P less than 0.01) and total weight of both lungs was reduced. We conclude that regional growth of lung parenchyma by cell proliferation depends in part on regional distribution of respiratory muscle activity.
    Mesh-Begriff(e) Animals ; Body Weight ; Cats ; Diaphragm/physiology ; Functional Residual Capacity ; Lung/anatomy & histology ; Lung/growth & development ; Lung/physiology ; Lung Compliance ; Organ Size ; Paralysis/pathology ; Paralysis/physiopathology ; Pressure ; Swine ; Tidal Volume
    Sprache Englisch
    Erscheinungsdatum 1986-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 8750-7587 ; 0021-8987 ; 0161-7567
    ISSN (online) 1522-1601
    ISSN 8750-7587 ; 0021-8987 ; 0161-7567
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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