Article ; Online: Polysaccharide-rich extract of Genipa americana leaves exerts anti-inflammatory effects modulated by platelet mediators.
2023 Volume 319, Issue Pt 2, Page(s) 117234
Abstract: Ethnopharmacological relevance: Genipa americana L. (Rubiaceae) leaves are traditionally used to treat fever, pharyngitis, healing, luxation and bruises.: Aim of the study: This study aimed to investigate the anti-inflammatory effect of the ... ...
| Abstract | Ethnopharmacological relevance: Genipa americana L. (Rubiaceae) leaves are traditionally used to treat fever, pharyngitis, healing, luxation and bruises. Aim of the study: This study aimed to investigate the anti-inflammatory effect of the polysaccharide-rich extract of G. americana leaves (PE-Ga) in acute inflammation models and underlying mechanisms associated with platelet activity. Materials and methods: Rats received PE-Ga (0.3-3.0 mg/kg; IV) 30 min before injection (IP or SC) of zymosan, serotonin, PGE Results: In vitro, PE-Ga inhibited ADP-induced platelet aggregation up to 49%. In the edema model, PE-Ga reduced (41%) the time-course of the edema induced by zymosan, mainly the last phase (62%), as well as that induced by PLA Conclusions: PE-Ga exerts antiplatelet and anti-inflammatory effects in acute inflammation induced by zymosan, being modulated by P-selectin and platelet serotonin, among other inflammatory mediators. |
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| MeSH term(s) | Rats ; Animals ; Plant Extracts/adverse effects ; P-Selectin ; Fluoxetine ; Serotonin ; Zymosan ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Inflammation/drug therapy ; Anti-Inflammatory Agents/adverse effects ; Rubiaceae ; Edema/chemically induced ; Edema/drug therapy ; Edema/metabolism ; Arginine ; Phospholipases A2 | |||||
| Chemical Substances | Plant Extracts ; P-Selectin ; Fluoxetine (01K63SUP8D) ; Serotonin (333DO1RDJY) ; Zymosan (9010-72-4) ; Polysaccharides ; Anti-Inflammatory Agents ; Arginine (94ZLA3W45F) ; Phospholipases A2 (EC 3.1.1.4) | |||||
| Language | English | |||||
| Publishing date | 2023-10-02 | |||||
| Publishing country | Ireland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 134511-4 | |||||
| ISSN | 1872-7573 ; 0378-8741 | |||||
| ISSN (online) | 1872-7573 | |||||
| ISSN | 0378-8741 | |||||
| DOI | 10.1016/j.jep.2023.117234 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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