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  1. Book ; Online: Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I

    Silva, Vera L. M. / Silva, Artur M. S.

    2022  

    Keywords Research & information: general ; Chemistry ; Organic chemistry ; pyrazolopyridopyridazine dione ; N-aminopyrazolopyrrolopyridine dione ; luminol ; photoluminescence ; pyrazole ; coumarin ; antimicrobial ; hydrazone ; biofilm ; Staphylococcus aureus ; S. epidermidis ; MRSA ; pyrazolyl-ureas ; pyrazole nucleus ; protein kinase inhibitors ; anti-inflammatory agents ; anticancer agents ; anti-pathogens agents ; nitrated pyrazoles-based ; energetic salts ; synthesis ; high energy density material ; insensitivity ; amination ; 4-halopyrazole ; Buchwald-Hartwig coupling ; Pd(dba)2 ; CuI mediated coupling ; aliphatic amine ; X-ray ; pyrazolate ; coinage metals ; metallacycles ; M06-2x ; pyrazolyl-s-triazine ; Fe(III) ; self-assembly ; Hirshfeld ; antimicrobial activity ; pyrazoles ; styrylpyrazoles ; biological activity ; organic synthesis ; reactivity ; homocoupling ; bipyrazole ; transition-metal catalysts ; metal-organic frameworks ; 1,3-dipolar cycloadditions ; 2,3-dihydropyrazolo[1,2-a]pyrazoles ; copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC) ; azomethine imines ; ynones ; bis(pyrazol-1-yl)alkanes ; carboxylation ; oxalyl chloride ; dicarboxylic acids ; alkylation ; superbasic medium ; 1,2,4-oxadiazoles ; spiropyrazolinium compounds ; in vitro antitubercular screening ; X-ray diffraction ; molecular docking ; polynuclear ; silver ; crystal structure ; pyrazolate ligand ; coordination polymer ; functionalization ; heterocyclic ; neurodegeneration ; Alzheimer's disease ; Parkinson's disease ; inhibitor ; antagonist ; antitumor scaffold ; enzymatic inhibitory ; N-heterocyclic compounds ; pyrazolo[1,5-a]pyrimidine ; pyrazolo[1,5-a]pyrimidines ; aromatic substitution ; electrooxidation ; C-H halogenation ; C-H thiocyanation ; N-N coupling ; cyclic voltammetry ; n/a
    Language 0|e
    Size 1 electronic resource (400 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021621821
    ISBN 9783036554228 ; 303655422X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Special Issue "Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds II".

    Silva, Vera L M / Silva, Artur M S

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: Pyrazole and its derivatives are considered ... ...

    Abstract Pyrazole and its derivatives are considered privileged
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article: Fucus vesiculosus

    Circuncisão, Ana R / Ferreira, Sónia S / Silva, Artur M S / Coimbra, Manuel A / Cardoso, Susana M

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Brown macroalgae are rich sources of nutrients and health-promoting compounds. Nevertheless, their consumption is still limited by their strong organoleptic characteristics, thus requiring the development of extraction strategies to profit from their ... ...

    Abstract Brown macroalgae are rich sources of nutrients and health-promoting compounds. Nevertheless, their consumption is still limited by their strong organoleptic characteristics, thus requiring the development of extraction strategies to profit from their nutritional value. To fulfil this, two sequential extraction approaches were developed, differing in the solvent used in the first extraction step, water in approach 1 or food-grade ethanol in approach 2, to obtain economic and affordable extracts rich in specific compounds from
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13040540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective.

    Silva, Carlos F M / Pinto, Diana C G A / Fernandes, Pedro A / Silva, Artur M S

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: Since the beginning of the XXI century, Leishmaniasis has been integrated into the World Health Organization's list of the 20 neglected tropical diseases, being considered a public health issue in more than 88 countries, especially in the tropics, ... ...

    Abstract Since the beginning of the XXI century, Leishmaniasis has been integrated into the World Health Organization's list of the 20 neglected tropical diseases, being considered a public health issue in more than 88 countries, especially in the tropics, subtropics, and the Mediterranean area. Statistically, this disease presents a world prevalence of 12 million cases worldwide, with this number being expected to increase shortly due to the 350 million people considered at risk and the 2-2.5 million new cases appearing every year. The lack of an appropriate and effective treatment against this disease has intensified the interest of many research groups to pursue the discovery and development of novel treatments in close collaboration with the WHO, which hopes to eradicate it shortly. This paper intends to highlight the quinoline scaffold's potential for developing novel antileishmanial agents and provide a set of structural guidelines to help the research groups in the medicinal chemistry field perform more direct drug discovery and development programs. Thus, this review paper presents a thorough compilation of the most recent advances in the development of new quinoline-based antileishmanial agents, with a particular focus on structure-activity relationship studies that should be considerably useful for the future of the field.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recent Advances in Fluorescent Theranostics for Alzheimer's Disease: A Comprehensive Survey on Design, Synthesis, and Properties.

    Francisco, Telmo N / Malafaia, Daniela / Melo, Lúcia / Silva, Artur M S / Albuquerque, Hélio M T

    ACS omega

    2024  Volume 9, Issue 12, Page(s) 13556–13591

    Abstract: Alzheimer's disease (AD) is the most common form of neurodegenerative dementia that is rapidly becoming a major health problem, especially in developed countries because of their increasing life expectancy. Two main problems are often associated with the ...

    Abstract Alzheimer's disease (AD) is the most common form of neurodegenerative dementia that is rapidly becoming a major health problem, especially in developed countries because of their increasing life expectancy. Two main problems are often associated with the disease: (i) the absence of a widely accessible "gold-standard" for early diagnosis and (ii) lack of effective therapies with disease-modifying effects. The recent success of the monoclonal antibody lecanemab played an important role not only in clarifying a possible druggable pathway but also in spelling the revival of small molecule drug discovery. Unlike bulky biologics, small molecules are structurally less complex, generally cheaper, and compatible with at-home oral consumption, making it feasible for people to start their drug regimen early and stay on it longer. In this sense, small-molecule near-infrared fluorescent theranostics have been gaining more and more attention from the scientific community, as they have the potential to simultaneously provide diagnostic outputs and deliver therapeutic action, paving the way toward personalized medicine in AD patients. They also have the potential to shift the diagnostic "status-quo" from expensive and limited-access PET radiotracers toward inexpensive and handy imaging tools widely available for primary patient screening and preclinical animal studies. Herein, we review the most recent advances in the field of fluorescent theranostics for Alzheimer's disease, detailing their design strategies, synthetic approaches and imaging and therapeutic properties
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c10417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Excited-State Proton Transfer in Luminescent Dyes: From Theoretical Insight to Experimental Evidence.

    Fontes, Luís F B / Rocha, João / Silva, Artur M S / Guieu, Samuel

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 57, Page(s) e202301540

    Abstract: The effective utilization of luminescent dyes often relies on a comprehensive understanding of their excitation and relaxation pathways. One such pathway, Excited-State Proton Transfer (ESPT), involves the tautomerization of the dye in its excited state, ...

    Abstract The effective utilization of luminescent dyes often relies on a comprehensive understanding of their excitation and relaxation pathways. One such pathway, Excited-State Proton Transfer (ESPT), involves the tautomerization of the dye in its excited state, resulting in a new structure that exhibits distinct emission properties, such as a very large Stokes' shift or dual-emission. Although the ESPT phenomenon is well-explained theoretically, its experimental demonstration can be challenging due to the presence of numerous other phenomena that can yield similar experimental observations. In this review, we propose that an all-encompassing methodology, integrating experimental findings, computational analyses, and a thorough evaluation of diverse mechanisms, is essential for verifying the occurrence of ESPT in luminescent dyes. Investigations have offered significant understanding of the elements impacting the ESPT process and the array of approaches that can be used to validate the existence of ESPT. These discoveries hold crucial ramifications for the advancement of molecular probes, sensors, and other applications that depend on ESPT as a detection mechanism.
    Language English
    Publishing date 2023-09-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Drug Discovery Based on Oxygen and Nitrogen (Non-)Heterocyclic Compounds Developed @LAQV-REQUI

    Sousa, Joana L C / Albuquerque, Hélio M T / Silva, Artur M S

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Artur Silva's research group has a long history in the field of medicinal chemistry. The development of new synthetic methods for oxygen (mostly polyphenols, e.g., 2- and 3-styrylchromones, xanthones, flavones) and nitrogen (e.g., pyrazoles, triazoles, ... ...

    Abstract Artur Silva's research group has a long history in the field of medicinal chemistry. The development of new synthetic methods for oxygen (mostly polyphenols, e.g., 2- and 3-styrylchromones, xanthones, flavones) and nitrogen (e.g., pyrazoles, triazoles, acridones, 4-quinolones) heterocyclic compounds in order to be assessed as antioxidant, anti-inflammatory, antidiabetic, and anticancer agents has been the main core work of our research interests. Additionally, the synthesis of steroid-type compounds as anti-Alzheimer drugs as well as of several chromophores as important dyes for cellular imaging broadened our research scope. In this review article, we intend to provide an enlightened appraisal of all the bioactive compounds and their biological properties that were synthesized and studied by our research group in the last two decades.
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16121668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity.

    Silva, Vera L M / Silva, Artur M S

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the ...

    Abstract Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecules. Concerning the reactivity of vinylpyrazoles, the topics surveyed herein include their use in cycloaddition reactions, free-radical polymerizations, halogenation and hydrohalogenation reactions, and more recently in transition-metal-catalyzed reactions, among other transformations. The current state of the art about vinylpyrazoles is presented with an eye to future developments regarding the chemistry of these interesting compounds. Styrylpyrazoles were not considered in this review, as they were the subject of a previous review article published in 2020.
    MeSH term(s) Cycloaddition Reaction ; Transition Elements
    Chemical Substances Transition Elements
    Language English
    Publishing date 2022-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: Titanium and Zinc Based Nanomaterials in Agriculture: A Promising Approach to Deal with (A)biotic Stresses?

    Silva, Sónia / Dias, Maria Celeste / Silva, Artur M S

    Toxics

    2022  Volume 10, Issue 4

    Abstract: Abiotic stresses, such as those induced by climatic factors or contaminants, and biotic stresses prompted by phytopathogens and pests inflict tremendous losses in agriculture and are major threats to worldwide food security. In addition, climate changes ... ...

    Abstract Abiotic stresses, such as those induced by climatic factors or contaminants, and biotic stresses prompted by phytopathogens and pests inflict tremendous losses in agriculture and are major threats to worldwide food security. In addition, climate changes will exacerbate these factors as well as their negative impact on crops. Drought, salinity, heavy metals, pesticides, and drugs are major environmental problems that need deep attention, and effective and sustainable strategies to mitigate their effects on the environment need to be developed. Besides, sustainable solutions for agrocontrol must be developed as alternatives to conventional agrochemicals. In this sense, nanotechnology offers promising solutions to mitigate environmental stress effects on plants, increasing plant tolerance to the stressor, for the remediation of environmental contaminants, and to protect plants against pathogens. In this review, nano-sized TiO
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10040172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Potential of MgO and MgCO3 nanoparticles in modulating lettuce physiology to drought

    Silva, Sónia / Dias, Maria C. / Silva, Artur M. S.

    Acta Physiol Plant. 2023 Feb., v. 45, no. 2 p.31-31

    2023  

    Abstract: Drought is of great concern for agriculture due to its negative impact on crop development and yield, which is being aggravated by climate changes. Aware of that, the present work explores the use of MgO and MgCO₃ nanoparticles (nMgO; nMgCO₃) as ... ...

    Abstract Drought is of great concern for agriculture due to its negative impact on crop development and yield, which is being aggravated by climate changes. Aware of that, the present work explores the use of MgO and MgCO₃ nanoparticles (nMgO; nMgCO₃) as potential mitigating agents of drought stress effects in lettuce. Stressed and unstressed plants were sprayed with 10 mg L⁻¹ of nMgO, nMgCO₃ or nMgO + nMgCO₃ (Mix) suspensions. Growth parameters, water content, carbohydrates, pigments, and photosynthesis were evaluated after 21 days experiment. Data revealed distinct response of lettuce to nanoparticles application depending on water conditions: unstressed plants accumulated more carbohydrates when treated with nMgO and/or nMgCO₃, and showed higher stomatal limitations; in water stressed plants, nanoparticle treatments induced chlorophyll a, b and carotenoids accumulation (nMgCO₃ and Mix). Concerning chlorophyll a fluorescence parameters, only a trend to increase effective efficiency of photosystem II in unstressed plants treated with nMgCO₃ was observed. Results highlight that nMgO and nMgCO₃ may have potential to modulate photosynthesis, driving plants to boost pigment accumulation under water stress, avoiding putative impairments in the photochemical phase of photosynthesis.
    Keywords carotenoids ; chlorophyll ; climate ; drought ; fluorescence ; lettuce ; nanoparticles ; photochemistry ; photosynthesis ; pigments ; water content ; water stress
    Language English
    Dates of publication 2023-02
    Size p. 31.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 783102-x
    ISSN 1861-1664 ; 0137-5881
    ISSN (online) 1861-1664
    ISSN 0137-5881
    DOI 10.1007/s11738-022-03507-2
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4051: Show issues

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