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  1. Article ; Online: Optimizing Hypertension Control Globally: WHF Roadmap.

    Silva, Beatriz / Pinto, Fausto J

    Current cardiology reports

    2022  

    Abstract: Purpose of review: Hypertension represents the most important cardiovascular risk factor, affecting over 4.06 billion adults worldwide. In this review, we will discuss potential barriers and their solutions to improve prevention, detection, and ... ...

    Abstract Purpose of review: Hypertension represents the most important cardiovascular risk factor, affecting over 4.06 billion adults worldwide. In this review, we will discuss potential barriers and their solutions to improve prevention, detection, and management of hypertension.
    Recent findings: The prevalence of hypertension has been increasing in low- and middle-income countries, requiring new strategies to improve its recognition and proper management. The World Heart Federation (WHF) developed a roadmap for hypertension, advising health system policies and clinical practices as part of its commitment to improving global cardiovascular health. The World Health Organization (WHO) has published in 2021 practical guidelines for the pharmacological treatment of hypertension in adults. Identifying potential roadblocks and solutions deserves high priority to improve the detection, management, and control of hypertension.
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-022-01807-0
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  2. Article: Review on milk substitutes from an environmental and nutritional point of view

    Silva, Beatriz Queiroz / Smetana, Sergiy

    Applied food research. 2022 June, v. 2, no. 1

    2022  

    Abstract: Milk consumption in humans lasts longer than in other mammals species. Today consumers' awareness of the environmental burden that some products carry, like milk, keeps growing. Consequently, they are looking for alternatives that are more ... ...

    Abstract Milk consumption in humans lasts longer than in other mammals species. Today consumers' awareness of the environmental burden that some products carry, like milk, keeps growing. Consequently, they are looking for alternatives that are more environmentally friendly and well as nutritionally similar. This review explores the data available in the literature and compares the nutritional profile and the environmental impact of several milk alternatives with the profile of milk from different mammals. Overall plant-based beverages available on the market shelves appear to be nutritionally richer than animal milk: their profile shows a possible fortification in some nutrients, which is a normal practice during the processing step of these products. On the environmental impact of these products, a lot of data is missing, making it impossible to make a full comparison across environmental categories. Overall, the environmental impact of plant-based milk is lower than milk, with exceptions in some categories. This study has many limitations since the available data for the different products is limited, for both nutritional profile and environmental impact. For example, while mammals’ milk is very well characterised, the biggest occurrence of missing data is found in the nutritional profile of plant-based beverages, where some products only have available information on macronutrients.
    Keywords environmental impact ; food research ; markets ; milk ; milk consumption ; nutrient content
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2772-5022
    DOI 10.1016/j.afres.2022.100105
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Adherence to pharmacological therapy in patients with hypertension: protocol of a qualitative study by focus groups.

    Rosendo-Silva, Beatriz / Prazeres, Filipe / Santiago, Luiz Miguel / Rosendo, Inês

    BMJ open

    2024  Volume 14, Issue 4, Page(s) e076416

    Abstract: Introduction: Non-adherence to antihypertensive medication significantly contributes to inadequate blood pressure control. Regarding non-pharmacological interventions to improve medication adherence, the question remains of which interventions yield the ...

    Abstract Introduction: Non-adherence to antihypertensive medication significantly contributes to inadequate blood pressure control. Regarding non-pharmacological interventions to improve medication adherence, the question remains of which interventions yield the highest efficacy.Understanding the complementary perspectives of patients and healthcare professionals can be valuable for designing strategies to enhance medication adherence. Few studies explored the perspectives of patients and healthcare professionals regarding medication adherence. None of them focused specifically on adherence to pharmacological therapy for hypertension in Portugal.Considering the high prevalence of non-adherence and its location-specific aspects, the priority should be identifying its barriers and developing tactics to address them.This study aims to gather the perspectives of patients with hypertension and healthcare professionals such as family doctors, nurses and community pharmacists from Portugal, regarding the most effective strategies to enhance antihypertensive medication adherence and to understand the factors contributing to non-adherence.
    Methods and analyses: We will conduct qualitative research through synchronous online focus groups of 6-10 participants. Some groups will involve patients with hypertension, while others will include family doctors, nurses and community pharmacists. The number of focus groups will depend on the achievement of theoretical saturation. A purposive sample will be used. Healthcare participants will be recruited via email, while patients will be recruited through their family doctors.The moderator will maintain neutrality while ensuring interactive contributions from every participant. Participants will be encouraged to express their opinions on the meeting summary. Meetings will be recorded and transcribed.Two researchers will perform content analyses using
    Ethics and dissemination: The Ethics Committee of the University of Coimbra has approved this study with the number: CE-026/2021. The results will be disseminated via peer-reviewed publications and national and international conferences.
    MeSH term(s) Humans ; Focus Groups ; Antihypertensive Agents/therapeutic use ; Hypertension/drug therapy ; Qualitative Research ; Blood Pressure/physiology ; Medication Adherence
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-076416
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  4. Article ; Online: Conceptualisation of an Ecodesign Framework for Sustainable Food Product Development across the Supply Chain

    Silva, Beatriz Q. / Vasconcelos, Marta W. / Smetana, Sergiy

    Environments. 2023 Mar. 30, v. 10, no. 4

    2023  

    Abstract: As the world population grows, the pressure to intensify an unsustainable food production system increases. At the same time, one-third of all the food produced is lost or wasted along the value chains. Therefore, it is crucial to develop methods to ... ...

    Abstract As the world population grows, the pressure to intensify an unsustainable food production system increases. At the same time, one-third of all the food produced is lost or wasted along the value chains. Therefore, it is crucial to develop methods to increase food production while decreasing resource usage and minimising the environmental impact. Ecodesign concepts have already been implemented in various sectors, reducing the environmental impact of products. However, published work has yet to analyse the potential of ecodesign for food production across the value chain. This review assesses the existing literature on ecodesign principles and proposes a conceptual framework of strategies to be applied to current food chains, addressing the challenges posed by current agrifood systems. We suggest that the relevant ecodesign principles fall into three main categories depending on the supply chain stage: “design for sustainable sourcing (DfSS)”, “design for optimised resource use (DfORU)”, and “design for end-of-life optimisation (DfEO).” Applying this framework across the supply chain could significantly reduce the environmental impact of food production and indirectly contribute to dietary change.
    Keywords design for environment ; environmental impact ; food production ; foods ; product development ; supply chain
    Language English
    Dates of publication 2023-0330
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2777960-9
    ISSN 2076-3298
    ISSN 2076-3298
    DOI 10.3390/environments10040059
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  5. Article ; Online: Resazurin Reduction-Based Assays Revisited: Guidelines for Accurate Reporting of Relative Differences on Metabolic Status.

    Vieira-da-Silva, Beatriz / Castanho, Miguel A R B

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 5

    Abstract: Cell viability and metabolic activity are ubiquitous parameters used in biochemistry, molecular biology, and biotechnological studies. Virtually all toxicology and pharmacological projects include at some point the evaluation of cell viability and/or ... ...

    Abstract Cell viability and metabolic activity are ubiquitous parameters used in biochemistry, molecular biology, and biotechnological studies. Virtually all toxicology and pharmacological projects include at some point the evaluation of cell viability and/or metabolic activity. Among the methods used to address cell metabolic activity, resazurin reduction is probably the most common. At variance with resazurin, resorufin is intrinsically fluorescent, which simplifies its detection. Resazurin conversion to resorufin in the presence of cells is used as a reporter of metabolic activity of cells and can be detected by a simple fluorometric assay. UV-Vis absorbance is an alternative technique but is not as sensitive. In contrast to its wide empirical "black box" use, the chemical and cell biology fundamentals of the resazurin assay are underexplored. Resorufin is further converted to other species, which jeopardizes the linearity of the assays, and the interference of extracellular processes has to be accounted for when quantitative bioassays are aimed at. In this work, we revisit the fundamentals of metabolic activity assays based on the reduction of resazurin. Deviation to linearity both in calibration and kinetics, as well as the existence of competing reactions for resazurin and resorufin and their impact on the outcome of the assay, are addressed. In brief, fluorometric ratio assays using low resazurin concentrations obtained from data collected at short time intervals are proposed to ensure reliable conclusions.
    MeSH term(s) Indicators and Reagents ; Oxazines/chemistry ; Xanthenes/chemistry ; Fluorometry
    Chemical Substances resazurin (1FN9YD6968) ; Indicators and Reagents ; Oxazines ; Xanthenes
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28052283
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    Zs.MO 81: Show issues

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  6. Article: Chronic-binge ethanol feeding aggravates systemic dyslipidemia in

    Hoebinger, Constanze / Rajcic, Dragana / Silva, Beatriz / Hendrikx, Tim

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1148827

    Abstract: Objective: Chronic ethanol consumption is known to cause alcohol-associated liver disease, which poses a global health concern as almost a quarter of heavy drinkers develop severe liver damage. Alcohol-induced liver disease ranges from a mild, ... ...

    Abstract Objective: Chronic ethanol consumption is known to cause alcohol-associated liver disease, which poses a global health concern as almost a quarter of heavy drinkers develop severe liver damage. Alcohol-induced liver disease ranges from a mild, reversible steatotic liver to alcoholic steatohepatitis and irreversible liver fibrosis and cirrhosis, ultimately requiring liver transplantation. While ethanol consumption is associated with dysregulated lipid metabolism and altered cholesterol homeostasis, the impact of dyslipidemia and pre-existing hypercholesterolemia on the development of alcohol-associated liver disease remains to be elucidated.
    Design: To address the influence of systemic dyslipidemia on ethanol-induced liver disease, chronic-binge ethanol feeding was applied to female C57BL/6J (wild type) mice and mice deficient for the low-density lipoprotein receptor (
    Results: Chronic-binge ethanol feeding did not alter systemic lipid levels in wild type mice. While increased systemic cholesterol levels in
    Conclusion: Our results highlight that chronic-binge ethanol feeding enhances systemic dyslipidemia in
    MeSH term(s) Female ; Mice ; Humans ; Animals ; Ethanol/toxicity ; Mice, Inbred C57BL ; Fatty Liver/chemically induced ; Fatty Liver/genetics ; Liver Diseases, Alcoholic/complications ; Liver Diseases, Alcoholic/metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/genetics ; Hypercholesterolemia/complications ; Hyperlipidemias/complications ; Dyslipidemias/complications ; Cholesterol ; Triglycerides ; Lipids
    Chemical Substances Ethanol (3K9958V90M) ; Cholesterol (97C5T2UQ7J) ; Triglycerides ; Lipids
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1148827
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  7. Article ; Online: The structure and matrix dynamics of bacterial biofilms as revealed by antimicrobial peptides' diffusion.

    Vieira-da-Silva, Beatriz / Castanho, Miguel A R B

    Journal of peptide science : an official publication of the European Peptide Society

    2023  Volume 29, Issue 6, Page(s) e3470

    Abstract: From the biological point of view, bacterial biofilms are communities of bacteria embedded in a self-produced gel matrix composed of polysaccharides, DNA, and proteins. Considering the biophysical point of view, the biofilm matrix is a highly dense, ... ...

    Abstract From the biological point of view, bacterial biofilms are communities of bacteria embedded in a self-produced gel matrix composed of polysaccharides, DNA, and proteins. Considering the biophysical point of view, the biofilm matrix is a highly dense, crowded medium that imposes constraints to solute diffusion, depending on the size, conformational dynamics, and net charge. From the pharmacological point of view, biofilms are additional difficulties to drug development as heterogeneity in oxygen and nutrient distribution, and consequently, heterogeneity in bacterial metabolic status leads to recalcitrance. For peptide scientists, biofilms are both a challenge and an opportunity. Biofilms can be intruded by peptides, revealing important biological, biophysical, and pharmacological insights. Peptides can be engineered for different sizes, flexibilities, and net charges, unravelling the determinants of diffusion; they kill bacteria by lysis, overcoming the hurdles of metabolic status heterogeneity, and they are able to kill bacteria in the biofilm core, leaving the matrix intact, that is, without causing bacterial biofilm dispersion as side effect. This concise review addresses the knowledge reached while interrogating bacterial biofilms with peptides and other reporter molecules, and the advances therefrom in biology, biophysics, and drug development.
    MeSH term(s) Antimicrobial Peptides ; Biofilms ; Bacteria ; Peptides/pharmacology ; Polysaccharides
    Chemical Substances Antimicrobial Peptides ; Peptides ; Polysaccharides
    Language English
    Publishing date 2023-01-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1234416-3
    ISSN 1099-1387 ; 1075-2617
    ISSN (online) 1099-1387
    ISSN 1075-2617
    DOI 10.1002/psc.3470
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    Zs.A 6200: Show issues Location:
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  8. Article ; Online: Cesarean Scar Pregnancy: A systematic review on expectant management.

    Silva, Beatriz / Viana Pinto, Pedro / Costa, Maria Antónia

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 288, Page(s) 36–43

    Abstract: A Cesarean Scar Pregnancy (CSP) is a variant of uterine ectopic pregnancy defined by full or partial implantation of the gestational sac in the scar of a previous cesarean section. The continuous increase of Cesarean Deliveries is causing a parallel ... ...

    Abstract A Cesarean Scar Pregnancy (CSP) is a variant of uterine ectopic pregnancy defined by full or partial implantation of the gestational sac in the scar of a previous cesarean section. The continuous increase of Cesarean Deliveries is causing a parallel increase in CSP and its complications. Considering its high morbidity, the most usual recommendation has been termination of pregnancy in the first trimester; however, several cases progress to viable births. The aim of this systematic review is to evaluate the outcome of CSP managed expectantly and understand whether sonographic signs could correlate to the outcomes. An online-based search of PubMed and Cochrane Library Databases was used to gather studies including women diagnosed with a CSP who were managed expectantly. The description of all cases was analysed by the authors in order to obtain information for each outcome. 47 studies of different types were retrieved, and the gestational outcome was available in 194 patients. Out of these, 39 patients (20,1%) had a miscarriage and 16 (8,3%) suffered foetal death. 50 patients (25,8%) had a term delivery and 81 (41,8%) patients had a preterm birth, out of which 27 (13,9%) delivered before 34 weeks of gestation. In 102 (52,6%) patients, a hysterectomy was performed. Placenta Accreta Spectrum (PAS) was a common disorder among CSP and was linked to a higher rate of complications such as foetal death, preterm birth, hysterectomy, haemorrhagic morbidity and surgical complications. Some of the analysed articles showed that sonographic signs with specific characteristics, such as type II and III CSP classification, Crossover Sign - 1, "In the niche" implantation and lower myometrial thickness could be related to worse outcomes of CSP. This article provides a good understanding of CSP as an entity that, although rare, presents with a high rate of relevant morbidity. It is also understood that pregnancies with confirmed PAS had an even higher rate of morbidity. Some sonographic signs were shown to predict the prognosis of these pregnancies and further investigation is necessary to validate one or more signs so they can be used for a more reliable counselling of women with CSP.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Humans ; Female ; Cesarean Section/adverse effects ; Premature Birth/etiology ; Cicatrix/etiology ; Watchful Waiting ; Pregnancy, Ectopic/etiology ; Pregnancy Outcome ; Placenta Accreta/etiology ; Fetal Death/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-07-01
    Publishing country Ireland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.06.030
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    Zs.A 837: Show issues Location:
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  9. Article ; Online: Effect of Hydrothermal Aging on Damping Properties in Sisal Mat-Reinforced Polyester Composites.

    Silva, Moisés F E / Silva, Beatriz R / Marques, Adrielle N / Mattedi, Silvana / Carvalho, Ricardo F

    Polymers

    2024  Volume 16, Issue 2

    Abstract: Hydrothermal aging is a matter of considerable concern for natural fiber-reinforced polymers; it can alter dimensional stability and induce microcracks and macro strain on the composite structure. This study applied a sorption kinetic model and examined ... ...

    Abstract Hydrothermal aging is a matter of considerable concern for natural fiber-reinforced polymers; it can alter dimensional stability and induce microcracks and macro strain on the composite structure. This study applied a sorption kinetic model and examined the effects of water on the damping factor of sisal mat-reinforced polyester composites. The experimental data were fitted well using a Boltzmann sigmoid function, suggesting a promising first step toward kinetic water sorption modeling. Additionally, a damping test was carried out using the impulse excitation technique, highlighting the composite material's dynamic response under varying water absorption conditions. The result showed that damping exhibited sensitivity to water absorption, increasing significantly during the first 24 h of immersion in water, then remained steady over time, inferring a critical time interval. An empirical model proved satisfactory with the correlation coefficient for sorption rates and damping of sisal mat polymeric composites.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16020166
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  10. Article: Topical Administration of a Nanoformulation of Chitosan-Hyaluronic Acid-Epoetin Beta in a Rat Model of Glaucoma.

    Silva, Beatriz / Gonçalves, Lídia M / Braz, Berta São / Delgado, Esmeralda

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: The present work investigates the effects of chitosan-hyaluronic acid-epoetin beta (CS/HA-EPOβ) nanoparticles after topical ocular administration in a rat glaucoma model. Wistar Hannover rats ( ...

    Abstract The present work investigates the effects of chitosan-hyaluronic acid-epoetin beta (CS/HA-EPOβ) nanoparticles after topical ocular administration in a rat glaucoma model. Wistar Hannover rats (
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020164
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