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Article ; Online: New flavone, and cytotoxicity activity of Rauia resinosa ethanolic extract and constituents

Sousa, Jordano Augusto Carvalho / Reis, Adriana Cotta Cardoso / Magalhães, Cíntia Lopes de Brito / Silva, Breno de Mello / Brandão, Geraldo Célio

Natural Product Research. 2023 July 18, v. 37, no. 14 p.2415-2420

2023

Abstract: The ethanolic extract from leaves of Rauia resinosa, Rutaceae, provided a new flavone, 5-hydroxy-5',6,7-trimethoxy-3',4'-methylenedioxyflavone (1), in addition to four known compounds: 3',4',5,5',7-pentamethoxyflavone (2), 5,7,8-trimethoxy-3'4'- ... ...

Abstract	The ethanolic extract from leaves of Rauia resinosa, Rutaceae, provided a new flavone, 5-hydroxy-5',6,7-trimethoxy-3',4'-methylenedioxyflavone (1), in addition to four known compounds: 3',4',5,5',7-pentamethoxyflavone (2), 5,7,8-trimethoxy-3'4'-methylenedioxyflavone (3), 3',4',5,7,8-pentamethoxyflavone (4) and β-sitosterol (5). The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR, UPLC-DAD-MS and UPLC-ESI-MS/MS, involving comparison with literature data. Cytotoxicity of leaves and stems extracts, their fractions and compounds (2), (3), (4) and (5) were evaluated against T24 (bladder carcinoma), TOV-21-G (ovarian adenocarcinoma) and HepG2 (liver carcinoma) cell lines.
Keywords	Rutaceae ; adenocarcinoma ; bladder ; cytotoxicity ; flavones ; liver ; research ; spectroscopy ; Rauia resinosa ; flavonoids ; cytotoxicity activity
Language	English
Dates of publication	2023-0718
Size	p. 2415-2420.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2039138
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Anti-arboviral activity and chemical characterization of hispidulin and ethanolic extracts from Millingtonia hortensis L.f. and Oroxylum indicum (L.) Kurz (Bignoniaceae)

Cardoso Reis, Adriana Cotta / Valente, Gabriel Mendonça / Silva, Breno de Mello / de Brito Magalhães, Cíntia Lopes / Kohlhoff, Markus / Brandão, Geraldo Célio

Natural Product Research. 2023 Feb. 16, v. 37, no. 4 p.613-617

2023

Abstract: Millingtonia hortensis L.f. and Oroxylum indicum (L.) Kurz (Bignoniaceae) are native species from the Asian continent. They are popularly used in traditional medicine and their extracts are rich in flavonoids. In this work, ethanolic extracts of stems ... ...

Abstract	Millingtonia hortensis L.f. and Oroxylum indicum (L.) Kurz (Bignoniaceae) are native species from the Asian continent. They are popularly used in traditional medicine and their extracts are rich in flavonoids. In this work, ethanolic extracts of stems and leaves of these species were evaluated against the Chikungunya, Zika and Mayaro virus. The extracts were subjected to analysis by ultra-efficient liquid chromatography coupled to mass spectrometry. Additionally, M. hortensis leaves extract was fractionated, leading to the isolation of hispidulin. Anti-arboviral activity against the three viruses was detected for M. hortensis leaves extract with EC₅₀ ranging from 37.8 to 134.1 µg/mL and for O. indicum stems extract with EC₅₀ ranging from 18.6 to 55.9 µg/mL. Hispidulin inhibited viral cytopathic effect of MAYV (EC₅₀ value 32.2 µM) and CHIKV (EC₅₀ value 78.8 µM). In LC-DAD-ESI-MS/MS analysis we characterized 25 flavonoids confirming once again the presence of these substances in extracts of these species.
Keywords	Mayaro virus ; Millingtonia hortensis ; Oroxylum indicum ; cytopathogenicity ; flavonoids ; indigenous species ; liquid chromatography ; mass spectrometry ; research ; traditional medicine ; Asia ; 6-methyl-scutellarein ; Chikungunya virus ; antiviral ; Millingtonia hortensis L.f. ; Oroxylum indicum (L.) Kurz ; Bignoniaceae
Language	English
Dates of publication	2023-0216
Size	p. 613-617.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2065485
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New flavone, and cytotoxicity activity of

Sousa, Jordano Augusto Carvalho / Reis, Adriana Cotta Cardoso / Magalhães, Cíntia Lopes de Brito / Silva, Breno de Mello / Brandão, Geraldo Célio

Natural product research

2022 Volume 37, Issue 14, Page(s) 2415–2420

Abstract: The ethanolic extract from leaves ... ...

Abstract	The ethanolic extract from leaves of
MeSH term(s)	Humans ; Tandem Mass Spectrometry ; Flavones/pharmacology ; Flavones/analysis ; Rutaceae/chemistry ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Carcinoma
Chemical Substances	Flavones ; Plant Extracts
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2039138
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Article ; Online: Anti-arboviral activity and chemical characterization of hispidulin and ethanolic extracts from

Cardoso Reis, Adriana Cotta / Valente, Gabriel Mendonça / Silva, Breno de Mello / de Brito Magalhães, Cíntia Lopes / Kohlhoff, Markus / Brandão, Geraldo Célio

Natural product research

2022 Volume 37, Issue 4, Page(s) 613–617

Abstract: Millingtonia ... ...

Abstract	Millingtonia hortensis
MeSH term(s)	Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Tandem Mass Spectrometry ; Bignoniaceae/chemistry ; Flavonoids/chemistry ; Ethanol ; Zika Virus ; Zika Virus Infection
Chemical Substances	hispidulin (N7F61604C2) ; Plant Extracts ; Flavonoids ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2065485
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neutralizing Antibodies Response for SARS-CoV-2 Among Young Inmates and Staff From a Juvenile Offender Institution in Brazil.

Borges, Lysandro Pinto / Vieira, Sarah Cristina Fontes / Gurgel, Ricardo Queiroz / Silva, Breno de Mello / Ferreira, Cyntia Silva / Santos, Samara Mayra Soares Alves Dos / Santana, Lucas Alves da Mota

Disaster medicine and public health preparedness

2023 Volume 17, Page(s) e496

MeSH term(s)	Humans ; SARS-CoV-2 ; Brazil/epidemiology ; Criminals ; COVID-19/epidemiology
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2023.18
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Article ; Online: Antioxidant and antiviral activity of fullerol against Zika virus.

Pereira, Samille Henriques / Almeida, Letícia Trindade / Ferraz, Ariane Coelho / Ladeira, Marina de Souza / Ladeira, Luiz Orlando / Magalhães, Cíntia Lopes de Brito / Silva, Breno de Mello

Acta tropica

2021 Volume 224, Page(s) 106135

Abstract: Neglected for years, Zika virus (ZIKV) has become one of the most relevant arboviruses in current public health. The recent Zika fever epidemic in the Americas generated a worldwide alert due to the association with diseases such as Guillain-Barré ... ...

Abstract	Neglected for years, Zika virus (ZIKV) has become one of the most relevant arboviruses in current public health. The recent Zika fever epidemic in the Americas generated a worldwide alert due to the association with diseases such as Guillain-Barré syndrome and congenital syndromes. Among the pathogenesis of ZIKV, recent studies suggest that oxidative stress plays an important role during infection and that compounds capable of modulating oxidative stress are promising as therapeutics. Furthermore, so far there are no specific and efficient antiviral drug or vaccine available against ZIKV. Thus, fullerol was evaluated in the context of infection by ZIKV, since it is a carbon nanomaterial known for its potent antioxidant action. In this study, fullerol did not alter cell viability at the concentrations tested, proving to be inert, beyond to presenting high antioxidant power at low concentrations. ZIKV infection of human glioblastoma increased the production of reactive oxygen species by 60% and modulated the Nrf-2 pathway activity negatively. After treatment with fullerol, both conditions were restored to baseline levels. Additionally, fullerol was able to reduce viral production by up to 90%. Therefore, our results suggest that fullerol as a promising candidate in the control of ZIKV infections, presenting both antioxidant and antiviral action.
MeSH term(s)	Antioxidants/pharmacology ; Antiviral Agents/pharmacology ; Guillain-Barre Syndrome ; Humans ; Zika Virus ; Zika Virus Infection/drug therapy
Chemical Substances	Antioxidants ; Antiviral Agents
Language	English
Publishing date	2021-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2021.106135
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antioxidant and antiviral activity of fullerol against Zika virus

Pereira, Samille Henriques / Almeida, Letícia Trindade / Ferraz, Ariane Coelho / Ladeira, Marina de Souza / Ladeira, Luiz Orlando / Magalhães, Cíntia Lopes de Brito / Silva, Breno de Mello

Acta tropica. 2021 Dec., v. 224

2021

Abstract	Neglected for years, Zika virus (ZIKV) has become one of the most relevant arboviruses in current public health. The recent Zika fever epidemic in the Americas generated a worldwide alert due to the association with diseases such as Guillain-Barré syndrome and congenital syndromes. Among the pathogenesis of ZIKV, recent studies suggest that oxidative stress plays an important role during infection and that compounds capable of modulating oxidative stress are promising as therapeutics. Furthermore, so far there are no specific and efficient antiviral drug or vaccine available against ZIKV. Thus, fullerol was evaluated in the context of infection by ZIKV, since it is a carbon nanomaterial known for its potent antioxidant action. In this study, fullerol did not alter cell viability at the concentrations tested, proving to be inert, beyond to presenting high antioxidant power at low concentrations. ZIKV infection of human glioblastoma increased the production of reactive oxygen species by 60% and modulated the Nrf-2 pathway activity negatively. After treatment with fullerol, both conditions were restored to baseline levels. Additionally, fullerol was able to reduce viral production by up to 90%. Therefore, our results suggest that fullerol as a promising candidate in the control of ZIKV infections, presenting both antioxidant and antiviral action.
Keywords	Zika virus ; antioxidant activity ; antiviral agents ; antiviral properties ; arboviruses ; cell viability ; fever ; glioblastoma ; humans ; oxidative stress ; pathogenesis ; public health ; reactive oxygen species ; therapeutics ; vaccines
Language	English
Dates of publication	2021-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2021.106135
Database	NAL-Catalogue (AGRICOLA)

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Article: Challenges in Direct Detection of Flaviviruses: A Review.

Dias, Bruna de Paula / Barbosa, Camila Cavadas / Ferreira, Cyntia Silva / Mayra Soares Alves Dos Santos, Samara / Arrieta, Orlando Alfredo Pineda / Malta, Wellington Carvalho / Gomes, Maria Laura Maximiano Dias / Alves E Silva, Mariela / Fonseca, Júlia de Matos / Borges, Lysandro Pinto / Silva, Breno de Mello

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: Arthropods transmit arboviruses via mosquito and tick bites to humans and other animals. The genus flavivirus, which causes diseases, sequelae, and thousands of deaths, mainly in developing and underdeveloped countries, is among the arboviruses of ... ...

Abstract	Arthropods transmit arboviruses via mosquito and tick bites to humans and other animals. The genus flavivirus, which causes diseases, sequelae, and thousands of deaths, mainly in developing and underdeveloped countries, is among the arboviruses of interest to public health. Given the importance of early and accurate diagnosis, this review analyzes the methods of direct detection of flaviviruses, such as reverse transcription loop-mediated isothermal amplification, microfluidics, localized surface plasmon resonance, and surface-enhanced Raman scattering, and presents the advantages, disadvantages, and detection limits identified in studies reported in the literature for each methodology. Among the different methods available, it is essential to balance four fundamental indicators to determine the ideal test: good sensitivity, high specificity, low false positive rate, and rapid results. Among the methods analyzed, reverse transcription loop-mediated isothermal amplification stands out, owing to result availability within a few minutes, with good sensitivity and specificity; in addition, it is the best-characterized methodology.
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12050643
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Article ; Online: SARS-CoV-2 mutations and where to find them: an

Gonçalves, Ricardo Lemes / Leite, Túlio César Rodrigues / Dias, Bruna de Paula / Caetano, Camila Carla da Silva / de Souza, Ana Clara Gomes / Batista, Ubiratan da Silva / Barbosa, Camila Cavadas / Reyes-Sandoval, Arturo / Coelho, Luiz Felipe Leomil / Silva, Breno de Mello

Journal of biomolecular structure & dynamics

2020 Volume 40, Issue 7, Page(s) 3336–3346

Abstract: Communicated by Ramaswamy H. Sarma. ...

Abstract	Communicated by Ramaswamy H. Sarma.
MeSH term(s)	COVID-19 ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutation ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-06
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1844052
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid diagnosis of COVID-19 in the first year of the pandemic: A systematic review.

Borges, Lysandro Pinto / Martins, Aline Fagundes / Silva, Breno de Mello / Dias, Bruna de Paula / Gonçalves, Ricardo Lemes / Souza, Daniela Raguer Valadão de / Oliveira, Makson Gleydson Brito de / Jesus, Pamela Chaves de / Serafini, Mairim Russo / Quintans, Jullyana Souza Siqueira / Coutinho, Henrique Douglas Melo / Martins, Natália / Júnior, Lucindo José Quintans

International immunopharmacology

2021 Volume 101, Issue Pt A, Page(s) 108144

Abstract: Background: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health threat and remains a challenge for modern medicine. Rapid and accurate diagnosis of COVID-19 is vital for proper disease and outbreak ... ...

Abstract	Background: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health threat and remains a challenge for modern medicine. Rapid and accurate diagnosis of COVID-19 is vital for proper disease and outbreak management. Our review aimed to analyze scientific articles published in the literature addressing the rapid tests available for COVID-19 diagnosis at the first year of the pandemic. Methods: A systematic review was performed from October 22 to 27, 2020, searching data published in PubMed and Google Scholar databases, using subject headings or keywords related to point of care and rapid test diagnostic for SARS-CoV-2 and COVID-19. Results: The first survey identified 403 articles, but only 23 met the defined criteria for the systematic analysis. The sensitivity and specificity parameters were assessed in 19 studies, and the data suggested that there was lower sensitivity in the period 1 to 7 days after the emergence of symptoms (∼38%) higher sensitivity at 8 to 14 days (∼90%), and the highest at 15 to 39 days (∼98%). Accuracy was reported in six studies, reporting values above 50%. Only three studies reported a possible cross-reaction. Conclusions: Our findings indicate that the rapid tests used in the first year of the pandemic were tested with a small number of samples and not adequately validated. And the studies that described them were conducted with little scientific rigor.
MeSH term(s)	Antigens, Viral/analysis ; COVID-19/diagnosis ; COVID-19 Testing/standards ; Cross Reactions ; Humans ; Pandemics ; Point-of-Care Testing/standards ; Sensitivity and Specificity
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2021-09-15
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.108144
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