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  1. Article: Editorial: Impact of COVID-19 pandemic on eating habits: 2-year legacy of social distancing times.

    Tebar, William R / Silva, Danilo R / Christofaro, Diego G D

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1188630

    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1188630
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  2. Article ; Online: The challenge of promoting physical activity in low-income and middle-income countries.

    Ramírez-Vélez, Robinson / Silva, Danilo R

    The Lancet. Global health

    2023  Volume 11, Issue 8, Page(s) e1158–e1159

    MeSH term(s) Humans ; Developing Countries ; Exercise ; Poverty ; Income
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00320-0
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  3. Article ; Online: Exploring the direction of the relationship between socioeconomic and physical activity inequalities: connotations for public policies.

    Werneck, André O / Araujo, Raphael H O / Silva, Danilo R

    Journal of public health (Oxford, England)

    2023  

    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdad250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The mediation role of social network size and perception in the association between physical activity and depressive symptoms: a prospective analysis from the SHARE study.

    Werneck, André O / Cunha, Paolo M / Silva, Danilo R

    Aging & mental health

    2023  Volume 27, Issue 9, Page(s) 1738–1743

    Abstract: Objectives: To investigate the mediating role of social network size and perceived quality in the associations of physical activity with quality of life and depressive symptoms in middle-aged and older adults.: Method: We analyzed information of 10, ... ...

    Abstract Objectives: To investigate the mediating role of social network size and perceived quality in the associations of physical activity with quality of life and depressive symptoms in middle-aged and older adults.
    Method: We analyzed information of 10,569 middle-aged and older adults from waves 2 (2006-2007), 4 (2011-2012), and 6 (2015) of the Survey of Health, Ageing, and Retirement in Europe study (SHARE). Data on physical activity (moderate and vigorous intensities), social network (size and quality), depressive symptoms (EURO-D scale), and quality of life (CASP) were self-reported. Sex, age, country of residency, schooling, occupational status, mobility, and baseline values of the outcome were used as covariates. We created mediation models to test the mediating effect of social network size and quality in the association between physical activity and depressive symptoms.
    Results: Social network size partly mediated the association between vigorous physical activity and depressive symptoms (7.1%; 95%CI: 1.7-12.6) as well as the association between moderate (9.9%; 1.6-19.7) and vigorous (8.1%; 0.7-15.4) physical activity and quality of life. Social network quality did not mediate any of the associations tested.
    Conclusion: We conclude that social network's size, but not satisfaction, mediates part of the association of physical activity with depressive symptoms and quality of life in middle-aged and older adults. Future physical activity interventions among middle-aged and older adults should consider increasing social interactions to facilitate benefits for mental health-related outcomes.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Depression/diagnosis ; Quality of Life ; Exercise ; Social Networking ; Perception
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2023.2177831
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  5. Book ; Online: How to fix a broken confidence estimator

    Cattelan, Luís Felipe P. / Silva, Danilo

    Evaluating post-hoc methods for selective classification with deep neural networks

    2023  

    Abstract: This paper addresses the problem of selective classification for deep neural networks, where a model is allowed to abstain from low-confidence predictions to avoid potential errors. We focus on so-called post-hoc methods, which replace the confidence ... ...

    Abstract This paper addresses the problem of selective classification for deep neural networks, where a model is allowed to abstain from low-confidence predictions to avoid potential errors. We focus on so-called post-hoc methods, which replace the confidence estimator of a given classifier without retraining or modifying it, thus being practically appealing. Considering neural networks with softmax outputs, our goal is to identify the best confidence estimator that can be computed directly from the unnormalized logits. This problem is motivated by the intriguing observation in recent work that many classifiers appear to have a "broken" confidence estimator, in the sense that their selective classification performance is much worse than what could be expected by their corresponding accuracies. We perform an extensive experimental study of many existing and proposed confidence estimators applied to 84 pretrained ImageNet classifiers available from popular repositories. Our results show that a simple $p$-norm normalization of the logits, followed by taking the maximum logit as the confidence estimator, can lead to considerable gains in selective classification performance, completely fixing the pathological behavior observed in many classifiers. As a consequence, the selective classification performance of any classifier becomes almost entirely determined by its corresponding accuracy. Moreover, these results are shown to be consistent under distribution shift. We also investigate why certain classifiers innately have a good confidence estimator that apparently cannot be improved by post-hoc methods.
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-05-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Is it possible to run after positive affective experiences instead of health benefits without tackling social inequalities?

    Araujo, Raphael H O / Werneck, André O / de Jesus, Gilmar M / Silva, Danilo R P

    Journal of sport and health science

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2673028-5
    ISSN 2213-2961 ; 2095-2546
    ISSN (online) 2213-2961
    ISSN 2095-2546
    DOI 10.1016/j.jshs.2024.04.008
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  7. Article: The atmospheric blocking influence over the South Brazil Bight during the 2013–2014 summer

    Silva, Danilo A / Dottori, Marcelo

    Regional studies in marine science. 2021 June, v. 45

    2021  

    Abstract: The 2013–2014 summer in the Southeast Brazil region set records for negative precipitation anomalies and the highest sea surface temperatures. Such event was attributed to the anomalous presence of atmospheric blocking, which prevented the propagation of ...

    Abstract The 2013–2014 summer in the Southeast Brazil region set records for negative precipitation anomalies and the highest sea surface temperatures. Such event was attributed to the anomalous presence of atmospheric blocking, which prevented the propagation of a cold front towards the Equator and the establishment of the South Atlantic Convergence Zone, two phenomena that regulate the precipitation regime in this area. These blocking episodes are relatively important to the climate in mid-latitudes, but the feedback of the coastal ocean is still poorly understood under these anomalous conditions. This paper investigates, from a numerical perspective, the impacts on the thermohaline properties and circulation in the South Brazil Bight (SBB). We found that enhanced shortwave radiation leads to intense surface heating and that the presence of northeasterly winds strengthens the coastal upwelling nearby Cabo Frio. The South Atlantic Coastal Waters, transported into the SBB, regulate the extreme heating in the northern half of the domain, while, in the southern half, the absence of cold waters leads to the development of a warm-water pool. The final thermohaline structure induced an enlargement and intensification of the northwestward currents south of São Sebastião Island. Between Ubatuba and Cabo Frio, in the northern half, the northeasterly winds developed an intense surface advection towards offshore, and in the northern region, compensated by an opposite advection, towards the coast. We conclude that the coastal ocean feedback could present extreme anomalous conditions during atmospheric blocking events, leading to impacts upon the thermodynamical properties. Further studies are needed to understand the impacts of these events on biogeochemical properties.
    Keywords advection ; climate ; coastal water ; coasts ; cold ; heat ; latitude ; marine science ; shortwave radiation ; summer ; Brazil
    Language English
    Dates of publication 2021-06
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2352-4855
    DOI 10.1016/j.rsma.2021.101815
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Handgrip strength, physical activity and incident mild cognitive impairment and dementia.

    Werneck, André O / Araujo, Raphael H O / Silva, Danilo R / Vancampfort, Davy

    Maturitas

    2023  Volume 176, Page(s) 107789

    Abstract: Objective: We analyzed the mediating role of handgrip strength in the association between moderate to vigorous physical activity and incident mild cognitive impairment and dementia.: Methods: We used prospective data from 14 European countries ... ...

    Abstract Objective: We analyzed the mediating role of handgrip strength in the association between moderate to vigorous physical activity and incident mild cognitive impairment and dementia.
    Methods: We used prospective data from 14 European countries participating in the Survey of Health, Ageing, and Retirement in Europe. 19,686 participants free of dementia and mild cognitive impairment (64.9 ± 8.7 years) were followed up for a mean of 10.2 years. Moderate to vigorous physical activity was self-reported, and handgrip strength was assessed with a dynamometer. Mild cognitive impairment was defined as 1.5 standard deviations below the mean of the standardized global cognition score, while dementia was determined by physician diagnosis. Gender, age, country, education, presence of chronic diseases, depressive symptoms, limitations in activities of daily living, body mass index, and baseline cognitive levels were used as covariates. Cox proportional hazards as well as mediation models were used.
    Results: Moderate to vigorous physical activity for at least 1 day per week was independently associated with lower incident mild cognitive impairment (HR: 0.85; 95%CI: 0.74-0.98). A 10 % increase in handgrip strength was associated a 6 % lower hazard for incident mild cognitive impairment (0.94; 0.92-0.97) and 5 % lower hazard for incident dementia (0.95; 0.93-0.98). Handgrip strength partly mediated the association of moderate to vigorous physical activity with mild cognitive impairment (Coefficient: 0.03; 95%CI: 0.01-0.05; 17.9 %).
    Conclusions: Physical activity is independently associated with a lower incidence of mild cognitive impairment.
    MeSH term(s) Humans ; Hand Strength ; Prospective Studies ; Activities of Daily Living ; Cognitive Dysfunction/diagnosis ; Exercise ; Surveys and Questionnaires ; Dementia/epidemiology ; Dementia/prevention & control
    Language English
    Publishing date 2023-06-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2023.107789
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    Zs.A 1432: Show issues Location:
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  9. Article ; Online: FoxO3 and oxidative stress: a multifaceted role in cellular adaptation.

    Bernardo, Victoria Simões / Torres, Flaviene Felix / da Silva, Danilo Grünig Humberto

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 1-2, Page(s) 83–99

    Abstract: Oxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of ...

    Abstract Oxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of physiological and pathological processes by regulating multiple gene regulatory networks involved in the modulation of numerous aspects of cellular metabolism, including fuel metabolism, cell death, and stress resistance. This review will also focus on regulatory mechanisms of FoxO3 expression and activity, such as crucial post-translational modifications and non-coding RNAs. Moreover, this work discusses and evidences some pathways to how this transcription factor and reactive oxygen species regulate each other, which may lead to the pathogenesis of various types of diseases. Therefore, in addition to being a promising therapeutic target, the FoxO3-regulated signaling pathways can also be used as reliable diagnostic and prognostic biomarkers and indicators for drug responsiveness.
    MeSH term(s) Humans ; Forkhead Box Protein O3/metabolism ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Oxidative Stress/genetics ; Signal Transduction
    Chemical Substances Forkhead Box Protein O3 ; Forkhead Transcription Factors ; FOXO3 protein, human
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-022-02281-5
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  10. Article ; Online: Internalization of extracellular vesicles from

    da Silva, Danilo R / Gonzalez, Claudio F / Lorca, Graciela L

    Journal of extracellular biology

    2023  Volume 2, Issue 7

    Abstract: Cells of all domains of life can secrete extracellular vesicles (EV). These secreted vesicles have been indicated as vehicles carrying molecules that facilitate intra- and inter-species interaction. ...

    Abstract Cells of all domains of life can secrete extracellular vesicles (EV). These secreted vesicles have been indicated as vehicles carrying molecules that facilitate intra- and inter-species interaction.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ISSN 2768-2811
    ISSN (online) 2768-2811
    DOI 10.1002/jex2.101
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