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Article ; Online: Stomach cancer incidence trends in selected Latin America countries: Age, period, and birth-cohort effects.

de Carvalho, Thayana Calixto / da Mota Borges, Anne Karin / Silva, Ilce Ferreira da

2023 Volume 85, Page(s) 102392

Abstract: Background: to explore the age, period, and birth-cohort effects on stomach cancer incidence trends during 3 decades in selected Latin American countries.: Methods: a time-trend study was performed using Cancer Incidence in Five Continents data from ... ...

Abstract	Background: to explore the age, period, and birth-cohort effects on stomach cancer incidence trends during 3 decades in selected Latin American countries. Methods: a time-trend study was performed using Cancer Incidence in Five Continents data from high-quality population-based cancer registries(PBCRs) in Latin American countries. Crude and age-standardized incidence rates(ASRIs) were calculated. Time trends in ASRIs were assessed using the average annual percentage change(AAPC). Age-period-cohort effects were estimated by Poisson regression for individuals aged between 20 and 79 years with stomach cancer informed by PBCRs from 1983 to 2012 in Cali(Colombia); from 1982 to 2011 in Costa Rica; and from 1988 to 2012 for Goiania(Brazil) and Quito(Ecuador). The goodness-of-fit model was tested using the deviance of the models. Results: a decrease in age-standardized incidence rates was observed for both genders in all populations covered by PBCRs, except for young men from Cali(AAPC 3.89 95 %IC: 1.32-7.29). The age effect was statistically significant in all areas, and the curve slope reached peaks in the older age groups. The cohort effect was observed in all PBCRs. Regarding the period effect, an increased ratio rate was observed for both genders in Costa Rica(1997-2001 women RR 1.11 95 %CI: 1.05-1.17; men RR 1.12 95 %CI: 1.08-1.17) and Goiânia(2003-2007 women RR 1.21 95 %CI: 1.08-1.35; men RR 1.09 95 %CI: 1.01-1.20), while Quito(1998-2002 women RR 0.89 95 %CI: 0.81-0.98; men RR 0.86 95 %CI: 0.79-0.93) presented a decrease. Conclusion: the present study showed a decreasing gastric cancer trend for over the past 30 years with gender and geographic variations. Such a decrease seems to be mainly a result of cohort effects, suggesting that the economic market opening process led to changes in the risk factor exposures over successive generations. These geographic and gender variations may reflect cultural/ethnic/gender differences and differences in dietary and smoking rate patterns. However, an increased incidence was observed for young men in Cali, and additional studies are needed to determine the cause of the increasing incidence in this group.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Young Adult ; Adult ; Middle Aged ; Incidence ; Stomach Neoplasms/epidemiology ; Latin America/epidemiology ; Cohort Effect ; Risk Factors ; Registries
Language	English
Publishing date	2023-06-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2023.102392
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Article ; Online: P53 Expression in benign Breast Disease Development: A Systematic Review.

Costa, Rafaela Soares Senra da / Silva, Ilce Ferreira Da

Asian Pacific journal of cancer prevention : APJCP

2020 Volume 21, Issue 9, Page(s) 2485–2491

Abstract: Background: Benign breast disease (BBD) is one of main breast cancer risk factors. Dysfunctions on p53 protein, which has a genome protective role, have been related to breast cancer developments. However, its role on BBD development is still unclear.!## ...

Abstract	Background: Benign breast disease (BBD) is one of main breast cancer risk factors. Dysfunctions on p53 protein, which has a genome protective role, have been related to breast cancer developments. However, its role on BBD development is still unclear. Methods: A systematic review of literature was proceeded according to PRISMA-P guidelines. PubMed, BVS, MEDLINE and Scholar Google were used as databases, complemented by a manual search in articles references. Articles searches were conducted from May to July 2019 and publications in English, Spanish and Portuguese were selected. P53 expression was set as outcome among women with BBD and were included only articles with good quality according STROBE tools. Data concerning p53 expression frequencies were independently extracted by two review authors, and eligible articles were synthesized. Results: From 12 studies selected for this review, the majority analyzed p53 expression in non-proliferative lesions and general p53 expressions ranged from 0 to 100%. P53 expression was more frequently observed in cases series studies (91.7%) and in studies conducted in Occidental Europe (41.7%). P53 expression was more frequent among tissues with fibrocystic disease (22.5%) and fibroadenoma (22.5%). Conclusion: When compared with all breast tissues types, benign breast disease corresponds to 34.39% of p53 expression. Second outcomes were not evaluated because the heterogeneity observed in selected studies. In addition, more studies considering ethnicity and benign breast disease classification should also be considered for further analysis.
MeSH term(s)	Breast Diseases/metabolism ; Breast Diseases/pathology ; Female ; Fibroadenoma/metabolism ; Fibroadenoma/pathology ; Humans ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2020-09-01
Publishing country	Thailand
Document type	Journal Article ; Systematic Review
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2020.21.9.2485
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Article ; Online: Time trends in colorectal cancer incidence in four regions of Latin America: 1983-2012.

Carvalho, Thayana Calixto de / Borges, Anne Karin da Mota / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Cadernos de saude publica

2021 Volume 37, Issue 10, Page(s) e00175720

Abstract: This study aimed to assess time trends in colorectal cancer incidence from 1983 to 2012 in Latin America. This was an ecological time-series study whose population consisted of individuals aged 20 years or older diagnosed with colorectal cancer. Data ... ...

Abstract	This study aimed to assess time trends in colorectal cancer incidence from 1983 to 2012 in Latin America. This was an ecological time-series study whose population consisted of individuals aged 20 years or older diagnosed with colorectal cancer. Data from population-based cancer registries in Cali (Colombia), Costa Rica, Goiânia (Brazil), and Quito (Ecuador), were used for rates estimation, while time trends estimations were proceeded by the Joinpoint Regression Program. The study showed an increase in colorectal cancer incidence in men and women in Cali (2.8% and 3.2%, respectively), Costa Rica (3.1% and 2.1%, respectively), and Quito (2.6% and 1.2%, respectively), whereas in Goiânia, only women showed an increase in colorectal cancer rates (3.3%). For colon cancer, we observed an increasing trend in incidence rates in men and women in Cali (3.1% and 2.9%, respectively), Costa Rica (3.9% and 2.8%, respectively), and Quito (2.9% and 1.8%). For rectal cancer, we observed an increasing trend in incidence in men and women in Cali (2.5% and 2.6%, respectively), Costa Rica (2.2% and 1%, respectively), and Goiânia (5.5% and 4.6%, respectively), while in Quito only men showed an upward trend (2.8%). The study found increases in colorectal cancer, colon cancer, and rectal cancer in four Latin America regions. This findings reflect lifestyle, such as dietary changes, following the economic opening, and the prevalence variations of colorectal cancer risk factors by sex and between the four studied regions. Finally, the different strategies adopted by regions for colorectal cancer diagnosis and screening seem to influence the observed variation between anatomical sites.
MeSH term(s)	Brazil/epidemiology ; Colorectal Neoplasms/epidemiology ; Female ; Humans ; Incidence ; Latin America/epidemiology ; Male ; Registries
Language	English
Publishing date	2021-11-12
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311X00175720
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Article ; Online: Exposição a metais em população adulta residente em áreas industriais: revisão sistemática da literatura.

Campos, Élida de Albuquerque / Silva, Ilce Ferreira da / Warden, Carmen Freire

Ciencia & saude coletiva

2019 Volume 26, Issue 6, Page(s) 2253–2270

Abstract: This study aimed to review studies of human biomonitoring (HBM) that evaluated exposure to lead (Pb), cadmium (Cd), mercury (Hg), nickel (Ni), arsenic (As) and manganese (Mn) in adults living close to industrial areas. A systematic review of studies was ... ...

Title translation	Exposure to metals in the adult population living in industrial areas: a systematic review of the literature.
Abstract	This study aimed to review studies of human biomonitoring (HBM) that evaluated exposure to lead (Pb), cadmium (Cd), mercury (Hg), nickel (Ni), arsenic (As) and manganese (Mn) in adults living close to industrial areas. A systematic review of studies was selected, without initial date limit through to December 2017, from the MEDLINE and BVS databases. Original studies in English, Portuguese or Spanish conducted among the adult population using blood and/or urine as biomarkers were included. The articles were evaluated according to methodological criteria, including studies with comparison groups and/or probabilistic sampling. Of the 28 studies selected, 54% were conducted in Europe, 36% in Asia, 7% in North America and 4% in Africa. Foundries, metal works and steel mills were the most frequently studied. Urine and blood were used in 82% and 50% of studies, respectively. The elements most investigated were Cd, Pb and As. Despite using heterogeneous methodologies, the results revealed higher metal concentrations, especially from As and Hg in general, than in the comparison group. This review highlights the need for more rigorous methodological studies of HBM, stressing the importance of public health vigilance among populations exposed to toxic metals, especially in developing countries.
MeSH term(s)	Adult ; Arsenic/analysis ; Cadmium/analysis ; Environmental Monitoring ; Europe ; Humans ; Lead/analysis ; Mercury/analysis
Chemical Substances	Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Mercury (FXS1BY2PGL) ; Arsenic (N712M78A8G)
Language	Portuguese
Publishing date	2019-08-11
Publishing country	Brazil
Document type	Journal Article ; Systematic Review
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-81232021266.07612019
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Article ; Online: Survival rates of breast cancer and predictive factors: a hospital-based study from western Amazon area in Brazil.

Fujimoto, Ruth Helena Pimenta / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Ciencia & saude coletiva

2019 Volume 24, Issue 1, Page(s) 261–273

Abstract: Breast cancer survival in Latin America countries is below Central European countries. Hospital-based breast cancer survival studies in western Amazon, Brazil, are lacking. This article aims to estimate hospital-based breast cancer survival in Rio Branco, ...

Abstract	Breast cancer survival in Latin America countries is below Central European countries. Hospital-based breast cancer survival studies in western Amazon, Brazil, are lacking. This article aims to estimate hospital-based breast cancer survival in Rio Branco, Acre, and predictor factors. Hospital-based cohort study of all women diagnosed with breast cancer (2007-2012) was proceeded. Information were obtained from medical reports, and follow-up was until 2013. One-, 2- and 5- years breast cancer specific-survival were estimated by Kaplan-Meier method. Crude and adjusted Harzards Ratios (HR) were estimated by proportional Cox regression model. One-, 2-, and 5-year overall breast cancer survival were 95.5%, 83.7%, and 87.3% respectively. Surgery combined to radiotherapy significantly affected 1-, 2-, and 5-year survival (99%, 94%, and 90.6%, respectively) as compared to other treatments (77%,57.1%, and 37.5%, respectively). Comparing to surgery combined to radiotherapy treatment, surgery alone increased the risk of death, independently of age and stage (HR = 7.23;95%CI:2.29-22.83). In Rio Branco, Acre, 5-year breast cancer survival is similar to more developed areas in Brazil. Surgery combined to radiotherapy was independently associated to a lower risk of death as compared to surgery alone and other treatment.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brazil ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cohort Studies ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Neoplasm Staging ; Proportional Hazards Models ; Retrospective Studies ; Survival Rate ; Time Factors ; Young Adult
Language	English
Publishing date	2019-01-24
Publishing country	Brazil
Document type	Comparative Study ; Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1413-8123
ISSN (online)	1678-4561
ISSN	1413-8123
DOI	10.1590/1413-81232018241.35422016
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Article ; Online: Histórico social, demográfico e de saúde dos povos indígenas do estado do Acre, Brasil.

Borges, Maria Fernanda de Sousa Oliveira / Silva, Ilce Ferreira da / Koifman, Rosalina

Ciencia & saude coletiva

2018 Volume 25, Issue 6, Page(s) 2237–2246

Abstract: The historical trajectory experienced by Brazilian Amerindians population lead to a complex social issues, which are expressed by a lack of health service access and socioeconomic disparities. Such reality is translated into a higher level of poverty, ... ...

Title translation	Social, demographic, and health policies history of indigenous peoples from the state of Acre, Brazil.
Abstract	The historical trajectory experienced by Brazilian Amerindians population lead to a complex social issues, which are expressed by a lack of health service access and socioeconomic disparities. Such reality is translated into a higher level of poverty, lower education level and worse health profile, as compared to non-indigenous counterparts. The current health policies for indigenous population in Brazil could not overcome the lack of specialized care access. thus, fragmented and unplanned health care still persist, with distortions in the process of social control. Therefore, increased morbidity and mortality rates, unequal health care access, lack of continuity of care, and administrative barriers are still frequent among Brazilian Amerindians. The indigenous peoples from the State of Acre, located in the Western Brazilian Amazon, reflects the situation of greater vulnerability among all the indigenous populations from the North Region of Brazil, sharing worse health outcomes as compared to the rest of the country. Thus, the purpose of this narrative review is to characterize the history of the Indian population in Brazil and the State of Acre, according to demographic, epidemiological and health policies.
MeSH term(s)	Brazil ; Environment ; Health Policy ; Health Services, Indigenous ; Humans ; Indigenous Peoples ; Population Groups
Language	Portuguese
Publishing date	2018-09-27
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-81232020256.12082018
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Article ; Online: Breastfeeding patterns and factors associated with early weaning in the Western Amazon.

Martins, Fernanda Andrade / Ramalho, Alanderson Alves / Andrade, Andréia Moreira de / Opitz, Simone Perufo / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Revista de saude publica

2021 Volume 55, Page(s) 21

Abstract: Objective: To characterize breastfeeding patterns in the first six months of life and factors associated with early weaning in a birth-cohort in Rio Branco, state of Acre.: Methods: This is a prospective study with all babies born between April and ... ...

Abstract	Objective: To characterize breastfeeding patterns in the first six months of life and factors associated with early weaning in a birth-cohort in Rio Branco, state of Acre. Methods: This is a prospective study with all babies born between April and June 2015. The mothers were interviewed soon after birth and between 6 and 15 months postpartum. At hospital discharge, breastfeeding was defined as exclusively (EBF), and breastfeeding (BF). In the follow-up, breastfeeding patterns were exclusive breastfeeding (EBF), predominant breastfeeding (PBF), and breastfeeding (BF). The interruption of breastfeeding in the first six months was classified as early weaning. The Kaplan Meier method (log-rank: 95%) was used to estimate the conditional probability of change in breastfeeding pattern, and early weaning risk. Crude and adjusted proportional Cox regression models, and their respective 95% confidence intervals (95%CI), were used to analyze the factors associated with early weaning. Results: The study included 833 infants in EBF (95.4%) and BF (4.6%) at hospital discharge. During the first six months of life, the infant likely discharged in EBF remaining in EBF, becoming PBF, and BF, were respectively 16.4%, 32.3%, and 56.5%. The weaning likely at six months was statistically higher for infants discharged in BF (47.4%) when compared with those discharged in EBF (26%). Factors associated with early weaning were BF at hospital discharge (HR = 1.82; 95%CI 1.06-3.11), no mother cross-breastfeeding (HR = 2.50; 95%CI 1.59-3.94), pacifier use (HR = 6.23; 95%CI 4.52-8.60), less than six months of breastfeeding intention (HR = 1.93; 95%CI 1.25-2.98), lack of breastfeeding in the first hour of life (HR = 1.45; 95%CI 1.10-1.92), and pregnancy alcohol consumption (HR = 1.88; 95%CI 1.34-2.90). Conclusion: Compared to infants in EBF, those in BF at hospital discharge were more likely to wean. Public health efforts should prioritize EBF at hospital discharge, promote breastfeeding in the first hour of life, and prevent alcohol consumption risks during pregnancy, cross-breastfeeding and pacifier use.
MeSH term(s)	Brazil/epidemiology ; Breast Feeding ; Female ; Humans ; Infant ; Mothers ; Pregnancy ; Prospective Studies ; Weaning
Language	Portuguese
Publishing date	2021-05-17
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/s1518-8787.2021055002134
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Article ; Online: Mortalidade por câncer em populações indígenas no Estado do Acre, Brasil.

Borges, Maria Fernanda de Sousa Oliveira / Koifman, Sergio / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Cadernos de saude publica

2019 Volume 35, Issue 5, Page(s) e00143818

Abstract: The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to ... ...

Title translation	Cancer mortality among indigenous population in Acre State, Brazil.
Abstract	The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to December 31st, 2012. The study analyzed the distribution death frequencies by sex and age. Standardized mortality ratio (SMR) was calculated taking Goiânia (Goiás State), Acre State, and the North Region of Brazil as the references. A total of 81 deaths were identified, the majority in men (59.3%) and in individuals over 70 years of age. The five main sites in men were stomach, liver, colon and rectum, leukemia, and prostate. The five main sites in women were uterine cervix, stomach, liver, leukemia, and uterus. In indigenous men there was an excess of deaths from stomach cancer compared to the populations of Goiânia (SMR = 2.72; 2.58-2.87), Acre State (SMR = 2.05; 1.94-2.16) and North region (SMR = 3.10; 2.93-3.27). The same was observed for deaths from hepatic cell carcinomas referenced against Goiânia (SMR = 3.89; 3.66-4.14), Acre State (SMR = 1.79; 1.68-1.91), and the North of Brazil (SMR = 4.04; 3.77-4.30). Among indigenous women, there was an excess of cervical cancer in comparison to Goiânia (SMR = 4.67; 4.41-4.93), Acre State (SMR = 2.12; 2.00-2.24), and the North (SMR = 2.60; 2.45-2.75). The estimates show that preventable neoplasms such as cervical cancer and those linked to underdevelopment, such as stomach and liver cancer, account for 49.4% of deaths among indigenous peoples. Compared to the reference population, mortality from liver, stomach, and colorectal cancer and leukemias was more than twice as high in indigenous men; among indigenous women, cervical, stomach, and liver cancer and leukemias were 30% higher.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brazil/epidemiology ; Cause of Death ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Indians, South American ; Indigenous Peoples/statistics & numerical data ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Neoplasms/classification ; Neoplasms/diagnosis ; Neoplasms/mortality ; Population Groups ; Prevalence ; Risk Factors ; Sex Factors ; Young Adult
Language	Portuguese
Publishing date	2019-05-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311X00143818
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Article ; Online: Characterization of women with cervical cancer assisted at Inca by histological type.

Rozario, Suelem do / Silva, Iléia Ferreira da / Koifman, Rosalina Jorge / Silva, Ilce Ferreira da

Revista de saude publica

2019 Volume 53, Page(s) 88

Abstract: Objective: To determine the distribution of sociodemographic, reproductive, clinical and lifestyle habits in the cohort of women diagnosed with cervical cancer, assisted at Inca between 2012 and 2014, according to the histological type.: Methods: ... ...

Abstract	Objective: To determine the distribution of sociodemographic, reproductive, clinical and lifestyle habits in the cohort of women diagnosed with cervical cancer, assisted at Inca between 2012 and 2014, according to the histological type. Methods: Retrospective observational study of a hospital cohort of 1,004 women diagnosed with cervical cancer. Data were obtained from the Inca hospital cancer registry, physical and electronic records. Results: The most frequent histological type was squamous cell carcinoma (83.9%). Approximately 70% of the women aged more than 40 years. The study includes non-white women (67.4%), with less than 8 years of education (51.9%), with onset of sexual activity up to 16 years of age (40.7%), who were pregnant before (95.5%), with more than one pregnancy (82.9%), and more than two children (52.7%); 45.8% of the women were smokers or former smokers. Cervical adenocarcinoma was positively associated with earlier staging (IA-IIA) (OR = 1.79; 95%CI 1.03-3.13), as well as women with ≥ 12 years of education (OR = 6.30; 95%CI 1.97-20,13), who had no children (OR = 3.81; 95%CI 1.20 - 12,08) or who had up to two children (OR = 1.74; 95%CI 1.05 - 2,87). Conclusions: The difference between histological types is highlighted, suggesting that women with cervical adenocarcinoma may represent a distinct clinical entity of cervical neoplasia, which may require different approaches from those used in squamous cell carcinoma.
MeSH term(s)	Adenocarcinoma/epidemiology ; Adenocarcinoma/pathology ; Adult ; Age Distribution ; Brazil/epidemiology ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Life Style ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Risk Factors ; Sexual Behavior ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/pathology
Language	Portuguese
Publishing date	2019-10-03
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/s1518-8787.2019053001218
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Article ; Online: Gene-Environment Interaction between Arg72Pro SNP and Selected Environmental Exposures among Brazilian Women Diagnosed with Benign Breast Disease.

Da Costa, Rafaela Soares Senra / Koifman, Rosalina Jorge / Esteves, Viviane Ferreira / Schilling, Marla Presa Raulino / Koifman, Sergio / Silva, Ilce Ferreira Da

Asian Pacific journal of cancer prevention : APJCP

2020 Volume 21, Issue 12, Page(s) 3477–3485

Abstract: Background: Benign breast disease (BBD) is a factor strongly associated with breast cancer worldwide. Arg72Pro SNP association with breast cancer is controversial due to the suggestion that environmental factors are required to modulate such risk. There ...

Abstract	Background: Benign breast disease (BBD) is a factor strongly associated with breast cancer worldwide. Arg72Pro SNP association with breast cancer is controversial due to the suggestion that environmental factors are required to modulate such risk. There are no studies evaluating these environmental interactions of the aforementioned SNP within BBD. Aim: To determine the frequency of SNP Arg72Pro in a cohort of women diagnosed with BBD; and to investigate gene-environmental interactions with environmental factors. Results: The genotype frequency was 44.6% for Arg/Pro, 39.3% for Arg/Arg genotype, and 16.3% for Pro/Pro homozygote. Gene-environment interaction analysis shows that when Arg/Arg is considered as reference, there is an ORinteraction with Arg/Pro and fabric exposure (OR=1.90;95%CI:1.04,3.48), solvents (OR=2.21;95%CI:1.01,4.83) and chlorine, bleaches, disinfectants, and liquid wax exposure (OR=2.52;95%CI:1.07,5.91). Analysis with Pro/Pro genotype as the reference showed an interaction between alcohol consumption and recessive model (OR=1.58;95%CI:1.00,2.51). Gene-environmental interactions were observed too between exposure to hair dyes, straighteners or relaxers and Arg/Arg (OR=3.26;95%CI:1.21,8.82). Conclusion: The Arg/Pro genotype was the most frequent in the BBD cohort. When compared with the Arg/Arg genotype, the presence of Arg/Pro genotype and solvents, fabric and cleaning products exposure increased the risk of BBD. When compared with Pro/Pro genotype, there were interactions between recessive model with alcohol consumption and exposure to hair products on the risk of BBD.
MeSH term(s)	Arginine/genetics ; Brazil/epidemiology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Cross-Sectional Studies ; Environmental Exposure/adverse effects ; Female ; Follow-Up Studies ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Genotype ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide ; Prognosis ; Risk Factors ; Tumor Suppressor Protein p53/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53 ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2020-12-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2020.21.12.3477
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