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Article ; Online: Probiotics, prebiotics, and synbiotics in childhood diarrhea.

Martins, E M S / Nascimento da Silva, L C / Carmo, M S

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2024 Volume 57, Page(s) e13205

Abstract: Acute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is ... ...

Abstract	Acute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and synbiotics are effective, which made such treatments increasingly present in clinical practice by reducing illness duration with minimal side effects. However, there are still controversies regarding some unwanted reactions in patients. The diversity of strains and the peculiarities of the pathogens that cause diarrhea require further studies to develop effective protocols for prevention and treatment. Here, we provide a descriptive review of childhood diarrhea, emphasizing treatment with probiotics, prebiotics, and synbiotics.
MeSH term(s)	Humans ; Probiotics/therapeutic use ; Synbiotics/administration & dosage ; Prebiotics/administration & dosage ; Diarrhea/microbiology ; Diarrhea/therapy ; Diarrhea/prevention & control ; Child ; Gastrointestinal Microbiome/physiology ; Child, Preschool
Chemical Substances	Prebiotics
Language	English
Publishing date	2024-04-19
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X2024e13205
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Article ; Online: Perinatal cortisol and blood glucose concentrations in bitches and neonatal puppies: effects of mode of whelping.

Lúcio, C F / Silva, L C G / Vannucchi, C I

Domestic animal endocrinology

2020 Volume 74, Page(s) 106483

Abstract: The decision on how and when to assist whelping is crucial for the survival rate of puppies and health status of the dam. However, medical or surgical therapy in dystocia can impact both maternal and neonatal stress and glucose response differently. This ...

Abstract	The decision on how and when to assist whelping is crucial for the survival rate of puppies and health status of the dam. However, medical or surgical therapy in dystocia can impact both maternal and neonatal stress and glucose response differently. This study aims to compare perinatal cortisol and glucose among different modes of delivery in bitches and neonates. We analyzed 50 puppies derived from 27 healthy bitches. According to the condition at birth, bitches and their puppies were allocated into either a Eutocia Group (vaginal birth with no whelping assistance), Fetal Dystocia Group (whelping assistance with fetal manipulation), Maternal Dystocia Group (whelping assistance because of partial uterine inertia corrected by oxytocin administration), or Cesarean Section Group (fetal or maternal dystocia bitches subjected to C-section). Maternal blood cortisol and glucose concentrations were analyzed during the perinatal period (prepartum, intrapartum, postpartum, and 1 h after postpartum). Neonatal blood samples were collected within 5 min and 1 h after birth for assessment of cortisol and glucose. Maternal dystocia bitches had higher cortisol concentrations at postpartum than the Fetal Dystocia Group. At 1 h postpartum, the Cesarean Section Group had higher cortisol concentrations compared with fetal dystocia bitches. The Eutocia Group presented increased cortisol concentrations at intrapartum and postpartum, whereas fetal dystocia bitches had higher intrapartum cortisol concentrations than at 1 h postpartum. The Maternal Dystocia Group presented higher postpartum cortisol concentrations than at prepartum and 1 h postpartum. Maternal glucose had a progressive increase throughout peripartum and was higher during postpartum and at 1 h postpartum. C-section bitches had the highest blood glucose concentration. Neonatal cortisol concentrations at birth were higher than 1 h after birth. Fetal dystocia puppies had higher cortisol concentrations, whereas caesarian section puppies had lower cortisol levels. Fetal dystocia and C-section puppies had higher glucose concentrations than the Eutocia Group. In conclusion, maternal dystocia leads to high cortisol concentrations in bitches immediately postpartum, whereas only fetal dystocia causes increased neonatal cortisol concentrations. Moreover, fetal dystocia and C-section are hyperglycemic obstetrical conditions for neonatal puppies; on the other hand, only C-section causes hyperglycemia in bitches.
MeSH term(s)	Animals ; Animals, Newborn/blood ; Blood Glucose ; Cesarean Section/veterinary ; Dog Diseases ; Dogs ; Dystocia/blood ; Dystocia/veterinary ; Female ; Hydrocortisone/blood ; Oxytocin/pharmacology ; Parturition/drug effects ; Parturition/physiology ; Postpartum Period ; Pregnancy
Chemical Substances	Blood Glucose ; Oxytocin (50-56-6) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2020-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	594468-5
ISSN	1879-0054 ; 0739-7240
ISSN (online)	1879-0054
ISSN	0739-7240
DOI	10.1016/j.domaniend.2020.106483
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Article: Perinatal cortisol and blood glucose concentrations in bitches and neonatal puppies: effects of mode of whelping

Lúcio, C.F / Silva, L.C.G / Vannucchi, C.I

Domestic animal endocrinology. 2021 Jan., v. 74

2021

Abstract	The decision on how and when to assist whelping is crucial for the survival rate of puppies and health status of the dam. However, medical or surgical therapy in dystocia can impact both maternal and neonatal stress and glucose response differently. This study aims to compare perinatal cortisol and glucose among different modes of delivery in bitches and neonates. We analyzed 50 puppies derived from 27 healthy bitches. According to the condition at birth, bitches and their puppies were allocated into either a Eutocia Group (vaginal birth with no whelping assistance), Fetal Dystocia Group (whelping assistance with fetal manipulation), Maternal Dystocia Group (whelping assistance because of partial uterine inertia corrected by oxytocin administration), or Cesarean Section Group (fetal or maternal dystocia bitches subjected to C-section). Maternal blood cortisol and glucose concentrations were analyzed during the perinatal period (prepartum, intrapartum, postpartum, and 1 h after postpartum). Neonatal blood samples were collected within 5 min and 1 h after birth for assessment of cortisol and glucose. Maternal dystocia bitches had higher cortisol concentrations at postpartum than the Fetal Dystocia Group. At 1 h postpartum, the Cesarean Section Group had higher cortisol concentrations compared with fetal dystocia bitches. The Eutocia Group presented increased cortisol concentrations at intrapartum and postpartum, whereas fetal dystocia bitches had higher intrapartum cortisol concentrations than at 1 h postpartum. The Maternal Dystocia Group presented higher postpartum cortisol concentrations than at prepartum and 1 h postpartum. Maternal glucose had a progressive increase throughout peripartum and was higher during postpartum and at 1 h postpartum. C-section bitches had the highest blood glucose concentration. Neonatal cortisol concentrations at birth were higher than 1 h after birth. Fetal dystocia puppies had higher cortisol concentrations, whereas caesarian section puppies had lower cortisol levels. Fetal dystocia and C-section puppies had higher glucose concentrations than the Eutocia Group. In conclusion, maternal dystocia leads to high cortisol concentrations in bitches immediately postpartum, whereas only fetal dystocia causes increased neonatal cortisol concentrations. Moreover, fetal dystocia and C-section are hyperglycemic obstetrical conditions for neonatal puppies; on the other hand, only C-section causes hyperglycemia in bitches.
Keywords	blood ; blood glucose ; cesarean section ; cortisol ; domestic animals ; dystocia ; glucose ; health status ; hyperglycemia ; oxytocin ; perinatal period ; survival rate
Language	English
Dates of publication	2021-01
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	594468-5
ISSN	1879-0054 ; 0739-7240
ISSN (online)	1879-0054
ISSN	0739-7240
DOI	10.1016/j.domaniend.2020.106483
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Article ; Online: A comprehensive resilience assessment of Mexican tree species and their relationship with drought events over the last century

Correa‐Díaz, A. / Villanueva‐Díaz, J. / Gómez‐Guerrero, A. / Martínez‐Bautista, H. / Castruita‐Esparza, L. U. / Horwath, W. R. / Silva, L. C. R.

Global Change Biology. 2023 July, v. 29, no. 13 p.3652-3666

2023

Abstract: The resilience of forests to drought events has become a major natural resource sustainability concern, especially in response to climate change. Yet, little is known about the legacy effects of repeated droughts, and tree species ability to respond ... ...

Abstract	The resilience of forests to drought events has become a major natural resource sustainability concern, especially in response to climate change. Yet, little is known about the legacy effects of repeated droughts, and tree species ability to respond across environmental gradients. In this study, we used a tree‐ring database (121 sites) to evaluate the overall resilience of tree species to drought events in the last century. We investigated how climate and geography affected the response at the species level. We evaluated temporal trends of resilience using a predictive mixed linear modeling approach. We found that pointer years (e.g., tree growth reduction) occurred during 11.3% of the 20th century, with an average decrease in tree growth of 66% compared to the previous period. The occurrence of pointer years was associated with negative values of the Standardized Precipitation Index (SPI, 81.6%) and Palmer Drought Severity Index (PDSI, 77.3%). Tree species differed in their resilience capacity, however, species inhabiting xeric conditions were less resistant but with higher recovery rates (e.g., Abies concolor, Pinus lambertiana, and Pinus jeffreyi). On average, tree species needed 2.7 years to recover from drought events, with extreme cases requiring more than a decade to reach pre‐drought tree growth rates. The main abiotic factor related to resilience was precipitation, confirming that some tree species are better adapted to resist the effects of droughts. We found a temporal variation for all tree resilience indices (scaled to 100), with a decreasing resistance (−0.56 by decade) and resilience (−0.22 by decade), but with a higher recovery (+1.72 by decade) and relative resilience rate (+0.33 by decade). Our results emphasize the importance of time series of forest resilience, particularly by distinguishing the species‐level response in the context of legacy of droughts, which are likely to become more frequent and intense under a changing climate.
Keywords	Abies concolor ; Pinus jeffreyi ; Pinus lambertiana ; atmospheric precipitation ; climate ; climate change ; databases ; drought ; environmental factors ; forests ; geography ; growth retardation ; growth rings ; temporal variation ; time series analysis ; tree growth ; trees
Language	English
Dates of publication	2023-07
Size	p. 3652-3666.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16705
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Article ; Online: Systemic therapies for salivary gland carcinomas: an overview of published clinical trials.

Silva, L-C / Pérez-de-Oliveira, M-E / Pedroso, C-M / Leite, A-A / Santos-Silva, A-R / Lopes, M-A / Junior, G-D / Martins, M-D / Wagner, V-P / Kowalski, L-P / Squarize, C-H / Castilho, R-M

Medicina oral, patologia oral y cirugia bucal

2024 Volume 29, Issue 2, Page(s) e280–e287

Abstract: Background: There is no consensus about effective systemic therapy for salivary gland carcinomas (sgcs). Our aim was summarized the clinical trials assessing the systemic therapies (ST) on sgcs.: Material and methods: Electronic searches were carried ...

Abstract	Background: There is no consensus about effective systemic therapy for salivary gland carcinomas (sgcs). Our aim was summarized the clinical trials assessing the systemic therapies (ST) on sgcs. Material and methods: Electronic searches were carried out through MEDLINE/pubmed, EMBASE, Scopus, Web of Science, and the Cochrane Library databases, and gray literature. Results: Seventeen different drugs were evaluated, and the most frequent histological subtype was adenoid cystic carcinoma (n=195, 45.5%). Stable disease, observed in 11 ST, achieved the highest rate in adenoid cystic carcinoma treated with sunitinib. The highest complete (11.1%) and partial response (30.5%) rates were seen in androgen receptor-positive tumors treated with leuprorelin acetate. Conclusions: Despite all the advances in this field, there is yet no effective evidence-based regimen of ST, with all the clinical trials identified showing low rates of complete and partial responses. Further, translational studies are urgently required to characterize molecular targets and effective ST.
MeSH term(s)	Humans ; Carcinoma, Adenoid Cystic/drug therapy ; Salivary Gland Neoplasms/drug therapy ; Databases, Factual ; Salivary Glands
Language	English
Publishing date	2024-03-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2171573-7
ISSN	1698-6946 ; 1698-4447
ISSN (online)	1698-6946
ISSN	1698-4447
DOI	10.4317/medoral.26264
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Article ; Online: A comprehensive resilience assessment of Mexican tree species and their relationship with drought events over the last century.

Correa-Díaz, A / Villanueva-Díaz, J / Gómez-Guerrero, A / Martínez-Bautista, H / Castruita-Esparza, L U / Horwath, W R / Silva, L C R

Global change biology

2023 Volume 29, Issue 13, Page(s) 3652–3666

Abstract	The resilience of forests to drought events has become a major natural resource sustainability concern, especially in response to climate change. Yet, little is known about the legacy effects of repeated droughts, and tree species ability to respond across environmental gradients. In this study, we used a tree-ring database (121 sites) to evaluate the overall resilience of tree species to drought events in the last century. We investigated how climate and geography affected the response at the species level. We evaluated temporal trends of resilience using a predictive mixed linear modeling approach. We found that pointer years (e.g., tree growth reduction) occurred during 11.3% of the 20th century, with an average decrease in tree growth of 66% compared to the previous period. The occurrence of pointer years was associated with negative values of the Standardized Precipitation Index (SPI, 81.6%) and Palmer Drought Severity Index (PDSI, 77.3%). Tree species differed in their resilience capacity, however, species inhabiting xeric conditions were less resistant but with higher recovery rates (e.g., Abies concolor, Pinus lambertiana, and Pinus jeffreyi). On average, tree species needed 2.7 years to recover from drought events, with extreme cases requiring more than a decade to reach pre-drought tree growth rates. The main abiotic factor related to resilience was precipitation, confirming that some tree species are better adapted to resist the effects of droughts. We found a temporal variation for all tree resilience indices (scaled to 100), with a decreasing resistance (-0.56 by decade) and resilience (-0.22 by decade), but with a higher recovery (+1.72 by decade) and relative resilience rate (+0.33 by decade). Our results emphasize the importance of time series of forest resilience, particularly by distinguishing the species-level response in the context of legacy of droughts, which are likely to become more frequent and intense under a changing climate.
MeSH term(s)	Trees ; Droughts ; Forests ; Pinus ; Abies/physiology ; Climate Change
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16705
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Article: Some aspects of rheumatism

SILVA, L C

Revista medica de Valparaiso

2007 Volume 2, Issue 2, Page(s) 102–109

Title translation	Algunos aspectos de los reumatismos
MeSH term(s)	Arthritis ; Arthritis, Rheumatoid ; Humans
Language	Spanish
Publishing date	2007-12-15
Publishing country	Chile
Document type	Journal Article
ISSN	0034-9917
ISSN	0034-9917
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Article ; Online: O bem-estar do doente paliativo

Ana Carolina Silva L. C. Ponte / José Luís Pais-Ribeiro

Cadernos de Saúde, Vol

revisão bibliográfica

2016 Volume 8

Abstract: O que nos faz sentir bem é uma interrogação desde a antiguidade. Tem-se verificado uma mudança de paradigma na investigação com uma maior atenção dedicada às variáveis positivas. Baseado numa conceção hedónica, o bem-estar subjetivo é um conceito-chave ... ...

Abstract	O que nos faz sentir bem é uma interrogação desde a antiguidade. Tem-se verificado uma mudança de paradigma na investigação com uma maior atenção dedicada às variáveis positivas. Baseado numa conceção hedónica, o bem-estar subjetivo é um conceito-chave da psicologia positiva que ao priorizar o ponto de vista das pessoas permite aceder à sua qualidade de vida percebida. O objetivo deste trabalho é conhecer o bem-estar do doente paliativo. Para tal foi efetuada uma ampla pesquisa acerca deste tema, recorrendo maioritariamente a artigos de revistas científicas internacionais e livros de referência. Abordam-se os conceitos de cuidados paliativos e de bem-estar e o estado da arte ao nível do bem-estar subjetivo. São ainda aprofundadas a realidade de ser um doente paliativo, os aspetos promotores e inibidores do seu bem-estar, bem como o papel da família e dos profissionais de saúde nesta equação. O artigo finaliza com a consideração que usufruir de cuidados paliativos assume um papel preponderante no bem-estar do doente, porém o seu acesso ainda é limitado. Com o acompanhamento adequado o doente paliativo pode alcançar uma boa perceção de bem-estar, mesmo em fim de vida.
Keywords	Bem-estar subjectivo ; Doente paliativo ; Revisão bibliográfica ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Universidade Católica Portuguesa, Instituto de Ciências da Saúde
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Arthroscopic evaluation of the synovial membrane and its relationship with histological changes and biomarkers in equine joint disease

Agreste, F.R. / Moreira, J.J. / Fülber, J. / Bogossian, P.M. / Chaible, L.M. / Silva, L.C.L.C. / Michelacci, Y.M. / Baccarin, R.Y.A.

Research in veterinary science. 2021 Nov., v. 140

2021

Abstract: The synovial membrane (SM) presents itself with distinctive characteristics during arthroscopic procedures in cases of osteoarthritis (OA) as well as osteochondritis dissecans (OCD) in horses. Most of the arthroscopic findings of the SM are limited to a ... ...

Abstract	The synovial membrane (SM) presents itself with distinctive characteristics during arthroscopic procedures in cases of osteoarthritis (OA) as well as osteochondritis dissecans (OCD) in horses. Most of the arthroscopic findings of the SM are limited to a description of a nonspecific inflammation state. In the present study, the macroscopic and histological aspects of the SM in OA and OCD horses were compared to those of healthy horses. The expression of interleukin (IL) in SM was also investigated. Besides, the concentrations of ILs and keratan sulfate (KS) in the synovial fluid (SF), and the molecular weights of the SF hyaluronic acid (HA) were also determined and correlated to the macroscopic and histological aspects of SM. This study included 10 healthy horses (control group), 12 horses with OA, and 12 with OCD. Macroscopic scores of the SM were higher in the OA group in comparison to the control and OCD groups. However, histological scores between OA and OCD were not different, and both were higher than the control group. Only in the OA group, there was a correlation between macroscopic and histological aspects of the SM, especially between volume and quantity of villi with perivascular inflammatory cells and synovial proliferation. The OA group has shown decreased expression of IL-10 in the SM, lower IL-10 and KS, and higher IL-1β and IL-6 in the SF in comparison to the control and OCD groups. There was a significant negative correlation between the macroscopic aspect of the SM and the molecular weights AH in the OA group. There was no correlation between the macroscopic aspect of the SM and all dosages in the OA and OCD group. In the OA joints, the evaluation of the shape of the SM during arthroscopy promotes a better indicator for joint inflammatory or tissue repair processes, while in the osteochondritic joints, investigation of the histological aspects are recommended to rule out an incipient OA development process. Both are helpful and should be considered to guide the postoperative treatment.
Keywords	arthroscopy ; biomarkers ; histology ; horses ; hyaluronic acid ; inflammation ; interleukin-10 ; interleukin-6 ; osteoarthritis ; osteochondritis dissecans ; research ; sulfates ; synovial fluid ; tissue repair ; veterinary medicine
Language	English
Dates of publication	2021-11
Size	p. 212-220.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2021.09.003
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Article ; Online: 1-Deoxysphingolipids.

Lone, M A / Santos, T / Alecu, I / Silva, L C / Hornemann, T

Biochimica et biophysica acta. Molecular and cell biology of lipids

2019 Volume 1864, Issue 4, Page(s) 512–521

Abstract: Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and ... ...

Abstract	Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.
MeSH term(s)	Animals ; Eukaryota/metabolism ; Gene Regulatory Networks ; Humans ; Molecular Structure ; Sphingolipids/chemistry ; Sphingolipids/metabolism
Chemical Substances	1-deoxysphingolipid ; Sphingolipids
Language	English
Publishing date	2019-01-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	60-7
ISSN	1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbalip.2018.12.013
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