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  1. Article ; Online: From moral rights to legal rights? Lessons from healthcare contexts.

    Da Silva, Michael

    Developing world bioethics

    2024  Volume 24, Issue 1, Page(s) 21–30

    Abstract: Many believe the existence of a moral right to some good should lead to recognition of a corresponding legal right to that good. If, for instance, there is a moral right to healthcare, it is natural to believe countries should recognize a legal right to ... ...

    Abstract Many believe the existence of a moral right to some good should lead to recognition of a corresponding legal right to that good. If, for instance, there is a moral right to healthcare, it is natural to believe countries should recognize a legal right to healthcare. This article demonstrates that justifying legal rights to healthcare is more difficult than many assume. The existence of a moral right is insufficient to justify recognition of a corresponding justiciable constitutional right. Further conditions on when it is appropriate to recognize constitutional rights are rarely satisfied in the healthcare case. And focusing on aspirational or statutory rights presents costs for those seeking to justify legal rights on the basis of corresponding moral ones while maintaining empirical challenges for justifying constitutional rights. This suggests movement from a moral right to a corresponding legal one is far from straightforward and justifies examining alternative means of realizing moral socio-economic rights such as the proposed moral right to healthcare.
    MeSH term(s) Humans ; Morals ; Civil Rights
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049034-3
    ISSN 1471-8847 ; 1471-8731
    ISSN (online) 1471-8847
    ISSN 1471-8731
    DOI 10.1111/dewb.12444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5461: Show issues Location:
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  2. Article ; Online: Morality and Access to Essential Medicines: Pairing the Theoretical and Practical.

    Da Silva, Michael / Albertsen, Andreas

    Developing world bioethics

    2024  Volume 24, Issue 1, Page(s) 3–5

    MeSH term(s) Humans ; Morals ; Health Services Accessibility ; Drugs, Essential
    Chemical Substances Drugs, Essential
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2049034-3
    ISSN 1471-8847 ; 1471-8731
    ISSN (online) 1471-8847
    ISSN 1471-8731
    DOI 10.1111/dewb.12445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to the Letter to the Editor "The risk of local anesthetic systemic toxicity is increased in patients with critically low weight and muscle mass".

    Nunes Silva, Marisa

    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

    2023  Volume 43, Issue 5, Page(s) 297

    MeSH term(s) Humans ; Anesthetics, Local/adverse effects ; Body Weight
    Chemical Substances Anesthetics, Local
    Language Portuguese
    Publishing date 2023-11-02
    Publishing country Portugal
    Document type Letter
    ZDB-ID 632718-7
    ISSN 2174-2030 ; 0870-2551 ; 0304-4750
    ISSN (online) 2174-2030
    ISSN 0870-2551 ; 0304-4750
    DOI 10.1016/j.repc.2023.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2865: Show issues Location:
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  4. Article: A hybrid-hierarchical genome assembly strategy to sequence the invasive golden mussel, Limnoperna fortunei

    Uliano da Silva, Marcela

    GigaScience, 7(2):gix128

    2017  

    Abstract: BACKGROUND: For more than 25 years, the golden mussel, Limnoperna fortunei, has aggressively invaded South American freshwaters, having travelled more than 5000 km upstream across 5 countries. Along the way, the golden mussel has outcompeted native ... ...

    Institution Leibniz-Institut für Zoo- und Wildtierforschung (Berlin)
    Abstract BACKGROUND: For more than 25 years, the golden mussel, Limnoperna fortunei, has aggressively invaded South American freshwaters, having travelled more than 5000 km upstream across 5 countries. Along the way, the golden mussel has outcompeted native species and economically harmed aquaculture, hydroelectric powers, and ship transit. We have sequenced the complete genome of the golden mussel to understand the molecular basis of its invasiveness and search for ways to control it. FINDINGS: We assembled the 1.6-Gb genome into 20 548 scaffolds with an N50 length of 312 Kb using a hybrid and hierarchical assembly strategy from short and long DNA reads and transcriptomes. A total of 60 717 coding genes were inferred from a customized transcriptome-trained AUGUSTUS run. We also compared predicted protein sets with those of complete molluscan genomes, revealing an exacerbation of protein-binding domains in L. fortunei. CONCLUSIONS: We built one of the best bivalve genome assemblies available using a cost-effective approach using Illumina paired-end, mate-paired, and PacBio long reads. We expect that the continuous and careful annotation of L. fortunei’s genome will contribute to the investigation of bivalve genetics, evolution, and invasiveness, as well as to the development of biotechnological tools for aquatic pest control.
    Keywords Amazon ; TLR ; bivalves ; blinding domain ; genomics ; transposon
    Language English
    Document type Article
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  5. Article ; Online: International Society Exposure Science Annual Meeting 2022-from exposure to human health: new developments and challenges in a changing environment.

    Viegas, S / Schlüter, U / Almeida-Silva, M

    Journal of exposure science & environmental epidemiology

    2023  Volume 33, Issue 4, Page(s) 620–621

    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-023-00567-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7529: Show issues

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  6. Article ; Online: Qualitative study exploring general dental practitioners' views of MIH and its management in the UK and Australia.

    Osborne, R / Silva, M / Taylor, G D

    International journal of paediatric dentistry

    2023  

    Abstract: Background: Molar-incisor hypomineralisation (MIH) is a prevalent condition, and how it is managed varies greatly between professional groups.: Aim: To explore, and compare, the UK and Australian general dental practitioners' management of MIH in ... ...

    Abstract Background: Molar-incisor hypomineralisation (MIH) is a prevalent condition, and how it is managed varies greatly between professional groups.
    Aim: To explore, and compare, the UK and Australian general dental practitioners' management of MIH in children.
    Design: Face-to-face (remote) semistructured interviews were undertaken, using country-specific topic guides. Participants were purposively sampled and recruited through national conferences and research networks (eviDent Foundation and Northern Dental Practice Based Research Network). Interviews (from each country) were audio-recorded, transcribed verbatim and independently analysed using thematic analysis.
    Results: Two major themes arose from the UK interviews: (i) decision-making complexities and understanding of treatment options and (ii) need for specialist input. The main Australian themes were (i) multidisciplinary approach to management supporting decision-making complexities and (ii) economic implications for care. Several difficulties, such as financial implications, multidisciplinary care and clinical decision-making, were identified as barriers to effectively managing MIH by GDPs in primary care.
    Conclusion: There are similarities and differences in the knowledge and management of MIH amongst UK and Australian nonspecialists. The different healthcare systems played a significant role in shaping how GDPs manage MIH with barriers relating to affordability, multidisciplinary care and clinical decision-making.
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070942-3
    ISSN 1365-263X ; 0960-7439
    ISSN (online) 1365-263X
    ISSN 0960-7439
    DOI 10.1111/ipd.13135
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  7. Article ; Online: Senile amyloidosis. Endoscopic findings as a starting point for diagnosis.

    Gonçalves, A / Azevedo-Silva, M / Vasconcelos, H

    Revista de gastroenterologia de Mexico (English)

    2023  Volume 88, Issue 3, Page(s) 287–288

    MeSH term(s) Humans ; Amyloidosis/diagnostic imaging ; Aging
    Language English
    Publishing date 2023-07-05
    Publishing country Mexico
    Document type Case Reports
    ZDB-ID 2828765-4
    ISSN 2255-534X ; 2255-534X
    ISSN (online) 2255-534X
    ISSN 2255-534X
    DOI 10.1016/j.rgmxen.2023.04.013
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  8. Book ; Thesis: Wirkung von Zoledronat auf Femur und Hüfte von Osteoporose-induzierten Schafen

    Pereira da Silva, Michaela

    2018  

    Author's details vorgelegt von Michaela Pereira da Silva
    Language German
    Size 70 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2019
    HBZ-ID HT020448232
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 E 602 order for loan Magazin

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  9. Article ; Online: Consumo de Bebidas Alcoólicas: Um Problema de Saúde Pública em Portugal.

    Sousa Silva, Margarida

    Acta medica portuguesa

    2022  Volume 35, Issue 7-8, Page(s) 605

    Title translation Consumption of Alcoholic Beverages: A Public Health Problem in Portugal.
    MeSH term(s) Humans ; Public Health ; Portugal/epidemiology ; Alcoholic Beverages ; Alcohol Drinking/epidemiology ; Students
    Language Portuguese
    Publishing date 2022-07-01
    Publishing country Portugal
    Document type Letter ; Comment
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.18456
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  10. Article ; Online: Immunogenic cell death in colorectal cancer: a review of mechanisms and clinical utility.

    De Silva, M / Tse, B C Y / Diakos, C I / Clarke, S / Molloy, M P

    Cancer immunology, immunotherapy : CII

    2024  Volume 73, Issue 3, Page(s) 53

    Abstract: Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide. Despite several clinical advances the survival of patients with advanced colorectal cancer remains limited, demanding newer approaches. The immune system plays ... ...

    Abstract Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide. Despite several clinical advances the survival of patients with advanced colorectal cancer remains limited, demanding newer approaches. The immune system plays a central role in cancer development, propagation, and treatment response. Within the bowel, the colorectal mucosa is a key barrier and site of immune regulation that is generally immunosuppressive. Nonetheless, within this tumour microenvironment, it is evident that anti-neoplastic treatments which cause direct cytotoxic and cytostatic effects may also induce immunogenic cell death (ICD), a form of regulated cell death that leads to an anti-tumour immune response. Therefore, novel ICD inducers and molecular biomarkers of ICD action are urgently needed to advance treatment options for advanced CRC. This article reviews our knowledge of ICD in CRC.
    MeSH term(s) Humans ; Immunogenic Cell Death ; Colorectal Neoplasms/drug therapy ; Immunosuppressive Agents ; Tumor Microenvironment
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2024-02-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-024-03641-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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