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  1. Article: Corrigendum: In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity.

    Silva, Nádia / Campinho, Marco António

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1228183

    Abstract: This corrects the article DOI: 10.3389/fendo.2023.1157685.]. ...

    Abstract [This corrects the article DOI: 10.3389/fendo.2023.1157685.].
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1228183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity.

    Silva, Nádia / Campinho, Marco António

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1157685

    Abstract: Background: Maternally derived thyroid hormone (T3) is a fundamental factor for vertebrate neurodevelopment. In humans, mutations on the thyroid hormones (TH) exclusive transporter monocarboxylic acid transporter 8 (: Methods: Using a zebrafish Mct8 ... ...

    Abstract Background: Maternally derived thyroid hormone (T3) is a fundamental factor for vertebrate neurodevelopment. In humans, mutations on the thyroid hormones (TH) exclusive transporter monocarboxylic acid transporter 8 (
    Methods: Using a zebrafish Mct8 knockdown model, with consequent inhibition of maternal thyroid hormones (MTH) uptake to the target cells, we analyzed genes modulated by MTH by qPCR in a temporal series from the start of segmentation through hatching. Survival (TUNEL) and proliferation (PH3) of neural progenitor cells (
    Discussion: The findings show that MTH allows the enrichment of neural progenitor pools, regulating the cell diversity output observed by the end of embryogenesis and that Mct8 impairment restricts CNS development. This work contributes to the understanding of the cellular mechanisms underlying human AHDS.
    MeSH term(s) Animals ; Humans ; Zebrafish/genetics ; Thyroid Hormones/metabolism ; Muscle Hypotonia/genetics ; Muscular Atrophy/metabolism ; Membrane Transport Proteins/metabolism
    Chemical Substances Thyroid Hormones ; Membrane Transport Proteins
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1157685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Review on Generation and Characterization of Copper Particles and Copper Composites Prepared by Mechanical Milling on a Lab-Scale.

    Sandoval, Sebastián Salazar / Silva, Nataly

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: This review aims to expose mechanical milling as an alternative method for generating copper-based particles (copper particles (CuP) and copper composites (CuC)); more specifically, via a top-down or bottom-up approach, on a lab-scale. This work will ... ...

    Abstract This review aims to expose mechanical milling as an alternative method for generating copper-based particles (copper particles (CuP) and copper composites (CuC)); more specifically, via a top-down or bottom-up approach, on a lab-scale. This work will also highlight the different parameters that can affect the size distribution, the type, and the morphology of the obtained CuP or CuC, such as the type of mechanical mill, ball-to-powder ratios (BPR), the milling speed, milling time, and the milling environment, among others. This review analyzes various papers based on the Cu-based particle generation route, which begins with a pretreatment step, then mechanical milling, its approach (top-down or bottom-up), and the post-treatment. Finally, the characterization methods of the resulting CuP and CuC through mechanical milling are also discussed.
    MeSH term(s) Copper ; Particle Size ; Powders
    Chemical Substances Copper (789U1901C5) ; Powders
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hidden figures: how legal experts influence the design of international institutions.

    De Silva, Nicole / Holthoefer, Anne

    European journal of international relations

    2023  Volume 30, Issue 1, Page(s) 52–77

    Abstract: Whose preferences influence the design of international institutions? Scholarship on the legalization of international politics and creation of international legal institutions largely adopts a state-centric perspective. Existing accounts, however, fail ... ...

    Abstract Whose preferences influence the design of international institutions? Scholarship on the legalization of international politics and creation of international legal institutions largely adopts a state-centric perspective. Existing accounts, however, fail to recognize how states often delegate authority over institutional design tasks to independent legal experts whose preferences may diverge from those of states. We develop a principal-agent (PA) framework for theorizing relations between states (collective principals) and legal actors (agents) in the design process, and for explaining how legal actors influence the design of international institutions. The legal dimensions of the PA relationship increase the likelihood of preference divergence between the collective principal and the agent, but also create conditions that enable the agent to opportunistically advance its own design preferences. We argue that the more information on states' preferences the agent has, the more effectively it can exploit its legal expertise to strategically select and justify design choices that maximize its own preferences and the likelihood of states' acceptance. Our analysis of two cases of delegated institutional design concerning international criminal law at the United Nations and the African Union supports our theoretical expectations. Extensive archival and interview data elucidate how agents' variable information on states' preferences affects their ability to effectively advance their design preferences. Our theory reveals how independent legal experts with delegated authority over design tasks influence institutional design processes and outcomes, which has practical and normative implications for the legalization of international politics.
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1482719-0
    ISSN 1460-3713 ; 1354-0661
    ISSN (online) 1460-3713
    ISSN 1354-0661
    DOI 10.1177/13540661231210931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Replacing plastic with corrugated cardboard: A carbon footprint analysis of disposable packaging in a B2B global supply chain—A case study

    Silva, Nathalie / Molina-Besch, Katrin

    Resources, Conservation & Recycling. 2023 Apr., v. 191 p.106871-

    2023  

    Abstract: Industry is increasingly committed to reduce its ecological footprint. One specific area of increased industrial interest is the use of plastic-free packaging. Plastic packaging is efficient from a supply chain perspective, but as waste risks causing ... ...

    Abstract Industry is increasingly committed to reduce its ecological footprint. One specific area of increased industrial interest is the use of plastic-free packaging. Plastic packaging is efficient from a supply chain perspective, but as waste risks causing disastrous environmental effects. This case study assesses the environmental impacts (from cradle to grave) of plastic cushioning inserts vs. corrugated cardboard cushioning inserts. The cushioning options have different measurements requiring different box sizes. The carbon footprint calculation covers the main phases of the packaging life cycle: manufacturing, transport and end-of-life processes. Calculation results show that the corrugated cardboard option has the highest carbon footprint, due to weight increase along with long transport distances and high dependence on airfreight. The results reinforce the importance of developing alternatives to plastic packaging without increasing packaging weight. Managerial implications and suggestions for policymakers are presented and discussed.
    Keywords carbon footprint ; cardboard ; case studies ; cradle-to-grave ; industry ; plastics ; supply chain ; Case study ; LCA ; Packaging ; Plastic
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1498716-8
    ISSN 0921-3449
    ISSN 0921-3449
    DOI 10.1016/j.resconrec.2023.106871
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: The scratch card gambler: a hidden reality.

    Maurício, Daniela / Rodrigues-Silva, Nuno

    Journal of gambling studies

    2022  Volume 39, Issue 3, Page(s) 1099–1110

    Abstract: Scratch cards-otherwise known as scratch tickets or instant lotteries-are a highly accessible type of lottery, due to its relative accessibility and affordability. In Portugal, the popularity of scratch cards has experienced substantial growth, with ... ...

    Abstract Scratch cards-otherwise known as scratch tickets or instant lotteries-are a highly accessible type of lottery, due to its relative accessibility and affordability. In Portugal, the popularity of scratch cards has experienced substantial growth, with almost no regulatory reaction whatsoever. This study aims to describe the sociodemographic characteristics of scratch card gamblers, prevalent gambling habits, and their perceptions regarding scratch card gambling. This study also determines the constancy of pathological scratch card gambling, and the possible impact of regulatory measures. We found that about half of the participants studied were at risk of pathological gambling and scratch cards seem to have a clear potential for enticing higher spending in vulnerable consumers, compared to other forms of gambling games. Perception biases regarding gambling are frequent and almost no one afflicted seeks help. Regulatory measures are crucial to regulate potential problematic behaviors, specifically in high-risk persons. There is an urgent need to act, made clear by both present findings and numerous precedent warnings regarding scratch card gambling hazards.
    MeSH term(s) Humans ; Gambling/psychology ; Behavior, Addictive ; Bias ; Surveys and Questionnaires ; Portugal
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016895-0
    ISSN 1573-3602 ; 1050-5350
    ISSN (online) 1573-3602
    ISSN 1050-5350
    DOI 10.1007/s10899-022-10136-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Family participation in the care of the critical patient: An exploratory study.

    Sepúlveda-Hermosilla, D / Irarrázabal-Vargas, L / Rojas Silva, N

    Enfermeria intensiva

    2022  Volume 33, Issue 4, Page(s) 173–184

    Abstract: Objectives: To determine the level of readiness of the healthcare team regarding family participation in the care of the critically ill adult and their relationship with the individual characteristics of the participants in a medical-surgical intensive ... ...

    Abstract Objectives: To determine the level of readiness of the healthcare team regarding family participation in the care of the critically ill adult and their relationship with the individual characteristics of the participants in a medical-surgical intensive care unit (ICU) in Santiago de Chile.
    Method: A cross-sectional correlational study using a quantitative method and including a focus group to explore the perception of healthcare staff of family participation in the care of the critically ill patient.
    Results: The level of readiness of the healthcare team for family participation in the care of the critically ill patient is medium, at 13.81 out of a total 20. The greater the readiness, the lower the age (r = -0.215; P = 0.019), the higher the rating of previous experience working with families (r = 0.304; P = 0.006), and the higher the perception of being comfortable with different activities in the care of the critical patient (r = 0.495: P < 0.001). The participants also state that the work environment of the unit, the patient's condition, the relatives' characteristics, personal judgement, and the preparedness of relatives affect their readiness.
    Conclusions: The results contribute towards determining the healthcare team's level of readiness in a setting where the subject of the study has not been implemented. The readiness of the healthcare team is medium, and is related to individual characteristics of the healthcare staff, and to organizational and family aspects. Therefore, strategies are required to address these aspects that might increase readiness.
    Language English
    Publishing date 2022-11-05
    Publishing country Spain
    Document type Journal Article
    ISSN 2529-9840
    ISSN (online) 2529-9840
    DOI 10.1016/j.enfie.2021.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Efficacy, tolerance and acceptability of pulsed dye laser on facial and neckline telangiectasias in systemic scleroderma: a prospective open-label monocentric study in 21 patients.

    Kottler, D / Dupechez, L / Martin Silva, N / Boutemy, J / Dumont, A / Maigné, G / Aouba, A / Dompmartin, A

    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

    2024  Volume 25, Issue 5-8, Page(s) 77–85

    Abstract: Facial and neckline telangiectasias have an underestimated yet important impact on quality of life of patients with systemic scleroderma (SSc). This monocentric, prospective, open-label, intra-patient comparative study was conducted in 21 consecutive ... ...

    Abstract Facial and neckline telangiectasias have an underestimated yet important impact on quality of life of patients with systemic scleroderma (SSc). This monocentric, prospective, open-label, intra-patient comparative study was conducted in 21 consecutive patients with SSc. Patients underwent 4 sessions of PDL 8 weeks apart. A final quadruple assessment was performed by several raters 2 months after the last session, based on the following criteria: change in telangiectasia number; subjective improvement score (LINKERT scale); impact on the quality of life (QoL; SKINDEX score); visual analog pain scale; adverse effects (AEs), including treatment discontinuation for PDL-induced purpura and patient satisfaction. The mean telangiectasia number decreased by 5 (32%) at the end of the protocol. Eighteen patients (85.7%) reported an improvement or a strong improvement, versus 73.81% for the expert committee. Immediate session pain (mean = 3.4/10) was slightly less than overall pain (mean = 4.6/10). Ten patients (47%) experienced at least one AE (oozing/crusts, edema, epidermal blistering), including PDL-induced purpura in 3 patients (14%). AEs were mostly transient (<1 week) and mild (CTCAE grade 1). All QoL parameters improved after treatment, and 85% of patients were satisfied.
    MeSH term(s) Humans ; Lasers, Dye/adverse effects ; Pain ; Prospective Studies ; Purpura ; Quality of Life ; Scleroderma, Systemic/complications ; Telangiectasis/etiology ; Telangiectasis/therapy ; Treatment Outcome
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2146360-8
    ISSN 1476-4180 ; 1476-4172
    ISSN (online) 1476-4180
    ISSN 1476-4172
    DOI 10.1080/14764172.2024.2313472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A revised, annotated checklist of Mexican non-biting midges (Diptera, Chironomidae).

    Bello-González, Orestes C / Andersen, Trond / Mercado-Silva, Norman

    ZooKeys

    2024  Volume 1191, Page(s) 237–286

    Abstract: An updated checklist of Mexican non-biting midges (Chironomidae) is presented. A total of 110 species of Chironomidae are known for Mexico: 52 species in 25 genera belong to the subfamily Chironominae, 30 species in 13 genera to Orthocladiinae, 21 ... ...

    Abstract An updated checklist of Mexican non-biting midges (Chironomidae) is presented. A total of 110 species of Chironomidae are known for Mexico: 52 species in 25 genera belong to the subfamily Chironominae, 30 species in 13 genera to Orthocladiinae, 21 species in nine genera to Tanypodinae, five species in two genera to Telmatogetoninae, and two species in one genus to Diamesinae. In addition, 41 genera without identified species are listed. The highest number of species (29) is recorded from the state of Campeche, while 19 species have been found in Veracruz and 15 in Nuevo León. Few or no records exist for states in Central and Northern Mexico, or those on the Pacific coast. The type localities for 34 species are in Mexico; of these, 27 species (25% of the total number of species recorded in the country) are endemic. Twenty-nine species recorded in Mexico have a Neotropical distribution, 15 a Nearctic distribution, and 39 species are distributed in both the Neotropical and Nearctic regions or more widely. It has been suggested that as many as 1000 species might occur in Mexico; so only a little more than 10% of the expected diversity has so far been recorded.
    Language English
    Publishing date 2024-02-14
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.1191.117223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Severity of SARS-CoV-2 infection among vaccinated individuals: A hospital-based study.

    Govindapala, Dumitha / Jayasekara, Priyamali / Rajramanan, Rajmohan / de Silva, Nipun

    The Ceylon medical journal

    2024  Volume 67, Issue 4, Page(s) 143–150

    Abstract: Introduction: Post-vaccination infections impart the need for real-world data on protection conferred by the vaccines against SARS-CoV-2. We aimed to evaluate the severity of post-vaccination COVID-19 and the predictors of severe disease.: Methods: ... ...

    Abstract Introduction: Post-vaccination infections impart the need for real-world data on protection conferred by the vaccines against SARS-CoV-2. We aimed to evaluate the severity of post-vaccination COVID-19 and the predictors of severe disease.
    Methods: This cross-sectional study analysed data from 307 patients admitted to the University Hospital KDU with confirmed COVID- 19 from March 1st to November 1st, 2021, after receiving at least a single dose of a vaccine against SARS-CoV-2. Vaccination status and the disease severity were classified using standard definitions. A binary logistic regression model was fitted to investigate severe/critical disease predictors.
    Results: Of the surveyed patients, 122(39.7%) were fully vaccinated, 127(41.4%) were partially vaccinated and 58 (18.9%) had developed the disease within 14 days of the first vaccine dose. Most were Sinopharm vaccine recipients (52.4 %). Non- severe disease was observed among 249(81.1%) patients and 47(15.3%) had severe disease, while 11(3.6%) needed ICU care (critical illness). Severe/critical disease was reported among 32(25.2%) partially vaccinated and 13(22.4%) patients who developed the disease within 14 days of the first vaccine dose. Of the patients deemed to have vaccine breakthrough infections (122 fully vaccinated patients), 13(10.6%) suffered severe/critical disease. Patients with comorbidity experienced more severe/critical illness (adjusted odds ratio [AOR]= 3.684, P=0.003) than those without pre-existing medical conditions. Disease progression to severe or critical illness was significantly higher among Sinopharm recipients than Covisheild recipients (AOR:2.064, P=0.048).
    Conclusions: Comorbidity was the most important predictor of severe COVID-19 irrespective of the vaccination status. Observed higher incidence of severe disease among Sinopharm recipients warrants more extensive population studies.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Critical Illness ; Cross-Sectional Studies ; Hospitals
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-02-28
    Publishing country Sri Lanka
    Document type Journal Article
    ZDB-ID 419365-9
    ISSN 0009-0875
    ISSN 0009-0875
    DOI 10.4038/cmj.v67i4.9742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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