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  1. Book: Computational methods in molecular biology

    Silva, Nayara S. R. / Gonçalves, Luana K. S.

    2017  

    Author's details Contributor Nayara R. S. Silva, Luana K. S. Gonçalves, et al
    Language English
    Size 232 Seiten, Illustrationen, Diagramme
    Publisher Koros Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019368028
    ISBN 978-1-78569-490-5 ; 1-78569-490-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 C 46 order for loan Magazin

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  2. Article ; Online: The efficacy of neuromuscular training, with minimal or no equipment, on performance of youth athletes: A systematic review with meta-analysis.

    Muller, Marina R / Lemes, Ítalo R / Silva, Michelle S de C / Silva, Nayara S / Hernández, Arely G M / Pinto, Rafael Z

    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

    2023  Volume 64, Page(s) 104–116

    Abstract: Objectives: To investigate the effects of neuromuscular training, with minimal or no equipment, on physical performance of youth athletes.: Design: Systematic review with meta-analysis.: Methods: MEDLINE, EMBASE, CENTRAL, CINAHL, PEDro and ... ...

    Abstract Objectives: To investigate the effects of neuromuscular training, with minimal or no equipment, on physical performance of youth athletes.
    Design: Systematic review with meta-analysis.
    Methods: MEDLINE, EMBASE, CENTRAL, CINAHL, PEDro and SportDiscuss from inception to March/2022.
    Selection criteria: youth athletes (15-24years), from Olympic team sports; used neuromuscular training 2-3 times/week for, at least, 6 weeks; had a control group/usual training group; physical performance as outcomes; randomized controlled trial.
    Data synthesis: Pooled estimate of standardized mean difference (SMD), and 95% confidence interval (95%CI).
    Results: Thirty-four studies (1111 participants) were included. Results showed that neuromuscular training improved power (SMD: 0.84 [95%CI: 0.58, 1.10]; n = 805; I
    Conclusion: Clinically, neuromuscular training with minimal equipment may be useful for teams with limited resources to improve mainly athletes' power and agility, including those interventions that were designed to injury prevention. Future high-quality studies are likely to change these estimates.
    MeSH term(s) Humans ; Adolescent ; Sports ; Muscle Strength/physiology ; Athletes ; Quadriceps Muscle ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2008604-0
    ISSN 1873-1600 ; 1466-853X
    ISSN (online) 1873-1600
    ISSN 1466-853X
    DOI 10.1016/j.ptsp.2023.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5218: Show issues Location:
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  3. Article ; Online: Complex regulatory networks influence pluripotent cell state transitions in human iPSCs.

    Arthur, Timothy D / Nguyen, Jennifer P / D'Antonio-Chronowska, Agnieszka / Matsui, Hiroko / Silva, Nayara S / Joshua, Isaac N / Luchessi, André D / Greenwald, William W Young / D'Antonio, Matteo / Pera, Martin F / Frazer, Kelly A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1664

    Abstract: Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing hundreds of hiPSCs derived from different individuals, we show the proportions of these pluripotent states vary considerably across lines. We discover 13 gene ... ...

    Abstract Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing hundreds of hiPSCs derived from different individuals, we show the proportions of these pluripotent states vary considerably across lines. We discover 13 gene network modules (GNMs) and 13 regulatory network modules (RNMs), which are highly correlated with each other suggesting that the coordinated co-accessibility of regulatory elements in the RNMs likely underlie the coordinated expression of genes in the GNMs. Epigenetic analyses reveal that regulatory networks underlying self-renewal and pluripotency are more complex than previously realized. Genetic analyses identify thousands of regulatory variants that overlapped predicted transcription factor binding sites and are associated with chromatin accessibility in the hiPSCs. We show that the master regulator of pluripotency, the NANOG-OCT4 Complex, and its associated network are significantly enriched for regulatory variants with large effects, suggesting that they play a role in the varying cellular proportions of pluripotency states between hiPSCs. Our work bins tens of thousands of regulatory elements in hiPSCs into discrete regulatory networks, shows that pluripotency and self-renewal processes have a surprising level of regulatory complexity, and suggests that genetic factors may contribute to cell state transitions in human iPSC lines.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells/metabolism ; Gene Regulatory Networks ; Chromatin/genetics ; Cell Differentiation/genetics ; Octamer Transcription Factor-3/genetics
    Chemical Substances Chromatin ; Octamer Transcription Factor-3
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45506-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Does the Number of Comorbidities Predict Pain and Disability in Older Adults With Chronic Low Back Pain? A Longitudinal Study With 6- and 12-Month Follow-ups.

    Lemes, Ítalo R / Morelhão, Priscila K / Verhagen, Arianne / Gobbi, Cynthia / Oliveira, Crystian B / Silva, Nayara S / Lustosa, Lygia P / Franco, Márcia R / Pinto, Rafael Z

    Journal of geriatric physical therapy (2001)

    2023  Volume 47, Issue 1, Page(s) 21–27

    Abstract: Background and purpose: People who live longer often live with multimorbidity. Nevertheless, whether the presence of multimorbidity affects pain and disability in older adults with chronic low back pain (LBP) remains unclear. The aim of this study was ... ...

    Abstract Background and purpose: People who live longer often live with multimorbidity. Nevertheless, whether the presence of multimorbidity affects pain and disability in older adults with chronic low back pain (LBP) remains unclear. The aim of this study was to investigate whether multimorbidity predicts pain intensity and disability at 6- and 12-month follow-ups in older adults with chronic LBP.
    Methods: This was a prospective, longitudinal study with 6- and 12-month follow-ups. Participants with chronic LBP (age ≥ 60 years) were recruited and interviewed at baseline, 6 months, and 12 months. Self-reported measures included the number of comorbidities, assessed through the Self-Administered Comorbidity Questionnaire, pain intensity, assessed with the 11-point Numerical Rating Scale, and disability, assessed with the Roland-Morris Disability Questionnaire. Data were analyzed using univariate and multivariate regression models.
    Results and discussion: A total of 220 participants were included. The number of comorbidities predicted pain intensity at 6-month (β= 0.31 [95% CI: 0.12 to 0.50]) and 12-month (β= 0.29 [95% CI: 0.08 to 0.50]) follow-ups. The number of comorbidities predicted disability at 6-month (β= 0.55 [95% CI: 0.20 to 0.90]) and 12-month (β= 0.40 [95% CI: 0.03 to 0.77]) follow-ups.
    Conclusion: The number of comorbidities at baseline predicted pain and disability at 6-month and 12-month follow-ups in older adults with chronic LBP. These results highlight the role of comorbidities as a predictive factor of pain and disability in patients with chronic LBP, emphasizing the need for timely and continuous interventions in older adults with multimorbidity to mitigate LBP-related pain and disability.
    MeSH term(s) Humans ; Aged ; Low Back Pain/epidemiology ; Longitudinal Studies ; Follow-Up Studies ; Prospective Studies ; Comorbidity ; Disability Evaluation
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250801-6
    ISSN 2152-0895 ; 1539-8412
    ISSN (online) 2152-0895
    ISSN 1539-8412
    DOI 10.1519/JPT.0000000000000400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article: Analysis of regulatory network modules in hundreds of human stem cell lines reveals complex epigenetic and genetic factors contribute to pluripotency state differences between subpopulations.

    Arthur, Timothy D / Nguyen, Jennifer P / D'Antonio-Chronowska, Agnieszka / Matsui, Hiroko / Silva, Nayara S / Joshua, Isaac N / Luchessi, André D / Young Greenwald, William W / D'Antonio, Matteo / Pera, Martin F / Frazer, Kelly A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Stem cells ... ...

    Abstract Stem cells exist
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.20.541447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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