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  1. Article ; Online: Double-checking chromosome segregation.

    Maiato, Helder / Silva, Sónia

    The Journal of cell biology

    2023  Volume 222, Issue 5

    Abstract: Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei-key intermediates of a rapid mutational process known as chromothripsis ... ...

    Abstract Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei-key intermediates of a rapid mutational process known as chromothripsis that is found in cancer and congenital disorders. The spindle assembly checkpoint (SAC) has been viewed as the sole surveillance mechanism that prevents chromosome segregation errors during mitosis and meiosis. However, different types of chromosome segregation errors stemming from incorrect kinetochore-microtubule attachments satisfy the SAC and are more frequent than previously anticipated. Remarkably, recent works have unveiled that most of these errors are corrected during anaphase and only rarely result in aneuploidy or formation of micronuclei. Here, we discuss recent progress in our understanding of the origin and fate of chromosome segregation errors that satisfy the SAC and shed light on the surveillance, correction, and clearance mechanisms that prevent their transmission, to preserve genomic stability.
    MeSH term(s) Humans ; Anaphase ; Aneuploidy ; Chromosome Segregation ; Kinetochores ; Microtubules ; Mitosis ; Spindle Apparatus ; Genomic Instability
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202301106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carta ao Editor: Recomendações na Abordagem do Doente com Hidradenite Supurativa.

    Ferreira Silva, Sónia / Rodrigues Ribeiro, Raquel / Cabanelas, Miguel

    Acta medica portuguesa

    2023  Volume 36, Issue 9, Page(s) 611–612

    Title translation Letter to the Editor: Guidelines for Management of Patients with Hidradenitis Suppurativa.
    MeSH term(s) Humans ; Hidradenitis Suppurativa/therapy
    Language Portuguese
    Publishing date 2023-08-24
    Publishing country Portugal
    Document type Letter ; Comment
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.20067
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  3. Article: Candida Albicans

    Henriques, Mariana / Silva, Sónia

    Microorganisms

    2021  Volume 9, Issue 4

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9040704
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  4. Article: Candida Albicans Virulence Factors and Its Pathogenicity

    Henriques, Mariana / Silva, Sónia

    Microorganisms. 2021 Mar. 29, v. 9, no. 4

    2021  

    Abstract: Candida albicans lives as commensal on the skin and mucosal surfaces of the genital, intestinal, vaginal, urinary, and oral tracts of 80% of healthy individuals [ ... ] ...

    Abstract Candida albicans lives as commensal on the skin and mucosal surfaces of the genital, intestinal, vaginal, urinary, and oral tracts of 80% of healthy individuals [...]
    Keywords Candida albicans ; intestines ; virulence
    Language English
    Dates of publication 2021-0329
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9040704
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  5. Article: Differential NMR and chromatography for the detection and analysis of adulteration of vetiver essential oils

    Schripsema, Jan / da Silva, Sônia Maria / Dagnino, Denise

    Talanta. 2022 Jan. 15, v. 237

    2022  

    Abstract: Adulteration of essential oils is a common and serious problem. Adequate and fast methods are required to establish the authenticity and purity. GC-MS, ¹H and ¹³C NMR were compared in combination with similarity calculations as well as differential ... ...

    Abstract Adulteration of essential oils is a common and serious problem. Adequate and fast methods are required to establish the authenticity and purity. GC-MS, ¹H and ¹³C NMR were compared in combination with similarity calculations as well as differential spectroscopy and chromatography for the authentication and determination of purity of vetiver essential oils. In the investigation of eight commercial oils ¹H and ¹³C NMR adequately detected all six adulterants encountered in four of the commercial samples, while GC-MS was not able to detect adulteration with vegetable oils. A great advantage of the combined use of similarity calculation and NMR is that the authenticity can be verified without the need of concomitant measurement of a standard sample. The calculation can be carried out with a registered reference spectrum, in the case of ¹H NMR acquired using the same magnetic field, but in the case of ¹³C NMR the spectrum can be obtained with another magnetic field. ¹H NMR has the advantage of high speed, and the results can be obtained within minutes. ¹³C NMR was found to be superior in its ability to provide unequivocal identification of eventual adulterants, with differential spectroscopy revealing all signals of the adulterants.
    Keywords adulterated products ; magnetic fields ; vegetables
    Language English
    Dates of publication 2022-0115
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2021.122928
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  6. Article ; Online: Titanium and Zinc Based Nanomaterials in Agriculture: A Promising Approach to Deal with (A)biotic Stresses?

    Silva, Sónia / Dias, Maria Celeste / Silva, Artur M S

    Toxics

    2022  Volume 10, Issue 4

    Abstract: Abiotic stresses, such as those induced by climatic factors or contaminants, and biotic stresses prompted by phytopathogens and pests inflict tremendous losses in agriculture and are major threats to worldwide food security. In addition, climate changes ... ...

    Abstract Abiotic stresses, such as those induced by climatic factors or contaminants, and biotic stresses prompted by phytopathogens and pests inflict tremendous losses in agriculture and are major threats to worldwide food security. In addition, climate changes will exacerbate these factors as well as their negative impact on crops. Drought, salinity, heavy metals, pesticides, and drugs are major environmental problems that need deep attention, and effective and sustainable strategies to mitigate their effects on the environment need to be developed. Besides, sustainable solutions for agrocontrol must be developed as alternatives to conventional agrochemicals. In this sense, nanotechnology offers promising solutions to mitigate environmental stress effects on plants, increasing plant tolerance to the stressor, for the remediation of environmental contaminants, and to protect plants against pathogens. In this review, nano-sized TiO
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10040172
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  7. Article ; Online: Nodular lesions in a newborn: what is the diagnosis?

    Ramos, Daniela / Silva, Sónia / Ramos, Leonor / Morais, Sofia

    BMJ case reports

    2022  Volume 15, Issue 11

    MeSH term(s) Humans ; Infant, Newborn ; Skin Diseases/diagnosis
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-252229
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  8. Article ; Online: RNase H1 Hybrid-Binding Domain-Based Tools for Cellular Biology Studies of DNA-RNA Hybrids in Mammalian Cells.

    Silva, Sónia / Guillén-Mendoza, Cristina / Aguilera, Andrés

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2528, Page(s) 115–125

    Abstract: R loops are abundant noncanonical DNA-RNA hybrid structures that can occur during DNA-based processes, such as transcription, replication and DNA damage, and can lead both to physiologically favorable and pathological outcomes. With an increasing body of ...

    Abstract R loops are abundant noncanonical DNA-RNA hybrid structures that can occur during DNA-based processes, such as transcription, replication and DNA damage, and can lead both to physiologically favorable and pathological outcomes. With an increasing body of work feeding the field of R loop biology, our understanding of the processes in which R loops intervene and the consequences of meddling with R loop formation and dissolution has greatly increased but it has also led to new questions and sometimes opposing possibilities. Proper detection of these structures is a crucial factor to advance our knowledge about R loops and factors associated with their formation and removal. Here, we describe the use of fluorescently tagged HBD, the hybrid-binding domain of RNase H1, as a tool for analyzing DNA-RNA hybrids in different contexts using live-cell microscopy and immunofluorescence experiments.
    MeSH term(s) Animals ; DNA/genetics ; Mammals/genetics ; R-Loop Structures ; RNA/chemistry ; RNA/genetics ; Ribonuclease H/metabolism
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2) ; Ribonuclease H (EC 3.1.26.4) ; ribonuclease HI (EC 3.1.26.4)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2477-7_8
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  9. Article ; Online: Job crafting, meaningful work and performance: a moderated mediation approach of presenteeism.

    Junça-Silva, Ana / Silva, Sónia / Caetano, António

    SN business & economics

    2022  Volume 2, Issue 4, Page(s) 31

    Abstract: This study aimed to (1) analyze the relationship between the three job crafting dimensions (task, cognitive and relational crafting) and performance; (2) explore whether meaningful work fully mediates the links between the three job crafting dimensions ... ...

    Abstract This study aimed to (1) analyze the relationship between the three job crafting dimensions (task, cognitive and relational crafting) and performance; (2) explore whether meaningful work fully mediates the links between the three job crafting dimensions and performance; (3) analyze if presenteeism moderates the indirect effect of meaningful work in the relationship between job crafting and performance. To achieve these goals, we collected data with 146 workers from a town hall. We analyzed the proposed moderated-mediation model using the PROCESS macro. The results showed that (1) the meaning in work mediated the relationship between the three job crafting dimensions and performance; (2) presenteeism moderated the mediated relationship between job crafting and performance via meaningful work, that is, lower levels of presenteeism were positively related to performance, in particular, when the levels of meaning in work were lower. These results show the importance of empowering employees to craft their work, as it appears to increase employees' performance, by enhancing the meaning attributed to the work. Promoting health conditions, at work, also seems to be relevant for performance once it may decrease levels of presenteeism. The cross-sectional design should be regarded as a limitation, and we assessed all the variables through self-reported measures. The present study contributes to the literature by analyzing the relationship of job crafting to performance via meaningful work, within the public administration context. Moreover, this study adds to the literature the conditional effect of presenteeism which has not been discussed in prior studies. This study aids in bridging this gap.
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-9399
    ISSN (online) 2662-9399
    DOI 10.1007/s43546-022-00203-8
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  10. Article ; Online: Sfl1 is required for Candida albicans biofilm formation under acidic conditions

    Gonçalves, Bruna / Barbosa, Ana / Soares, Ana Raquel / Henriques, Mariana / Silva, Sónia

    Biochimie. 2023 June, v. 209 p.37-43

    2023  

    Abstract: Candida albicans is a common Candida species, responsible for infections in various anatomical sites under different environmental conditions, aggravated in the presence of its biofilms. As such, this study aimed to reveal the regulation of C. albicans ... ...

    Abstract Candida albicans is a common Candida species, responsible for infections in various anatomical sites under different environmental conditions, aggravated in the presence of its biofilms. As such, this study aimed to reveal the regulation of C. albicans biofilms under acidic conditions by the transcription factor Sfl1, whose role on biofilm formation is unclear. For that, microbiologic and transcriptomic analyses were performed with the knock-out mutant C. albicans sfl1Δ/sfl1Δ and its parental strain SN76, grown in planktonic and biofilm lifestyles at pH 4 (vaginal pH). The results revealed that despite being a filamentation repressor Sf1 is required for maximal biofilm formation under acidic conditions. Additionally, Sfl1 was found to induce 275 and 126 genes in biofilm and planktonic cells, respectively, with an overlap of 19 genes. The functional distribution of Sfl1 targets was similar in planktonic and biofilm modes but an enrichment of carbohydrate metabolism function was found in biofilm cells, including some genes encoding proteins involved in the biofilm matrix production. Furthermore, this study shows that the regulatory network of Sfl1 in acidic biofilms is complex and includes positive and negative regulation of transcription factors involved in adhesion and biofilm formation, such as Ahr1, Brg1, Tye7, Tec1, Wor1, and some of their targets. Overall, this study shows that Sfl1 is a relevant regulator of C. albicans biofilm formation in acidic environments and contributes to a better understanding of C. albicans virulence under acidic conditions.
    Keywords Candida albicans ; adhesion ; biofilm ; carbohydrate metabolism ; knockout mutants ; pH ; plankton ; transcription factors ; transcriptomics ; virulence ; Candida biofilm ; Filamentation ; Acidic environment ; Sfl1 targets ; Regulation network
    Language English
    Dates of publication 2023-06
    Size p. 37-43.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 120345-9
    ISSN 0300-9084
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2023.01.011
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